{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:06:50Z","timestamp":1791875210627,"version":"4.3.4"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0220459","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T17:39:23Z","timestamp":1565285963000},"page":"e0220459","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Novel association of five HLA alleles with HIV-1 progression in Spanish long-term non progressor patients"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8276-9731","authenticated-orcid":true,"given":"Eva","family":"Ram\u00edrez de Arellano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"D\u00edez-Fuertes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto Erick","family":"de la Torre Tarazona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7391-2081","authenticated-orcid":true,"given":"Susana","family":"S\u00e1nchez-Lara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Lao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Vicario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Gonz\u00e1lez-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7414-8812","authenticated-orcid":true,"given":"Federico","family":"Pulido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix","family":"Gutierrez-Rodero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Iribarren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pompeyo","family":"Viciana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Vilches","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Capa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Alcam\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Del Val","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,8,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/382722a0","article-title":"Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene","volume":"382","author":"M Samson","year":"1996","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1126\/science.273.5283.1856","article-title":"Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study","volume":"273","author":"M Dean","year":"1996","journal-title":"Science"},{"key":"ref3","first-page":"959","article-title":"Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study","volume":"277","author":"MW Smith","year":"1997","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1126\/science.279.5349.389","article-title":"Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant","volume":"279","author":"C Winkler","year":"1998","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1073\/pnas.96.8.4581","article-title":"Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression","volume":"96","author":"H Liu","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"14467","DOI":"10.1073\/pnas.97.26.14467","article-title":"Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10","volume":"97","author":"HD Shin","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.med.54.101601.152346","article-title":"The influence of HLA genotype on AIDS","volume":"54","author":"M Carrington","year":"2003","journal-title":"Annu Rev Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/infdis\/jis717","article-title":"IL28B single-nucleotide polymorphism rs12979860 is associated with spontaneous HIV control in white subjects","volume":"207","author":"K Machmach","year":"2013","journal-title":"J Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1097\/01.aids.0000432474.76873.5f","article-title":"Identification of TRIM22 single nucleotide polymorphisms associated with loss of inhibition of HIV-1 transcription and advanced HIV-1 disease","volume":"27","author":"S Ghezzi","year":"2013","journal-title":"AIDS"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1073\/pnas.050567397","article-title":"HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors","volume":"97","author":"SA Migueles","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.4049\/jimmunol.179.5.3133","article-title":"Viral replication capacity as a correlate of HLA B57\/B5801-associated nonprogressive HIV-1 infection","volume":"179","author":"M Navis","year":"2007","journal-title":"J Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1126\/science.283.5408.1748","article-title":"HLA and HIV-1: Heterozygote advantage and B*35-Cw*04 disadvantage","volume":"283","author":"M Carrington","year":"1999","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/nm1333","article-title":"AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis","volume":"11","author":"X Gao","year":"2005","journal-title":"Nat Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5140","DOI":"10.1073\/pnas.071548198","article-title":"Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity","volume":"98","author":"PO Flores-Villanueva","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/QAD.0b013e32831db247","article-title":"Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection","volume":"23","author":"D Van Manen","year":"2009","journal-title":"AIDS"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/ng.486","article-title":"HLA-C cell surface expression and control of HIV\/AIDS correlate with a variant upstream of HLA-C","volume":"41","author":"R Thomas","year":"2009","journal-title":"Nat Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/ng1885","article-title":"A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC","volume":"38","author":"PI de Bakker","year":"2006","journal-title":"Nat Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e3907","DOI":"10.1371\/journal.pone.0003907","article-title":"Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study","volume":"3","author":"C Dalmasso","year":"2008","journal-title":"PLoS ONE"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1086\/605892","article-title":"Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03)","volume":"200","author":"S Le Clerc","year":"2009","journal-title":"J Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1126\/science.1143767","article-title":"A whole-genome association study of major determinants for host control of HIV-1","volume":"317","author":"J Fellay","year":"2007","journal-title":"Science"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1086\/596067","article-title":"Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)","volume":"199","author":"S Limou","year":"2009","journal-title":"J Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1126\/science.1195271","article-title":"The major genetic determinants of HIV-1 control affect HLA class I peptide presentation","volume":"330","author":"F Pereyra","year":"2010","journal-title":"Science"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1093\/infdis\/jir833","article-title":"Single-nucleotide polymorphism-defined class I and class III major histocompatibility complex genetic subregions contribute to natural long-term nonprogression in HIV infection","volume":"205","author":"J Guergnon","year":"2012","journal-title":"J Infect Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e1003515","DOI":"10.1371\/journal.ppat.1003515","article-title":"Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls","volume":"9","author":"PJ McLaren","year":"2013","journal-title":"PLoS Pathog"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e01123","DOI":"10.7554\/eLife.01123","article-title":"A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control","volume":"2","author":"I Bartha","year":"2013","journal-title":"Elife"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1399-0039.2010.01578.x","article-title":"Allelic and haplotypic HLA frequency distribution in Spanish hematopoietic patients. Implications for unrelated donor searching","volume":"77","author":"A Balas","year":"2011","journal-title":"Tissue Antigens"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1742-4690-6-27","article-title":"The Spanish HIV BioBank: a model of cooperative HIV research","volume":"6","author":"I Garcia-Merino","year":"2009","journal-title":"Retrovirology"},{"key":"ref28","first-page":"23","article-title":"Spanish cohort of naive HIV-infected patients (CoRIS): rationale, organization and initial results","volume":"25","author":"AM Caro-Murillo","year":"2007","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1086\/651114","article-title":"ZNRD1 (zinc ribbon domain-containing 1) is a host cellular factor that influences HIV-1 replication and disease progression","volume":"50","author":"E Ballana","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"D423","DOI":"10.1093\/nar\/gku1161","article-title":"The IPD and IMGT\/HLA database: allele variant databases","volume":"43","author":"J Robinson","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1097\/QAD.0b013e32833c3219","article-title":"HLA-B alleles associate consistently with HIV heterosexual transmission, viral load, and progression to AIDS, but not susceptibility to infection","volume":"24","author":"X Gao","year":"2010","journal-title":"AIDS"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/qjmed\/89.3.177","article-title":"Association of HLA types A1-B8-DR3 and B27 with rapid and slow progression of HIV disease","volume":"89","author":"AJ McNeil","year":"1996","journal-title":"QJM"},{"issue":"16","key":"ref33","doi-asserted-by":"crossref","first-page":"8202","DOI":"10.1128\/JVI.00116-10","article-title":"Influence of HLA class I and HLA-KIR compound genotypes on HIV-infection and markers of disease progression in a Manjako community in West Africa","volume":"84","author":"LM Yindom","year":"2010","journal-title":"J Virol"},{"issue":"11","key":"ref34","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1093\/infdis\/jix483","article-title":"Control of HIV-1 by an HLA-B*52:01-C*12:02 Protective Haplotype","volume":"216","author":"T Chikata","year":"2017","journal-title":"J Infect Dis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1182\/blood.V93.3.936","article-title":"Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in human immunodeficiency virus-1-infected individuals","volume":"93","author":"M Magierowska","year":"1999","journal-title":"Blood"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/0140-6736(90)90995-H","article-title":"A1, Cw7, B8, DR3 HLA antigen combination associated with rapid decline of T-helper lymphocytes in HIV-1 infection. A report from the Multicenter AIDS Cohort Study","volume":"335","author":"RA Kaslow","year":"1990","journal-title":"Lancet"},{"key":"ref37","first-page":"21","article-title":"HLA antigen frequencies in children born to HIV-infected mothers","volume":"9","author":"DC Kilpatrick","year":"1991","journal-title":"Dis Markers"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1089\/0889222041524616","article-title":"Human leukocyte antigen (HLA) B*18 and protection against mother-to-child HIV type 1 transmission","volume":"20","author":"C Farquhar","year":"2004","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1128\/JVI.71.2.1256-1264.1997","article-title":"Overlapping epitopes in human immunodeficiency virus type 1 gp120 presented by HLA A, B, and C molecules\u2014Effects of viral variation on cytotoxic T-lymphocyte recognition","volume":"71","author":"CC Wilson","year":"1997","journal-title":"Journal of Virology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1086\/315854","article-title":"HLA class I alleles associated with susceptibility or resistance to human immunodeficiency virus type 1 infection among a population in Chaco Province, Argentina","volume":"182","author":"AH de Sorrentino","year":"2000","journal-title":"J Infect Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2013.09.002","article-title":"Human leukocyte antigen B distribution in HIV discordant cohort from India","volume":"156","author":"DV Chaudhari","year":"2013","journal-title":"Immunol Lett"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"8276","DOI":"10.1128\/JVI.76.16.8276-8284.2002","article-title":"Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1","volume":"76","author":"J Tang","year":"2002","journal-title":"J Virol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1086\/314862","article-title":"Consistent associations of HLA class I and II and transporter gene products with progression of human immunodeficiency virus type 1 infection in homosexual men","volume":"180","author":"IP Keet","year":"1999","journal-title":"J Infect Dis"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1097\/00002030-199715000-00015","article-title":"Identification of a novel HLA-A24-restricted cytotoxic T-lymphocyte epitope within HIV-1 NEF","volume":"11","author":"PJR Goulder","year":"1997","journal-title":"AIDS"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"8437","DOI":"10.1128\/JVI.78.16.8437-8445.2004","article-title":"Frequent transmission of cytotoxic-T-lymphocyte escape mutants of human immunodeficiency virus type 1 in the highly HLA-A24-positive Japanese population","volume":"78","author":"T Furutsuki","year":"2004","journal-title":"J Virol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"9879","DOI":"10.1128\/JVI.00320-10","article-title":"Additive contribution of HLA class I alleles in the immune control of HIV-1 infection","volume":"84","author":"A Leslie","year":"2010","journal-title":"J Virol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1007\/s11427-013-4555-4","article-title":"Frequency of HLA-A 03 associates with HIV-1 infection in a Chinese cohort","volume":"56","author":"W Zhang","year":"2013","journal-title":"Sci China Life Sci"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/gene.2014.14","article-title":"Association of the HLA-B*52 allele with non-progression to AIDS in Brazilian HIV-1-infected individuals","volume":"15","author":"SL Teixeira","year":"2014","journal-title":"Genes Immun"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2172-9-1","article-title":"HLA class I supertypes: a revised and updated classification","volume":"9","author":"J Sidney","year":"2008","journal-title":"BMC Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e11079","DOI":"10.1371\/journal.pone.0011079","article-title":"Host and viral genetic correlates of clinical definitions of HIV-1 disease progression","volume":"5","author":"C Casado","year":"2010","journal-title":"PLoS ONE"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.imbio.2011.12.012","article-title":"Differential prevalence of the HLA-C -35 CC genotype among viremic long term non-progressor and elite controller HIV+ individuals","volume":"217","author":"E Ballana","year":"2012","journal-title":"Immunobiology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0220459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T09:19:49Z","timestamp":1610788789000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0220459"}},"subtitle":[],"editor":[{"given":"Srinivas","family":"Mummidi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,8,8]]},"references-count":51,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0220459","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,8]]}}}