{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:21:18Z","timestamp":1792614078643,"version":"4.5.0"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81860283, 81671486, 81270668"],"award-info":[{"award-number":["81860283, 81671486, 81270668"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0217095","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T17:35:46Z","timestamp":1559324146000},"page":"e0217095","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Flutamide ameliorates uterine decidualization and angiogenesis in the mouse hyperandrogenemia model during mid-pregnancy"],"prefix":"10.1371","volume":"14","author":[{"given":"Han","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dainan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuezhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4711-5449","authenticated-orcid":true,"given":"Haibin","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,5,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jsbmb.2018.04.008","article-title":"Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy","volume":"182","author":"S Patel","year":"2018","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref2","first-page":"1","article-title":"The Effect of Metformin on the Endometrium of Women with Polycystic Ovary Syndrome","volume":"2018","author":"C Dragamestianos","journal-title":"Gynecol Obstet Invest"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1159\/000491894","article-title":"MicroRNA-16 Promotes Ovarian Granulosa Cell Proliferation and Suppresses Apoptosis Through Targeting PDCD4 in Polycystic Ovarian Syndrome","volume":"48","author":"X Fu","year":"2018","journal-title":"Cell Physiol Biochem"},{"issue":"2","key":"ref4","first-page":"45","article-title":"The diagnosis of polycystic ovary syndrome in adolescents","volume":"4","author":"AH Roe","year":"2011","journal-title":"Rev Obstet Gynecol"},{"key":"ref5","article-title":"Ovulation induction in polycystic ovary syndrome","author":"T Tanbo","year":"2018","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ebiom.2017.03.023","article-title":"Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome","volume":"18","author":"Y Zhang","year":"2017","journal-title":"EBioMedicine"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13643-015-0105-4","article-title":"The effectiveness and safety of treatments used for polycystic ovarian syndrome management in adolescents: a systematic review and network meta-analysis protocol","volume":"4","author":"RA Al Khalifah","year":"2015","journal-title":"Syst Rev"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1159\/000341579","article-title":"Adipokines, insulin resistance and hyperandrogenemia in obese patients with polycystic ovary syndrome: cross-sectional correlations and the effects of weight loss","volume":"5","author":"N Spanos","year":"2012","journal-title":"Obes Facts"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jpag.2013.03.007","article-title":"Differences in the management of adolescents with polycystic ovary syndrome across pediatric specialties","volume":"26","author":"B Auble","year":"2013","journal-title":"J Pediatr Adolesc Gynecol"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1055\/s-0035-1552582","article-title":"The emerging role of angiogenic factor dysregulation in the pathogenesis of polycystic ovarian syndrome","volume":"33","author":"R Tal","year":"2015","journal-title":"Semin Reprod Med"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S1472-6483(10)60577-9","article-title":"Uterine NK cells in murine pregnancy","volume":"16","author":"MJ Bilinski","year":"2008","journal-title":"Reprod Biomed Online"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1210\/er.2003-0021","article-title":"Natural killer cells in pregnancy and recurrent pregnancy loss: endocrine and immunologic perspectives","volume":"26","author":"C Dosiou","year":"2005","journal-title":"Endocr Rev"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"R91","DOI":"10.1530\/REP-14-0271","article-title":"Uterine natural killer cells: supervisors of vasculature construction in early decidua basalis","volume":"149","author":"MT Ratsep","year":"2015","journal-title":"Reproduction"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12958-017-0290-1","article-title":"The regulation of ovary and conceptus on the uterine natural killer cells during early pregnancy","volume":"15","author":"H Gong","year":"2017","journal-title":"Reprod Biol Endocrinol"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2174\/1871530317666170912153934","article-title":"A Novel Potential Reproductive Effects of Pterocarpus marsupium Methanolic Extract on Testosterone Propionate Induced Polycystic Ovary Syndrome in Female Albino Rats","volume":"17","author":"AL Hugar","year":"2017","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"issue":"5","key":"ref16","first-page":"1967","article-title":"Testosterone decreases the expression of endometrial pinopode and L-selectin ligand (MECA-79) in adult female rats during uterine receptivity period","volume":"7","author":"HM Mokhtar","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1136\/acupmed-2015-010788","article-title":"Moxibustion relieves visceral hyperalgesia via inhibition of transient receptor potential vanilloid 1 (TRPV1) and heat shock protein (HSP) 70 expression in rat bone marrow cells","volume":"34","author":"W Zou","year":"2016","journal-title":"Acupunct Med"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10735-010-9256-8","article-title":"Hormonal regulation of uterine natural killer cells in mouse preimplantation uterus","volume":"41","author":"H Kuang","year":"2010","journal-title":"J Mol Histol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jhazmat.2015.04.065","article-title":"Maternal exposure to di-(2-ethylhexyl) phthalate disrupts placental growth and development in pregnant mice","volume":"297","author":"T Zong","year":"2015","journal-title":"J Hazard Mater"},{"issue":"1","key":"ref20","first-page":"414","article-title":"Effects of hypoxiainducible factor1alpha on endometrial receptivity of women with polycystic ovary syndrome","volume":"17","author":"D Zhao","year":"2018","journal-title":"Mol Med Rep"},{"issue":"12","key":"ref21","doi-asserted-by":"crossref","first-page":"e52037","DOI":"10.1371\/journal.pone.0052037","article-title":"Delta-like ligand (DLL)1 expression in early mouse decidua and its localization to uterine natural killer cells","volume":"7","author":"KY Degaki","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/humrep\/dev067","article-title":"Estrogen-dependent regulation of human uterine natural killer cells promotes vascular remodelling via secretion of CCL2","volume":"30","author":"DA Gibson","year":"2015","journal-title":"Hum Reprod"},{"issue":"9","key":"ref23","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1002\/emmm.201302618","article-title":"VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy","volume":"5","author":"M Kim","year":"2013","journal-title":"EMBO Mol Med"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"5575","DOI":"10.1210\/en.2012-1528","article-title":"Overexpression of cyclin D3 improves decidualization defects in Hoxa-10(-\/-) mice","volume":"153","author":"JM Sroga","year":"2012","journal-title":"Endocrinology"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ydbio.2005.11.016","article-title":"Hoxa-10 deficiency alters region-specific gene expression and perturbs differentiation of natural killer cells during decidualization","volume":"290","author":"MA Rahman","year":"2006","journal-title":"Dev Biol"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1210\/jc.2002-021072","article-title":"Regulation of HOXA-10 expression by testosterone in vitro and in the endometrium of patients with polycystic ovary syndrome","volume":"88","author":"D Cermik","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00404-017-4295-y","article-title":"Effects of a hyperandrogenaemic state on the proliferation and decidualization potential in human endometrial stromal cells","volume":"295","author":"A Freis","year":"2017","journal-title":"Arch Gynecol Obstet"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0217095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:11:34Z","timestamp":1588968694000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0217095"}},"subtitle":[],"editor":[{"given":"Zeng-Ming","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,5,31]]},"references-count":27,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0217095","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,31]]}}}