{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:26:41Z","timestamp":1787509601121,"version":"build-2736575974"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0217079","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T13:32:47Z","timestamp":1559827967000},"page":"e0217079","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":70,"title":["ZnO-NPs embedded biodegradable thiolated bandage for postoperative surgical site infection: In vitro and in vivo evaluation"],"prefix":"10.1371","volume":"14","author":[{"given":"Rabia","family":"Arshad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3970-5003","authenticated-orcid":true,"given":"Muhammad Farhan","family":"Sohail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafiz Shoaib","family":"Sarwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohail","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Zajif","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqra","family":"Afzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarwat","family":"Jahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Anees-ur-Rehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gul","family":"Shahnaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"ref1","first-page":"137","article-title":"Postoperative abdominal wound infection\u2013epidemiology, risk factors, identification, and management","volume":"2","author":"SC Azoury","year":"2015","journal-title":"Clinical wound care management and research"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1002\/jps.24610","article-title":"Advanced Therapeutic Dressings for Effective Wound Healing\u2014A Review","volume":"104","author":"J Boateng","year":"2015","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"ref3","article-title":"Clinical Presentations of Soft-Tissue Infections and Surgical Site Infections","author":"S Florman","year":"2001","journal-title":"Clinical Infectious Diseases"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.jvs.2016.07.017","article-title":"Surgical Site Infection: Incidence, Prediction, and Risk Factors Following Open Lower Extremity Bypass Surgery","volume":"64","author":"FM Davis","year":"2016","journal-title":"Journal of Vascular Surgery"},{"key":"ref5","article-title":"Development of a new chitosan hydrogel for wound dressin","author":"Maximiano P. Ribeiro","year":"2009","journal-title":"Wound Repair and Regeneration"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1083\/jcb.201212020","article-title":"Wound healing revised: a novel reepithelialization mechanism revealed by in vitro and in silico models","volume":"203","author":"K Safferling","year":"2013","journal-title":"J Cell Biol"},{"key":"ref7","doi-asserted-by":"crossref","DOI":"10.1503\/cjs.017916","article-title":"Analyzing the risk factors influencing surgical site infections: The site of environmental factors","volume":"60","author":"JL Alfonso-Sanchez","year":"2017","journal-title":"Can J Surg"},{"issue":"53","key":"ref8","article-title":"Bacteriological Profile of Post-Operative Wound Infection","volume":"6","author":"S Roy","year":"2016","journal-title":"Asian Journal of Biomedical and Pharmaceutical Sciences"},{"key":"ref9","article-title":"New antimicrobial chitosan derivatives for wound dressing applications","author":"Oana Maria Dragostin","year":"2016","journal-title":"Carbohydrate Polymers"},{"key":"ref10","article-title":"New antimicrobial chitosan derivatives for wound dressingapplications","author":"Oana Maria Dragostina","year":"2016","journal-title":"New antimicrobial chitosan derivatives for wound dressingapplications"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.nantod.2017.06.008","article-title":"Evolution and clinical translation of drug delivery nanomaterials","volume":"15","author":"S Hassan","year":"2017","journal-title":"Nano Today"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejpb.2011.09.010","article-title":"Thiolated chitosan: development and in vivo evaluation of an oral delivery system for leuprolide","volume":"80","author":"J Iqbal","year":"2012","journal-title":"Eur J Pharm Biopharm"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.msec.2014.08.031","article-title":"Antimicrobial activity of the metals and metal oxide nanoparticles","volume":"44","author":"SM Dizaj","year":"2014","journal-title":"Materials Science and Engineering: C"},{"key":"ref14","doi-asserted-by":"crossref","DOI":"10.1007\/s40820-015-0040-x","article-title":"Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism","author":"DM Amna Sirelkhatim","year":"2015"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.addr.2005.07.002","article-title":"Thiomers: A new generation of mucoadhesive polymers","volume":"57","author":"A Bernkop-Schn\u00fcrch","year":"2005","journal-title":"Advanced drug delivery reviews"},{"issue":"37","key":"ref16","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.1039\/C6TB01348A","article-title":"Folate grafted thiolated chitosan enveloped nanoliposomes with enhanced oral bioavailability and anticancer activity of docetaxel","volume":"4","author":"MF Sohail","year":"2016","journal-title":"Journal of Materials Chemistry B"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF03353614","article-title":"Synthesis, characterization and biocompatibility studies of zinc oxide (ZnO) nanorods for biomedical application","volume":"2","author":"R Gopikrishnan","year":"2010","journal-title":"Nano-Micro Letters"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1021\/am300292v","article-title":"Flexible and microporous chitosan hydrogel\/nano ZnO composite bandages for wound dressing: in vitro and in vivo evaluation","volume":"4","author":"P Sudheesh Kumar","year":"2012","journal-title":"ACS applied materials & interfaces"},{"issue":"Suppl 1","key":"ref19","first-page":"53","article-title":"Exploration of alginate hydrogel\/nano zinc oxide composite bandages for infected wounds","volume":"10","author":"A Mohandas","year":"2015","journal-title":"International journal of nanomedicine"},{"key":"ref20","first-page":"1","article-title":"Formulation and In Vitro Characterization of Thiolated Buccoadhesive Film of Fluconazole","author":"K Naz","year":"2016","journal-title":"AAPS PharmSciTech"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.carbpol.2010.07.028","article-title":"Development of mucoadhesive thiolated chitosan nanoparticles for biomedical applications","volume":"83","author":"A Anitha","year":"2011","journal-title":"Carbohydrate Polymers"},{"key":"ref22","article-title":"Advanced multi-targeted composite biomaterial dressing for pain and infection control in chronic leg ulcers","author":"Ovidio Catanzano","year":"2017","journal-title":"Carbohydrate Polymers"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ajps.2013.12.002","article-title":"Insights into the swelling process and drug release mechanisms from cross-linked pectin\/high amylose starch matrices","volume":"9","author":"FM Carbinatto","year":"2014","journal-title":"Asian Journal of Pharmaceutical Sciences"},{"key":"ref24","article-title":"Formulation and In Vitro Characterization of Thiolated Buccoadhesive Film of Fluconazole","author":"Kiran Naz","year":"2016","journal-title":"AAPS pharm sci tech"},{"issue":"1","key":"ref25","first-page":"177","article-title":"Mucoadhesive wound healing film of Doxycycline Hydrochloride","volume":"23","author":"Renuka Mishra","year":"2012","journal-title":"Reviews in Mineralogy and Geochemistry"},{"issue":"11","key":"ref26","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.addr.2005.07.001","article-title":"The basics and underlying mechanisms of mucoadhesion","volume":"57","author":"JD Smart","year":"2005","journal-title":"Advanced drug delivery reviews"},{"issue":"2","key":"ref27","first-page":"287","article-title":"In vitro evaluation of transdermal patches of flurbiprofen with ethyl cellulose","volume":"71","author":"A Idrees","year":"2014","journal-title":"Acta Pol Pharm"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11095-012-0898-y","article-title":"Evaluation of wound healing potential of \u03b2-chitin hydrogel\/nano zinc oxide composite bandage","volume":"30","author":"S Kumar","year":"2013","journal-title":"Pharmaceutical research"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"945","DOI":"10.3389\/fphar.2017.00945","article-title":"Antioxidants Attenuate Isolation-and L-DOPA-Induced Aggression in Mice","volume":"8","author":"S Hira","year":"2018","journal-title":"Front Pharmacol"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.carbpol.2013.03.034","article-title":"In vivo evaluation of chitosan-PVP-titanium dioxide nanocomposite as wound dressing material","volume":"95","author":"D Archana","year":"2013","journal-title":"Carbohydr Polym"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nm0402-410","article-title":"In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens","volume":"8","author":"AM Dickinson","year":"2002","journal-title":"Nature medicine"},{"issue":"2","key":"ref32","first-page":"62","article-title":"Synthesis and in vitro evaluation of thiolated chitosan-dextran sulfate nanoparticles for the delivery of letrozole","volume":"1","author":"MR Saboktakin","year":"2010","journal-title":"J Pharm Educ Res"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.carbpol.2008.03.022","article-title":"Mucoadhesion of pectin as evidence by wettability and chain interpenetration","volume":"74","author":"P Sriamornsak","year":"2008","journal-title":"Carbohydr Polym"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1177\/088532828700200404","article-title":"Porous Collagen Sponge Wound Dressings: in vivo and in vitro Studies","volume":"2","author":"CJ Doillon","year":"1987","journal-title":"Journal of Biomaterials Applications"},{"key":"ref35","article-title":"cross-linking of Thiolated Chitosan Films: Effects On the Cell Adhesion, Degradation and Cyclic Mechanical Properties","author":"R Ball","year":"2012","journal-title":"Biomaterials"},{"issue":"11","key":"ref36","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/cup.12782","article-title":"Mucin as a diagnostic clue in dermatopathology","volume":"43","author":"A Fernandez-Flores","year":"2016","journal-title":"Journal of cutaneous pathology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0168-3659(85)90050-1","article-title":"Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues","volume":"2","author":"NA Peppas","year":"1985","journal-title":"J Control Release"},{"key":"ref38","article-title":"Wound Healing","author":"J-H Cherng","year":"2018"},{"issue":"1","key":"ref39","first-page":"21","article-title":"Binding of acrylic polymers to mucin\/epithelial surfaces: structure-property relationships","volume":"5","author":"J Gu","year":"1988","journal-title":"Crit Rev Ther Drug Carrier Syst"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijpharm.2013.12.015","article-title":"Natural and synthetic polymers for wounds and burns dressing","volume":"463","author":"GD Mogo\u015fanu","year":"2014","journal-title":"Int J Pharm"},{"issue":"12","key":"ref41","article-title":"Mucoadhesive drug delivery system: a review","volume":"1","author":"R Asija","year":"2013","journal-title":"Journal of Drug Discovery And Therapeutics"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/app.12270","article-title":"A comparative study of swelling properties of hydrogels based on poly (acrylamide-co-methyl methacrylate) containing physical and chemical crosslinks","volume":"89","author":"T Begam","year":"2003","journal-title":"Journal of applied polymer science"},{"issue":"1","key":"ref43","first-page":"119","article-title":"Thiolated chitosan nanoparticles for enhancing oral absorption of docetaxel: preparation, in vitro and ex vivo evaluation","volume":"6","author":"S Saremi","year":"2011","journal-title":"Int J Nanomedicine"},{"issue":"0","key":"ref44","article-title":"Mannosylated thiolated paromomycin-loaded PLGA nanoparticles for the oral therapy of visceral leishmaniasis","author":"I Afzal","year":"2019","journal-title":"Nanomedicine"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ijpharm.2006.05.065","article-title":"Preparation, characterization and in vitro drug release studies of novel polymeric nanoparticles","volume":"323","author":"S Nimesh","year":"2006","journal-title":"International journal of pharmaceutics"},{"issue":"1","key":"ref46","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s11671-018-2532-3","article-title":"Properties of zinc oxide nanoparticles and their activity against microbes","volume":"13","author":"KS Siddiqi","year":"2018","journal-title":"Nanoscale research letters"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Yu J, Baek M, Chung H, Choi S, editors. Effects of physicochemical properties of zinc oxide nanoparticles on cellular uptake. Journal of Physics: Conference Series; 2011: IOP Publishing.","DOI":"10.1088\/1742-6596\/304\/1\/012007"},{"issue":"5","key":"ref48","first-page":"149","article-title":"Staphylococcus aureus isolated from septic caesaerean wound at Ile Ife Nigeria: Antibiotics susceptibility patterns","volume":"3","author":"AO Adejuwon","year":"2011","journal-title":"International Journal of Medicine and Medical Sciences"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40824-016-0063-5","article-title":"Physical, morphological, and wound healing properties of a polyurethane foam-film dressing","volume":"20","author":"SM Lee","year":"2016","journal-title":"Biomaterials research"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1039\/C5RA21821G","article-title":"A nano zinc oxide doped electrospun scaffold improves wound healing in a rodent model","volume":"6","author":"H Chhabra","year":"2016","journal-title":"RSC Advances"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0217079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:10:23Z","timestamp":1588968623000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0217079"}},"subtitle":[],"editor":[{"given":"Amitava","family":"Mukherjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,6]]},"references-count":50,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0217079","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,6]]}}}