{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T18:10:59Z","timestamp":1779905459687,"version":"3.53.1"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0218293","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T17:36:17Z","timestamp":1561052177000},"page":"e0218293","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["A multiple modulation synthesis method with high spatial resolution for noninvasive neurostimulation"],"prefix":"10.1371","volume":"14","author":[{"given":"Qiaoqin","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3850-0057","authenticated-orcid":true,"given":"Xiaozheng","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabiao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1038\/sj.npp.1301165","article-title":"Three-Year Outcomes in Deep Brain Stimulation for Highly Resistant Obsessive\u2013Compulsive Disorder","volume":"31","author":"BD Greenberg","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"ref2","first-page":"1","article-title":"Electric field depth\u2013focality tradeoff in transcranial magnetic stimulation: Simulation comparison of 50 coil designs","volume":"6","author":"Z-D Deng","year":"2013","journal-title":"Brain Stimul Basic Transl Clin Res Neuromodulation"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1088\/1741-2560\/5\/2\/007","article-title":"Transcranial current stimulation focality using disc and ring electrode configurations: FEM analysis","volume":"5","author":"A Datta","year":"2008","journal-title":"J Neural Eng"},{"key":"ref4","first-page":"187","article-title":"A Review on Brain Stimulation Using Low Intensity Focused Ultrasound","volume":"7","author":"E Rezayat","year":"2016","journal-title":"Basic Clin Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nn.3620","article-title":"Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans","volume":"17","author":"W Legon","year":"2014","journal-title":"Nat Neurosci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.cell.2017.05.024","article-title":"Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields","volume":"169","author":"N Grossman","year":"2017","journal-title":"Cell"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2522\/ptj.20080060","article-title":"Electrical Stimulation Using Kilohertz-Frequency Alternating Current","volume":"89","author":"AR Ward","year":"2009","journal-title":"Phys Ther"},{"key":"ref8","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-02928-3","article-title":"Direct effects of transcranial electric stimulation on brain circuits in rats and humans","volume":"9","author":"M V\u00f6r\u00f6slakos","year":"2018","journal-title":"Nat Commun"},{"key":"ref9","article-title":"Electric Fields of the Brain: the Neurophysics of EEG","author":"PL Nunez","year":"2006"},{"key":"ref10","article-title":"Dielectric Properties of Body Tissues","author":"D Andreuccetti","year":"2002","journal-title":"Dielectric Properties of Body Tissues"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1109\/TBME.2002.800754","article-title":"Frequency- and time-domain FEM models of EMG: capacitive effects and aspects of dispersion","volume":"49","author":"NS Stoykov","year":"2002","journal-title":"IEEE Trans Biomed Eng"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1113\/jphysiol.1952.sp004764","article-title":"A quantitative description of membrane current and its application to conduction and excitation in nerve","volume":"117","author":"AL Hodgkin","year":"1952","journal-title":"J Physiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1162\/neco.1997.9.6.1179","article-title":"The NEURON Simulation Environment","volume":"9","author":"ML Hines","year":"1997","journal-title":"Neural Comput"},{"key":"ref14","article-title":"Modeling and simulation in medicine and the life sciences","author":"FC Hoppensteadt","year":"2010"},{"key":"ref15","article-title":"Fatigue: Neural and Muscular Mechanisms","author":"PA Pierce","year":"1995"},{"key":"ref16","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511541612","article-title":"The NEURON Book","author":"NT Carnevale","year":"2006"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1136\/jnnp.2003.032029","article-title":"Targeting the subthalamic nucleus for deep brain stimulation: technical approach and fusion of pre- and postoperative MR images to define accuracy of lead placement","volume":"76","author":"NA Hamid","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jneumeth.2004.10.020","article-title":"Electrical stimulation of excitable tissue: design of efficacious and safe protocols","volume":"141","author":"DR Merrill","year":"2005","journal-title":"J Neurosci Methods"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/mus.1148","article-title":"Variation in motor threshold with frequency using kHz frequency alternating current","volume":"24","author":"AR Ward","year":"2001","journal-title":"Muscle Nerve"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1109\/51.395310","article-title":"Stimulus waveforms for selective neural stimulation","volume":"14","author":"WM Grill","year":"1995","journal-title":"IEEE Eng Med Biol Mag"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.brs.2018.09.010","article-title":"Can transcranial electric stimulation with multiple electrodes reach deep targets?","volume":"12","author":"Y Huang","year":"2019","journal-title":"Brain Stimulat"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.neuroimage.2015.12.019","article-title":"The New York Head\u2014A precise standardized volume conductor model for EEG source localization and tES targeting","volume":"140","author":"Y Huang","year":"2016","journal-title":"NeuroImage"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neuroimage.2018.02.005","article-title":"Targeting alpha-band oscillations in a cortical model with amplitude-modulated high-frequency transcranial electric stimulation","volume":"173","author":"E Negahbani","year":"2018","journal-title":"NeuroImage"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10827-006-0015-5","article-title":"Simulation of high-frequency sinusoidal electrical block of mammalian myelinated axons","volume":"22","author":"N Bhadra","year":"2007","journal-title":"J Comput Neurosci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0218293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:34:41Z","timestamp":1588970081000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0218293"}},"subtitle":[],"editor":[{"given":"Jun","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,20]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0218293","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,20]]}}}