{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:00:09Z","timestamp":1790834409875,"version":"4.1.0"},"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0220738","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T13:26:06Z","timestamp":1567171566000},"page":"e0220738","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Predicting vaccine effectiveness in livestock populations: A theoretical framework applied to PRRS virus infections in pigs"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0684-0583","authenticated-orcid":true,"given":"Vasiliki","family":"Bitsouni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3159-596X","authenticated-orcid":true,"given":"Samantha","family":"Lycett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Opriessnig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Doeschl-Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,8,30]]},"reference":[{"issue":"3","key":"pone.0220738.ref001","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1128\/CMR.00005-07","article-title":"Current status of Vet. vaccines","volume":"20","author":"EN Meeusen","year":"2007","journal-title":"Clin Microbiol Rev"},{"issue":"6919","key":"pone.0220738.ref002","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nature01343","article-title":"Modelling vaccination strategies against foot-and-mouth disease","volume":"421","author":"M Keeling","year":"2003","journal-title":"Nature"},{"key":"pone.0220738.ref003","article-title":"The development of veterinary vaccines: a review of traditional methods and modern biotechnology approaches","author":"S Jorge","year":"2017","journal-title":"Biotechnology Research and Innovation"},{"issue":"1","key":"pone.0220738.ref004","doi-asserted-by":"crossref","first-page":"18","DOI":"10.7774\/cevr.2012.1.1.18","article-title":"A review of vaccine development and research for industry animals in Korea","volume":"1","author":"NH Lee","year":"2012","journal-title":"Clinical and Experimental Vaccine Research"},{"issue":"3","key":"pone.0220738.ref005","first-page":"585","article-title":"New technology for improved vaccine safety and efficacy","volume":"17","author":"JA Roth","year":"2001","journal-title":"Vet Clin: Food A"},{"issue":"4","key":"pone.0220738.ref006","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1128\/JVI.77.4.2522-2529.2003","article-title":"Effective vaccination against long-term gammaherpesvirus latency","volume":"77","author":"SA Tibbetts","year":"2003","journal-title":"J Virol"},{"issue":"2","key":"pone.0220738.ref007","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tube.2013.11.003","article-title":"A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data","volume":"94","author":"H McShane","year":"2014","journal-title":"Tuberculosis"},{"issue":"1","key":"pone.0220738.ref008","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5501\/wjv.v1.i1.23","article-title":"Porcine reproductive and respiratory syndrome virus vaccines: Immunogenicity, efficacy and safety aspects","volume":"1","author":"W Charerntantanakul","year":"2012","journal-title":"World J Virol"},{"issue":"1","key":"pone.0220738.ref009","doi-asserted-by":"crossref","first-page":"207","DOI":"10.20506\/rst.32.1.2201","article-title":"Recent developments in livestock and wildlife brucellosis vaccination","volume":"32","author":"S Olsen","year":"2013","journal-title":"Rev Sci Tech"},{"issue":"3","key":"pone.0220738.ref010","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.tvjl.2005.07.015","article-title":"Effects of two commercial European modified-live vaccines against porcine reproductive and respiratory syndrome viruses in pregnant gilts","volume":"172","author":"M Scortti","year":"2006","journal-title":"Vet J"},{"issue":"5","key":"pone.0220738.ref011","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1749-7345.2009.00279.x","article-title":"Use of modified live vaccines in aquaculture","volume":"40","author":"CA Shoemaker","year":"2009","journal-title":"Journal of the World Aquaculture Society"},{"issue":"3","key":"pone.0220738.ref012","doi-asserted-by":"crossref","first-page":"519","DOI":"10.20506\/rst.21.3.1366","article-title":"Unapparent foot and mouth disease infection (sub-clinical infections and carriers): implications for control","volume":"21","author":"P Sutmoller","year":"2002","journal-title":"Revue scientifique et technique-Office international des \u00e9pizooties"},{"key":"pone.0220738.ref013","unstructured":"Bishop S, Chesnais J, Stear M. Breeding for disease resistance: issues and opportunities. In: Proc. 7th World Congress on Genetics Applied to Livestock Production, Montpellier, Communication 13\u201301); 2002. p. 597\u2013604."},{"issue":"2","key":"pone.0220738.ref014","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1079\/AHR200469","article-title":"Genetic variation and responses to vaccines","volume":"5","author":"EJ Glass","year":"2004","journal-title":"Anim. Health Res. Rev"},{"issue":"1","key":"pone.0220738.ref015","first-page":"10","article-title":"Effect of maternal antibody upon vaccination with infectious bovine rhinotracheitis and bovine virus diarrhea vaccines","volume":"49","author":"A Menanteau-Horta","year":"1985","journal-title":"Can. J. Comp. Med"},{"key":"pone.0220738.ref016","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3389\/fvets.2018.00310","article-title":"Can We Breed Cattle for Lower Bovine TB Infectivity?","author":"S Tsairidou","year":"2018","journal-title":"Frontiers Vet Sci"},{"key":"pone.0220738.ref017","doi-asserted-by":"crossref","DOI":"10.1515\/9781400841035","volume-title":"Modeling infectious diseases in humans and animals","author":"MJ Keeling","year":"2008"},{"issue":"1","key":"pone.0220738.ref018","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1297-9686-46-15","article-title":"A unifying theory for genetic epidemiological analysis of binary disease data","volume":"46","author":"D Lipschutz-Powell","year":"2014","journal-title":"Genetics Selection Evolution"},{"issue":"1-2","key":"pone.0220738.ref019","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.virusres.2010.08.016","article-title":"Control and elimination of porcine reproductive and respiratory syndrome virus","volume":"154","author":"CA Corzo","year":"2010","journal-title":"Virus Res"},{"issue":"1798","key":"pone.0220738.ref020","doi-asserted-by":"crossref","first-page":"20141341","DOI":"10.1098\/rspb.2014.1341","article-title":"Reactive vaccination in the presence of disease hotspots","volume":"282","author":"AS Azman","year":"2015","journal-title":"Proc R Soc B"},{"issue":"28","key":"pone.0220738.ref021","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1016\/j.vaccine.2009.04.022","article-title":"Challenges for porcine reproductive and respiratory syndrome virus (PRRSV) vaccinology","volume":"27","author":"TG Kimman","year":"2009","journal-title":"Vaccine"},{"issue":"1","key":"pone.0220738.ref022","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev-animal-022114-111025","article-title":"Porcine Reproductive and Respiratory Syndrome Virus (PRRSV): Pathogenesis and Interaction with the Immune System","volume":"4","author":"JK Lunney","year":"2016","journal-title":"Annual Rev Animal Biosc"},{"key":"pone.0220738.ref023","unstructured":"Hill H. Overview and history of mystery swine disease (swine infertility respiratory syndrome). In: Proceedings of the mystery swine disease committee meeting. vol. 6. Livestock Conservation Institute Madison, WI, USA; 1990. p. 29\u201330."},{"issue":"2","key":"pone.0220738.ref024","first-page":"72","article-title":"Assessment of the economic impact of porcine reproductive and respiratory syndrome virus on United States pork producers","volume":"21","author":"DJ Holtkamp","year":"2013","journal-title":"J Swine Health Prod"},{"issue":"1","key":"pone.0220738.ref025","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13567-016-0391-4","article-title":"Review on the transmission porcine reproductive and respiratory syndrome virus between pigs and farms and impact on vaccination","volume":"47","author":"E Pileri","year":"2016","journal-title":"Vet Res"},{"key":"pone.0220738.ref026","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.3389\/fmicb.2017.01635","article-title":"Improved vaccine against PRRSV: current progress and future perspective","volume":"8","author":"Y Nan","year":"2017","journal-title":"Frontiers in Microbiol"},{"issue":"1-3","key":"pone.0220738.ref027","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s12026-014-8549-5","article-title":"Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic","volume":"59","author":"J Butler","year":"2014","journal-title":"Immunol Res"},{"issue":"3","key":"pone.0220738.ref028","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.tvjl.2007.05.022","article-title":"The challenge of PRRS immunology","volume":"177","author":"E Mateu","year":"2008","journal-title":"Vet J"},{"key":"pone.0220738.ref029","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3389\/fgene.2012.00260","article-title":"Control of porcine reproductive and respiratory syndrome (PRRS) through genetic improvements in disease resistance and tolerance","volume":"3","author":"R Rowland","year":"2012","journal-title":"Frontiers in Genetics"},{"issue":"1-2","key":"pone.0220738.ref030","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.virusres.2010.07.016","article-title":"Porcine reproductive and respiratory syndrome in China","volume":"154","author":"L Zhou","year":"2010","journal-title":"Virus Res"},{"issue":"46","key":"pone.0220738.ref031","doi-asserted-by":"crossref","first-page":"8192","DOI":"10.1016\/j.vaccine.2011.09.013","article-title":"Immunological solutions for treatment and prevention of porcine reproductive and respiratory syndrome (PRRS)","volume":"29","author":"MP Murtaugh","year":"2011","journal-title":"Vaccine"},{"issue":"1-2","key":"pone.0220738.ref032","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.virusres.2010.09.003","article-title":"Taming PRRSV: revisiting the control strategies and vaccine design","volume":"154","author":"R Thanawongnuwech","year":"2010","journal-title":"Virus Res"},{"issue":"2","key":"pone.0220738.ref033","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/tbed.12016","article-title":"Porcine reproductive and respiratory syndrome virus vaccines: current status and strategies to a universal vaccine","volume":"61","author":"J Hu","year":"2014","journal-title":"Transbound Emerg Dis"},{"issue":"1","key":"pone.0220738.ref034","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1297-9716-44-115","article-title":"Safety of porcine reproductive and respiratory syndrome modified live virus (MLV) vaccine strains in a young pig infection model","volume":"44","author":"FJ Mart\u00ednez-Lobo","year":"2013","journal-title":"Vet Res"},{"issue":"6","key":"pone.0220738.ref035","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1099\/0022-1317-82-6-1263","article-title":"Reversion of a live porcine reproductive and respiratory syndrome virus vaccine investigated by parallel mutations","volume":"82","author":"HS Nielsen","year":"2001","journal-title":"J Gen Virol"},{"issue":"1","key":"pone.0220738.ref036","first-page":"1","article-title":"Efficacy of Fostera PRRS modified live virus vaccine against a Canadian heterologous virulent field strain of porcine reproductive and respiratory syndrome virus","volume":"80","author":"C Savard","year":"2016","journal-title":"Can J Vet Res"},{"issue":"47","key":"pone.0220738.ref037","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.1016\/j.vaccine.2013.09.023","article-title":"Enhancing neutralizing antibody production by an interferon-inducing porcine reproductive and respiratory syndrome virus strain","volume":"31","author":"R Wang","year":"2013","journal-title":"Vaccine"},{"issue":"24","key":"pone.0220738.ref038","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1136\/vr.161.24.809","article-title":"Failure of an inactivated vaccine against porcine reproductive and respiratory syndrome to protect gilts against a heterologous challenge with PRRSV","volume":"161","author":"M Scortti","year":"2007","journal-title":"Vet Rec"},{"issue":"1-3","key":"pone.0220738.ref039","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.vetmic.2007.02.009","article-title":"Assessment of the efficacy of commercial porcine reproductive and respiratory syndrome virus (PRRSV) vaccines based on measurement of serologic response, frequency of gamma-IFN-producing cells and virological parameters of protection upon challenge","volume":"123","author":"FA Zuckermann","year":"2007","journal-title":"Vet Microbiol"},{"issue":"1","key":"pone.0220738.ref040","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1743-422X-8-323","article-title":"The assessment of efficacy of porcine reproductive respiratory syndrome virus inactivated vaccine based on the viral quantity and inactivation methods","volume":"8","author":"H Kim","year":"2011","journal-title":"Virol J"},{"issue":"1","key":"pone.0220738.ref041","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1089\/088282404322875430","article-title":"Impact of immunizations with porcine reproductive and respiratory syndrome virus on lymphoproliferative recall responses of CD8+ T cells","volume":"17","author":"J Bassaganya-Riera","year":"2004","journal-title":"Viral Immunol"},{"issue":"6","key":"pone.0220738.ref042","first-page":"266","article-title":"Long-term administration of a commercial porcine reproductive and respiratory syndrome virus (PRRSV)-inactivated vaccine in PRRSV-endemically infected sows","volume":"53","author":"V Papatsiros","year":"2006","journal-title":"Zoonoses Public Hlth"},{"issue":"21","key":"pone.0220738.ref043","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/j.vaccine.2015.03.040","article-title":"Porcine reproductive and respiratory syndrome virus (PRRSv) modified-live vaccine reduces virus transmission in experimental conditions","volume":"33","author":"N Rose","year":"2015","journal-title":"Vaccine"},{"issue":"1","key":"pone.0220738.ref044","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3201\/eid1301.060438","article-title":"Model for assessing human papillomavirus vaccination strategies","volume":"13","author":"EH Elbasha","year":"2007","journal-title":"Emerg infect Dis"},{"issue":"3","key":"pone.0220738.ref045","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1208\/s12248-011-9284-7","article-title":"Modeling the effects of vaccination and treatment on pandemic influenza","volume":"13","author":"Z Feng","year":"2011","journal-title":"AAPS J"},{"issue":"16","key":"pone.0220738.ref046","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1098\/rsif.2006.0207","article-title":"The evolutionary epidemiology of vaccination","volume":"4","author":"S Gandon","year":"2007","journal-title":"J R Soc Interface"},{"key":"pone.0220738.ref047","volume-title":"Infectious diseases of humans: dynamics and control","author":"RM Anderson","year":"1992"},{"issue":"11","key":"pone.0220738.ref048","doi-asserted-by":"crossref","first-page":"e0166596","DOI":"10.1371\/journal.pone.0166596","article-title":"Evaluation of Control Strategies for Porcine Reproductive and Respiratory Syndrome (PRRS) in Swine Breeding Herds Using a Discrete Event Agent-Based Model","volume":"11","author":"AG Arruda","year":"2016","journal-title":"PloS ONE"},{"issue":"1","key":"pone.0220738.ref049","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1017\/S0950268899003246","article-title":"Introduction, persistence and fade-out of porcine reproductive and respiratory syndrome virus in a Dutch breeding herd: a mathematical analysis","volume":"124","author":"G Nodelijk","year":"2000","journal-title":"Epidemiol Infect"},{"issue":"1","key":"pone.0220738.ref050","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1128\/JCM.41.1.58-62.2003","article-title":"Duration of infection and proportion of pigs persistently infected with porcine reproductive and respiratory syndrome virus","volume":"41","author":"RW Wills","year":"2003","journal-title":"J Clin Microbiol"},{"issue":"3","key":"pone.0220738.ref051","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2460\/ajvr.75.3.260","article-title":"Stochastic model of porcine reproductive and respiratory syndrome virus control strategies on a swine farm in the United States","volume":"75","author":"J Jeong","year":"2014","journal-title":"Am J Vet Res"},{"issue":"1","key":"pone.0220738.ref052","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.vetmic.2014.11.007","article-title":"Vaccination with a genotype 1 modified live vaccine against porcine reproductive and respiratory syndrome virus significantly reduces viremia, viral shedding and transmission of the virus in a quasi-natural experimental model","volume":"175","author":"E Pileri","year":"2015","journal-title":"Vet Microbiol"},{"issue":"5","key":"pone.0220738.ref053","doi-asserted-by":"crossref","first-page":"565","DOI":"10.2460\/ajvr.68.5.565","article-title":"Effect of vaccination with a modified-live porcine reproductive and respiratory syndrome virus vaccine on dynamics of homologous viral infection in pigs","volume":"68","author":"JP Cano","year":"2007","journal-title":"Am J Vet Res"},{"issue":"2","key":"pone.0220738.ref054","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.vaccine.2011.10.075","article-title":"Effect of modified-live porcine reproductive and respiratory syndrome virus (PRRSv) vaccine on the shedding of wild-type virus from an infected population of growing pigs","volume":"30","author":"DC Linhares","year":"2012","journal-title":"Vaccine"},{"issue":"1","key":"pone.0220738.ref055","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1297-9716-43-69","article-title":"Infectiousness of pigs infected by the Porcine Reproductive and Respiratory Syndrome virus (PRRSV) is time-dependent","volume":"43","author":"C Charpin","year":"2012","journal-title":"Vet Res"},{"issue":"4","key":"pone.0220738.ref056","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.prevetmed.2009.11.001","article-title":"A stochastic mathematical model of the within-herd transmission dynamics of porcine reproductive and respiratory syndrome virus (PRRSV): fade-out and persistence","volume":"93","author":"C Evans","year":"2010","journal-title":"Prev Vet Med"},{"issue":"3","key":"pone.0220738.ref057","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/03079450050045431","article-title":"Acute infectious bursal disease in poultry: a review","volume":"29","author":"TPVD Berg","year":"2000","journal-title":"Avian Pathol"},{"issue":"1","key":"pone.0220738.ref058","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.vetmic.2006.04.004","article-title":"The challenge for the next generation of feline calicivirus vaccines","volume":"117","author":"AD Radford","year":"2006","journal-title":"Vet Microbiol"},{"issue":"7","key":"pone.0220738.ref059","doi-asserted-by":"crossref","first-page":"e1002198","DOI":"10.1371\/journal.pbio.1002198","article-title":"Imperfect vaccination can enhance the transmission of highly virulent pathogens","volume":"13","author":"AF Read","year":"2015","journal-title":"PLoS Biology"},{"issue":"1520","key":"pone.0220738.ref060","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1098\/rspb.2003.2370","article-title":"Imperfect vaccination: some epidemiological and evolutionary consequences","volume":"270","author":"S Gandon","year":"2003","journal-title":"Proc Biol Sci"},{"issue":"12","key":"pone.0220738.ref061","doi-asserted-by":"crossref","first-page":"e0144265","DOI":"10.1371\/journal.pone.0144265","article-title":"Economic analysis of vaccination strategies for PRRS control","volume":"10","author":"DC Linhares","year":"2015","journal-title":"PloS ONE"},{"issue":"11","key":"pone.0220738.ref062","doi-asserted-by":"crossref","first-page":"e1901","DOI":"10.1371\/journal.pntd.0001901","article-title":"Urban cholera transmission hotspots and their implications for reactive vaccination: evidence from Bissau city, Guinea bissau","volume":"6","author":"AS Azman","year":"2012","journal-title":"PLoS Neglect Trop D"},{"issue":"18","key":"pone.0220738.ref063","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1098\/rsif.2007.1038","article-title":"Time is of the essence: exploring a measles outbreak response vaccination in Niamey, Niger","volume":"5","author":"R Grais","year":"2007","journal-title":"J R Soc Interface"},{"issue":"4","key":"pone.0220738.ref064","doi-asserted-by":"crossref","first-page":"e0172638","DOI":"10.1371\/journal.pone.0172638","article-title":"Land altitude, slope, and coverage as risk factors for Porcine Reproductive and Respiratory Syndrome (PRRS) outbreaks in the United States","volume":"12","author":"AG Arruda","year":"2017","journal-title":"PloS ONE"},{"key":"pone.0220738.ref065","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.prevetmed.2016.03.010","article-title":"Network, cluster and risk factor analyses for porcine reproductive and respiratory syndrome using data from swine sites participating in a disease control program","volume":"128","author":"A Arruda","year":"2016","journal-title":"Prev Vet Med"},{"issue":"1-2","key":"pone.0220738.ref066","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0167-5877(01)00260-4","article-title":"Risk factors for infection of sow herds with porcine reproductive and respiratory syndrome (PRRS) virus","volume":"53","author":"S Mortensen","year":"2002","journal-title":"Prev Vet Med"},{"issue":"1","key":"pone.0220738.ref067","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1051\/vetres:2008048","article-title":"Infectivity of porcine circovirus type 2 DNA in semen from experimentally-infected boars","volume":"40","author":"DM Madson","year":"2009","journal-title":"Vet Res"},{"issue":"47","key":"pone.0220738.ref068","doi-asserted-by":"crossref","first-page":"6700","DOI":"10.1016\/j.vaccine.2012.08.045","article-title":"Distinguishing vaccine efficacy and effectiveness","volume":"30","author":"E Shim","year":"2012","journal-title":"Vaccine"},{"key":"pone.0220738.ref069","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.prevetmed.2018.02.005","article-title":"Modelling the economic efficiency of using different strategies to control Porcine Reproductive & Respiratory Syndrome at herd level","volume":"152","author":"H Nathues","year":"2018","journal-title":"Prev Vet Med"},{"issue":"2","key":"pone.0220738.ref070","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.virol.2003.07.009","article-title":"Quasispecies variation of porcine reproductive and respiratory syndrome virus during natural infection","volume":"317","author":"TL Goldberg","year":"2003","journal-title":"Virol"},{"issue":"4","key":"pone.0220738.ref071","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0378-1135(00)00196-6","article-title":"Heterogeneity of porcine reproductive and respiratory syndrome virus: implications for current vaccine efficacy and future vaccine development","volume":"74","author":"X Meng","year":"2000","journal-title":"Vet Microbiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0220738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T13:52:44Z","timestamp":1695131564000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0220738"}},"subtitle":[],"editor":[{"given":"Yongchang","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,8,30]]},"references-count":71,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0220738","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/563205","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,30]]}}}