{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T09:15:46Z","timestamp":1768295746407,"version":"3.49.0"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0216872","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T17:50:33Z","timestamp":1557856233000},"page":"e0216872","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Development of a pre-clinical experimental simulation model of the natural porcine knee with appropriate ligamentous constraints"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6524-1698","authenticated-orcid":true,"given":"Aiqin","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Ingham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise M.","family":"Jennings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"ref1","unstructured":"UK AR. Osteoarthritis in General Practice. 2013."},{"issue":"286","key":"ref2","first-page":"94","article-title":"Long-term results of the total condylar knee arthroplasty. A 15-year survivorship study","author":"CS Ranawat","year":"1993","journal-title":"Clinical orthopaedics and related research"},{"issue":"388","key":"ref3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00003086-200107000-00014","article-title":"The Genesis total knee prosthesis: a 10-year followup study","author":"RS Laskin","year":"2001","journal-title":"Clinical orthopaedics and related research"},{"issue":"388","key":"ref4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/00003086-200107000-00005","article-title":"Total condylar knee arthroplasty: a long-term followup","author":"V Pavone","year":"2001","journal-title":"Clinical orthopaedics and related research"},{"issue":"388","key":"ref5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/00003086-200107000-00004","article-title":"Total condylar knee replacement: a 20-year followup study","author":"JA Rodriguez","year":"2001","journal-title":"Clinical orthopaedics and related research"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2106\/JBJS.M.00545","article-title":"Younger age is associated with a higher risk of early periprosthetic joint infection and aseptic mechanical failure after total knee arthroplasty","volume":"96","author":"JP Meehan","year":"2014","journal-title":"The Journal of bone and joint surgery American volume"},{"issue":"10077","key":"ref7","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/S0140-6736(17)30059-4","article-title":"The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study","volume":"389","author":"LE Bayliss","year":"2017","journal-title":"Lancet"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1016\/j.jbiomech.2015.07.043","article-title":"Tribology studies of the natural knee using an animal model in a new whole joint natural knee simulator","volume":"48","author":"A Liu","year":"2015","journal-title":"Journal of biomechanics"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0021-9290(96)00118-2","article-title":"A knee simulating machine for performance evaluation of total knee replacements","volume":"30","author":"PS Walker","year":"1997","journal-title":"Journal of biomechanics"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0021-9290(00)00094-4","article-title":"The use of a force-controlled dynamic knee simulator to quantify the mechanical performance of total knee replacement designs during functional activity","volume":"33","author":"JD DesJardins","year":"2000","journal-title":"Journal of biomechanics"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1115\/1.1330735","article-title":"Total knee replacement polyethylene stresses during loading in a knee simulator","volume":"123","author":"VL Giddings","year":"2001","journal-title":"J Tribol-T Asme"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1243\/09544119JEIM57","article-title":"Validation of the soft tissue restraints in a force-controlled knee simulator","volume":"220","author":"M van Houtem","year":"2006","journal-title":"Proceedings of the Institution of Mechanical Engineers Part H, Journal of engineering in medicine"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"258","DOI":"10.2106\/00004623-198264020-00018","article-title":"An in vitro biomechanical evaluation of anterior-posterior motion of the knee. Tibial displacement, rotation, and torque","volume":"64","author":"T Fukubayashi","year":"1982","journal-title":"The Journal of bone and joint surgery American volume"},{"key":"ref14","unstructured":"BS ISO 14243\u20131:2009. Implants for surgery\u2013Wear of total knee-joint prostheses\u2013Part 1 Loading and displacement parameters for wear-testing machines with load control and corresponding environmental conditions for test."},{"key":"ref15","unstructured":"Haider H, Walker PS. Analysis and recommendations for the optimum spring configurations for soft tissue restraint in force-control knee simulator testing. 48th Annual Meeting of the Orthopaedic Research Society; Dallas, Texas2002."},{"key":"ref16","unstructured":"Haider H, Sekundiak T, Garvin K, editors. Simulation of the spring-based soft tissue restraint in testing knee wear under force control. Proceedings of the First International Conference on Mechanics of Biomaterials &amp; Tissues; 2005; Hawaii, USA."},{"key":"ref17","article-title":"UHMWPE biomaterials handbook ultra high molecular weight polyethylene in total joint replacement and medical devices","author":"SM Kurtz","year":"2016"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.triboint.2008.03.012","article-title":"Tribological testing of articular cartilage of the medial compartment of the knee using a friction simulator","volume":"41","author":"L McCann","year":"2008","journal-title":"Tribol Int"},{"key":"ref19","article-title":"Biometry: The Principles and Practice of Statistics in Biological Research","author":"RR Sokal","year":"1995"},{"key":"ref20","unstructured":"Liu A. Data associated with \u2018Development of a pre-clinical experimental simulation model of the natural porcine knee with appropriate ligamentous constraints\u2019 University of Leeds. [Dataset]. 2018. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.5518\/475\" xlink:type=\"simple\">https:\/\/doi.org\/10.5518\/475<\/ext-link>"},{"issue":"15","key":"ref21","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1016\/j.jbiomech.2007.05.022","article-title":"A direct comparison of patient and force-controlled simulator total knee replacement kinematics","volume":"40","author":"JD DesJardins","year":"2007","journal-title":"Journal of biomechanics"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1089\/ten.teb.2009.0452","article-title":"Animal models for cartilage regeneration and repair","volume":"16","author":"CR Chu","year":"2010","journal-title":"Tissue Eng Part B Rev"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s11999-014-3974-2","article-title":"Validation of porcine knee as a sex-specific model to study human anterior cruciate ligament disorders","volume":"473","author":"AM Kiapour","year":"2015","journal-title":"Clinical orthopaedics and related research"},{"issue":"12","key":"ref24","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1002\/jor.23594","article-title":"Orientation changes in the cruciate ligaments of the knee during skeletal growth: A porcine model","volume":"35","author":"SG Cone","year":"2017","journal-title":"J Orthop Res"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"e0192027","DOI":"10.1371\/journal.pone.0192027","article-title":"Novel technique for repairing posterior medial meniscus root tears using porcine knees and biomechanical study","volume":"13","author":"JL Wu","year":"2018","journal-title":"PLoS One"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0216872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T01:44:45Z","timestamp":1588988685000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0216872"}},"subtitle":[],"editor":[{"given":"John Leicester","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,5,14]]},"references-count":25,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0216872","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,14]]}}}