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HIV\/AIDS Diagnostics Technology Landscape 5th edition October 2015 [cited 2017 06 Feb 2017 ]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/aidsfree.usaid.gov\/sites\/default\/files\/hivaids_diag_tech.pdf\" xlink:type=\"simple\">https:\/\/aidsfree.usaid.gov\/sites\/default\/files\/hivaids_diag_tech.pdf<\/ext-link>."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev-med-092112-143017","article-title":"Emerging technologies for point-of-care management of HIV infection","volume":"66","author":"H Shafiee","year":"2015","journal-title":"Annual review of medicine"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1093\/infdis\/jir789","article-title":"Detection of Acute HIV Infection: A Field Evaluation of the Determine\u00ae HIV-1\/2 Ag\/Ab Combo Test","volume":"205","author":"NE Rosenberg","year":"2012","journal-title":"The Journal of Infectious Diseases"},{"issue":"18","key":"ref6","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1097\/QAD.0000000000000855","article-title":"Field accuracy of 4th generation rapid diagnostic tests for acute HIV-1: a systematic review","volume":"29","author":"JM Lewis","year":"2015","journal-title":"AIDS (London, England)"},{"key":"ref7","unstructured":"WHO. WHO list of prequalified in vitro diagnostic products 2019 [updated 04 April 2019; cited 2019 06 May]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.who.int\/diagnostics_laboratory\/evaluations\/190404_prequalified_product_list.pdf\" xlink:type=\"simple\">https:\/\/www.who.int\/diagnostics_laboratory\/evaluations\/190404_prequalified_product_list.pdf<\/ext-link>."},{"key":"ref8","unstructured":"WHO. WHO Prequalification of In Vitro Diagnostics Public Report: m-PIMA HIV-1\/2 VL 2019 [updated April 2019; cited 2019 06 May]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.who.int\/diagnostics_laboratory\/evaluations\/pq-list\/190408_pqdx_0359_032_00_pqpr_mpima.pdf\" xlink:type=\"simple\">https:\/\/www.who.int\/diagnostics_laboratory\/evaluations\/pq-list\/190408_pqdx_0359_032_00_pqpr_mpima.pdf<\/ext-link>."},{"key":"ref9","unstructured":"WHO. Virological Technologies: progress of the active applications in the prequalification of IVDs assessment pipeline 2019 [updated 23 April 2019; cited 2019 06 May]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.who.int\/diagnostics_laboratory\/190423_vl.pdf?ua=1\" xlink:type=\"simple\">https:\/\/www.who.int\/diagnostics_laboratory\/190423_vl.pdf?ua=1<\/ext-link>."},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1128\/JCM.03325-14","article-title":"Laboratory evaluation of the Liat HIV Quant (IQuum) whole-blood and plasma HIV-1 viral load assays for point-of-care testing in South Africa","volume":"53","author":"L Scott","year":"2015","journal-title":"Journal of clinical microbiology"},{"key":"ref11","first-page":"01673","article-title":"Performance of the Xpert\u00ae HIV-1 Viral Load assay: A systematic review and meta-analysis","author":"M Nash","year":"2018","journal-title":"Journal of clinical 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clinical microbiology"},{"issue":"12","key":"ref38","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1128\/JCM.01594-16","article-title":"Point-of-care Cepheid Xpert HIV-1 viral load test in rural African communities is feasible and reliable","volume":"54","author":"S Moyo","year":"2016","journal-title":"Journal of clinical microbiology"},{"issue":"8","key":"ref39","doi-asserted-by":"crossref","first-page":"e754","DOI":"10.1016\/S2214-109X(17)30247-4","article-title":"Use of the GeneXpert tuberculosis system for HIV viral load testing in India","volume":"5","author":"M Nash","year":"2017","journal-title":"The Lancet Global Health"},{"issue":"9","key":"ref40","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1128\/JCM.00593-14","article-title":"SAMBA HIV semiquantitative test, a new point-of-care viral-load-monitoring assay for resource-limited settings","volume":"52","author":"AV Ritchie","year":"2014","journal-title":"Journal of clinical microbiology"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1515\/cclm-2015-0522","article-title":"Comparative evaluation of the Aptima HIV-1 Quant Dx assay and COBAS TaqMan HIV-1 v2. 0 assay using the Roche High Pure System for the quantification of HIV-1 RNA in plasma","volume":"54","author":"G Schalasta","year":"2016","journal-title":"Clinical Chemistry and Laboratory Medicine"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jcv.2017.05.006","article-title":"Comparison of the Hologic Aptima HIV-1 Quant Dx Assay to the Roche COBAS Ampliprep\/COBAS TaqMan HIV-1 Test v2. 0 for the quantification of HIV-1 RNA in plasma samples","volume":"92","author":"K Sch\u00f8nning","year":"2017","journal-title":"Journal of Clinical Virology"},{"issue":"10","key":"ref43","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1099\/jmm.0.000514","article-title":"Performance of point-of-care Xpert HIV-1 plasma viral load assay at a tertiary HIV care centre in Southern India","volume":"66","author":"CR Swathirajan","year":"2017","journal-title":"Journal of medical microbiology"},{"issue":"4","key":"ref44","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1128\/JCM.02853-14","article-title":"Leukodepletion as a point-of-care method for monitoring HIV-1 viral load in whole blood","volume":"53","author":"L Titchmarsh","year":"2015","journal-title":"Journal of clinical microbiology"},{"issue":"6","key":"ref45","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nm0696-625","article-title":"HIV viral load markers in clinical practice","volume":"2","author":"MS Saag","year":"1996","journal-title":"Nature medicine"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"e85869","DOI":"10.1371\/journal.pone.0085869","article-title":"Systematic Review of the Performance of HIV Viral Load Technologies on Plasma Samples","volume":"9","author":"KA Sollis","year":"2014","journal-title":"PLOS ONE"},{"key":"ref47","unstructured":"WHO. WHO Prequalification of In Vitro Diagnostics PUBLIC REPORT Product: Xpert\u00ae HIV-1 Viral Load 2017 [cited 2018 17 April ]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/diagnostics_laboratory\/evaluations\/pq-list\/hiv-vrl\/170720_final_pq_report_pqdx_0192_0193_0194_0195_070-00.pdf?ua=1\" xlink:type=\"simple\">http:\/\/www.who.int\/diagnostics_laboratory\/evaluations\/pq-list\/hiv-vrl\/170720_final_pq_report_pqdx_0192_0193_0194_0195_070-00.pdf?ua=1<\/ext-link>."},{"key":"ref48","unstructured":"WHO. CONSOLIDATED GUIDELINES ON THE USE OF ANTIRETROVIRAL DRUGS FOR TREATING AND PREVENTING HIV INFECTION 2016 [cited 2018 16 April]. Second:[Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/208825\/9789241549684_eng.pdf?sequence=1\" xlink:type=\"simple\">http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/208825\/9789241549684_eng.pdf?sequence=1<\/ext-link>."},{"key":"ref49","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1097\/QAI.0000000000001319","article-title":"Scale-up of Early Infant HIV Diagnosis and Improving Access to Pediatric HIV Care in Global Plan Countries: Past and Future Perspectives","volume":"75","author":"S Essajee","year":"2017","journal-title":"JAIDS Journal of Acquired Immune Deficiency Syndromes"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/ije\/dyq255","article-title":"Net survival of perinatally and postnatally HIV-infected children: a pooled analysis of individual data from sub-Saharan Africa","volume":"40","author":"M Marston","year":"2011","journal-title":"International Journal of Epidemiology"},{"issue":"1","key":"ref51","doi-asserted-by":"crossref","DOI":"10.7448\/IAS.17.1.18914","article-title":"Early severe HIV disease precedes early antiretroviral therapy in infants: Are we too late?","volume":"17","author":"S Innes","year":"2014","journal-title":"Journal of the International AIDS Society"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/aid.2016.0021","article-title":"A Proposed Framework for the Implementation of Early Infant Diagnosis Point-of-Care","volume":"33","author":"D Karidia","year":"2017","journal-title":"AIDS Research and Human Retroviruses"},{"key":"ref53","unstructured":"WHO. PROGRESS REPORT 2016: PREVENT HIV, TEST AND TREAT ALL 2016 [cited 2018 10 April]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/251713\/WHO-HIV-2016.24-eng.pdf?sequence=1\" xlink:type=\"simple\">http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/251713\/WHO-HIV-2016.24-eng.pdf?sequence=1<\/ext-link>."},{"key":"#cr-split#-ref54.1","unstructured":"WHO. Global Action Plan on HIV Drug Resistance 2017-2021: 2018 Progress Report: WHO"},{"key":"#cr-split#-ref54.2","unstructured":"2018 [updated July cited 2018 09 October ]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/273049\/WHO-CDS-HIV-18.12-eng.pdf?ua=1\" xlink:type=\"simple\">http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/273049\/WHO-CDS-HIV-18.12-eng.pdf?ua=1<\/ext-link>."},{"key":"ref55","unstructured":"WHO. Low-cost tools for diagnosing and monitoring HIV infection in low-resource settings 2012 [cited 2018 14 April]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/bulletin\/volumes\/90\/12\/12-102780\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/bulletin\/volumes\/90\/12\/12-102780\/en\/<\/ext-link>."},{"issue":"S7","key":"ref56","doi-asserted-by":"crossref","first-page":"e25008","DOI":"10.1002\/jia2.25008","article-title":"Scaling up HIV viral load\u2013lessons from the large-scale implementation of HIV early infant diagnosis and CD4 testing","volume":"20","author":"T Peter","year":"2017","journal-title":"Journal of the International AIDS Society"},{"issue":"8","key":"ref57","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/cid\/ciw001","article-title":"Scale-up of Routine Viral Load Testing in Resource-Poor Settings: Current and Future Implementation Challenges","volume":"62","author":"T Roberts","year":"2016","journal-title":"Clinical Infectious Diseases"},{"key":"ref58","unstructured":"MSF. Making Viral Load Routine 2016 [cited 2018 09 October ]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.msf.org\/sites\/msf.org\/files\/making_viral_load_routine_part_1_programmatic_strategies.pdf\" xlink:type=\"simple\">https:\/\/www.msf.org\/sites\/msf.org\/files\/making_viral_load_routine_part_1_programmatic_strategies.pdf<\/ext-link>."},{"issue":"9","key":"ref59","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1097\/QAD.0000000000000277","article-title":"Acute HIV-1 infection in sub-Saharan Africa: a common occurrence overlooked","volume":"28","author":"KA Powers","year":"2014","journal-title":"AIDS"},{"issue":"1","key":"ref60","doi-asserted-by":"crossref","first-page":"21579","DOI":"10.7448\/IAS.20.1.21579","article-title":"Clinical and public health implications of acute and early HIV detection and treatment: a scoping review","volume":"20","author":"SE Rutstein","year":"2017","journal-title":"Journal of the International AIDS Society"},{"issue":"0 3","key":"ref61","doi-asserted-by":"crossref","first-page":"S221","DOI":"10.1097\/QAD.0000000000000924","article-title":"Targeted screening of at-risk adults for acute HIV-1 infection in sub-Saharan Africa","volume":"29","author":"EJ Sanders","year":"2015","journal-title":"AIDS"},{"key":"ref62","unstructured":"Fund TG. 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Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.theglobalfund.org\/media\/5765\/psm_viralloadearlyinfantdiagnosis_content_en.pdf?u=636737337280000000\" xlink:type=\"simple\">https:\/\/www.theglobalfund.org\/media\/5765\/psm_viralloadearlyinfantdiagnosis_content_en.pdf?u=636737337280000000<\/ext-link>."},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s12916-014-0173-7","article-title":"Feasibility of HIV point-of-care tests for resource-limited settings: challenges and solutions","volume":"12","author":"W Stevens","year":"2014","journal-title":"BMC Medicine"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0218369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:59:08Z","timestamp":1588967948000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0218369"}},"subtitle":[],"editor":[{"given":"Kwasi","family":"Torpey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,27]]},"references-count":64,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0218369","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,27]]}}}