{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:50:23Z","timestamp":1766087423964,"version":"3.37.3"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T00:00:00Z","timestamp":1556236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0215956","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T18:48:55Z","timestamp":1556304535000},"page":"e0215956","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Survival and death of intestinal cells infected by Chlamydia trachomatis"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7253-8799","authenticated-orcid":true,"given":"Claudio","family":"Foschi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Bortolotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Marziali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8051-4981","authenticated-orcid":true,"given":"Letizia","family":"Polito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7397-6560","authenticated-orcid":true,"given":"Antonella","family":"Marangoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bolognesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,4,26]]},"reference":[{"year":"2015","key":"ref1","article-title":"Sexually transmitted infection in Europe 2013"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/aje\/kws583","article-title":"Risk of pelvic inflammatory disease following <italic>Chlamydia trachomatis<\/italic> infection: analysis of prospective studies with a multistate model","volume":"178","author":"MJ Price","year":"2013","journal-title":"Am J Epidemiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1099\/jmm.0.000261","article-title":"<italic>Chlamydia trachomatis<\/italic> infection prevalence and serovar distribution in a high-density urban area in the north of Italy","volume":"65","author":"C Foschi","year":"2016","journal-title":"J Med Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1099\/jmm.0.000781","article-title":"Sexually transmitted rectal infections in a cohort of \u2018men having sex with men\u2019","volume":"67","author":"C Foschi","year":"2018","journal-title":"J Med Microbiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1128\/MR.55.1.143-190.1991","article-title":"Interaction of chlamydiae and host cells in vitro","volume":"55","author":"JW Moulder","year":"1991","journal-title":"Microbiol Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nrmicro.2016.30","article-title":"Chlamydia cell biology and pathogenesis","volume":"14","author":"C Elwell","year":"2016","journal-title":"Nat Rev Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"a010256","DOI":"10.1101\/cshperspect.a010256","article-title":"Chlamydial intracellular survival strategies","volume":"3","author":"RJ Bastidas","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"31495","DOI":"10.1074\/jbc.M602796200","article-title":"The secreted protease factor CPAF is responsible for degrading pro-apoptotic BH3-only proteins in Chlamydia trachomatis-infected cells","volume":"281","author":"M Pirbhai","year":"2006","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1111\/j.1462-5822.2011.01642.x","article-title":"HIF-1\u03b1 is involved in mediating apoptosis resistance to <italic>Chlamydia trachomatis<\/italic>-infected cells","volume":"13","author":"M Sharma","year":"2011","journal-title":"Cell Microbiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"11430","DOI":"10.1073\/pnas.0703218104","article-title":"Mechanisms of host cell exit by the intracellular bacterium Chlamydia","volume":"104","author":"K Hybiske","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/mpat.2001.0460","article-title":"Chlamydia trachomatis-induced apoptosis occurs in uninfected McCoy cells late in the developmental cycle and is regulated by the intracellular redox state","volume":"31","author":"J Sch\u00f6ier","year":"2001","journal-title":"Microb Pathog"},{"key":"ref12","first-page":"1","article-title":"Activation of caspase-3 during <italic>Chlamydia trachomatis<\/italic>-induced apoptosis at a late stage","volume":"18","author":"J Matsuo","year":"2018","journal-title":"Can J Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"29024","DOI":"10.1038\/srep29024","article-title":"Lactobacillus crispatus inhibits the infectivity of Chlamydia trachomatis elementary bodies, in vitro study","volume":"6","author":"P Nardini","year":"2016","journal-title":"Sci Rep"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.atherosclerosis.2015.05.023","article-title":"<italic>Chlamydia pneumoniae<\/italic> acute liver infection affects hepatic cholesterol and triglyceride metabolism in mice","volume":"241","author":"A Marangoni","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.phymed.2015.11.006","article-title":"Apoptosis and necroptosis induced by stenodactylin in neuroblastoma cells can be completely prevented through caspase inhibition plus catalase or necrostatin-1","volume":"23","author":"L Polito","year":"2016","journal-title":"Phytomedicine"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/jmp.12272","article-title":"Development of a rectal sexually transmitted infection (STI) Model in Rhesus macaques using Chlamydia trachomatis serovars E and L2","volume":"46","author":"TR Henning","year":"2017","journal-title":"J Med Primatol"},{"key":"ref17","first-page":"76","article-title":"Growth characteristics of Chlamydia trachomatis in human intestinal epithelial Caco-2 cells","author":"I Lantos","year":"2018","journal-title":"Pathog Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.tim.2017.12.002","article-title":"Chlamydia Spreading from the Genital Tract to the Gastrointestinal Tract\u2014A Two-Hit Hypothesis","volume":"26","author":"G Zhong","year":"2018","journal-title":"Trends Microbiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/jac\/dkx392","article-title":"Chlamydia trachomatis antimicrobial susceptibility in colorectal and endocervical cells","volume":"73","author":"C Foschi","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"6057","DOI":"10.1128\/IAI.00760-06","article-title":"Characterization of host cell death induced by <italic>Chlamydia trachomatis<\/italic>","volume":"74","author":"S Ying","year":"2006","journal-title":"Infect Immun"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2174\/157339507779802179","article-title":"Host-Cell Survival and Death During Chlamydia Infection","volume":"3","author":"S Ying","year":"2007","journal-title":"Curr Immunol Rev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3109\/08820139.2010.485626","article-title":"Characterization of apoptotic activities during chlamydia trachomatis infection in primary cervical epithelial cells","volume":"39","author":"V Vats","year":"2010","journal-title":"Immunol Invest"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1128\/IAI.00725-09","article-title":"Production of reactive oxygen species is turned on and rapidly shut down in epithelial cells infected with Chlamydia trachomatis","volume":"78","author":"G Boncompain","year":"2010","journal-title":"Infect Immun"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/cdd.2017.65","article-title":"Initiation and execution mechanisms of necroptosis: an overview","volume":"24","author":"S Grootjans","year":"2017","journal-title":"Cell Death Differ"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-pathol-052016-100247","article-title":"Necroptosis: Mechanisms and Relevance to Disease","volume":"12","author":"L Galluzzi","year":"2017","journal-title":"Annu Rev Pathol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"6282","DOI":"10.1038\/ncomms7282","article-title":"RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL","volume":"6","author":"KE Lawlor","year":"2015","journal-title":"Nat Commun"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"26789","DOI":"10.1074\/jbc.M109.026823","article-title":"Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis","volume":"284","author":"AA Abdul-Sater","year":"2009","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/infdis\/jit009","article-title":"Prevention of Chlamydia-induced infertility by inhibition of local caspase activity","volume":"207","author":"JU Igietseme","year":"2013","journal-title":"J Infect Dis"},{"key":"ref29","article-title":"Chlamydia trachomatis fails to protect its growth niche against pro-apoptotic insults","author":"BS Sixt","year":"2018","journal-title":"Cell Death Differ"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1111\/cmi.12598","article-title":"Infection of epithelial cells with Chlamydia trachomatis inhibits TNF-induced apoptosis at the level of receptor internalization while leaving non-apoptotic TNF-signalling intact","volume":"18","author":"C Waguia Kontchou","year":"2016","journal-title":"Cell Microbiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"S865","DOI":"10.1093\/cid\/civ756","article-title":"Lymphogranuloma Venereum 2015: Clinical Presentation, Diagnosis, and Treatment","volume":"61","author":"BP Stoner","year":"2015","journal-title":"Clin Infect Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1128\/IAI.69.2.1109-1119.2001","article-title":"Rapid, transient phosphatidylserine externalization induced in host cells by infection with Chlamydia spp","volume":"69","author":"SR Goth","year":"2001","journal-title":"Infect Immun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1084\/jem.182.5.1545","article-title":"Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl","volume":"182","author":"SJ Martin","year":"1995","journal-title":"J Exp Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.4049\/jimmunol.161.8.4220","article-title":"Apoptosis of epithelial cells and macrophages due to infection with the obligate intracellular pathogen Chlamydia psittaci","volume":"161","author":"DM Ojcius","year":"1998","journal-title":"J Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"7233","DOI":"10.1128\/jb.179.23.7233-7242.1997","article-title":"Host cell phospholipids are trafficked to and then modified by Chlamydia trachomatis","volume":"179","author":"JL Wylie","year":"1997","journal-title":"J Bacteriol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1084\/jem.20101157","article-title":"Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums","volume":"207","author":"KS Ravichandran","year":"2010","journal-title":"J Exp Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/1756-0500-7-230","article-title":"Infection of human monocytes by Chlamydia pneumoniae and Chlamydia trachomatis: an in vitro comparative study","volume":"7","author":"A Marangoni","year":"2014","journal-title":"BMC Res Notes"},{"key":"ref38","article-title":"Immunobiology of monocytes and macrophages during Chlamydia trachomatis infection","author":"M Lausen","year":"2018","journal-title":"Microbes Infect"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0215956","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T03:14:51Z","timestamp":1694834091000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0215956"}},"subtitle":[],"editor":[{"given":"David M.","family":"Ojcius","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,4,26]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0215956","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2019,4,26]]}}}