{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:10:33Z","timestamp":1781518233275,"version":"3.54.1"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T00:00:00Z","timestamp":1560470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011199","name":"FP7 Ideas: European Research Council","doi-asserted-by":"publisher","award":["602461"],"award-info":[{"award-number":["602461"]}],"id":[{"id":"10.13039\/100011199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0218411","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T17:40:36Z","timestamp":1560534036000},"page":"e0218411","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cerebral microbleeds are not associated with postoperative delirium and postoperative cognitive dysfunction in older individuals"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2330-9839","authenticated-orcid":true,"given":"Gunnar","family":"Lachmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Kant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Lammers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Windmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Spies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saya","family":"Speidel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Borchers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hadzidiakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Hendrikse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Winterer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0759-8407","authenticated-orcid":true,"given":"Jeroen","family":"de Bresser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"BIOCOG Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,6,14]]},"reference":[{"key":"ref1","unstructured":"Association AP. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. 2013."},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/MCC.0000000000000327","article-title":"Peri- and postoperative cognitive and consecutive functional problems of elderly patients","volume":"22","author":"A Muller","year":"2016","journal-title":"Curr Opin Crit Care"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1097\/ACO.0b013e32834c7b44","article-title":"Delirium in the postanaesthesia period","volume":"24","author":"U Guenther","year":"2011","journal-title":"Curr Opin Anaesthesiol"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1056\/NEJMoa1112923","article-title":"Cognitive trajectories after postoperative delirium","volume":"367","author":"JS Saczynski","year":"2012","journal-title":"N Engl J Med"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1056\/NEJMra052321","article-title":"Delirium in older persons","volume":"354","author":"SK Inouye","year":"2006","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fnagi.2015.00112","article-title":"Biomarkers of postoperative delirium and cognitive dysfunction","volume":"7","author":"G Androsova","year":"2015","journal-title":"Front Aging Neurosci"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/j.1365-2044.2008.05523.x","article-title":"Delirium is associated with early postoperative cognitive dysfunction","volume":"63","author":"JL Rudolph","year":"2008","journal-title":"Anaesthesia"},{"key":"ref8","article-title":"MRI Markers of Neurodegenerative and Neurovascular Changes in Relation to Postoperative Delirium and Postoperative Cognitive Decline","author":"IMJ Kant","year":"2017","journal-title":"Am J Geriatr Psychiatry"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/jamaneurol.2016.1017","article-title":"Association of Cerebral Microbleeds With Cognitive Decline and Dementia","volume":"73","author":"S Akoudad","year":"2016","journal-title":"JAMA Neurol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.eurpsy.2017.10.004","article-title":"Personalized risk prediction of postoperative cognitive impairment\u2014rationale for the EU-funded BioCog project","volume":"50","author":"G Winterer","year":"2018","journal-title":"European psychiatry: the journal of the Association of European Psychiatrists"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.pnpbp.2007.01.011","article-title":"Automated Neuropsychological Test Battery (CANTAB) in mild cognitive impairment and in Alzheimer's disease","volume":"31","author":"A Egerhazi","year":"2007","journal-title":"Progress in neuro-psychopharmacology & biological psychiatry"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jpainsymman.2004.07.009","article-title":"Fast, systematic, and continuous delirium assessment in hospitalized patients: the nursing delirium screening scale","volume":"29","author":"JD Gaudreau","year":"2005","journal-title":"J Pain Symptom Manage"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"941","DOI":"10.7326\/0003-4819-113-12-941","article-title":"Clarifying confusion: the confusion assessment method. A new method for detection of delirium","volume":"113","author":"SK Inouye","year":"1990","journal-title":"Ann Intern Med"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/CCM.0b013e3181cabb42","article-title":"Different assessment tools for intensive care unit delirium: which score to use?","volume":"38","author":"A Luetz","year":"2010","journal-title":"Critical care medicine"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1034\/j.1399-6576.2001.045003275.x","article-title":"The assessment of postoperative cognitive function","volume":"45","author":"LS Rasmussen","year":"2001","journal-title":"Acta anaesthesiologica Scandinavica"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1093\/aje\/kwt312","article-title":"Comparison of random forest and parametric imputation models for imputing missing data using MICE: a CALIBER study","volume":"179","author":"AD Shah","year":"2014","journal-title":"Am J Epidemiol"},{"issue":"21","key":"ref17","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1212\/WNL.0b013e3181c34a7d","article-title":"The Microbleed Anatomical Rating Scale (MARS): reliability of a tool to map brain microbleeds","volume":"73","author":"SM Gregoire","year":"2009","journal-title":"Neurology"},{"issue":"8","key":"ref18","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S1474-4422(13)70124-8","article-title":"Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration","volume":"12","author":"JM Wardlaw","year":"2013","journal-title":"Lancet Neurol"},{"key":"ref19","author":"P. Schmidt","year":"2017"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1474-4422(13)70060-7","article-title":"Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging","volume":"12","author":"JM Wardlaw","year":"2013","journal-title":"Lancet Neurol"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.jagp.2013.01.061","article-title":"White-matter hyperintensities predict delirium after cardiac surgery","volume":"21","author":"Y Hatano","year":"2013","journal-title":"Am J Geriatr Psychiatry"},{"issue":"9","key":"ref22","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1002\/pon.3262","article-title":"Association of pre-operative brain pathology with post-operative delirium in a cohort of non-small cell lung cancer patients undergoing surgical resection","volume":"22","author":"JC Root","year":"2013","journal-title":"Psychooncology"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"e87375","DOI":"10.1371\/journal.pone.0087375","article-title":"Low pre-existing gray matter volume in the medial temporal lobe and white matter lesions are associated with postoperative cognitive dysfunction after cardiac surgery","volume":"9","author":"K Maekawa","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/ALN.0000000000000080","article-title":"A pilot study evaluating presurgery neuroanatomical biomarkers for postoperative cognitive decline after total knee arthroplasty in older adults","volume":"120","author":"CC Price","year":"2014","journal-title":"Anesthesiology"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1161\/STROKEAHA.114.007533","article-title":"Impact of perioperative infarcts after cardiac surgery","volume":"46","author":"N Patel","year":"2015","journal-title":"Stroke"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/CIRCULATIONAHA.115.016261","article-title":"Cerebral Microbleeds Are Associated With an Increased Risk of Stroke: The Rotterdam Study","volume":"132","author":"S Akoudad","year":"2015","journal-title":"Circulation"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1016\/j.neurobiolaging.2015.02.024","article-title":"Brain atrophy and white-matter hyperintensities are not significantly associated with incidence and severity of postoperative delirium in older persons without dementia","volume":"36","author":"M Cavallari","year":"2015","journal-title":"Neurobiol Aging"},{"issue":"8","key":"ref28","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1212\/WNL.0000000000001279","article-title":"Inflammatory biomarkers, cerebral microbleeds, and small vessel disease: Framingham Heart Study","volume":"84","author":"A Shoamanesh","year":"2015","journal-title":"Neurology"},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1161\/STROKEAHA.114.004130","article-title":"Risk factors, stroke prevention treatments, and prevalence of cerebral microbleeds in the Framingham Heart Study","volume":"45","author":"JR Romero","year":"2014","journal-title":"Stroke"},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/jocs.12643","article-title":"The Presence of New MRI Lesions and Cognitive Decline After Cardiac Surgery: A Systematic Review","volume":"30","author":"N Patel","year":"2015","journal-title":"J Card Surg"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0022-510X(02)00252-6","article-title":"Vascular dementia may be the most common form of dementia in the elderly","volume":"203\u2013204","author":"GC Roman","year":"2002","journal-title":"J Neurol Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0218411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T06:02:29Z","timestamp":1589004149000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0218411"}},"subtitle":[],"editor":[{"given":"Jonathan H.","family":"Sherman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,14]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0218411","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,14]]}}}