{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:53:29Z","timestamp":1784825609940,"version":"3.55.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0219047","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T17:30:19Z","timestamp":1561743019000},"page":"e0219047","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Innate-like T cells in children with sickle cell disease"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7068-4530","authenticated-orcid":true,"given":"Slimane","family":"Allali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Machavoine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Rignault-Bricard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentine","family":"Brousse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariane","family":"de Montalembert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Hermine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Trovati","family":"Maciel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2891-2269","authenticated-orcid":true,"given":"Maria","family":"Leite-de-Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,6,28]]},"reference":[{"issue":"10091","key":"ref1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0140-6736(17)30193-9","article-title":"Sickle cell disease","volume":"390","author":"RE Ware","year":"2017","journal-title":"Lancet"},{"issue":"24","key":"ref2","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1182\/blood-2013-05-498311","article-title":"Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies","volume":"122","author":"D Manwani","year":"2013","journal-title":"Blood"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1182\/blood-2015-09-618538","article-title":"Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology","volume":"127","author":"D Zhang","year":"2016","journal-title":"Blood"},{"issue":"7","key":"ref4","first-page":"611","article-title":"Elevated immunoreactive tumor necrosis factor and interleukin-1 in sickle cell disease","volume":"84","author":"RB Francis Jr.","year":"1992","journal-title":"J Natl Med Assoc"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1182\/blood.V92.7.2551","article-title":"Plasma endothelin-1, cytokine, and prostaglandin E2 levels in sickle cell disease and acute vaso-occlusive sickle crisis","volume":"92","author":"E Graido-Gonzalez","year":"1998","journal-title":"Blood"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1365-2141.1994.tb08318.x","article-title":"Circulating cytokines in sickle cell patients during steady state","volume":"87","author":"H Croizat","year":"1994","journal-title":"Br J Haematol"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/10245330310001604719","article-title":"Cytokines in sickle cell disease","volume":"8","author":"A Pathare","year":"2003","journal-title":"Hematology"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/ajh.20196","article-title":"Cytokine profile of sickle cell disease in Oman","volume":"77","author":"A Pathare","year":"2004","journal-title":"Am J Hematol"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1684\/ecn.2013.0328","article-title":"Altered levels of pro-inflammatory cytokines in sickle cell disease patients during vaso-occlusive crises and the steady state condition","volume":"24","author":"B Keikhaei","year":"2013","journal-title":"Eur Cytokine Netw"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1179\/1607845415Y.0000000048","article-title":"Association of homocysteine and inflammatory-related molecules in sickle cell anemia","volume":"21","author":"W Vilas-Boas","year":"2016","journal-title":"Hematology"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nri3389","article-title":"Shades of grey\u2014the blurring view of innate and adaptive immunity","volume":"13","author":"LL Lanier","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.immuni.2018.03.009","article-title":"Unconventional T Cell Targets for Cancer Immunotherapy","volume":"48","author":"DI Godfrey","year":"2018","journal-title":"Immunity"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nri3384","article-title":"Six-of-the-best: unique contributions of gammadelta T cells to immunology","volume":"13","author":"P Vantourout","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"ref14","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41577-018-0034-2","article-title":"Tissue-specific functions of invariant natural killer T cells","volume":"18","author":"CM Crosby","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/bs.ai.2015.03.003","article-title":"Activation and Function of iNKT and MAIT Cells","volume":"127","author":"S Chandra","year":"2015","journal-title":"Adv Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.coi.2017.07.009","article-title":"MAIT cells in infectious diseases","volume":"48","author":"M Salou","year":"2017","journal-title":"Curr Opin Immunol"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.immuni.2009.06.020","article-title":"Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals","volume":"31","author":"B Martin","year":"2009","journal-title":"Immunity"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.3389\/fimmu.2018.01750","article-title":"Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung Infections","volume":"9","author":"F Trottein","year":"2018","journal-title":"Front Immunol"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nm.2817","article-title":"IL-23 induces spondyloarthropathy by acting on ROR-gammat+ CD3+CD4-CD8- entheseal resident T cells","volume":"18","author":"JP Sherlock","year":"2012","journal-title":"Nat Med"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s11926-015-0507-2","article-title":"IL-23 responsive innate-like T cells in spondyloarthritis: the less frequent they are, the more vital they appear","volume":"17","author":"K Venken","year":"2015","journal-title":"Curr Rheumatol Rep"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.3389\/fimmu.2018.01489","article-title":"It Takes "Guts" to Cause Joint Inflammation: Role of Innate-Like T Cells","volume":"9","author":"C Mortier","year":"2018","journal-title":"Front Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.clim.2017.11.009","article-title":"Circulating IL-17-producing mucosal-associated invariant T cells (MAIT) are associated with symptoms in children with asthma","volume":"188","author":"G Lezmi","year":"2018","journal-title":"Clin Immunol"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1084\/jem.20061551","article-title":"Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia","volume":"204","author":"ML Michel","year":"2007","journal-title":"J Exp Med"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/ni.3726","article-title":"IL-17(+) gammadelta T cells as kick-starters of inflammation","volume":"18","author":"PH Papotto","year":"2017","journal-title":"Nat Immunol"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1182\/blood-2009-02-205492","article-title":"NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines","volume":"114","author":"KL Wallace","year":"2009","journal-title":"Blood"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"e74664","DOI":"10.1371\/journal.pone.0074664","article-title":"NF-kappaB is activated in CD4+ iNKT cells by sickle cell disease and mediates rapid induction of adenosine A2A receptors","volume":"8","author":"G Lin","year":"2013","journal-title":"PLoS One"},{"issue":"17","key":"ref27","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1182\/blood-2012-11-465963","article-title":"Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenoson","volume":"121","author":"JJ Field","year":"2013","journal-title":"Blood"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"5758","DOI":"10.4049\/jimmunol.1003043","article-title":"Proinflammatory environment dictates the IL-17-producing capacity of human invariant NKT cells","volume":"186","author":"L Moreira-Teixeira","year":"2011","journal-title":"J Immunol"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","first-page":"e105422","DOI":"10.1371\/journal.pone.0105422","article-title":"Innate-like and conventional T cell populations from hemodialyzed and kidney transplanted patients are equally compromised","volume":"9","author":"M Baron","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1172\/JCI10726","article-title":"Sickle cell anemia as an inflammatory disease","volume":"106","author":"OS Platt","year":"2000","journal-title":"J Clin Invest"},{"issue":"7188","key":"ref31","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nature06764","article-title":"Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome","volume":"452","author":"JD Milner","year":"2008","journal-title":"Nature"},{"issue":"9","key":"ref32","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1056\/NEJMra0707449","article-title":"Interleukin-17 and type 17 helper T cells","volume":"361","author":"P Miossec","year":"2009","journal-title":"N Engl J Med"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/imm.12142","article-title":"Interleukin-17A: a unique pathway in immune-mediated diseases: psoriasis, psoriatic arthritis and rheumatoid arthritis","volume":"141","author":"BW Kirkham","year":"2014","journal-title":"Immunology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-065X.2008.00699.x","article-title":"The roles of IL-17A in inflammatory immune responses and host defense against pathogens","volume":"226","author":"Y Iwakura","year":"2008","journal-title":"Immunol Rev"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.cyto.2008.07.017","article-title":"An overview of IL-17 function and signaling","volume":"43","author":"SL Gaffen","year":"2008","journal-title":"Cytokine"},{"issue":"8","key":"ref36","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.4049\/jimmunol.0903162","article-title":"IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation","volume":"184","author":"L Roussel","year":"2010","journal-title":"J Immunol"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cyto.2015.01.003","article-title":"Update on the role of Interleukin 17 in rheumatologic autoimmune diseases","volume":"75","author":"C Konya","year":"2015","journal-title":"Cytokine"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12969-017-0221-x","article-title":"Coexistent sickle-cell anemia and autoimmune disease in eight children: pitfalls and challenges","volume":"16","author":"V Li-Thiao-Te","year":"2018","journal-title":"Pediatr Rheumatol Online J"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cyto.2013.10.009","article-title":"Chronic inflammatory state in sickle cell anemia patients is associated with HBB(*)S haplotype","volume":"65","author":"IC Bandeira","year":"2014","journal-title":"Cytokine"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1128\/CVI.00145-09","article-title":"Pattern of serum cytokine expression and T-cell subsets in sickle cell disease patients in vaso-occlusive crisis","volume":"17","author":"BO Musa","year":"2010","journal-title":"Clin Vaccine Immunol"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1177\/1076029611420992","article-title":"Biomarkers of inflammation, growth factor, and coagulation activation in patients with sickle cell disease","volume":"18","author":"MH Qari","year":"2012","journal-title":"Clin Appl Thromb Hemost"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1186\/ar4147","article-title":"Expression of regulatory receptors on gammadelta T cells and their cytokine production in Behcet\u2019s disease","volume":"15","author":"G Parlakgul","year":"2013","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"ref43","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/bjh.13326","article-title":"Immune parameter analysis of children with sickle cell disease on hydroxycarbamide or chronic transfusion therapy","volume":"169","author":"RS Nickel","year":"2015","journal-title":"Br J Haematol"},{"issue":"2","key":"ref44","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jaci.2015.01.014","article-title":"Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms","volume":"136","author":"TS Hinks","year":"2015","journal-title":"J Allergy Clin Immunol"},{"issue":"9","key":"ref45","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1111\/j.1398-9995.2008.01687.x","article-title":"T-cell activation during exacerbations: a longitudinal study in refractory asthma","volume":"63","author":"E Mamessier","year":"2008","journal-title":"Allergy"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0219047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T14:33:14Z","timestamp":1610116394000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0219047"}},"subtitle":[],"editor":[{"given":"Philippe","family":"Connes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,28]]},"references-count":45,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0219047","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,28]]}}}