{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:28:27Z","timestamp":1792985307674,"version":"4.5.0"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Deanship of Scientific Research, King Saud University.","award":["33"],"award-info":[{"award-number":["33"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0220548","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T13:35:45Z","timestamp":1565616945000},"page":"e0220548","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":69,"title":["The implication of the crosstalk of Nrf2 with NOXs, and HMGB1 in ethanol-induced gastric ulcer: Potential protective effect is afforded by Raspberry Ketone"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3983-868X","authenticated-orcid":true,"given":"Amira M.","family":"Badr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naglaa F.","family":"EL- Orabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab A.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.2147\/IJN.S44108","article-title":"Thymoquinone-loaded nanostructured lipid carriers: preparation, gastroprotection, in vitro toxicity, and pharmacokinetic properties after extravascular administration","volume":"8","author":"SI Abdelwahab","year":"2013","journal-title":"Int J Nanomedicine"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"26819","DOI":"10.1038\/srep26819","article-title":"Acute Toxicity and Gastroprotection Studies of a New Schiff Base Derived Manganese (II) Complex against HCl\/Ethanol-Induced Gastric Ulcerations in Rats","volume":"6","author":"MY Ibrahim","year":"2016","journal-title":"Sci Rep"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1152\/physrev.00040.2012","article-title":"Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases","volume":"94","author":"A Bhattacharyya","year":"2014","journal-title":"Physiol Rev"},{"key":"ref4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19123824","article-title":"The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders","volume":"19","author":"A Tarafdar","year":"2018","journal-title":"Int J Mol Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cbi.2015.10.018","article-title":"Apocynin protects against ethanol-induced gastric ulcer in rats by attenuating the upregulation of NADPH oxidases 1 and 4","volume":"242","author":"RN El-Naga","year":"2015","journal-title":"Chem Biol Interact"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3164\/jcbn.17-139","article-title":"Role of NRF2 in protection of the gastrointestinal tract against oxidative stress","volume":"63","author":"A. Yanaka","year":"2018","journal-title":"J Clin Biochem Nutr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.phrs.2018.06.013","article-title":"Canonical and non-canonical mechanisms of Nrf2 activation","volume":"134","author":"CA Silva-Islas","year":"2018","journal-title":"Pharmacol Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbagen.2014.11.021","article-title":"Nrf2 regulates ROS production by mitochondria and NADPH oxidase","volume":"1850","author":"S Kovac","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.pharep.2017.07.004","article-title":"Baicalin protects against gastroduodenal ulcers via the modulation of Nrf2 expression: Experimental, biochemical, and histological analyses","volume":"69","author":"T Zhang","year":"2017","journal-title":"Pharmacol Rep"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/jphp.12532","article-title":"Alpha-boswellic acid protects against ethanol-induced gastric injury in rats: involvement of nuclear factor erythroid-2-related factor 2\/heme oxygenase-1 pathway","volume":"68","author":"Y Zhang","year":"2016","journal-title":"J Pharm Pharmacol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.2147\/OTT.S167197","article-title":"HMGB1\/RAGE axis mediates the apoptosis, invasion, autophagy, and angiogenesis of the renal cell carcinoma","volume":"11","author":"C-Z Wu","year":"2018","journal-title":"Onco Targets Ther"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e80130","DOI":"10.1371\/journal.pone.0080130","article-title":"High-mobility group box 1 inhibits gastric ulcer healing through Toll-like receptor 4 and receptor for advanced glycation end products","volume":"8","author":"Y Nadatani","year":"2013","journal-title":"PloS one"},{"key":"ref13","article-title":"Helicobacter pylori Activates HMGB1 Expression and Recruits RAGE into Lipid Rafts to Promote Inflammation in Gastric Epithelial Cells","volume":"7","author":"H-J Lin","year":"2016","journal-title":"Front Immunol"},{"key":"ref14","first-page":"1","article-title":"Aloin Reduces HMGB1-Mediated Septic Responses and Improves Survival in Septic Mice by Activation of the SIRT1 and PI3K\/Nrf2\/HO-1 Signaling Axis","author":"S Yang","year":"2019","journal-title":"Am J Chin Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.intimp.2019.01.022","article-title":"Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2\/HO-1-dependent pathway","volume":"69","author":"Y Yu","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.7150\/ijms.20984","article-title":"Ulcer Prevention Effect Of 3,4,5-Tihydroxy-N0-[(2-Methyl-1H-Indol-3yl)Methylidene]Benzohydrazide In HCl\/Ethanol-Induced Gastric Mucosal Damage In Rats","volume":"14","author":"F Tayeby","year":"2017","journal-title":"Int J Med Sci"},{"key":"ref17","first-page":"1973","article-title":"Prophylactic effects of Clausena excavata Burum. f. leaf extract in ethanol-induced gastric ulcers","volume":"10","author":"SFA Albaayit","year":"2016","journal-title":"Drug Des Devel Ther"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/10408398.2013.767221","article-title":"Fruit Polyphenols: A Review of Anti-inflammatory Effects in Humans","volume":"56","author":"SV Joseph","year":"2016","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref19","first-page":"93","article-title":"Oxidative stress-mediated HMGB1 biology","volume":"6","author":"Y Yu","year":"2015","journal-title":"Frontiers in Physiology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.3390\/ijms12084819","article-title":"Evaluation of in vitro and in vivo depigmenting activity of raspberry ketone from Rheum officinale","volume":"12","author":"C-HV Lin","year":"2011","journal-title":"Int J Mol Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1089\/jmf.2011.1717","article-title":"Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis","volume":"15","author":"L Wang","year":"2012","journal-title":"J Med Food"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.lfs.2017.12.013","article-title":"Raspberry ketone protects against isoproterenol-induced myocardial infarction in rats","volume":"194","author":"V Khan","year":"2018","journal-title":"Life Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.biopha.2018.11.079","article-title":"Raspberry ketone and Garcinia Cambogia rebalanced disrupted insulin resistance and leptin signaling in rats fed high fat fructose diet","volume":"110","author":"RT Attia","year":"2019","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ejphar.2018.05.028","article-title":"An optimized dose of raspberry ketones controls hyperlipidemia and insulin resistance in male obese rats: Effect on adipose tissue expression of adipocytokines and Aquaporin 7","volume":"832","author":"ET Mehanna","year":"2018","journal-title":"Eur J Pharmacol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jtcme.2018.05.001","article-title":"Protective activity of geraniol against acetic acid and Helicobacter pylori- induced gastric ulcers in rats","volume":"9","author":"SK Bhattamisra","year":"2019","journal-title":"J Tradit Complement Med"},{"key":"ref26","doi-asserted-by":"crossref","DOI":"10.3390\/nu10060763","article-title":"Amelioration of Ethanol-Induced Gastric Ulcers in Rats Pretreated with Phycobiliproteins of Arthrospira (Spirulina) Maxima","volume":"10","author":"O Guzm\u00e1n-G\u00f3mez","year":"2018","journal-title":"Nutrients"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.phymed.2014.10.002","article-title":"Protective role of ellagitannins from Eucalyptus citriodora against ethanol-induced gastric ulcer in rats: impact on oxidative stress, inflammation and calcitonin-gene related peptide","volume":"22","author":"E Al-Sayed","year":"2015","journal-title":"Phytomedicine"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"UK Laemmli","year":"1970","journal-title":"Nature"},{"key":"ref29","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23040749","article-title":"Molecular Mechanisms of Melatonin Protection from Gastric Mucosal Apoptotic Injury in Experimental Burns","volume":"23","author":"M Hristova","year":"2018","journal-title":"Molecules"},{"key":"ref30","author":"HM Carleton","year":"1980"},{"key":"ref31","first-page":"6619","article-title":"Profiling of major fatty acids in different raw and roasted sesame seeds cultivars","volume":"11","author":"M Biglar","year":"2012","journal-title":"African Journal of Biotechnology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/j.1440-1746.2008.05333.x","article-title":"Artemisia asiatica extracts protect against ethanol-induced injury in gastric mucosa of rats","volume":"23","author":"SW Park","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"ref33","first-page":"348","article-title":"Gastroprotective Effects of PMK-S005 against Ethanol-Induced Acute Gastric Damage in Rats","volume":"10","author":"YJ Choi","year":"2016","journal-title":"Gut Liver"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.taap.2013.05.035","article-title":"Protective effect of tetrahydrocoptisine against ethanol-induced gastric ulcer in mice","volume":"272","author":"W Li","year":"2013","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/JEP.S125383","article-title":"Evaluation of anti-ulcer activity of the leaf extract of Osyris quadripartita Decne. (Santalaceae) in rats","volume":"9","author":"M Abebaw","year":"2017","journal-title":"J Exp Pharmacol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.freeradbiomed.2011.12.023","article-title":"Molecular mechanism of indomethacin-induced gastropathy","volume":"52","author":"SK Yadav","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2016.12.048","article-title":"Redox signaling in the gastrointestinal tract","volume":"104","author":"S P\u00e9rez","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Q. Ma","year":"2013","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.4049\/jimmunol.173.5.3467","article-title":"Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals","volume":"173","author":"N Li","year":"2004","journal-title":"J Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1136\/gutjnl-2012-303731","article-title":"Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium","volume":"63","author":"H Chen","year":"2014","journal-title":"Gut"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.pestbp.2015.03.007","article-title":"NADPH oxidase mediated maneb- and paraquat-induced oxidative stress in rat polymorphs: Crosstalk with mitochondrial dysfunction","volume":"123","author":"S Shukla","year":"2015","journal-title":"Pestic Biochem Physiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1007\/s11064-015-1536-y","article-title":"Angiotensin II triggers apoptosis via enhancement of NADPH oxidase-dependent oxidative stress in a dopaminergic neuronal cell line","volume":"40","author":"H-R Zhao","year":"2015","journal-title":"Neurochem Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.freeradbiomed.2011.04.022","article-title":"Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo","volume":"51","author":"AC Brewer","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"42302","DOI":"10.1074\/jbc.M408275200","article-title":"NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells","volume":"279","author":"S Papaiahgari","year":"2004","journal-title":"J Biol Chem"},{"key":"ref45","first-page":"90","article-title":"Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate","volume":"6","author":"D Burtenshaw","year":"2017","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.imbio.2014.12.014","article-title":"Protective effect of \u03b4-amyrone against ethanol-induced gastric ulcer in mice","volume":"220","author":"W Li","year":"2015","journal-title":"Immunobiology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cbi.2013.11.011","article-title":"Protective effect of chelerythrine against ethanol-induced gastric ulcer in mice","volume":"208","author":"W-F Li","year":"2014","journal-title":"Chem Biol Interact"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1007\/s11064-016-2024-8","article-title":"Tumor Necrosis Factor Alpha Induces Neural Stem Cell Apoptosis Through Activating p38 MAPK Pathway","volume":"41","author":"N-N Chen","year":"2016","journal-title":"Neurochem Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e0122417","DOI":"10.1371\/journal.pone.0122417","article-title":"Diosmin protects against ethanol-induced gastric injury in rats: novel anti-ulcer actions","volume":"10","author":"HH Arab","year":"2015","journal-title":"PloS one"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2119\/molmed.2013.00164","article-title":"The Role of HMGB1 in the Pathogenesis of Inflammatory and Autoimmune Diseases","volume":"20","author":"M Magna","year":"2014","journal-title":"Mol Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"C917","DOI":"10.1152\/ajpcell.00401.2005","article-title":"High mobility group box 1 protein interacts with multiple Toll-like receptors","volume":"290","author":"JS Park","year":"2006","journal-title":"Am J Physiol, Cell Physiol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1128\/IAI.01370-10","article-title":"Helicobacter pylori VacA Induces Programmed Necrosis in Gastric Epithelial Cells","volume":"79","author":"JN Radin","year":"2011","journal-title":"Infection and Immunity"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"8862","DOI":"10.1002\/jcp.27548","article-title":"Downregulation of HMGB1 is required for the protective role of Nrf2 in EMT-mediated PF","volume":"234","author":"J Qu","year":"2019","journal-title":"J Cell Physiol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/fcp.12255","article-title":"Gastroprotective effect of esculin on ethanol-induced gastric lesion in mice","volume":"31","author":"W Li","year":"2017","journal-title":"Fundam Clin Pharmacol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/j.bbamcr.2015.03.012","article-title":"Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment","volume":"1853","author":"C Correia","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1084\/jem.20052203","article-title":"Role of HMGB1 in apoptosis-mediated sepsis lethality","volume":"203","author":"S Qin","year":"2006","journal-title":"J Exp Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0220548","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T10:43:06Z","timestamp":1589020986000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0220548"}},"subtitle":[],"editor":[{"given":"Partha","family":"Mukhopadhyay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,8,12]]},"references-count":56,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0220548","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,12]]}}}