{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:11:38Z","timestamp":1791292298112,"version":"4.1.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0217626","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T17:36:21Z","timestamp":1559842581000},"page":"e0217626","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Different mechanisms of serum complement activation in the plasma of common (Chelydra serpentina) and alligator (Macrochelys temminckii) snapping turtles"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0006-1025","authenticated-orcid":true,"given":"Sarah","family":"Baker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8916-2070","authenticated-orcid":true,"given":"Ethan","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lancia","family":"Darville-Bowleg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Merchant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev.iy.04.040186.002443","article-title":"The membrane attack complex of complement","volume":"4","author":"H M\u00fcller-Eberhard","year":"1986","journal-title":"Ann Rev Immunol"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.1923","article-title":"Complement: a key component for immune surveillance and homeostasis","volume":"11","author":"D Ricklin","year":"2010","journal-title":"Nature Immunol"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1046\/j.1365-2567.2000.00009.x","article-title":"The role of complement in the acquired immune response","volume":"100","author":"CH Nielsen","year":"2000","journal-title":"Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-3233(08)60458-1","article-title":"Activation of the complement system by antibody-antigen complexes: the classical pathway","volume":"33","author":"RR Porter","year":"1979","journal-title":"Adv Protein Chem"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/pro.5560060201","article-title":"The internal thioester and the covalent binding properties of the complement proteins C3 and C4","volume":"6","author":"SKA Law","year":"1997","journal-title":"Prot Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1749-6632.1983.tb18116.x","article-title":"Initiation of the alternative complement pathway due to spontaneous hydrolysis of the thioester of C3","volume":"421","author":"MK Pangburn","year":"1983","journal-title":"Ann NY Acad Sci"},{"issue":"24","key":"ref7","doi-asserted-by":"crossref","first-page":"25307","DOI":"10.1074\/jbc.M400701200","article-title":"Human mannose-binding lectin and L-ficolin function as specific pattern recognition proteins in the lectin activation pathway of complement","volume":"279","author":"YG Ma","year":"2004","journal-title":"J Biol Chem"},{"issue":"2\u20133","key":"ref8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0161-5890(01)00038-4","article-title":"The mannan-binding lectin pathway of complement activation: biology and disease association","volume":"38","author":"SV Petersen","year":"2001","journal-title":"Mol Immunol"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000463070","article-title":"The pathobiology of the terminal complement complexes","volume":"6","author":"AP Dalmasso","year":"1989","journal-title":"Complement Inflamm"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1242\/jeb.038315","article-title":"Commentary understanding the vertebrate immune system: Insights from the reptilian perspective","volume":"213","author":"LM Zimmerman","year":"2010","journal-title":"J Exp Biol"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.9734\/IJBCRR\/2014\/7825","article-title":"Characterization of serum complement activity in three species of crocodilians from southeast Mexico","volume":"4","author":"M Merchant","year":"2014","journal-title":"Int. J. Biochem. Res. Rev"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0145-305X(02)00070-8","article-title":"Evolutionary immunobiology: new approaches, new paradigms","volume":"27","author":"G Warr","year":"2003","journal-title":"Dev Comp Immunol"},{"issue":"8","key":"ref13","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1641\/0006-3568(2000)050[0653:TGDORD]2.0.CO;2","article-title":"The global decline of reptiles, d\u00e9j\u00e0 vu amphibians","volume":"50","author":"JW Gibbons","year":"2000","journal-title":"Bioscience"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/biosci\/biy095","article-title":"Where have all the turtles gone, and why does it matter?","volume":"68","author":"JE Lovich","year":"2018","journal-title":"Bioscience"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cbpc.2005.03.009","article-title":"Identification of alternative pathway serum complement activity in the blood of the American alligator (<italic>Alligator mississippiensis<\/italic>)","volume":"141","author":"ME Merchant","year":"2005","journal-title":"Comp Biochem Physiol B"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.cbpa.2006.01.009","article-title":"Characterization of serum complement activity of the saltwater (<italic>Crocodylus porosus<\/italic>) and freshwater (<italic>Crocodylus johnstoni<\/italic>) crocodiles","volume":"143","author":"M Merchant","year":"2006","journal-title":"Comp Biochem Physiol A"},{"issue":"1","key":"ref17","first-page":"64","article-title":"Characterization of serum complement activity of the broad snouted caiman (<italic>Caiman latirostris<\/italic>, Crocodilia: Alligatoridae)","volume":"49","author":"P Siroski","year":"2010","journal-title":"Zool Stud"},{"issue":"2\u20134","key":"ref18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.vetimm.2009.07.016","article-title":"Identification and characterization of serum complement activity in the American crocodile (<italic>Crocodylus acutus<\/italic>)","volume":"133","author":"M Merchant","year":"2010","journal-title":"Vet Immunol Immunopathol"},{"issue":"2","key":"ref19","first-page":"110","article-title":"Serum complement activity in two species of diverse west African crocodiles","volume":"2","author":"M Merchant","year":"2013","journal-title":"Entomol Ornithol Herpetol"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1590\/S1984-46702009000400020","article-title":"Innate immune activity of <italic>Phrynops geoffroanus<\/italic> (Testudines, Chelidae)","volume":"26","author":"BO Ferronato","year":"2009","journal-title":"Zoologia"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ygcen.2018.03.016","article-title":"Seasonal changes in baseline corticosterone, association with innate immunity, and effects of confinement in free-ranging eastern box turtles, <italic>Terrapene carolina carolina<\/italic>","volume":"262","author":"JM West","year":"2018","journal-title":"Gen Comp Endocrinol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ympev.2017.07.006","article-title":"Phylogenomic analyses of 539 highly informative loci dates a fully resolved time tree for the major clades of living turtles (Testudines)","volume":"115","author":"HB Shaffer","year":"2017","journal-title":"Mol Phylogenet and Evol"},{"key":"ref23","article-title":"The alligator snapping turtle: Biology and conservation","author":"PCH Pritchard","year":"2006"},{"key":"ref24","doi-asserted-by":"crossref","DOI":"10.56021\/9780801891212","article-title":"Turtles of the United States and Canada","author":"CH Ernst","year":"2009"},{"key":"ref25","first-page":"1","article-title":"Antibacterial properties of plasma from the common (<italic>Chelydra serpentina<\/italic>) and alligator (<italic>Macrochelys temminckii<\/italic>) snapping turtles","author":"SJ Baker","year":"2018","journal-title":"J Exp Zool A"},{"key":"ref26","first-page":"1","article-title":"Turtles of the world: Annotated checklist and atlas of taxonomy, synonymy, distribution, and conservation status (8th ed.)","volume":"7","author":"AGJ Rhodin","year":"2017","journal-title":"Chelon Res Monogr"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/jez.2089","article-title":"Repeatability and sources of variation of the bacteria-killing assay in the common snapping turtle","volume":"327","author":"ML Beck","year":"2017","journal-title":"J Exp Zool A"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4236\/abc.2012.24043","article-title":"Characterization of serum complement activity in serum of the Komodo dragon (<italic>Varanus komodoensis<\/italic>)","volume":"2","author":"M Merchant","year":"2012","journal-title":"Adv Biol Chem"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.peptides.2012.07.001","article-title":"Overview on the recent study of antimicrobial peptides: Origins, functions, relative mechanisms and application","volume":"37","author":"Y Li","year":"2012","journal-title":"Peptides"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1084\/jem.115.6.1231","article-title":"The complement-dependent bacterilytic activity of normal human serum","volume":"115","author":"AC Wardlaw","year":"1962","journal-title":"J Exper Med"},{"issue":"8","key":"ref31","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1139\/z90-246","article-title":"Radiotelemetry of body temperatures of free-ranging snapping turtles (<italic>Chelydra serpentina<\/italic>) during summer","volume":"68","author":"GP Brown","year":"1990","journal-title":"Can J Zool"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0306-4565(89)90027-2","article-title":"Growth, selected temperature, and CTM of young snapping turtles, <italic>Chelydra serpentina<\/italic>","volume":"14","author":"LU Williamson","year":"1989","journal-title":"J Therm Biol"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.2307\/1446490","article-title":"Nutritional status and mean selected temperature of hatchling snapping turtles (<italic>Chelydra serpentina<\/italic>): is there a thermophilic response to feeding?","author":"TW Knight","year":"1990","journal-title":"Copeia"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1656\/1528-7092(2008)7[331:SADOTA]2.0.CO;2","article-title":"Status and distribution of the alligator snapping turtle (<italic>Macrochelys temminckii<\/italic>) in southeastern Missouri","volume":"7","author":"PA Shipman","year":"2008","journal-title":"Southeast Nat"},{"issue":"21","key":"ref35","doi-asserted-by":"crossref","first-page":"10025","DOI":"10.1016\/S0021-9258(19)70418-9","article-title":"The effect of methylamine on the structure and function of the fourth component cascade of human complement, C4","volume":"255","author":"JP Gorski","year":"1980","journal-title":"J. Biol. Chem"},{"issue":"44","key":"ref36","doi-asserted-by":"crossref","first-page":"43437","DOI":"10.1074\/jbc.M306620200","article-title":"Mutations in the \u03b1-chain of C4BP that selectively affect its factor I cofactor function","volume":"278","author":"AM Blom","year":"2003","journal-title":"J Biol Chem"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1084\/jem.114.1.29","article-title":"Anaphylaxis in chopped guinea pig liver: III. Effect of carbon monoxide, cyanide, salicylaldoxime, and ionic strength","volume":"114","author":"KF Austen","year":"1961","journal-title":"J Exp Med"},{"key":"ref38","first-page":"66","article-title":"Molecular aspects of the properdin system","volume":"12","author":"O Gotze","year":"1977","journal-title":"Monogr. Allergy"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1046\/j.1365-3148.2002.00408.x","article-title":"Mannan-binding protein and its role in innate immunity","volume":"12","author":"DC Kilpatrick","year":"2002","journal-title":"Transfusion Med"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1399-0039.2006.00649.x","article-title":"Mannose-binding lectin in innate immunity: past, present and future","volume":"68","author":"RM Drommett","year":"2006","journal-title":"Tissue Antigens"},{"issue":"4","key":"ref41","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1462-5822.2005.00506.x","article-title":"How C-type lectins detect pathogens","volume":"7","author":"A Cambi","year":"2005","journal-title":"Cell Microbiol"},{"issue":"6400","key":"ref42","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/360127a0","article-title":"Structure of a C-type mannose-binding protein complexed with an oligosaccharide","volume":"360","author":"W Weis","year":"1992","journal-title":"Nature"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cbpb.2011.11.001","article-title":"Isolation and identification of the primary structure of a lectin protein from the serum of the American alligator (<italic>Alligator mississippiensis<\/italic>)","volume":"161","author":"LNF Darville","year":"2012","journal-title":"Comp Biochem Physiol B"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0219772","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0217626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T07:39:22Z","timestamp":1721374762000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0217626"}},"subtitle":[],"editor":[{"given":"Sebastian D.","family":"Fugmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,6]]},"references-count":43,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0217626","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0219772","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,6]]}}}