{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:55:53Z","timestamp":1770749753647,"version":"3.50.0"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","award":["AID-OAA-A-15-00035"],"award-info":[{"award-number":["AID-OAA-A-15-00035"]}],"id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0218710","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T17:38:01Z","timestamp":1561570681000},"page":"e0218710","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Evaluating the potential impact and cost-effectiveness of dapivirine vaginal ring pre-exposure prophylaxis for HIV prevention"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6166-1561","authenticated-orcid":true,"given":"Meghan","family":"Reidy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Gardiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carel","family":"Pretorius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4936-0264","authenticated-orcid":true,"given":"Robert","family":"Glaubius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3439-1199","authenticated-orcid":true,"given":"Kristine","family":"Torjesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8228-4577","authenticated-orcid":true,"given":"Katharine","family":"Kripke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"key":"ref1","unstructured":"AIDSinfo [Internet]. Geneva: UNAIDS. [cited 2018 June 25]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/aidsinfo.unaids.org\/\" xlink:type=\"simple\">http:\/\/aidsinfo.unaids.org\/<\/ext-link>"},{"key":"ref2","article-title":"Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV","year":"2015"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1017\/S0021932012000715","article-title":"Access to contraceptive methods and prevalence of use","volume":"45","author":"J Ross","year":"2013","journal-title":"J Biosoc Sci"},{"issue":"22","key":"ref4","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1056\/NEJMoa1506110","article-title":"Use of a vaginal ring containing dapivirine for HIV-1 prevention in women","volume":"375","author":"JM Baeten","year":"2016","journal-title":"N Engl J Med"},{"key":"ref5","unstructured":"Brown E, Palantee-Philips T, Marzinke M, Hendrix C, Dezutti C, Soto-Torres L, et al. Residual dapivirine ring levels indicate higher adherence to vaginal ring is associated with HIV-1 protection. Presented at: IAS 2016. 21st International AIDS Conference, 2016 18\u201322 July; Durban, South Africa. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/natap.org\/2016\/IAC\/IAC_38.htm\" xlink:type=\"simple\">http:\/\/natap.org\/2016\/IAC\/IAC_38.htm<\/ext-link>"},{"key":"ref6","unstructured":"Baeten J, Palanee-Phillips T, Mgodi N, Mayo A, Nel A, Rosenberg Z, Hillier SL, Brown E. High uptake and reduced HIV-1 incidence in an open-label trial of the dapivirine ring. Presented at: CROI 2018. 25th Conference on Retroviruses and Opportunistic Infections; 2018 4\u20137 March; Boston, MA. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.croiconference.org\/sessions\/high-uptake-and-reduced-hiv-1-incidence-open-label-trial-dapivirine-ring\" xlink:type=\"simple\">http:\/\/www.croiconference.org\/sessions\/high-uptake-and-reduced-hiv-1-incidence-open-label-trial-dapivirine-ring<\/ext-link>"},{"key":"ref7","unstructured":"Nel A, Van Nierkerk N, Van Baelen B, Rosenberg Z. HIV incidence and adherence in DREAM: an open-label trial of dapivirine vaginal ring. Presented at: CROI 2018. 25th Conference on Retroviruses and Opportunistic Infections; 2018 4\u20137 March; Boston, MA. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.croiconference.org\/sessions\/hiv-incidence-and-adherence-dream-open-label-trial-dapivirine-vaginal-ring\" xlink:type=\"simple\">http:\/\/www.croiconference.org\/sessions\/hiv-incidence-and-adherence-dream-open-label-trial-dapivirine-vaginal-ring<\/ext-link>"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0140-6736(15)00056-2","article-title":"Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial","volume":"387","author":"S McCormack","year":"2016","journal-title":"Lancet"},{"key":"ref9","unstructured":"Avenir Health: Spectrum Model [software]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.avenirhealth.org\/software-spectrum.php\" xlink:type=\"simple\">http:\/\/www.avenirhealth.org\/software-spectrum.php<\/ext-link>"},{"key":"ref10","unstructured":"Joint United Nations Programme on HIV\/AIDS (UNAIDS). 90-90-90: an ambitious treatment target to help end the AIDS epidemic. Geneva: UNAIDS; 2014. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/90-90-90_en.pdf\" xlink:type=\"simple\">http:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/90-90-90_en.pdf<\/ext-link>"},{"key":"ref11","unstructured":"Kenya National Bureau of Statistics, Ministry of Health\/Kenya, National AIDS Control Council\/Kenya, Kenya Medical Research Institute, National Council for Population and Development\/Kenya, and ICF International. Kenya demographic and health survey 2014. 2015. Rockville, MD, USA: Kenya National Bureau of Statistics, Ministry of Health\/Kenya, National AIDS Control Council\/Kenya, Kenya Medical Research Institute, National Council for Population and Development\/Kenya, and ICF International."},{"key":"ref12","unstructured":"National Department of Health\/South Africa, Statistics South Africa, South African Medical Research Council, and ICF. South Africa demographic and health survey 2016: key indicator report. 2017. Pretoria, South Africa: Statistics South Africa."},{"key":"ref13","unstructured":"Uganda Bureau of Statistics (UBOS) and ICF International. Uganda demographic and health survey 2011. 2012. Kampala, Uganda: UBOS and ICF International."},{"key":"ref14","unstructured":"Zimbabwe National Statistics Agency and ICF International. Zimbabwe Demographic and Health Survey 2015: Final Report. 2016. Rockville, Maryland, USA: Zimbabwe National Statistics Agency (ZIMSTAT) and ICF International."},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"e1002444","DOI":"10.1371\/journal.pmed.1002444","article-title":"HIV pre-exposure prophylaxis and early antiretroviral treatment among female sex workers in South Africa: results from a prospective observational demonstration project","volume":"14","author":"R Eakle","year":"2017","journal-title":"PLoS Med"},{"key":"ref16","unstructured":"Behanzin L, Guedou FA, Geraldo N, Matsetse EG, Aza-Gnandji M, et al. PrEP and early antiretroviral therapy demonstration project: challenges to ensure follow-up and adherence among female sex workers in Cotonou, Benin. Presented at: HIVR4P 2016. 2nd HIV Research for Prevention Conference; 2016 17\u201320 October; Chicago, Illinois."},{"key":"ref17","unstructured":"Phanitsiri S, Kiragu M, Nnakabonge I, Wachihi C, Tagar E, Kimani P, et al. The unit cost of delivering oral PrEP as part of a combination HIV prevention package: results from the IPCP-Kenya demonstration project. Poster presented at: ICASA 2017. 19th International Conference on AIDS and STIs in Africa; 2017 4\u20139 Dec; Abidjan, Cote d\u2019Ivoire."},{"key":"ref18","unstructured":"Jamieson L, Meyer-Rath G, Gomez G, Johnson LF. The impact of differential uptake by HIV risk group on the effect and cost-effectiveness of PrEP in different populations in South Africa. Presented at IAEN 2018. 10th International AIDS Economic Network Pre-Conference; 2018 20\u201321 July; Amsterdam, Netherlands. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.iaen.org\/documents\/D2_Lise_Jamieson.pptx\" xlink:type=\"simple\">http:\/\/www.iaen.org\/documents\/D2_Lise_Jamieson.pptx<\/ext-link>"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2147\/IJWH.S185712","article-title":"\u201cWe are not the same\u201d: African women\u2019s view of multipurpose prevention products in the TRIO clinical study","volume":"11","author":"MK Shapley-Quinn","year":"2019","journal-title":"International Journal of Women\u2019s Health"},{"issue":"4","key":"ref20","first-page":"394","article-title":"Young Women\u2019s Stated Preferences for Biomedical HIV Prevention: Results of a Discrete Choice Experiment in Kenya and South Africa","volume":"80","author":"AM Minnis","year":"2019","journal-title":"JAIDS"},{"key":"ref21","unstructured":"Joint United Nations Programme on HIV\/AIDS (UNAIDS). Global AIDS update 2018. Miles to go: closing gaps, breaking barriers, righting injustices. Geneva: UNAIDS; 2018. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/miles-to-go_en.pdf\" xlink:type=\"simple\">http:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/miles-to-go_en.pdf<\/ext-link>"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0218710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T05:39:28Z","timestamp":1589002768000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0218710"}},"subtitle":[],"editor":[{"given":"Nelly Rwamba","family":"Mugo","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,26]]},"references-count":21,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0218710","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,26]]}}}