{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:51:11Z","timestamp":1790394671448,"version":"4.1.0"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG010026"],"award-info":[{"award-number":["AG010026"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK71771"],"award-info":[{"award-number":["DK71771"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0216236","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T22:15:47Z","timestamp":1556576147000},"page":"e0216236","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Whole body glucoregulation and tissue-specific glucose uptake in a novel Akt substrate of 160 kDa knockout rat model"],"prefix":"10.1371","volume":"14","author":[{"given":"Edward B.","family":"Arias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5311-1722","authenticated-orcid":true,"given":"Gregory D.","family":"Cartee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,4,29]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00125-014-3395-5","article-title":"Roles of TBC1D1 and TBC1D4 in insulin- and exercise-stimulated glucose transport of skeletal muscle","volume":"58","author":"GD Cartee","year":"2015","journal-title":"Diabetologia"},{"issue":"17","key":"ref2","doi-asserted-by":"crossref","first-page":"14599","DOI":"10.1074\/jbc.C300063200","article-title":"Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation","volume":"278","author":"H Sano","year":"2003","journal-title":"J Biol Chem"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrm3351","article-title":"Regulation of glucose transport by insulin: traffic control of GLUT4","volume":"13","author":"D Leto","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7513","key":"ref4","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nature13425","article-title":"A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes","volume":"512","author":"I Moltke","year":"2014","journal-title":"Nature"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"E1191","DOI":"10.1152\/ajpendo.00602.2006","article-title":"Prior exercise increases phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle","volume":"292","author":"EB Arias","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2337\/diabetes.54.1.41","article-title":"Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity","volume":"54","author":"MD Bruss","year":"2005","journal-title":"Diabetes"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.2337\/db13-1686","article-title":"Postexercise improvement in insulin-stimulated glucose uptake occurs concomitant with greater AS160 phosphorylation in muscle from normal and insulin-resistant rats","volume":"63","author":"CM Castorena","year":"2014","journal-title":"Diabetes"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"E242","DOI":"10.1152\/ajpendo.00194.2009","article-title":"Increased AS160 phosphorylation, but not TBC1D1 phosphorylation, with increased postexercise insulin sensitivity in rat skeletal muscle","volume":"297","author":"K Funai","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"39230","DOI":"10.1038\/srep39230","article-title":"Insulin-induced Effects on the Subcellular Localization of AKT1, AKT2 and AS160 in Rat Skeletal Muscle","volume":"6","author":"X Zheng","year":"2016","journal-title":"Scientific reports"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.2337\/db06-0150","article-title":"Distinct Signals Regulate AS160 Phosphorylation in Response to Insulin, AICAR, and Contraction in Mouse Skeletal Muscle","volume":"55","author":"HF Kramer","year":"2006","journal-title":"Diabetes"},{"issue":"42","key":"ref11","doi-asserted-by":"crossref","first-page":"31478","DOI":"10.1074\/jbc.M605461200","article-title":"AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle","volume":"281","author":"HF Kramer","year":"2006","journal-title":"J Biol Chem"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"598","DOI":"10.2337\/db16-0530","article-title":"Enhanced Muscle Insulin Sensitivity After Contraction\/Exercise Is Mediated by AMPK","volume":"66","author":"R Kjobsted","year":"2017","journal-title":"Diabetes"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.2337\/db11-1572","article-title":"Exercise alleviates lipid-induced insulin resistance in human skeletal muscle-signaling interaction at the level of TBC1 domain family member 4","volume":"61","author":"C Pehmoller","year":"2012","journal-title":"Diabetes"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s00125-009-1294-y","article-title":"Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle","volume":"52","author":"JT Treebak","year":"2009","journal-title":"Diabetologia"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.2337\/diabetes.54.6.1692","article-title":"Insulin-Stimulated Phosphorylation of the Akt Substrate AS160 Is Impaired in Skeletal Muscle of Type 2 Diabetic Subjects","volume":"54","author":"HK Karlsson","year":"2005","journal-title":"Diabetes"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.2337\/db13-0229","article-title":"Impairments in site-specific AS160 phosphorylation and effects of exercise training","volume":"62","author":"LA Consitt","year":"2013","journal-title":"Diabetes"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.2337\/diab.30.12.1000","article-title":"The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization","volume":"30","author":"RA DeFronzo","year":"1981","journal-title":"Diabetes"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"E1273","DOI":"10.1152\/ajpendo.00316.2012","article-title":"Deletion of Rab GAP AS160 modifies glucose uptake and GLUT4 translocation in primary skeletal muscles and adipocytes and impairs glucose homeostasis","volume":"303","author":"MN Lansey","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1042\/BJ20120702","article-title":"AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues","volume":"449","author":"HY Wang","year":"2013","journal-title":"Biochem J"},{"issue":"10","key":"ref20","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1007\/s00125-003-1180-y","article-title":"Peripheral insulin resistance develops in transgenic rats overexpressing phosphoenolpyruvate carboxykinase in the kidney","volume":"46","author":"BJ Lamont","year":"2003","journal-title":"Diabetologia"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/BF02427092","article-title":"In vivo insulin resistance in individual peripheral tissues of the high fat fed rat: assessment by euglycaemic clamp plus deoxyglucose administration","volume":"29","author":"EW Kraegen","year":"1986","journal-title":"Diabetologia"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"746","DOI":"10.2337\/db14-0368","article-title":"&quot;Deletion of both Rab-GTPase-activating proteins TBC1D1 and TBC1D4 in mice eliminates insulin- and AICAR-stimulated glucose transport [corrected]","volume":"64","author":"A Chadt","year":"2015","journal-title":"Diabetes"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"E276","DOI":"10.1152\/ajpendo.00342.2015","article-title":"Rab GAPs AS160 and Tbc1d1 play nonredundant roles in the regulation of glucose and energy homeostasis in mice","volume":"310","author":"SR Hargett","year":"2016","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.2337\/db16-0416","article-title":"The Inactivation of RabGAP Function of AS160 Promotes Lysosomal Degradation of GLUT4 and Causes Postprandial Hyperglycemia and Hyperinsulinemia","volume":"65","author":"B Xie","year":"2016","journal-title":"Diabetes"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"995","DOI":"10.2337\/db11-1299","article-title":"A novel method to measure glucose uptake and myosin heavy chain isoform expression of single fibers from rat skeletal muscle","volume":"61","author":"JG Mackrell","year":"2012","journal-title":"Diabetes"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/978-1-4939-8897-6_17","article-title":"Measuring Both Glucose Uptake and Myosin Heavy Chain Isoform Expression in Single Rat Skeletal Muscle Fibers","volume":"1889","author":"MW Pataky","year":"2019","journal-title":"Methods Mol Biol"},{"issue":"6121","key":"ref27","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex genome engineering using CRISPR\/Cas systems","volume":"339","author":"L Cong","year":"2013","journal-title":"Science"},{"issue":"6121","key":"ref28","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.1232033","article-title":"RNA-guided human genome engineering via Cas9","volume":"339","author":"P Mali","year":"2013","journal-title":"Science"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.cell.2016.05.053","article-title":"Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine","volume":"165","author":"MW Popp","year":"2016","journal-title":"Cell"},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"FA Ran","year":"2013","journal-title":"Nat Protoc"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1472-6750-14-69","article-title":"A single blastocyst assay optimized for detecting CRISPR\/Cas9 system-induced indel mutations in mice","volume":"14","author":"T Sakurai","year":"2014","journal-title":"BMC Biotechnol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1038\/srep03355","article-title":"Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA","volume":"3","author":"D Mashiko","year":"2013","journal-title":"Scientific reports"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s11248-006-9002-x","article-title":"Advances in transgenic rat production","volume":"15","author":"WE Filipiak","year":"2006","journal-title":"Transgenic Res"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2337\/diacare.18.2.245","article-title":"The use of areas under curves in diabetes research","volume":"18","author":"DB Allison","year":"1995","journal-title":"Diabetes Care"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"e38835","DOI":"10.1371\/journal.pone.0038835","article-title":"Tissue-specific responses of IGF-1\/insulin and mTOR signaling in calorie restricted rats","volume":"7","author":"N Sharma","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"390","DOI":"10.2337\/diabetes.55.02.06.db05-0686","article-title":"Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse","volume":"55","author":"JE Ayala","year":"2006","journal-title":"Diabetes"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"PK Smith","year":"1985","journal-title":"Anal Biochem"},{"issue":"5","key":"ref38","first-page":"E902","article-title":"Growth hormone reduces glucose transport but not GLUT-1 or GLUT-4 in adult and old rats","volume":"268","author":"GD Cartee","year":"1995","journal-title":"Am J Physiol"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1152\/jappl.1994.76.2.979","article-title":"Suitability of 2-deoxyglucose for in vitro measurement of glucose transport activity in skeletal muscle","volume":"76","author":"PA Hansen","year":"1994","journal-title":"J Appl Physiol"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1152\/japplphysiol.00631.2011","article-title":"Clustering of GLUT4, TUG, and RUVBL2 protein levels correlate with myosin heavy chain isoform pattern in skeletal muscles, but AS160 and TBC1D1 levels do not","volume":"111","author":"CM Castorena","year":"2011","journal-title":"Journal of applied physiology"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cmet.2010.12.005","article-title":"Mice with AS160\/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking","volume":"13","author":"S Chen","year":"2011","journal-title":"Cell Metab"},{"issue":"43","key":"ref42","doi-asserted-by":"crossref","first-page":"32841","DOI":"10.1074\/jbc.M513087200","article-title":"Akt2 regulates cardiac metabolism and cardiomyocyte survival","volume":"281","author":"B DeBosch","year":"2006","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ijcard.2016.12.083","article-title":"Glucose transporters in healthy heart and in cardiac disease","volume":"230","author":"L. Szablewski","year":"2017","journal-title":"Int J Cardiol"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.bbadis.2015.01.009","article-title":"Sarcoplasmic reticulum Ca2+ ATPase pump is a major regulator of glucose transport in the healthy and diabetic heart","volume":"1852","author":"AP Waller","year":"2015","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1152\/physrev.00006.2004","article-title":"Myocardial substrate metabolism in the normal and failing heart","volume":"85","author":"WC Stanley","year":"2005","journal-title":"Physiol Rev"},{"issue":"7","key":"ref46","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1194\/jlr.R082933","article-title":"Dynamic role of the transmembrane glycoprotein CD36 (SR-B2) in cellular fatty acid uptake and utilization","volume":"59","author":"JFC Glatz","year":"2018","journal-title":"J Lipid Res"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"330","DOI":"10.2337\/diabetes.53.2.330","article-title":"Ca(2+) and AMPK Both Mediate Stimulation of Glucose Transport by Muscle Contractions","volume":"53","author":"DC Wright","year":"2004","journal-title":"Diabetes"},{"issue":"6","key":"ref48","doi-asserted-by":"crossref","first-page":"E1062","DOI":"10.1152\/ajpendo.00561.2004","article-title":"Contraction- and hypoxia-stimulated glucose transport is mediated by a Ca2+-dependent mechanism in slow-twitch rat soleus muscle","volume":"288","author":"DC Wright","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1152\/physrev.00015.2009","article-title":"Myocardial fatty acid metabolism in health and disease","volume":"90","author":"GD Lopaschuk","year":"2010","journal-title":"Physiol Rev"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2741\/1216","article-title":"Glucose transport in the heart","volume":"9","author":"ED Abel","year":"2004","journal-title":"Front Biosci"},{"issue":"4","key":"ref51","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1194\/jlr.M023424","article-title":"Insulin and AMPK regulate FA translocase\/CD36 plasma membrane recruitment in cardiomyocytes via Rab GAP AS160 and Rab8a Rab GTPase","volume":"53","author":"D Samovski","year":"2012","journal-title":"J Lipid Res"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"e0124491","DOI":"10.1371\/journal.pone.0124491","article-title":"PKB-Mediated Thr649 Phosphorylation of AS160\/TBC1D4 Regulates the R-Wave Amplitude in the Heart","volume":"10","author":"C Quan","year":"2015","journal-title":"PLoS One"},{"issue":"12","key":"ref53","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1172\/JCI7605","article-title":"Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart","volume":"104","author":"ED Abel","year":"1999","journal-title":"J Clin Invest"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0216236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:18:44Z","timestamp":1588965524000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0216236"}},"subtitle":[],"editor":[{"given":"Julie A.","family":"Chowen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,4,29]]},"references-count":53,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0216236","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,29]]}}}