{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T17:25:24Z","timestamp":1780680324613,"version":"3.54.1"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","award":["108-wf-eva-01"],"award-info":[{"award-number":["108-wf-eva-01"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0216337","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T17:54:52Z","timestamp":1556819692000},"page":"e0216337","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy and safety of femoral nerve block for the positioning of femur fracture patients before a spinal block \u2013 A systematic review and meta-analysis"],"prefix":"10.1371","volume":"14","author":[{"given":"Yuan-Pin","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Wang","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Chia Wen","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chyi-Huey","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Jen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4514-1678","authenticated-orcid":true,"given":"Sheng-Wei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1595-6553","authenticated-orcid":true,"given":"Chiehfeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,5,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s00223-014-9850-y","article-title":"Incidence rates and trends of hip\/femur fractures in five European countries: comparison using e-healthcare records databases","volume":"94","author":"G Requena","year":"2014","journal-title":"Calcif Tissue Int"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/BOT.0b013e318206cd06","article-title":"Use of femoral shaft fracture classification for predicting the risk of associated injuries","volume":"25","author":"VS Nikolaou","year":"2011","journal-title":"J Orthop Trauma"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.5435\/00124635-199405000-00002","article-title":"Hip Fractures: I. Overview and evaluation and treatment of femoral-neck fractures.","volume":"2","author":"KJ Koval","year":"1994","journal-title":"J Am Acad Orthop Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/bjaceaccp\/mkt006","article-title":"Anaesthetic management of patients with hip fractures: an update","volume":"13","author":"L Maxwell","year":"2013","journal-title":"Contin Educ Anaesth Crit Care Pain"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/ALN.0b013e3182545e7c","article-title":"Comparative effectiveness of regional versus general anesthesia for hip fracture surgery in adults","volume":"117","author":"MD Neuman","year":"2012","journal-title":"Anesthesiology"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000521.pub2","article-title":"Anaesthesia for hip fracture surgery in adults","author":"MJ Parker","year":"2004","journal-title":"The Cochrane database of systematic reviews"},{"key":"ref7","first-page":"355","article-title":"Anesthesia for orthopedic surgery","author":"TA Duc","year":"1994"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.36076\/ppj.2008\/11\/S105","article-title":"Opioid complications and side effects","volume":"11","author":"R Benyamin","year":"2008","journal-title":"Pain Physician"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1213\/ANE.0000000000002489","article-title":"Peripheral nerve blocks for hip fractures: a Cochrane review","volume":"126","author":"J Guay","year":"2018","journal-title":"Anesth Analg"},{"key":"ref10","first-page":"928","article-title":"Pain relief during positioning for spinal anesthesia in patients with femoral fracture: a comparison between femoral nerve block and intravenous nalbuphine","volume":"7","author":"H Durrani","year":"2013","journal-title":"Pak J Med Health Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2147\/LRA.S8600","article-title":"Femoral nerve block versus fentanyl: analgesia for positioning patients with fractured femur","volume":"3","author":"A Iamaroon","year":"2010","journal-title":"Local Reg Anesth"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"705","DOI":"10.4103\/0019-5049.147146","article-title":"Comparative evaluation of femoral nerve block and intravenous fentanyl for positioning during spinal anaesthesia in surgery of femur fracture","volume":"58","author":"A Jadon","year":"2014","journal-title":"Indian J Anaesth"},{"key":"ref13","first-page":"507","article-title":"A randomized prospective study of comparison of IV fentanyl vs. femoral nerve block to facilitate administration of subarachnoid block in sitting position for femur fracture surgeries","volume":"3","author":"PV Pakhare","year":"2016","journal-title":"Indian Journal of Clinical Anaesthesia"},{"key":"ref14","first-page":"125","article-title":"Ultrasound guided femoral nerve block to provide analgesia for positioning patients with femur fracture before subarachnoid block: comparison with intravenous fentanyl","volume":"14","author":"S Ranjit","year":"2016","journal-title":"Kathmandu University Medical Journal"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"321","DOI":"10.18203\/2349-2902.isj20160252","article-title":"Comparative study of efficacy of femoral nerve block and IV fentanyl for positioning during femur fracture surgery","author":"E Reddy","year":"2016","journal-title":"International Surgery Journal"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1213\/01.ANE.0000134812.00471.44","article-title":"Analgesia before performing a spinal block in the sitting position in patients with femoral shaft fracture: a comparison between femoral nerve block and intravenous fentanyl","volume":"99","author":"S Sia","year":"2004","journal-title":"Anesth Analg"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4103\/0259-1162.176403","article-title":"Intravenous analgesia with opioids versus femoral nerve block with 0.2% ropivacaine as preemptive analgesic for fracture femur: a randomized comparative study","volume":"10","author":"AP Singh","year":"2016","journal-title":"Anesth Essays Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2047-0525-1-4","article-title":"Analgesic efficacy of continuous femoral nerve block commenced prior to operative fixation of fractured neck of femur","volume":"1","author":"S Szucs","year":"2012","journal-title":"Perioperative Medicine"},{"key":"ref19","first-page":"2298","article-title":"Comparative evaluation of femoral nerve block and intravenous fentanyl for positioning during spinal anaesthesia in surgeries of femur fracture","volume":"3","author":"A Vats","year":"2016","journal-title":"International Journal of Contemporary Medical Research"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"D Moher","year":"2009","journal-title":"PLoS Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"JP Higgins","year":"2011","journal-title":"BMJ (Clinical research ed)"},{"key":"ref22","article-title":"The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomized studies in meta-analysis","author":"G Wells","year":"2011"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.bpa.2011.08.005","article-title":"Research methods for meta-analyses","volume":"25","author":"NL Pace","year":"2011","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"JP Higgins","year":"2002","journal-title":"Stat Med"},{"key":"ref25","article-title":"Miller\u2019s Anesthesia","author":"CB SG Berde","year":"2009"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e13502","DOI":"10.1097\/MD.0000000000013502","article-title":"Fascia iliaca compartment block versus intravenous analgesic for positioning of femur fracture patients before a spinal block: A PRISMA-compliant meta-analysis","volume":"97","author":"YP Hsu","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.jasms.2009.01.001","article-title":"Overtone mobility spectrometry: part 2. Theoretical considerations of resolving power","volume":"20","author":"SJ Valentine","year":"2009","journal-title":"J Am Soc Mass Spectrom"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1002\/sim.2380","article-title":"A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints","volume":"25","author":"RM Harbord","year":"2006","journal-title":"Stat Med"},{"key":"ref29","first-page":"e54","article-title":"Nerve stimulator versus ultrasound guided femoral nerve block; a randomized clinical Trial","volume":"5","author":"A Forouzan","year":"2017","journal-title":"Emerg (Tehran)"},{"key":"ref30","first-page":"E521","article-title":"DNB. Effectiveness of lateral decubitus position for preventing post-dural puncture headache: a meta-analysis","volume":"20","author":"MD Andres Zorrilla-Vaca MaJKM","year":"2017","journal-title":"Pain Physician"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1365-2044.2007.05328.x","article-title":"A national survey into the peri-operative anaesthetic management of patients presenting for surgical correction of a fractured neck of femur","volume":"63","author":"M Sandby-Thomas","year":"2008","journal-title":"Anaesthesia"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1213\/01.ANE.0000072705.86142.5D","article-title":"Onset time, quality of blockade, and duration of three-in-one blocks with levobupivacaine and bupivacaine","volume":"97","author":"B Urbanek","year":"2003","journal-title":"Anesth Analg"},{"key":"ref33","first-page":"111","article-title":"Analgesia prior to spinal block in the lateral position in elderly patients with a femoral neck fracture: a comparison of fascia iliaca compartment block and intravenous alfentanil","volume":"26","author":"M Yun","year":"2009","journal-title":"Eur J Anaesth"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/2151458511432758","article-title":"Pain reporting, opiate dosing, and the adverse effects of opiates after hip or knee replacement in patients 60 years old or older","volume":"3","author":"BM Petre","year":"2012","journal-title":"Geriatr Orthop Surg Rehabil"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1007\/s11999-013-3363-2","article-title":"The influence of anesthesia and pain management on cognitive dysfunction after joint arthroplasty: a systematic review","volume":"472","author":"MG Zywiel","year":"2014","journal-title":"Clin Orthop Relat Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/ALN.0000000000000564","article-title":"Postoperative opioid-induced respiratory depression: a closed claims analysis","volume":"122","author":"LA Lee","year":"2015","journal-title":"Anesthesiology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/AAP.0000000000000133","article-title":"Preoperative fascia iliaca compartment block for positioning patients with hip fractures for central nervous blockade: a randomized trial","volume":"39","author":"M Diakomi","year":"2014","journal-title":"Reg Anesth Pain Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e7382","DOI":"10.1097\/MD.0000000000007382","article-title":"Femoral nerve block versus fascia iliaca block for pain control in total knee and hip arthroplasty: a meta-analysis from randomized controlled trials","volume":"96","author":"X Wang","year":"2017","journal-title":"Medicine (Baltimore)"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0216337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T08:53:11Z","timestamp":1663404791000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0216337"}},"subtitle":[],"editor":[{"given":"JianJun","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,5,2]]},"references-count":38,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0216337","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,2]]}}}