{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:16:21Z","timestamp":1780474581677,"version":"3.54.1"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for Clinical and Applied Cancer Research","award":["011-2017SD"],"award-info":[{"award-number":["011-2017SD"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0217340","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T17:33:45Z","timestamp":1561052025000},"page":"e0217340","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Systemic management of malignant meningiomas: A comparative survival and molecular marker analysis between Octreotide in combination with Everolimus and Sunitinib"],"prefix":"10.1371","volume":"14","author":[{"given":"Andr\u00e9s F.","family":"Cardona","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Ruiz-Pati\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zyanya Lucia","family":"Zatarain-Barr\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Hakim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Armando","family":"Mej\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Fernando","family":"Ram\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Useche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Berm\u00fadez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Pineda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernando","family":"Cifuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Ricaurte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Eduardo","family":"Pino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Bala\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1164-3779","authenticated-orcid":true,"given":"Oscar","family":"Arrieta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"issue":"Suppl 4","key":"ref1","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/neuonc\/nov189","article-title":"CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008\u20132012","volume":"17","author":"QT Ostrom","year":"2015","journal-title":"Neuro Oncol"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11060-010-0386-3","article-title":"Epidemiology and etiology of meningioma","volume":"99","author":"J Wiemels","year":"2010","journal-title":"Journal of neuro-oncology"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"E3","DOI":"10.3171\/FOC\/2008\/24\/5\/E3","article-title":"Hitting a moving target: evolution of a treatment paradigm for atypical meningiomas amid changing diagnostic criteria","volume":"24","author":"BE Pearson","year":"2008","journal-title":"Neurosurg Focus"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary","volume":"131","author":"DN Louis","year":"2016","journal-title":"Acta neuropathologica"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3171\/2014.7.JNS131644","article-title":"Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review","volume":"122","author":"L Rogers","year":"2015","journal-title":"J Neurosurg"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1097\/00000478-199712000-00008","article-title":"Meningioma grading: an analysis of histologic parameters","volume":"21","author":"A Perry","year":"1997","journal-title":"Am J Surg Pathol"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1002\/(SICI)1097-0142(19990501)85:9<2046::AID-CNCR23>3.0.CO;2-M","article-title":"&quot;Malignancy&quot; in meningiomas: a clinicopathologic study of 116 patients, with grading implications","volume":"85","author":"A Perry","year":"1999","journal-title":"Cancer"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1055\/s-0038-1636502","article-title":"Meningiomas: Overview and New Directions in Therapy","volume":"38","author":"N Wang","year":"2018","journal-title":"Seminars in neurology"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"e383","DOI":"10.1016\/S1470-2045(16)30321-7","article-title":"EANO guidelines for the diagnosis and treatment of meningiomas","volume":"17","author":"R Goldbrunner","year":"2016","journal-title":"The Lancet Oncology"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1080\/14737175.2016.1184087","article-title":"Systemic therapy for recurrent meningioma","volume":"16","author":"E Le Rhun","year":"2016","journal-title":"Expert review of neurotherapeutics"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/neuonc\/not330","article-title":"Historical benchmarks for medical therapy trials in surgery- and radiation-refractory meningioma: a RANO review","volume":"16","author":"T Kaley","year":"2014","journal-title":"Neuro Oncol"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1053\/hupa.2001.27119","article-title":"Immunohistochemical study of Ki-67 (MIB-1), p53 protein, p21WAF1, and p27KIP1 expression in benign, atypical, and anaplastic meningiomas","volume":"32","author":"VJ Amatya","year":"2001","journal-title":"Hum Pathol"},{"issue":"10","key":"ref13","first-page":"13185","article-title":"Expression of somatostatin receptors (SSTR1-SSTR5) in meningiomas and its clinicopathological significance","volume":"8","author":"CB Silva","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1212\/01.wnl.0000271382.62776.b7","article-title":"Recurrent meningioma: salvage therapy with long-acting somatostatin analogue","volume":"69","author":"MC Chamberlain","year":"2007","journal-title":"Neurology"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s00280-014-2422-z","article-title":"Recurrent high-grade meningioma: a phase II trial with somatostatin analogue therapy","volume":"73","author":"M Sim\u00f3","year":"2014","journal-title":"Cancer Chemother Pharmacol"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1212\/WNL.0000000000001153","article-title":"Phase II study of monthly pasireotide LAR (SOM230C) for recurrent or progressive meningioma","volume":"84","author":"AD Norden","year":"2015","journal-title":"Neurology"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11060-015-1812-3","article-title":"Combined treatment by octreotide and everolimus: Octreotide enhances inhibitory effect of everolimus in aggressive meningiomas","volume":"124","author":"T Graillon","year":"2015","journal-title":"Journal of neuro-oncology"},{"issue":"15","key":"ref18","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1200\/JCO.2017.35.15_suppl.2011","article-title":"A phase II of everolimus and octreotide for patients with refractory and documented progressive meningioma (CEVOREM)","volume":"35","author":"T Graillon","year":"2017","journal-title":"Journal of Clinical Oncology"},{"issue":"4","key":"ref19","first-page":"B4626","article-title":"Intracranial meningiomas, the VEGF-A pathway, and peritumoral brain oedema","volume":"60","author":"D. Nassehi","year":"2013","journal-title":"Dan Med J"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/neuonc\/nou148","article-title":"Phase II trial of sunitinib for recurrent and progressive atypical and anaplastic meningioma","volume":"17","author":"TJ Kaley","year":"2015","journal-title":"Neuro Oncol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0217340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:37:20Z","timestamp":1588966640000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0217340"}},"subtitle":[],"editor":[{"given":"Jung Weon","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,20]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0217340","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,20]]}}}