{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:43:58Z","timestamp":1790502238880,"version":"4.1.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T00:00:00Z","timestamp":1560124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FRM","award":["SPF20151234951"],"award-info":[{"award-number":["SPF20151234951"]}]},{"name":"Agence national de la recherche","award":["M\u00e9diterran\u00e9e Infection 10-IAHU-03"],"award-info":[{"award-number":["M\u00e9diterran\u00e9e Infection 10-IAHU-03"]}]},{"name":"FEDER PRIMMI","award":["Fonds Europ\u00e9en de D\u00e9veloppement R\u00e9gional - Plateformes de Recherche et d\u2019Innovation Mutualis\u00e9es M\u00e9diterran\u00e9e Infection"],"award-info":[{"award-number":["Fonds Europ\u00e9en de D\u00e9veloppement R\u00e9gional - Plateformes de Recherche et d\u2019Innovation Mutualis\u00e9es M\u00e9diterran\u00e9e Infection"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    <jats:italic>Coxiella burnetii<\/jats:italic>\n                    , the agent causing Q fever, has been associated with B-cell non-Hodgkin lymphoma (NHL). To better clarify this link, we analysed the genetic transcriptomic profile of peripheral blood leukocytes from patients with\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>burnetii<\/jats:italic>\n                    infection to identify possible links to lymphoma. Microarray analyses revealed that 1189 genes were expressed differently (p &lt;.001 and fold change \u22654) in whole blood of patients with\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>burnetii<\/jats:italic>\n                    infection compared to controls. In addition, 95 genes expressed in patients with non-Hodgkin lymphoma (NHL) and in patients with\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>burnetii<\/jats:italic>\n                    persistent infection have allowed us to establish the \u2018\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>burnetii<\/jats:italic>\n                    -associated NHL signature\u2019. Among these, 33 genes previously found modulated in\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>burnetii<\/jats:italic>\n                    -associated -NHL by the microarray analysis were selected and their mRNA expression levels were measured in distinct\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>burnetii<\/jats:italic>\n                    -induced pathologies, namely, acute Q fever, focalized persistent infection, lymphadenitis and\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>burnetii<\/jats:italic>\n                    -associated NHL. Specific genes involved in anti-apoptotic process were found highly expressed in leukocytes from patients with\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>burnetii<\/jats:italic>\n                    associated-NHL:\n                    <jats:italic>MIR17HG<\/jats:italic>\n                    ,\n                    <jats:italic>REL<\/jats:italic>\n                    and\n                    <jats:italic>SP100<\/jats:italic>\n                    . This signature differed from that found for NHL-control group. Patients with\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>burnetii<\/jats:italic>\n                    lymphadenitis presented significant elevated levels of\n                    <jats:italic>BCL2<\/jats:italic>\n                    and\n                    <jats:italic>ETS1<\/jats:italic>\n                    mRNAs. Altogether, we identified a specific transcriptionnal signature for NHL during\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>burnetii<\/jats:italic>\n                    infection reflecting the up-regulation of anti-apoptotic processes and the fact that lymphadenitis might constitute a critical step towards lymphomagenesis.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0217542","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T13:32:02Z","timestamp":1560173522000},"page":"e0217542","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["RETRACTED: A transcriptional signature associated with non-Hodgkin lymphoma in the blood of patients with Q fever"],"prefix":"10.1371","volume":"14","author":[{"given":"Cl\u00e9a","family":"Melenotte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Mezouar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Ben Amara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Benatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Chiaroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Devaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"Costello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Kroemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Mege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Raoult","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,6,10]]},"reference":[{"key":"pone.0217542.ref001","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1182\/blood-2015-11-677203","article-title":"Identifying 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