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Ilastik: Interactive learning and segmentation toolkit. Proceedings\u2014International Symposium on Biomedical Imaging. IEEE; 2011. pp. 230\u2013233. <comment>doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1109\/ISBI.2011.5872394\" xlink:type=\"simple\">10.1109\/ISBI.2011.5872394<\/ext-link><\/comment>"},{"key":"ref22","first-page":"653","article-title":"Carving: scalable interactive segmentation of neural volume electron microscopy images","volume":"14","author":"CN Str\u00e4ehle","year":"2011","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"ref23","article-title":"Ilastik Preprocessing and Segmentation\u2014Tom de Vries","author":"T de Vries","year":"2018","journal-title":"Ilastik Preprocessing and Segmentation\u2014Tom de Vries"},{"key":"ref24","first-page":"1076","article-title":"BoneJ: Free and extensible bone image analysis in ImageJ. 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Dijkstra","year":"1959","journal-title":"Numer Math"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1109\/MPUL.2011.942929","article-title":"Medical Image Analysis: A visual approach","volume":"2","author":"F Ritter","year":"2011","journal-title":"IEEE Pulse"},{"key":"ref28","article-title":"Vessel Selector MeVisLab\u2014UPF\u2014Tom de Vries","author":"T de Vries","year":"2018","journal-title":"Vessel Selector MeVisLab\u2014UPF\u2014Tom de Vries"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/uog.82","article-title":"Coronary artery blood flow velocities in various fetal conditions","volume":"21","author":"AA Baschat","year":"2003","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.medengphy.2011.07.032","article-title":"The role of blood flow distribution in the regulation of cerebral oxygen availability in fetal growth restriction","volume":"34","author":"O Luria","year":"2012","journal-title":"Med Eng Phys"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e1003667","DOI":"10.1371\/journal.pcbi.1003667","article-title":"A computational model of the fetal circulation to quantify blood redistribution in intrauterine growth restriction","volume":"10","author":"P Garcia-Canadilla","year":"2014","journal-title":"PLoS Comput Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1651-2227.2004.tb00233.x","article-title":"Coronary arteries in fetal life: physiology, malformations and the \u201cheart-sparing effect","volume":"93","author":"R. 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Anrep","year":"1929","journal-title":"J Physiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.amjcard.2013.01.290","article-title":"Relation of Distribution of Coronary Blood Flow Volume to Coronary Artery Dominance","volume":"111","author":"S Sakamoto","year":"2013","journal-title":"Am J Cardiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"R48","DOI":"10.1152\/ajpregu.00180.2017","article-title":"IUGR decreases cardiomyocyte endowment and alters cardiac metabolism in a sex- and cause-of-IUGR-specific manner","volume":"315","author":"KJ Botting","year":"2018","journal-title":"Am J Physiol Integr Comp Physiol"},{"key":"ref36","article-title":"Chronic hypoxemia in late gestation decreases cardiomyocyte number but does not change expression of hypoxia-responsive genes","volume":"3","author":"KJ Botting","year":"2014","journal-title":"J Am Heart Assoc. 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