{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:24:07Z","timestamp":1780050247875,"version":"3.53.1"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["016.186.012"],"award-info":[{"award-number":["016.186.012"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["825.14.021"],"award-info":[{"award-number":["825.14.021"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["884655, 089795"],"award-info":[{"award-number":["884655, 089795"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003092","name":"Diabetes Fonds","doi-asserted-by":"publisher","award":["2017.81.014"],"award-info":[{"award-number":["2017.81.014"]}],"id":[{"id":"10.13039\/501100003092","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0217925","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T17:31:35Z","timestamp":1559669495000},"page":"e0217925","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Low extracellular magnesium does not impair glucose-stimulated insulin secretion"],"prefix":"10.1371","volume":"14","author":[{"given":"Lisanne M. M.","family":"Gommers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances M.","family":"Ashcroft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2372-8486","authenticated-orcid":true,"given":"Jeroen H. F.","family":"de Baaij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,6,4]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.5001\/omj.2012.68","article-title":"Type 2 diabetes mellitus: a review of current trends","volume":"27","author":"AB Olokoba","year":"2012","journal-title":"Oman Med J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12915-015-0140-6","article-title":"Q&A: insulin secretion and type 2 diabetes: why do beta-cells fail?","volume":"13","author":"J Cantley","year":"2015","journal-title":"BMC Biol"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"366","DOI":"10.2215\/CJN.02960906","article-title":"Hypomagnesemia in patients with type 2 diabetes.","volume":"2","author":"PC Pham","year":"2007","journal-title":"Clinical journal of the American Society of Nephrology: CJASN"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1530\/EJE-16-0517","article-title":"Determinants of hypomagnesemia in patients with type 2 diabetes mellitus","volume":"176","author":"S Kurstjens","year":"2017","journal-title":"European journal of endocrinology"},{"issue":"3","key":"ref5","first-page":"282","article-title":"Oral magnesium supplementation: an adjuvant alternative to facing the worldwide challenge of type 2 diabetes","volume":"82","author":"F Guerrero-Romero","year":"2014","journal-title":"Cir Cir"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1530\/acta.0.1210016","article-title":"Dietary magnesium supplements improve B-cell response to glucose and arginine in elderly non-insulin dependent diabetic subjects","volume":"121","author":"G Paolisso","year":"1989","journal-title":"Acta endocrinologica"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2337\/diacare.12.4.265","article-title":"Improved insulin response and action by chronic magnesium administration in aged NIDDM subjects","volume":"12","author":"G Paolisso","year":"1989","journal-title":"Diabetes care"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/dmrr.1206","article-title":"Insulin secretion is decreased in non-diabetic individuals with hypomagnesaemia","volume":"27","author":"M Rodriguez-Moran","year":"2011","journal-title":"Diabetes Metab Res Rev"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.atherosclerosis.2006.11.024","article-title":"Relationship between serum magnesium values, lipids and anthropometric risk factors","volume":"196","author":"EW Randell","year":"2008","journal-title":"Atherosclerosis"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1365-2362.2010.02422.x","article-title":"Magnesium improves the beta-cell function to compensate variation of insulin sensitivity: double-blind, randomized clinical trial","volume":"41","author":"F Guerrero-Romero","year":"2011","journal-title":"Eur J Clin Invest"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1079\/BJN2000294","article-title":"Magnesium deficiency improves glucose homeostasis in the rat: studies in vivo and in isolated islets in vitro","volume":"85","author":"MA Reis","year":"2001","journal-title":"The British journal of nutrition"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0026-0495(87)90011-4","article-title":"Glucose homeostasis in magnesium-deficient rats","volume":"36","author":"C Legrand","year":"1987","journal-title":"Metabolism: clinical and experimental"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1038\/ncomms5639","article-title":"Reversible changes in pancreatic islet structure and function produced by elevated blood glucose.","volume":"5","author":"MF Brereton","year":"2014","journal-title":"Nat Commun"},{"issue":"1","key":"ref14","first-page":"80","article-title":"Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes","volume":"119","author":"CA Girard","year":"2009","journal-title":"The Journal of clinical investigation"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1113\/expphysiol.1983.sp002715","article-title":"Beta cell membrane potential and insulin release; role of calcium and calcium:magnesium ratio","volume":"68","author":"I Atwater","year":"1983","journal-title":"Q J Exp Physiol"},{"issue":"1","key":"ref16","first-page":"17","article-title":"In vitro relationship between magnesium and insulin secretion","volume":"7","author":"J Ishizuka","year":"1994","journal-title":"Magnes Res"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3181\/00379727-200-43459","article-title":"Role of extracellular magnesium in insulin secretion from rat insulinoma cells","volume":"200","author":"M Murakami","year":"1992","journal-title":"Proc Soc Exp Biol Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/ncomms1108","article-title":"TRPM7 is essential for Mg(2+) homeostasis in mammals","volume":"1","author":"LV Ryazanova","year":"2010","journal-title":"Nat Commun"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0092-8674(03)00556-7","article-title":"Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7","volume":"114","author":"C Schmitz","year":"2003","journal-title":"Cell"},{"key":"ref20","article-title":"TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival","author":"L Mittermeier","year":"2019","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1085\/jgp.20028740","article-title":"TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions","volume":"121","author":"MK Monteilh-Zoller","year":"2003","journal-title":"The Journal of general physiology"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s00125-017-4224-4","article-title":"Serum magnesium and the risk of prediabetes: a population-based cohort study","volume":"60","author":"BCT Kieboom","year":"2017","journal-title":"Diabetologia"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2337\/db15-1028","article-title":"Hypomagnesemia in Type 2 Diabetes: A Vicious Circle?","volume":"65","author":"LM Gommers","year":"2016","journal-title":"Diabetes"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1684\/mrh.2009.0195","article-title":"The biochemical function of Mg(2)+ in insulin secretion, insulin signal transduction and insulin resistance","volume":"23","author":"T. Gunther","year":"2010","journal-title":"Magnesium research"},{"key":"ref25","article-title":"Increased NEFA levels reduce blood Mg(2+) in hypertriacylglycerolaemic states via direct binding of NEFA to Mg(2).","author":"S Kurstjens","year":"2018","journal-title":"Diabetologia"},{"key":"ref26","article-title":"Magnesium deficiency prevents high-fat-diet-induced obesity in mice","author":"S Kurstjens","year":"2018","journal-title":"Diabetologia"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0217925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T02:42:18Z","timestamp":1608172938000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0217925"}},"subtitle":[],"editor":[{"given":"Amar","family":"Abderrahmani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,4]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0217925","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,4]]}}}