{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:51:34Z","timestamp":1792795894119,"version":"4.5.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T00:00:00Z","timestamp":1558051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0216358","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T17:26:42Z","timestamp":1558114002000},"page":"e0216358","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":50,"title":["Anticancer effects of a non-narcotic opium alkaloid medicine, papaverine, in human glioblastoma cells"],"prefix":"10.1371","volume":"14","author":[{"given":"Mana","family":"Inada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Shindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyousuke","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2239-6208","authenticated-orcid":true,"given":"Akira","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuharu","family":"Akasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ichimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sei-ichi","family":"Tanuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,5,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.immunol.021908.132603","article-title":"HMGB1 and RAGE in inflammation and cancer","volume":"28","author":"GP Sims","year":"2010","journal-title":"Annual Review of Immunology"},{"issue":"1\u20132","key":"ref2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbagrm.2009.11.014","article-title":"High-mobility group box 1 and cancer","volume":"1799","author":"D Tang","year":"2010","journal-title":"Biochimica et Biophysica Acta"},{"issue":"5","key":"ref3","first-page":"6799","article-title":"The function and mechanism of HMGB1 in lung cancer and its potential therapeutic implications","volume":"15","author":"L Wu","year":"2018","journal-title":"Oncology Letters"},{"issue":"38","key":"ref4","doi-asserted-by":"crossref","first-page":"64534","DOI":"10.18632\/oncotarget.17885","article-title":"The dual role and therapeutic potential of high-mobility group box 1 in cancer","volume":"8","author":"SJ He","year":"2017","journal-title":"Oncotarget"},{"issue":"4","key":"ref5","first-page":"4627","article-title":"In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system","volume":"15","author":"A El-Far","year":"2018","journal-title":"Oncology Letters"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1016\/j.bmc.2008.03.046","article-title":"Structure-based discovery of a novel non-peptidic small molecular inhibitor of caspase-3","volume":"16","author":"J Sakai","year":"2008","journal-title":"Bioorganic & Medicinal Chemistry"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.bbrc.2019.01.136","article-title":"Papaverine identified as an inhibitor of high mobility group box 1\/receptor for advanced glycation end-products interaction suppresses high mobility group box 1-mediated inflammatory responses","volume":"511","author":"K Tamada","year":"2019","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/jlac.18480660121","article-title":"Vorl\u00e4ufige Notiz \u00fcber eine neue organische Base im Opium","volume":"66","author":"G Merck","year":"1848","journal-title":"Justus Liebigs Annalen der Chemie"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1054\/jocn.2001.1036","article-title":"The efficacy of papaverine administration by different routes for the treatment of experimental acute cerebral vasospasm","volume":"9","author":"HM Liu","year":"2002","journal-title":"Journal of Clinical Neuroscience: official journal of the Neurosurgical Society of Australasia"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1021\/jm060653b","article-title":"Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors","volume":"50","author":"TA Chappie","year":"2007","journal-title":"Journal of Medicinal Chemistry"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/MRR.0b013e32833d6cb2","article-title":"Efficacies of papaverine and sildenafil in the treatment of erectile dysfunction in early-stage paraplegic men","volume":"34","author":"N Yildiz","year":"2011","journal-title":"International Journal of Rehabilitation Research Internationale Zeitschrift fur Rehabilitationsforschung Revue internationale de recherches de readaptation"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1046\/j.1442-2042.1999.00069.x","article-title":"The effect of papaverine on morphologic differentiation, proliferation and invasive potential of human prostatic cancer LNCaP cells","volume":"6","author":"T Goto","year":"1999","journal-title":"International Journal of Urology: official journal of the Japanese Urological Association"},{"issue":"2a","key":"ref13","first-page":"761","article-title":"Papaverine combined with prostaglandin E2 synergistically induces neuron-like morphological changes and decrease of malignancy in human prostatic cancer LNCaP cells","volume":"20","author":"T Shimizu","year":"2000","journal-title":"Anticancer Research"},{"issue":"1","key":"ref14","first-page":"112","article-title":"Papaverine selectively inhibits human prostate cancer cell (PC-3) growth by inducing mitochondrial mediated apoptosis, cell cycle arrest and downregulation of NF-kappaB\/PI3K\/Akt signalling pathway","volume":"22","author":"H Huang","year":"2017","journal-title":"Journal of BUON: official journal of the Balkan Union of Oncology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40199-015-0101-1","article-title":"Non-addictive opium alkaloids selectively induce apoptosis in cancer cells compared to normal cells","volume":"23","author":"M Afzali","year":"2015","journal-title":"Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3109\/15376516.2015.1045656","article-title":"Cell cycle arrest and apoptogenic properties of opium alkaloids noscapine and papaverine on breast cancer stem cells","volume":"25","author":"S Sajadian","year":"2015","journal-title":"Toxicology Mechanisms and Methods"},{"issue":"8","key":"ref17","doi-asserted-by":"crossref","first-page":"11846","DOI":"10.3390\/molecules190811846","article-title":"Antiproliferative effect of the isoquinoline alkaloid papaverine in hepatocarcinoma HepG-2 cells\u2014inhibition of telomerase and induction of senescence","volume":"19","author":"SK Noureini","year":"2014","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"42","key":"ref18","doi-asserted-by":"crossref","first-page":"10756","DOI":"10.1073\/pnas.1808945115","article-title":"Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism","volume":"115","author":"M Benej","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0167-8140(02)00078-6","article-title":"Radiotherapy for newly diagnosed malignant glioma in adults: a systematic review","volume":"64","author":"N Laperriere","year":"2002","journal-title":"Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nrc2818","article-title":"Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma","volume":"10","author":"JT Huse","year":"2010","journal-title":"Nature Reviews Cancer"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2174\/1874467211205010102","article-title":"Temozolomide: mechanisms of action, repair and resistance","volume":"5","author":"J Zhang","year":"2012","journal-title":"Current Molecular Pharmacology"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1021\/pr9010537","article-title":"Protein expression profiles of necrosis and apoptosis induced by 5-fluoro-2&apos;-deoxyuridine in mouse cancer cells","volume":"9","author":"A Sato","year":"2010","journal-title":"Journal of Proteome Research"},{"issue":"23","key":"ref23","doi-asserted-by":"crossref","first-page":"16451","DOI":"10.18632\/oncotarget.24731","article-title":"Cross resistance to diverse anticancer nicotinamide phosphoribosyltransferase inhibitors induced by FK866 treatment","volume":"9","author":"Y Ogino","year":"2018","journal-title":"Oncotarget"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11060-007-9488-y","article-title":"HMGB1 as an autocrine stimulus in human T98G glioblastoma cells: role in cell growth and migration","volume":"87","author":"R Bassi","year":"2008","journal-title":"Journal of Neuro-oncology"},{"issue":"8","key":"ref25","first-page":"751","article-title":"Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma","volume":"111","author":"H Xue","year":"1998","journal-title":"Chinese Medical Journal"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1006\/bbrc.2001.6029","article-title":"Quantitative analysis of papaverine-mediated blood-brain barrier disruption in rats","volume":"289","author":"AK Bhattacharjee","year":"2001","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jns.2016.05.054","article-title":"Akt and beta-catenin contribute to TMZ resistance and EMT of MGMT negative malignant glioma cell line","volume":"367","author":"GZ Yi","year":"2016","journal-title":"Journal of the Neurological Sciences"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1385\/NCC:2:2:124","article-title":"Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage","volume":"2","author":"JK Liu","year":"2005","journal-title":"Neurocritical Care"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"E12","DOI":"10.3171\/foc.2006.21.3.12","article-title":"Update on endovascular therapies for cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage","volume":"21","author":"CM Sayama","year":"2006","journal-title":"Neurosurgical Focus"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/cc5958","article-title":"Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage","volume":"11","author":"SG Keyrouz","year":"2007","journal-title":"Critical Care (London, England)"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0216358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T10:11:46Z","timestamp":1607854306000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0216358"}},"subtitle":[],"editor":[{"given":"Ilya","family":"Ulasov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,5,17]]},"references-count":30,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0216358","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,17]]}}}