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Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.nice.org.uk\/guidance\/cg172\/resources\/myocardial-infarction-cardiac-rehabilitation-and-prevention-of-further-cardiovascular-disease-pdf-35109748874437\" xlink:type=\"simple\">https:\/\/www.nice.org.uk\/guidance\/cg172\/resources\/myocardial-infarction-cardiac-rehabilitation-and-prevention-of-further-cardiovascular-disease-pdf-35109748874437<\/ext-link> [accessed 31 May 2017].","key":"ref2"},{"unstructured":"BACPR. Cardiovascular disease prevention and rehabilitation. 2012. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.bacpr.com\/resources\/46C_BACPR_Standards_and_Core_Components_2012.pdf\" xlink:type=\"simple\">http:\/\/www.bacpr.com\/resources\/46C_BACPR_Standards_and_Core_Components_2012.pdf<\/ext-link> [accessed 31 May 2017].","key":"ref3"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1177\/2047487312449597","article-title":"Secondary prevention in the clinical management of patients with cardiovascular diseases. Core components, standards and outcome measures for referral and delivery: a policy statement from the cardiac rehabilitation section of the European association for cardiovascular prevention &amp; rehabilitation. 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Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/acpicr.com\/sites\/default\/files\/ACPICRStandards2015.pdf\" xlink:type=\"simple\">http:\/acpicr.com\/sites\/default\/files\/ACPICRStandards2015.pdf<\/ext-link>","key":"ref12"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1249\/MSS.0000000000001842","article-title":"Incidence of VO2max Responders to Personalized vs Standardized Exercise Prescription","volume":"51","author":"RM Weatherwax","year":"2019","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13102-015-0011-z","article-title":"Is a threshold-based model a superior method to the relative percent concept for establishing individual exercise intensity? a randomized controlled trial","volume":"7","author":"AE Wolpern","year":"2015","journal-title":"BMC Sports Sci Med Rehab"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"e000519","DOI":"10.1136\/openhrt-2016-000519","article-title":"Does cardiac rehabilitation meet minimum standards: an observational study using UK national audit?","volume":"4","author":"P Doherty","year":"2017","journal-title":"Open Heart"},{"issue":"5","key":"ref16","first-page":"538","article-title":"Normal cardiopulmonary responses during incremental exercise in 20- to 70-yr-old men","volume":"26","author":"O Inbar","year":"1994","journal-title":"Med Sci Sports Exerc"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/02701367.1982.10605252","article-title":"Effect of age and other factors on maximal heart rate","volume":"53","author":"BR Londeree","year":"1982","journal-title":"Res Q Exercise Sport"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1088\/0967-3334\/28\/3\/R01","article-title":"Photoplethysmography and its application in clinical physiological measurement","volume":"28","author":"J Allen","year":"2007","journal-title":"Physiol Meas"},{"issue":"06","key":"ref19","doi-asserted-by":"crossref","first-page":"E206","DOI":"10.1055\/s-0043-120195","article-title":"Validity and reliability of the Apple Watch for measuring heart rate during exercise","volume":"1","author":"A Khushhal","year":"2017","journal-title":"Sports Med Open"},{"year":"1939","author":"H. 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