{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:29:11Z","timestamp":1762507751127,"version":"3.37.3"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0217562","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T17:27:43Z","timestamp":1559669263000},"page":"e0217562","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Menopausal status is associated with a high risk for residual disease after cervical conization with positive margins"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4755-170X","authenticated-orcid":true,"given":"Jo\u00e3o Paolo","family":"Bilibio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heleusa Ione","family":"Monego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia Luiza Appel","family":"Binda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"dos Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,6,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2016.03.021","article-title":"Risk factors for residual disease after cervical conization in patients with cervical intraepithelial neoplasia grades 2 and 3 and positive surgical margins","volume":"201","author":"A Ayhan","year":"2016","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"1","key":"ref2","first-page":"83","article-title":"Jan","volume":"33","author":"R Shaco-Levy","year":"2014","journal-title":"Jan"},{"issue":"Suppl 5","key":"ref3","doi-asserted-by":"crossref","first-page":"F88","DOI":"10.1016\/j.vaccine.2012.06.095","article-title":"Evidence regarding human papillomavirus testing in secondary prevention of cervical cancer","volume":"30","author":"M Arbyn","year":"2012","journal-title":"Vaccine"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"540","DOI":"10.14740\/jocmr2171w","article-title":"Positive endocervical margins at conization: repeat conization or colposcopic follow-up? A retrospective study","volume":"7","author":"A Chambo Filho","year":"2015","journal-title":"J Clin Med Res"},{"issue":"6","key":"ref5","first-page":"996","article-title":"The significance of positive margins in loop electrosurgical cone biopsies","volume":"84","author":"JC Felix","year":"1994","journal-title":"Obstet Gynecol"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ygyno.2005.01.003","article-title":"Recurrent smear abnormalities where repeat loop treatment is not possible: is hysterectomy the answer?","volume":"97","author":"N Das","year":"2005","journal-title":"Gynecol Oncol"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/LGT.0b013e31824ca9d5","article-title":"American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer","volume":"16","author":"D Saslow","year":"2012","journal-title":"J Low Genit Tract Dis"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/LGT.0000000000000079","article-title":"Is there any predictor for residual disease after cervical conization with positive surgical margins for HSIL or microinvasive cervical cancer?","volume":"19","author":"T Tasci","year":"2015","journal-title":"J Low Genit Tract Dis"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"e0131790","DOI":"10.1371\/journal.pone.0131790","article-title":"Conization Using an Electrosurgical Knife for Cervical Intraepithelial Neoplasia and Microinvasive Carcinoma","volume":"10","author":"L Xiang","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/jog.12929","article-title":"Predictors of recurrent\/residual disease after loop electrosurgical excisional procedure","volume":"42","author":"K Chikazawa","year":"2016","journal-title":"J Obstet Gynaecol Res"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0928-8244(03)00202-5","article-title":"Regulation of innate and adaptive immunity by the female sex hormones oestradiol and progesterone","volume":"38","author":"KW Beagley","year":"2003","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"3","key":"ref12","first-page":"234","article-title":"Jun","volume":"19","author":"F Abdi","year":"2016","journal-title":"Jun"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/aji.12252","article-title":"Regulation of mucosal immunity in the female reproductive tract: the role of sex hormones in immune protection against sexually transmitted pathogens","volume":"72","author":"CR Wira","year":"2014","journal-title":"Am J Reprod Immunol"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/aogs.12025","article-title":"The appropriate cone depth to avoid endocervical margin involvement is dependent on age and disease severity","volume":"92","author":"HS Bae","year":"2013","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/j.1471-0528.1993.tb14292.x","article-title":"Histological incomplete excision of CIN after large loop excision of the transformation zone (LLETZ) merits careful follow up, not retreatment","volume":"100","author":"N Mahadevan","year":"1993","journal-title":"Br J Obstet Gynaecol"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0029-7844(96)00505-4","article-title":"Persistent intraepithelial neoplasia after excision for cervical intraepithelial neoplasia grade III","volume":"89","author":"F Gardeil","year":"1997","journal-title":"Obstet Gynecol"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/LGT.0000000000000287","article-title":"Loop Electrosurgical Excision Procedure Instead of Cold-Knife Conization for Cervical Intraepithelial Neoplasia in Women With Unsatisfactory Colposcopic Examinations: A Systematic Review and Meta-Analysis","volume":"21","author":"SA El-Nashar","year":"2017","journal-title":"J Low Genit Tract Dis"},{"issue":"3","key":"ref18","first-page":"463","article-title":"High-grade squamous intraepithelial lesion with endocervical cone margin involvement after cervical loop electrosurgical excision: what should a clinician do?","volume":"7","author":"S Siriaree","year":"2006","journal-title":"Asian Pac J Cancer Prev"},{"issue":"11","key":"ref19","first-page":"334","article-title":"High-grade intraepithelial cervical lesions: evaluation of the factors determining an unfavorable outcome after conization","volume":"33","author":"FV Fonseca","year":"2011","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"4","key":"ref20","first-page":"691","article-title":"Cervical cone measurements and residual disease in LLETZ conisation for cervical intraepithelial neoplasia","volume":"25","author":"D Papoutsis","year":"2011","journal-title":"In Vivo"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ejogrb.2012.08.016","article-title":"Minimal cold knife conization height for high-grade cervical squamous intraepithelial lesion treatment","volume":"165","author":"LM Kliemann","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000345864","article-title":"Appropriate cone dimensions to achieve negative excision margins after large loop excision of transformation zone in the uterine cervix for cervical intraepithelial neoplasia","volume":"75","author":"D Papoutsis","year":"2013","journal-title":"Gynecol Obstet Invest"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1111\/j.1600-0463.2007.00769.x","article-title":"Cervical intraepithelial neoplasia grade 3 lesions can regress","volume":"115","author":"AC Munk","year":"2007","journal-title":"APMIS"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ijgo.2015.09.020","article-title":"Multivariate analysis of risk factors for the persistence of high-grade squamous intraepithelial lesions following loop electrosurgical excision procedure","volume":"133","author":"PP Dos Santos Melli","year":"2016","journal-title":"Int J Gynaecol Obstet"},{"key":"ref25","unstructured":"J Brazilian Cervical Cancer Screening Guidelines. Brazilian Cervical Cancer Screening Guidelines. Nacional de C\u00e2ncer Jos\u00e9 Alencar Gomes da Silva. Coordena\u00e7\u00e3o de Preven\u00e7\u00e3o e Vigil\u00e2ncia ivis\u00e3o de Detec\u00e7\u00e3o Precoce e Apoio \u00e0 Organiza\u00e7\u00e3o de Rede. Rio de Janeiro 2016. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/bvsms.saude.gov.br\/bvs\/controle_cancer\" xlink:type=\"simple\">http:\/\/bvsms.saude.gov.br\/bvs\/controle_cancer<\/ext-link>"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0217562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:34:21Z","timestamp":1589009661000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0217562"}},"subtitle":[],"editor":[{"given":"Magdalena","family":"Grce","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,4]]},"references-count":25,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0217562","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2019,6,4]]}}}