{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T13:50:52Z","timestamp":1776952252877,"version":"3.51.4"},"reference-count":87,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0218078","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T13:37:02Z","timestamp":1560433022000},"page":"e0218078","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["GWAS and PheWAS of red blood cell components in a Northern Nevadan cohort"],"prefix":"10.1371","volume":"14","author":[{"given":"Robert W.","family":"Read","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen A.","family":"Schlauch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gai","family":"Elhanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Metcalf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony D.","family":"Slonim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1385-8298","authenticated-orcid":true,"given":"Ramsey","family":"Aweti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2027-0449","authenticated-orcid":true,"given":"Robert","family":"Borkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2646-8958","authenticated-orcid":true,"given":"Joseph J.","family":"Grzymski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,6,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1161\/01.HYP.5.5.757","article-title":"Elevated blood viscosity in patients with borderline essential hypertension","volume":"5","author":"RL Letcher","year":"1983","journal-title":"Hypertension"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1161\/01.CIR.93.9.1677","article-title":"Mean red cell volume as a correlate of blood pressure","volume":"93","author":"DS Sharp","year":"1996","journal-title":"Circulation"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0735-1097(02)01938-1","article-title":"Anemia as a risk factor for cardiovascular disease in the atherosclerosis risk in communities (aric) study","volume":"40","author":"MJ Sarnak","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1161\/01.HYP.0000157526.07977.ec","article-title":"Association of Blood Pressure With Blood Viscosity in American Indians The Strong Heart Study","volume":"45","author":"G de Simone","year":"2005","journal-title":"Hypertension"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1093\/hmg\/ddt087","article-title":"Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network","volume":"22","author":"Z Chen","year":"2013","journal-title":"Hum Mol Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF01307186","article-title":"Platelets and cancer metastasis: a causal relationship?","volume":"11","author":"KV Honn","year":"1992","journal-title":"Cancer Metastasis Rev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1212\/WNL.51.3_Suppl_3.S9","article-title":"The role of platelets in ischemic stroke","volume":"51","author":"GJD Zoppo","year":"1998","journal-title":"Neurology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1073\/pnas.98.4.1805","article-title":"Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria","volume":"98","author":"A Pain","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1474-51510200038-5","article-title":"Platelets and cardiovascular disease","volume":"1","author":"S Willoughby","year":"2002","journal-title":"Eur J Cardiovasc Nurs"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.thromres.2004.02.007","article-title":"The impact of peripheral arterial disease on circulating platelets","volume":"113","author":"RD McBane","year":"2004","journal-title":"Thromb Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1161\/01.RES.0000160077.17427.57","article-title":"Platelets and chemokines in atherosclerosis: partners in crime","volume":"96","author":"C. Weber","year":"2005","journal-title":"Circ Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1161\/ATVBAHA.110.207514","article-title":"Platelets: linking hemostasis and cancer","volume":"30","author":"S Jain","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1182\/blood-2008-10-184234","article-title":"A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function","volume":"113","author":"N Soranzo","year":"2009","journal-title":"Blood"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s11239-007-0159-9","article-title":"Effects of high altitude and sea level on mean platelet volume and platelet count in patients with acute coronary syndrome","volume":"27","author":"AT Alper","year":"2009","journal-title":"J Thromb Thrombolysis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s004840050120","article-title":"The effect of high altitude on platelet counts, thrombopoietin and erythropoietin levels in young Bolivian airmen visiting the Andes","volume":"43","author":"JG Hudson","year":"1999","journal-title":"Int J Biometeorol"},{"key":"ref16","first-page":"2","article-title":"(null) KN. Effect of high altitude on haematological parameters","volume":"41","author":"A Shrivastava","year":"2010","journal-title":"Indian J Prev Soc Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/ng.467","article-title":"A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium","volume":"41","author":"N Soranzo","year":"2009","journal-title":"Nat Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00439-013-1355-7","article-title":"A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects","volume":"133","author":"K Shameer","year":"2014","journal-title":"Hum Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/ajh.20868","article-title":"Evidence for linkage of red blood cell size and count: genome-wide scans in the Framingham Heart Study","volume":"82","author":"J-P Lin","year":"2007","journal-title":"Am J Hematol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"11346","DOI":"10.1073\/pnas.0611393104","article-title":"Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults","volume":"104","author":"SL Thein","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"11869","DOI":"10.1073\/pnas.0804799105","article-title":"DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease","volume":"105","author":"G Lettre","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.ajhg.2009.10.005","article-title":"Sequence variants in three loci influence monocyte counts and erythrocyte volume","volume":"85","author":"MAR Ferreira","year":"2009","journal-title":"Am J Hum Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ng.466","article-title":"Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium","volume":"41","author":"SK Ganesh","year":"2009","journal-title":"Nat Genet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ajhg.2008.11.015","article-title":"A Genome-wide Association Study Identifies Three Loci Associated with Mean Platelet Volume","volume":"84","author":"C Meisinger","year":"2009","journal-title":"Am J Hum Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3324\/haematol.2010.035287","article-title":"Determinants of platelet count in humans","volume":"96","author":"ME Daly","year":"2010","journal-title":"Haematologica"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/ng.531","article-title":"Genome-wide association study of hematological and biochemical traits in a Japanese population","volume":"42","author":"Y Kamatani","year":"2010","journal-title":"Nat Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e13011","DOI":"10.1371\/journal.pone.0013011","article-title":"A Genome-Wide Association Study of Red Blood Cell Traits Using the Electronic Medical Record","volume":"5","author":"IJ Kullo","year":"2010","journal-title":"PLoS ONE"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature10659","article-title":"New gene functions in megakaryopoiesis and platelet formation","volume":"480","author":"C Gieger","year":"2011","journal-title":"Nature"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e1002067","DOI":"10.1371\/journal.pgen.1002067","article-title":"Identification of nine novel loci associated with white blood cell subtypes in a Japanese population","volume":"7","author":"Y Okada","year":"2011","journal-title":"PLoS Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e1002139","DOI":"10.1371\/journal.pgen.1002139","article-title":"Maps of Open Chromatin Guide the Functional Follow-Up of Genome-Wide Association Signals: Application to Hematological Traits","volume":"7","author":"DS Paul","year":"2011","journal-title":"PLoS Genet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1093\/hmg\/dds028","article-title":"TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia","volume":"21","author":"P An","year":"2012","journal-title":"Hum Mol Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.mayocp.2012.01.016","article-title":"Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits","volume":"87","author":"K Ding","year":"2012","journal-title":"Mayo Clin Proc"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1093\/hmg\/dds534","article-title":"GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children","volume":"22","author":"J Li","year":"2013","journal-title":"Hum Mol Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1126\/science.1222794","article-title":"Systematic Localization of Common Disease-Associated Variation in Regulatory DNA","volume":"337","author":"MT Maurano","year":"2012","journal-title":"Science"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e1002491","DOI":"10.1371\/journal.pgen.1002491","article-title":"A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans","volume":"8","author":"R Qayyum","year":"2012","journal-title":"PLoS Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature11677","article-title":"Seventy-five genetic loci influencing the human red blood cell","volume":"492","author":"P van der Harst","year":"2012","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bcmd.2014.07.006","article-title":"DNA polymorphisms at BCL11A, HBS1L-MYB and Xmn1-HBG2 site loci associated with fetal hemoglobin levels in sickle cell anemia patients from Northern Brazil","volume":"53","author":"GL Cardoso","year":"2014","journal-title":"Blood Cells Mol Dis"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"614","DOI":"10.7150\/ijms.8582","article-title":"TMPRSS6 rs855791 Polymorphism Influences the Susceptibility to Iron Deficiency Anemia in Women at Reproductive Age","volume":"11","author":"S-N Pei","year":"2014","journal-title":"Int J Med Sci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e0125215","DOI":"10.1371\/journal.pone.0125215","article-title":"Erythropoietin in the general population: reference ranges and clinical, biochemical and genetic correlates","volume":"10","author":"N Grote Beverborg","year":"2015","journal-title":"PLoS ONE"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12881-015-0148-3","article-title":"Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer","volume":"16","author":"SN Mtatiro","year":"2015","journal-title":"BMC Med Genet"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms7691","article-title":"Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms","volume":"6","author":"W Tapper","year":"2015","journal-title":"Nat Commun"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/03630269.2016.1253586","article-title":"Genetic Variants at BCL11A and HBS1L-MYB loci Influence Hb F Levels in Chinese Zhuang \u03b2-Thalassemia Intermedia Patients","volume":"40","author":"Y Lai","year":"2016","journal-title":"Hemoglobin"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1158\/2159-8290.CD-16-0023","article-title":"Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia","volume":"6","author":"SE Maharry","year":"2016","journal-title":"Cancer Discovery"},{"key":"ref44","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.22207","article-title":"Protective BCL11A and HBS1L-MYB polymorphisms in a cohort of 102 Congolese patients suffering from sickle cell anemia","volume":"32","author":"TM Mikobi","year":"2018","journal-title":"J Clin Lab Anal"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.gene.2017.11.031","article-title":"Association of genetic polymorphisms with erythrocyte traits: Verification of SNPs reported in a previous GWAS in a Japanese population","volume":"642","author":"T Seiki","year":"2018","journal-title":"Gene"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e0160573","DOI":"10.1371\/journal.pone.0160573","article-title":"Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases","volume":"11","author":"A Verma","year":"2016","journal-title":"PLoS ONE"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.ajhg.2018.02.017","article-title":"PheWAS and Beyond: The Landscape of Associations with Medical Diagnoses and Clinical Measures across 38,662 Individuals from Geisinger","volume":"102","author":"A Verma","year":"2018","journal-title":"Am J Hum Genet"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","article-title":"GCTA: a tool for genome-wide complex trait analysis","volume":"88","author":"J Yang","year":"2011","journal-title":"Am J Hum Genet"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.ajhg.2008.09.012","article-title":"Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes","volume":"83","author":"X Yuan","year":"2008","journal-title":"Am J Hum Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1182\/blood-2015-07-660308","article-title":"Sex-specific differences in genetic and nongenetic determinants of mean platelet volume: results from the Gutenberg Health Study","volume":"127","author":"M Panova-Noeva","year":"2016","journal-title":"Blood"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e1000730","DOI":"10.1371\/journal.pgen.1000730","article-title":"Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis","volume":"5","author":"DI Chasman","year":"2009","journal-title":"PLoS Genet"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/ng.970","article-title":"Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma","volume":"43","author":"JC Chambers","year":"2011","journal-title":"Nat Genet"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1093\/hmg\/dds361","article-title":"Genome-wide association study identifies a new locus JMJD1C at 10q21 that may influence serum androgen levels in men","volume":"21","author":"G Jin","year":"2012","journal-title":"Hum Mol Genet"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e1002805","DOI":"10.1371\/journal.pgen.1002805","article-title":"A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation","volume":"8","author":"AD Coviello","year":"2012","journal-title":"PLoS Genet"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1210\/js.2017-00050","article-title":"Genetics of Sex Hormone-Binding Globulin and Testosterone Levels in Fertile and Infertile Men of Reproductive Age","volume":"1","author":"M Grigorova","year":"2017","journal-title":"J Endocr Soc"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ajhg.2016.05.003","article-title":"Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases","volume":"99","author":"SM Tajuddin","year":"2016","journal-title":"Am J Hum Genet"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1056\/NEJMoa0807917","article-title":"Shared and distinct genetic variants in type 1 diabetes and celiac disease","volume":"359","author":"DJ Smyth","year":"2008","journal-title":"N Engl J Med"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1053\/j.gastro.2014.04.022","article-title":"Genome-wide association study identifies variants associated with autoimmune hepatitis type 1","volume":"147","author":"YS de Boer","year":"2014","journal-title":"Gastroenterology"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"P4879","DOI":"10.1093\/eurheartj\/eht310.P4879","article-title":"Mean platelet volume and platelet count in acute coronary syndrome patients: role of a genetic variants on chr7q22.3 and chr3p13-p21","volume":"34","author":"B Giusti","year":"2013","journal-title":"Eur Heart J"},{"issue":"Suppl 1","key":"ref60","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1538-7836.2011.04359.x","article-title":"The genetics of common variation affecting platelet development, function and pharmaceutical targeting","volume":"9","author":"AD Johnson","year":"2011","journal-title":"J Thromb Haemost"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"e0178095","DOI":"10.1371\/journal.pone.0178095","article-title":"SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume","volume":"12","author":"S Zou","year":"2017","journal-title":"PLoS ONE"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1042\/BJ20141404","article-title":"Platelet Rho GTPases-a focus on novel players, roles and relationships","volume":"466","author":"R Goggs","year":"2015","journal-title":"Biochem J"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"36748","DOI":"10.1074\/jbc.M300702200","article-title":"CD226 Mediates Platelet and Megakaryocytic Cell Adhesion to Vascular Endothelial Cells","volume":"278","author":"H Kojima","year":"2003","journal-title":"J Biol Chem"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"42072","DOI":"10.1074\/jbc.M403726200","article-title":"Dok-6, a Novel p62 Dok Family Member, Promotes Ret-mediated Neurite Outgrowth","volume":"279","author":"RJ Crowder","year":"2004","journal-title":"J Biol Chem"},{"key":"ref65","first-page":"297","article-title":"Vitamin D deficiency in patients with liver cirrhosis","volume":"29","author":"C Konstantakis","year":"2016","journal-title":"Ann Gastroenterol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0025-7125(16)30339-X","article-title":"Microcytic anemia. Differential diagnosis and management of iron deficiency anemia","volume":"76","author":"AC Massey","year":"1992","journal-title":"Med Clin North Am"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/ajh.23682","article-title":"Iron deficiency alters megakaryopoiesis and platelet phenotype independent of thrombopoietin","volume":"89","author":"R Evstatiev","year":"2014","journal-title":"Am J Hematol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1182\/blood-2014-03-559815","article-title":"JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation","volume":"124","author":"R Besancenot","year":"2014","journal-title":"Blood"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/bjh.12349","article-title":"Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study","volume":"162","author":"P Noris","year":"2013","journal-title":"Br J Haematol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"109275","DOI":"10.1155\/2015\/109275","article-title":"Links between Vitamin D Deficiency and Cardiovascular Diseases","volume":"2015","author":"I Mozos","year":"2015","journal-title":"Biomed Res Int"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3343\/alm.2014.34.2.98","article-title":"Mean platelet volume and vitamin D level","volume":"34","author":"M Cumhur Cure","year":"2014","journal-title":"Ann Lab Med"},{"key":"ref72","first-page":"1","article-title":"Inverse relationship between vitamin D levels and platelet indices in Korean adults","volume":"22","author":"YC Park","year":"2017","journal-title":"Hematology"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"2423547","DOI":"10.1155\/2016\/2423547","article-title":"Potential Role of Protein Disulfide Isomerase in Metabolic Syndrome-Derived Platelet Hyperactivity","volume":"2016","author":"RS Gaspar","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1089\/met.2008.0083","article-title":"Native platelet aggregation and response to aspirin in persons with the metabolic syndrome and its components","volume":"7","author":"D Vaidya","year":"2009","journal-title":"Metab Syndr Relat Disord"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"834153","DOI":"10.1155\/2008\/834153","article-title":"Platelet counts and platelet activation markers in obese subjects","volume":"2008","author":"D Samocha-Bonet","year":"2008","journal-title":"Mediators Inflamm"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.3748\/wjg.v23.i18.3228","article-title":"Platelets in liver disease, cancer and regeneration","volume":"23","author":"T Kurokawa","year":"2017","journal-title":"World J Gastroenterol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1002\/hep.28526","article-title":"Platelets: No longer bystanders in liver disease","volume":"64","author":"A Chauhan","year":"2016","journal-title":"Hepatology"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1080\/09537100902964759","article-title":"The role of alcohol on platelets, thymus and cognitive performance among HIV-infected subjects: are they related?","volume":"20","author":"MJ M\u00edguez-Burbano","year":"2009","journal-title":"Platelets"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1136\/bmj.293.6549.715","article-title":"Platelet function defects in chronic alcoholism","volume":"293","author":"DP Mikhailidis","year":"1986","journal-title":"Br Med J (Clin Res Ed)"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/nprot.2010.116","article-title":"Data quality control in genetic case-control association studies","volume":"5","author":"CA Anderson","year":"2010","journal-title":"Nature Protocols"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"e730","DOI":"10.1038\/tp.2015.208","article-title":"Genome-wide association analysis identifies genetic variations in subjects with myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"6","author":"KA Schlauch","year":"2016","journal-title":"Transl Psychiatry"},{"key":"ref82","first-page":"1656","article-title":"Single-nucleotide polymorphisms in a cohort of significantly obese women without cardiometabolic diseases","volume":"106","author":"KA Schlauch","year":"2018","journal-title":"Int J Obes (Lond)"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/nprot.2014.071","article-title":"Quality control and conduct of genome-wide association meta-analyses","volume":"9","author":"TW Winkler","year":"2014","journal-title":"Nature Protocols"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/sim.973","article-title":"Sample size requirements for matched case\u2010control studies of gene\u2013environment interaction","volume":"21","author":"WJ Gauderman","year":"2002","journal-title":"Stat Med"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1093\/bioinformatics\/btu197","article-title":"R PheWAS: data analysis and plotting tools for phenome-wide association studies in the R environment","volume":"30","author":"RJ Carroll","year":"2014","journal-title":"Bioinformatics"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/nbt.2749","article-title":"Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data","volume":"31","author":"JC Denny","year":"2013","journal-title":"Nat Biotechnol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0218078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T16:53:17Z","timestamp":1588956797000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0218078"}},"subtitle":[],"editor":[{"given":"Honghuang","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,13]]},"references-count":87,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0218078","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/475467","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,13]]}}}