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Regulations of the People\u2019s Republic of China on residence registration. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.npc.gov.cn\/wxzl\/gongbao\/2000-12\/10\/content_5004332.htm\" xlink:type=\"simple\">http:\/\/www.npc.gov.cn\/wxzl\/gongbao\/2000-12\/10\/content_5004332.htm<\/ext-link>"},{"key":"ref27","first-page":"893","article-title":"Chinese guideline for type 2 diabetes (2013 ed)","volume":"30","year":"2014","journal-title":"Chin J Endocrinol Metab"},{"key":"ref28","year":"2005"},{"key":"ref29","unstructured":"WHO Collaborating Centre for Drug Statistics Methodology. ATC\/DDD Index 2018. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.whocc.no\/atc_ddd_index\/\" xlink:type=\"simple\">https:\/\/www.whocc.no\/atc_ddd_index\/<\/ext-link>"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00228-014-1780-0","article-title":"Optimizing elderly pharmacotherapy: polypharmacy vs. undertreatment. 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