{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:25:27Z","timestamp":1785803127422,"version":"3.56.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0216665","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T17:35:43Z","timestamp":1557423343000},"page":"e0216665","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Reduction of the PI3K\/Akt related signaling activities in skeletal muscle tissues involves insulin resistance in intrauterine growth restriction rats with catch-up growth"],"prefix":"10.1371","volume":"14","author":[{"given":"Yan","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongling","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5990-4117","authenticated-orcid":true,"given":"Xinli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,5,9]]},"reference":[{"key":"ref1","first-page":"29","article-title":"Perinatal mortality and morbidity of growth restricted fetuses and newborns (own experience)\u2014first report","volume":"21","author":"K Pankiewicz","year":"2017","journal-title":"Dev Period Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s00404-017-4341-9","article-title":"Fetal growth restriction: current knowledge","volume":"295","author":"LM Nardozza","year":"2017","journal-title":"Arch Gynecol Obstet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2174\/1389201017666160301104323","article-title":"Intra-uterine Growth Retardation as a Risk Factor of Postnatal Metabolic Disorders","volume":"17","author":"R Mierzynski","year":"2016","journal-title":"Curr Pharm Biotechnol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2147\/DMSO.S115890","article-title":"Prevalence of diabetes and obesity in association with prematurity and growth restriction","volume":"10","author":"G Kopec","year":"2017","journal-title":"Diabetes Metab Syndr Obes"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/BF00400248","article-title":"Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis","volume":"35","author":"CN Hales","year":"1992","journal-title":"Diabetologia"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11886-016-0755-4","article-title":"Genetics of Insulin Resistance and the Metabolic Syndrome","volume":"18","author":"AE Brown","year":"2016","journal-title":"Curr Cardiol Rep"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.bbalip.2014.11.008","article-title":"Phosphoinositides: Key modulators of energy metabolism","volume":"1851","author":"D Bridges","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1042\/BST0330346","article-title":"Role of protein kinase B in insulin-regulated glucose uptake","volume":"33","author":"GI Welsh","year":"2005","journal-title":"Biochem Soc Trans"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"364381","DOI":"10.1155\/2011\/364381","article-title":"Consequences in infants that were intrauterine growth restricted","volume":"2011","author":"E Cosmi","year":"2011","journal-title":"J Pregnancy"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.pcl.2004.01.004","article-title":"Abnormal fetal growth: intrauterine growth retardation, small for gestational age, large for gestational age","volume":"51","author":"UG Das","year":"2004","journal-title":"Pediatr Clin North Am"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2796.2007.01800.x","article-title":"Experimental IUGR and later diabetes","volume":"261","author":"MS Martin-Gronert","year":"2007","journal-title":"J Intern Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1007\/s00125-006-0459-1","article-title":"Patterns of growth among children who later develop type 2 diabetes or its risk factors","volume":"49","author":"JG Eriksson","year":"2006","journal-title":"Diabetologia"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1001\/archpediatrics.2011.167","article-title":"Crossing growth percentiles in infancy and risk of obesity in childhood","volume":"165","author":"EM Taveras","year":"2011","journal-title":"Arch Pediatr Adolesc Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3892\/mmr.2012.1134","article-title":"Maternal protein restriction in rats leads to reduced pgc-1alpha expression via altered DNA methylation in skeletal muscle","volume":"7","author":"Y Zeng","year":"2013","journal-title":"Mol Med Rep"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1007\/s001250051074","article-title":"Maternal low protein diet in rats programmes fatty acid desaturase activities in the offspring","volume":"41","author":"SE Ozanne","year":"1998","journal-title":"Diabetologia"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1203\/PDR.0b013e3181a7c5fd","article-title":"Neonatal catch up growth increases diabetes susceptibility but improves behavioral and cardiovascular outcomes of low birth weight male mice","volume":"66","author":"GM Hermann","year":"2009","journal-title":"Pediatr Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/pr.2012.123","article-title":"Downregulating SOCS3 with siRNA ameliorates insulin signaling and glucose metabolism in hepatocytes of IUGR rats with catch-up growth","volume":"72","author":"J Ye","year":"2012","journal-title":"Pediatr Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1007\/s00125-018-4694-z","article-title":"Programming of central and peripheral insulin resistance by low birthweight and postnatal catch-up growth in male mice","volume":"61","author":"LM Berends","year":"2018","journal-title":"Diabetologia"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5523","DOI":"10.1021\/acs.biochem.5b00805","article-title":"Structural Dynamics of Insulin Receptor and Transmembrane Signaling","volume":"54","author":"SA Tatulian","year":"2015","journal-title":"Biochemistry"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrm.2017.89","article-title":"Biochemical and cellular properties of insulin receptor signalling","volume":"19","author":"RA Haeusler","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2310\/JIM.0b013e3182746f95","article-title":"Insulin signaling and insulin resistance","volume":"61","author":"EG Beale","year":"2013","journal-title":"J Investig Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"T1","DOI":"10.1530\/JOE-13-0327","article-title":"Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms","volume":"220","author":"S Guo","year":"2014","journal-title":"J Endocrinol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11010-016-2878-8","article-title":"Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance","volume":"426","author":"KC Nandipati","year":"2017","journal-title":"Mol Cell Biochem"},{"key":"ref24","article-title":"Akt activation: A potential strategy to ameliorate insulin resistance","author":"Z Zhang","year":"2017","journal-title":"Diabetes Res Clin Pract"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrm3330","article-title":"The functions and regulation of the PTEN tumour suppressor","volume":"13","author":"MS Song","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev.pathol.4.110807.092311","article-title":"PTEN and the PI3-kinase pathway in cancer","volume":"4","author":"N Chalhoub","year":"2009","journal-title":"Annu Rev Pathol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cmet.2007.03.006","article-title":"The GLUT4 glucose transporter","volume":"5","author":"S Huang","year":"2007","journal-title":"Cell Metab"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.diabet.2014.01.005","article-title":"Molecular mechanisms of GLUT4 regulation in adipocytes","volume":"40","author":"R Govers","year":"2014","journal-title":"Diabetes Metab"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.dsx.2014.09.015","article-title":"PPAR gamma gene\u2014a review","volume":"9","author":"C Janani","year":"2015","journal-title":"Diabetes Metab Syndr"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nm.3159","article-title":"PPAR\u03b3 signaling and metabolism: the good, the bad and the future","volume":"19","author":"M Ahmadian","year":"2013","journal-title":"Nat Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.tcb.2016.01.002","article-title":"Nuclear Mechanisms of Insulin Resistance","volume":"26","author":"S Kang","year":"2016","journal-title":"Trends Cell Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/cphy.c160022","article-title":"Transcriptional Regulation of Adipogenesis","volume":"7","author":"P Mota de S\u00e1","year":"2017","journal-title":"Compr Physiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"E287","DOI":"10.1152\/ajpendo.00440.2004","article-title":"PARgamma-mediated insulin sensitization: the importance of fat versus muscle","volume":"288","author":"U Kintscher","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.beem.2007.08.001","article-title":"Thrifty energy metabolism in catch-up growth trajectories to insulin and leptin resistance","volume":"22","author":"AG Dulloo","year":"2008","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1083\/jcb.126.5.1123","article-title":"Insulin resistance, diabetes, and the insulin-regulated trafficking of GLUT-4","volume":"126","author":"DE James","year":"1994","journal-title":"J Cell Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"7267910","DOI":"10.1155\/2017\/7267910","article-title":"MicroRNAs-Mediated Regulation of Skeletal Muscle GLUT4 Expression and Translocation in Insulin Resistance","volume":"2017","author":"JV Esteves","year":"2017","journal-title":"J Diabetes Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"E935","DOI":"10.1152\/ajpendo.00342.2004","article-title":"GLUT4 expression and subcellular localization in the intrauterine growth-restricted adult rat female offspring","volume":"288","author":"M Thamotharan","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"508","DOI":"10.7150\/ijbs.11241","article-title":"Modulation of glucose transporter protein by dietary flavonoids in type 2 diabetes mellitus","volume":"11","author":"F Hajiaghaalipour","year":"2015","journal-title":"Int J Biol Sci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2174\/156800908784293659","article-title":"The PTEN\/PI3K\/AKT signalling pathway in cancer, therapeutic implications","volume":"8","author":"A Carnero","year":"2008","journal-title":"Curr Cancer Drug Targets"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrm3330","article-title":"The functions and regulation of the PTEN tumour suppressor","volume":"13","author":"MS Song","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref41","first-page":"3667","article-title":"PTEN, Insulin Resistance and Cancer","volume":"23","author":"A Li","year":"2017","journal-title":"Curr Pharm Des"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1128\/MCB.25.6.2498-2510.2005","article-title":"Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue","volume":"25","author":"C Kurlawalla-Martinez","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.3892\/mmr.2015.3771","article-title":"Suppression of phosphatase and tensin homolog protects insulin-resistant cells from apoptosis","volume":"12","author":"DF Wang","year":"2015","journal-title":"Mol Med Rep"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/alzrt208","article-title":"Diets involved in PPAR and PI3K\/AKT\/PTEN pathway may contribute to neuroprotection in a traumatic brain injury","volume":"5","author":"Y Kitagishi","year":"2013","journal-title":"Alzheimers Res Ther"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0960-9822(01)00225-1","article-title":"Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN","volume":"11","author":"L Patel","year":"2001","journal-title":"Curr Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.beem.2007.08.001","article-title":"Thrifty energy metabolism in catch-up growth trajectories to insulin and leptin resistance","volume":"22","author":"AG Dulloo","year":"2008","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1442-200X.2010.03204.x","article-title":"Non-catch-up growth in intrauterine growth-retarded rats showed glucose intolerance and increased expression of PDX-1 mRNA","volume":"53","author":"JS Lim","year":"2011","journal-title":"Pediatr Int"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1080\/14767058.2016.1224838","article-title":"Low-birth-weight, but not catch-up growth, correlates with insulin resistance and resistin level in SGA infants at 12 months","volume":"30","author":"V Giapros","year":"2017","journal-title":"J Matern Fetal Neonatal Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0216665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:21:06Z","timestamp":1589008866000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0216665"}},"subtitle":[],"editor":[{"given":"Makoto","family":"Kanzaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,5,9]]},"references-count":48,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0216665","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,9]]}}}