{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:36:25Z","timestamp":1787740585854,"version":"build-2784847793"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0219536","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T17:29:43Z","timestamp":1564594183000},"page":"e0219536","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparative evaluation of anesthetic efficacy of 1.8 mL and 3.6 mL of articaine in irreversible pulpitis of the mandibular molar: A randomized clinical trial"],"prefix":"10.1371","volume":"14","author":[{"given":"Stella Agra","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Carolina Ratto Tempestini","family":"Horliana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio Mendes","family":"Pannuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1842-9521","authenticated-orcid":true,"given":"Paulo Henrique","family":"Braz-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina Gisele Costa","family":"Bispo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas Aparecida","family":"Buscariolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney Garcia","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2384-5183","authenticated-orcid":true,"given":"Isabel Peixoto","family":"Tortamano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,7,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.joen.2011.02.015","article-title":"Effect of combination of preoperative ibuprofen\/acetaminophen on the success of the inferior alveolar nerve block in patients with symptomatic irreversible pulpitis","volume":"37","author":"M Simpson","year":"2011","journal-title":"J Endod"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.joen.2013.04.007","article-title":"Is a volume of 3.6 mL better than 1.8 mL for inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis?","volume":"39","author":"S Fowler","year":"2013","journal-title":"J Endod"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0099-2399(06)81366-X","article-title":"Endodontic anesthesia in mandibular molars: a clinical study","volume":"19","author":"HP Cohen","year":"1993","journal-title":"J Endod"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/00004770-200310000-00004","article-title":"The significance of needle deflection in success of the inferior alveolar nerve block in patients with irreversible pulpitis","volume":"29","author":"S Kennedy","year":"2003","journal-title":"J Endod"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.joen.2008.10.020","article-title":"A comparison of the anesthetic efficacy of articaine and lidocaine in patients with irreversible pulpitis","volume":"35","author":"IP Tortamano","year":"2009","journal-title":"J Endod"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.joen.2012.01.008","article-title":"Comparison of the anesthetic efficacy between bupivacaine and lidocaine in patients with irreversible pulpitis of mandibular molar","volume":"38","author":"RM Sampaio","year":"2012","journal-title":"J Endod"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S1079-2104(97)90372-3","article-title":"Anesthetic efficacy of the supplemental intraosseous injection of 3% mepivacaine in irreversible pulpitis","volume":"84","author":"D Reisman","year":"1997","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2344\/15-00019.1","article-title":"Effect of Preoperative Pain on Inferior Alveolar Nerve Block","volume":"62","author":"V Aggarwal","year":"2015","journal-title":"Anesth Prog"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0099-2399(98)80011-3","article-title":"Anesthetic efficacy of the supplemental intraosseous injection for teeth with irreversible pulpitis","volume":"24","author":"SA Parente","year":"1998","journal-title":"J Endod"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0099-2399(98)80053-8","article-title":"Anesthetic efficacy of the supplemental intraosseous injection of 2% lidocaine with 1:100,000 epinephrine in irreversible pulpitis","volume":"24","author":"J Nusstein","year":"1998","journal-title":"J Endod"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1046\/j.1365-2591.2002.00592.x","article-title":"Supplementary routes to local anaesthesia","volume":"35","author":"JG Meechan","year":"2002","journal-title":"Int Endod J"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"522","DOI":"10.4103\/0972-0707.144578","article-title":"Anesthetic efficacy of the supplemental X-tip intraosseous injection using 4% articaine with 1:100,000 adrenaline in patients with irreversible pulpitis: An in vivo study","volume":"17","author":"AC Bhuyan","year":"2014","journal-title":"J Conserv Dent"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.joen.2006.06.006","article-title":"Articaine for supplemental intraosseous anesthesia in patients with irreversible pulpitis","volume":"32","author":"J Bigby","year":"2006","journal-title":"J Endod"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cden.2009.12.003","article-title":"Local anesthesia strategies for the patient with a &quot;hot&quot; tooth","volume":"54","author":"JM Nusstein","year":"2010","journal-title":"Dent Clin North Am"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.joen.2008.11.025","article-title":"Articaine for supplemental buccal mandibular infiltration anesthesia in patients with irreversible pulpitis when the inferior alveolar nerve block fails","volume":"35","author":"R Matthews","year":"2009","journal-title":"J Endod"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.joen.2012.10.012","article-title":"Efficacy of articaine versus lidocaine in block and infiltration anesthesia administered in teeth with irreversible pulpitis: a prospective, randomized, double-blind study","volume":"39","author":"H Ashraf","year":"2013","journal-title":"J Endod"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/iej.12283","article-title":"Comparison of the anaesthetic efficacy of different volumes of 4% articaine (1.8 and 3.6 mL) as supplemental buccal infiltration after failed inferior alveolar nerve block","volume":"48","author":"M Singla","year":"2015","journal-title":"Int Endod J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.joen.2011.01.016","article-title":"Comparative evaluation of local infiltration of articaine, articaine plus ketorolac, and dexamethasone on anesthetic efficacy of inferior alveolar nerve block with lidocaine in patients with irreversible pulpitis","volume":"37","author":"V Aggarwal","year":"2011","journal-title":"J Endod"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.joen.2015.01.003","article-title":"Comparison of anesthetic efficacy between lidocaine with and without magnesium sulfate USP 50% for inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis","volume":"41","author":"KP Shetty","year":"2015","journal-title":"J Endod"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/01.DON.0000140565.88940.60","article-title":"Anesthetic effectiveness of the supplemental intraligamentary injection, administered with a computer-controlled local anesthetic delivery system, in patients with irreversible pulpitis","volume":"31","author":"J Nusstein","year":"2005","journal-title":"J Endod"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1016\/j.tripleo.2009.06.012","article-title":"Anesthetic efficacy of inferior alveolar nerve block plus buccal infiltration or periodontal ligament injections with articaine in patients with irreversible pulpitis in the mandibular first molar","volume":"108","author":"S Fan","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1365-2591.2012.02050.x","article-title":"Comparison of the anaesthetic efficacy of and heart rate changes after periodontal ligament or intraosseous X-Tip injection in mandibular molars: a randomized controlled clinical trial","volume":"45","author":"M Zarei","year":"2012","journal-title":"Int Endod J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0099-2399(06)81125-8","article-title":"Evaluation of lidocaine in human inferior alveolar nerve block","volume":"23","author":"GM Yared","year":"1997","journal-title":"J Endod"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.joen.2012.02.003","article-title":"Comparative Evaluation of 1.8 mL and 3.6 mL of 2% Lidocaine with 1:200,000 Epinephrine for Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Prospective, Randomized Single-blind Study","volume":"38","author":"V Aggarwal","year":"2012","journal-title":"J Endod"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0099-2399(89)80091-3","article-title":"An evaluation of volumes and concentrations of lidocaine in human inferior alveolar nerve block","volume":"15","author":"DL Vreeland","year":"1989","journal-title":"J Endod"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.joen.2010.05.012","article-title":"Prospective, randomized single-blind study of the anesthetic efficacy of 1.8 and 3.6 milliliters of 2% lidocaine with 1:50,000 epinephrine for inferior alveolar nerve block","volume":"36","author":"M Wali","year":"2010","journal-title":"J Endod"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.joen.2015.05.015","article-title":"A Comparison of Different Volumes of Articaine for Inferior Alveolar Nerve Block for Molar Teeth with Symptomatic Irreversible Pulpitis","volume":"41","author":"R Abazarpoor","year":"2015","journal-title":"J Endod"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2344\/anpr-65-01-03","article-title":"Volume of Anesthetic agents and IANB: A Systematic Review","volume":"65","author":"AS Milani","year":"2018","journal-title":"Anesth Prog"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1590\/0103-6440201600663","article-title":"Anesthetic Efficacy in Irreversible Pulpitis: A Randomized Clinical Trial","volume":"27","author":"CE Allegretti","year":"2016","journal-title":"Braz Dent J"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0099-2399(87)80097-3","article-title":"An evaluation of an electric pulp tester as a measure of analgesia in human vital teeth","volume":"13","author":"LJ Dreven","year":"1987","journal-title":"J Endod"},{"key":"ref31","first-page":"25","article-title":"A clinical evaluation of the electric pulp tester as an indicator of local anesthesia","volume":"21","author":"AJ Certosimo","year":"1996","journal-title":"Oper Dent"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/j.0022-0337.2002.66.1.tb03505.x","article-title":"Development of new pain management strategies","volume":"66","author":"KM Hargreaves","year":"2002","journal-title":"J Dent Educ"},{"key":"ref33","first-page":"55","article-title":"Dental pulp neurophysiology: part 1. Clinical and diagnostic implications","volume":"75","author":"A Abd-Elmeguid","year":"2009","journal-title":"J Can Dent Assoc"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.tripleo.2009.11.016","article-title":"Efficacy of combining a buccal infiltration with an inferior alveolar nerve block for mandibular molars with irreversible pulpitis","volume":"109","author":"M Parirokh","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.jpainsymman.2010.08.016","article-title":"Studies comparing Numerical Rating Scales, Verbal Rating Scales, and Visual Analogue Scales for assessment of pain intensity in adults: a systematic literature review","volume":"41","author":"MJ Hjermstad","year":"2011","journal-title":"J Pain Symptom Manage"},{"issue":"7","key":"ref36","first-page":"1584","article-title":"Learning from pain scales: patient perspective","volume":"30","author":"P Clark","year":"2003","journal-title":"J Rheumatol"},{"issue":"suppl 2","key":"ref37","doi-asserted-by":"crossref","first-page":"17s","DOI":"10.11606\/S1518-8787.2017051007070","article-title":"Main characteristics of patients of primary health care services in Brazil","volume":"51","author":"IA Guibu","year":"2017","journal-title":"Rev Saude Publica"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/01.DON.0000125317.21892.8F","article-title":"Anesthetic efficacy of articaine for inferior alveolar nerve blocks in patients with irreversible pulpitis","volume":"30","author":"E Claffey","year":"2004","journal-title":"J Endod"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0219536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T23:31:50Z","timestamp":1664062310000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0219536"}},"subtitle":[],"editor":[{"given":"Spyridon N.","family":"Papageorgiou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,7,31]]},"references-count":38,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0219536","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,31]]}}}