{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:40:55Z","timestamp":1773898855603,"version":"3.50.1"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0218197","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T17:36:21Z","timestamp":1560360981000},"page":"e0218197","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Static spatial growth restriction micropatterning of endothelial colony forming cells influences their morphology and gene expression"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9812-2262","authenticated-orcid":true,"given":"Matthew W.","family":"Hagen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica T.","family":"Hinds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0002-9610(87)90803-8","article-title":"Autogenous reversed vein bypass for lower extremity ischemia in patients with absent or inadequate greater saphenous vein","volume":"153","author":"LM Taylor","year":"1987","journal-title":"Am J Surg"},{"key":"ref2","article-title":"The tissue-engineered vascular graft\u2014past, present, and future","volume":"22","author":"S Pashneh-Tala","year":"2015","journal-title":"Tissue Eng Part B Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ejvs.2003.12.027","article-title":"Saphenous vein versus PTFE for above-knee femoropopliteal bypass. A review of the literature","volume":"27","author":"P Klinkert","year":"2004","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1126\/science.275.5302.964","article-title":"Isolation of putative progenitor endothelial cells for angiogenesis","volume":"275","author":"T Asahara","year":"1997","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1002\/sctm.16-0360","article-title":"Endothelial progenitors: a consensus statement on nomenclature","volume":"6","author":"RJ Medina","year":"2017","journal-title":"Stem Cells Transl Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0039-6060(99)70025-5","article-title":"Clinical autologous in vitro endothelialization of infrainguinal ePTFE grafts in 100 patients: A 9-year experience","volume":"126","author":"M Deutsch","year":"1999","journal-title":"Surgery"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jvs.2008.08.101","article-title":"Long-term experience in autologous in vitro endothelialization of infrainguinal ePTFE grafts","volume":"49","author":"M Deutsch","year":"2009","journal-title":"J Vasc Surg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e115163","DOI":"10.1371\/journal.pone.0115163","article-title":"Engineering an endothelialized vascular graft: a rational approach to study design in a non-human primate model","volume":"9","author":"DEJ Anderson","year":"2014","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s12265-013-9539-z","article-title":"Blood outgrowth endothelial cells alter remodeling of completely biological engineered grafts implanted into the sheep femoral artery","volume":"7","author":"LA Meier","year":"2014","journal-title":"J Cardiovasc Transl Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/2231159a0","article-title":"Arterial wall shear and distribution of early atheroma in man","volume":"223","author":"CG Caro","year":"1969","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/path.1700750202","article-title":"Changes in the endothelium of the aorta and the behaviour of macrophages in experimental atheroma of rabbits","volume":"75","author":"JC Poole","year":"1958","journal-title":"J Pathol Bacteriol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1089\/ten.tea.2012.0300","article-title":"Dynamic shear stress regulation of inflammatory and thrombotic pathways in baboon endothelial outgrowth cells","volume":"19","author":"RF Ankeny","year":"2013","journal-title":"Tissue Eng Part A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1161\/01.ATV.15.1.2","article-title":"Expression of ICAM-1 and VCAM-1 and monocyte adherence in arteries exposed to altered shear stress","volume":"15","author":"PL Walpola","year":"1995","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1089\/ten.tea.2010.0290","article-title":"Fluid shear stress alters the hemostatic properties of endothelial outgrowth cells","volume":"18","author":"AE Ensley","year":"2012","journal-title":"Tissue Eng Part A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1182\/blood-2002-01-0046","article-title":"Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Kr\u00fcppel-like factor (KLF2)","volume":"100","author":"RJ Dekker","year":"2002","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.fluid.40.111406.102119","article-title":"Blood flow in end-to-side anastomoses","volume":"40","author":"F Loth","year":"2008","journal-title":"Annu Rev Fluid Mech"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/0741-5214(92)90019-5","article-title":"Anastomotic intimal hyperplasia: Mechanical injury or flow induced","volume":"15","author":"HS Bassiouny","year":"1992","journal-title":"J Vasc Surg"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1007\/s10439-011-0352-z","article-title":"Endothelial cell micropatterning: Methods, effects, and applications","volume":"39","author":"DEJ Anderson","year":"2011","journal-title":"Ann Biomed Eng"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.bbrc.2008.04.167","article-title":"Endothelial cell cytoskeletal alignment independent of fluid shear stress on micropatterned surfaces","volume":"371","author":"KB Vartanian","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbrc.2012.09.034","article-title":"Extracellular matrix production and regulation in micropatterned endothelial cells","volume":"427","author":"DEJ Anderson","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1089\/1076327041348365","article-title":"Simple approach to micropattern cells on common culture substrates by tuning substrate wettability","volume":"10","author":"JL Tan","year":"2004","journal-title":"Tissue Eng"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1529\/biophysj.107.127761","article-title":"Micropatterned structural control suppresses mechanotaxis of endothelial cells","volume":"95","author":"X Lin","year":"2008","journal-title":"Biophys J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"C333","DOI":"10.1152\/ajpcell.00340.2009","article-title":"Cytoskeletal structure regulates endothelial cell immunogenicity independent of fluid shear stress","volume":"298","author":"KB Vartanian","year":"2010","journal-title":"Am J Physiol Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"5418","DOI":"10.1016\/j.biomaterials.2010.03.045","article-title":"Modulation of human vascular endothelial cell behaviors by nanotopographic cues","volume":"31","author":"SJ Liliensiek","year":"2010","journal-title":"Biomaterials"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/jbm.a.32225","article-title":"Distinct extracellular matrix microenvironments of progenitor and carotid endothelial cells","volume":"91A","author":"KB Vartanian","year":"2009","journal-title":"J Biomed Mater Res Part A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000368223","article-title":"Thrombotic Responses of Endothelial Outgrowth Cells to Protein-Coated Surfaces","volume":"199","author":"DEJ Anderson","year":"2014","journal-title":"Cells Tissues Organs"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1089\/ten.tea.2014.0032","article-title":"Endothelial outgrowth cells regulate coagulation, platelet accumulation, and respond to tumor necrosis factor similar to carotid endothelial cells","volume":"21","author":"J Glynn","year":"2015","journal-title":"Tissue Eng Part A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: An open-source platform for biological-image analysis","volume":"9","author":"J Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"ref29","article-title":"R: A language and environment for statistical computing","year":"2018"},{"key":"ref30","article-title":"infer: Tidy Statistical Inference","author":"A Bray","year":"2018","journal-title":"infer: Tidy Statistical Inference"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/bimj.200810425","article-title":"Simultaneous inference in general parametric models","volume":"50","author":"T Hothorn","year":"2008","journal-title":"Biometrical J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1214\/088342304000000396","article-title":"Permutation Methods: A Basis for Exact Inference","volume":"19","author":"MD Ernst","year":"2004","journal-title":"Stat Sci"},{"key":"ref33","first-page":"20","article-title":"Endothelial outgrowth cells: function and performance in vascular grafts","author":"J Glynn","year":"2013","journal-title":"Tissue Eng Part B Rev"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/jbm.a.31672","article-title":"Potential of baboon endothelial progenitor cells for tissue engineered vascular grafts","volume":"86A","author":"MT Hinds","year":"2008","journal-title":"J Biomed Mater Res Part A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s11626-999-0050-4","article-title":"Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates","volume":"35","author":"LE Dike","year":"1999","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0002-9440(10)63002-7","article-title":"Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes","volume":"167","author":"RJ Dekker","year":"2005","journal-title":"Am J Pathol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1095\/biolreprod62.2.412","article-title":"Cell cycle synchronization of porcine fetal fibroblasts: effects of serum deprivation and reversible cell cycle inhibitors","volume":"62","author":"WA Kues","year":"2000","journal-title":"Biol Reprod"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11626-011-9470-z","article-title":"Endothelial colony-forming cells show a mature transcriptional response to shear stress","volume":"48","author":"AD Egorova","year":"2012","journal-title":"Vitr Cell Dev Biol\u2014Anim"},{"key":"ref39","first-page":"1471","article-title":"Heterogeneous distribution of Weibel-Palade bodies and von Willebrand factor along the porcine vascular tree","volume":"139","author":"J Gebrane-Youn\u00e8s","year":"1991","journal-title":"Am J Pathol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s004010051058","article-title":"Local variation in expression of pro- and antithrombotic factors in vascular endothelium of human autopsy brain","volume":"98","author":"H Tohgi","year":"1999","journal-title":"Acta Neuropathol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1016\/j.biomaterials.2012.02.047","article-title":"Integration of basal topographic cues and apical shear stress in vascular endothelial cells","volume":"33","author":"JT Morgan","year":"2012","journal-title":"Biomaterials"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.biomaterials.2016.01.036","article-title":"Planar and tubular patterning of micro and nano-topographies on poly(vinyl alcohol) hydrogel for improved endothelial cell responses","volume":"84","author":"MFA Cutiongco","year":"2016","journal-title":"Biomaterials"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.biomaterials.2017.10.037","article-title":"Functional differences between healthy and diabetic endothelial cells on topographical cues","volume":"153","author":"MFA Cutiongco","year":"2018","journal-title":"Biomaterials"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1002\/stem.1488","article-title":"Dysfunction of endothelial progenitor cells from smokers and chronic obstructive pulmonary disease patients due to increased dna damage and senescence","volume":"31","author":"KE Paschalaki","year":"2013","journal-title":"Stem Cells"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.bpj.2014.12.023","article-title":"Cooperative effects of matrix stiffness and fluid shear stress on endothelial cell behavior","volume":"108","author":"JC Kohn","year":"2015","journal-title":"Biophys J"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0049-3848(81)90080-3","article-title":"The binding of purified factor VIII\/von Willebrand factor to collagens of differing type and form","volume":"24","author":"DM Scott","year":"1981","journal-title":"Thromb Res"},{"key":"ref47","first-page":"1","article-title":"Biomimetic Modification of Poly(vinyl alcohol): Encouraging Endothelialization and Preventing Thrombosis with Antiplatelet Monotherapy","author":"DEJ Anderson","year":"2019","journal-title":"Acta Biomater"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0218197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T01:44:12Z","timestamp":1588988652000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0218197"}},"subtitle":[],"editor":[{"given":"Alain-Pierre","family":"Gadeau","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,12]]},"references-count":47,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0218197","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,12]]}}}