{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:19:04Z","timestamp":1778678344275,"version":"3.51.4"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2016R1D1A1B01010566"],"award-info":[{"award-number":["2016R1D1A1B01010566"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1C1B6005185"],"award-info":[{"award-number":["2018R1C1B6005185"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0217521","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T13:30:10Z","timestamp":1561555810000},"page":"e0217521","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Somatic mosaic truncating mutations of PPM1D in blood can result from expansion of a mutant clone under selective pressure of chemotherapy"],"prefix":"10.1371","volume":"14","author":[{"given":"Borahm","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongju","family":"Won","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Tae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Rak","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/sj.onc.1209927","article-title":"The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase","volume":"26","author":"M Oliva-Trastoy","year":"2007","journal-title":"Oncogene"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ccr.2007.08.033","article-title":"The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop","volume":"12","author":"X Lu","year":"2007","journal-title":"Cancer Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/ng.2995","article-title":"Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas","volume":"46","author":"L Zhang","year":"2014","journal-title":"Nat Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s11060-007-9470-8","article-title":"Medulloblastomas overexpress the p53-inactivating oncogene WIP1\/PPM1D","volume":"86","author":"RC Castellino","year":"2008","journal-title":"J Neurooncol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nature11725","article-title":"Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer","volume":"493","author":"E Ruark","year":"2013","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e110218","DOI":"10.1371\/journal.pone.0110218","article-title":"Overexpression of wip1 is associated with biologic behavior in human clear cell renal cell carcinoma","volume":"9","author":"S Liu","year":"2014","journal-title":"PLoS One"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1038\/modpathol.2010.121","article-title":"PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study","volume":"23","author":"MB Lambros","year":"2010","journal-title":"Mod Pathol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3892\/etm.2014.1762","article-title":"PPM1D is a prognostic marker and therapeutic target in colorectal cancer","volume":"8","author":"TS Peng","year":"2014","journal-title":"Exp Ther Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/bjc.2015.79","article-title":"Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients","volume":"112","author":"A Zajkowicz","year":"2015","journal-title":"Br J Cancer"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e0115635","DOI":"10.1371\/journal.pone.0115635","article-title":"WIP1 phosphatase as a potential therapeutic target in neuroblastoma","volume":"10","author":"M Richter","year":"2015","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1083\/jcb.201210031","article-title":"Gain-of-function mutations of PPM1D\/Wip1 impair the p53-dependent G1 checkpoint","volume":"201","author":"P Kleiblova","year":"2013","journal-title":"J Cell Biol"},{"key":"ref12","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djt323","article-title":"PPM1D mutations in circulating white blood cells and the risk for ovarian cancer","volume":"106","author":"MR Akbari","year":"2014","journal-title":"J Natl Cancer Inst"},{"key":"ref13","article-title":"PPM1D Mosaic Truncating Variants in Ovarian Cancer Cases May Be Treatment-Related Somatic Mutations","volume":"108","author":"PDP Pharoah","year":"2016","journal-title":"J Natl Cancer Inst"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1093\/bioinformatics\/btu356","article-title":"Toward better understanding of artifacts in variant calling from high-coverage samples","volume":"30","author":"H Li","year":"2014","journal-title":"Bioinformatics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ng.806","article-title":"A framework for variation discovery and genotyping using next-generation DNA sequencing data","volume":"43","author":"MA DePristo","year":"2011","journal-title":"Nat Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"K Wang","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1093\/bioinformatics\/btq330","article-title":"Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor","volume":"26","author":"W McLaren","year":"2010","journal-title":"Bioinformatics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"JT Robinson","year":"2011","journal-title":"Nat Biotechnol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"S Richards","year":"2015","journal-title":"Genet Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10555-008-9127-x","article-title":"The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways","volume":"27","author":"X Lu","year":"2008","journal-title":"Cancer Metastasis Rev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.4161\/cc.25694","article-title":"Genetic variants and mutations of PPM1D control the response to DNA damage","volume":"12","author":"C Dudgeon","year":"2013","journal-title":"Cell Cycle"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6517","DOI":"10.1093\/emboj\/19.23.6517","article-title":"p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation","volume":"19","author":"M Takekawa","year":"2000","journal-title":"Embo j"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"251","DOI":"10.4161\/cc.23057","article-title":"Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis","volume":"12","author":"L Macurek","year":"2013","journal-title":"Cell Cycle"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1001\/jamaoncol.2015.6053","article-title":"Somatic Mosaic Mutations in PPM1D and TP53 in the Blood of Women With Ovarian Carcinoma","volume":"2","author":"EM Swisher","year":"2016","journal-title":"JAMA Oncol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: molecular mechanisms of action","volume":"740","author":"S Dasari","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.stem.2018.10.004","article-title":"PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy","volume":"23","author":"JI Hsu","year":"2018","journal-title":"Cell Stem Cell"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41467-018-02858-0","article-title":"Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential","volume":"9","author":"TN Wong","year":"2018","journal-title":"Nat Commun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1056\/NEJMoa1409405","article-title":"Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence","volume":"371","author":"G Genovese","year":"2014","journal-title":"N Engl J Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1038\/nm.3733","article-title":"Age-related mutations associated with clonal hematopoietic expansion and malignancies","volume":"20","author":"M Xie","year":"2014","journal-title":"Nat Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1200\/JCO.2016.71.6712","article-title":"Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma","volume":"35","author":"CJ Gibson","year":"2017","journal-title":"J Clin Oncol"},{"key":"ref31","article-title":"PPM1D truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells","author":"JD Kahn","year":"2018","journal-title":"Blood"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0217521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:28:40Z","timestamp":1588962520000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0217521"}},"subtitle":[],"editor":[{"given":"Klaus","family":"Brusgaard","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,26]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0217521","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,26]]}}}