{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:02:13Z","timestamp":1740146533715,"version":"3.37.3"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0220789","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:28:05Z","timestamp":1564752485000},"page":"e0220789","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Failures in the case management of children with uncomplicated malaria in Bata district of Equatorial Guinea and associated factors"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7617-6799","authenticated-orcid":true,"given":"Pablo","family":"Su\u00e1rez-S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bel\u00e9n","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Nzang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Policarpo","family":"Ncogo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilde","family":"Riloha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Berzosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agust\u00edn","family":"Benito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0177-6885","authenticated-orcid":true,"given":"Mar\u00eda","family":"Romay-Barja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,8,2]]},"reference":[{"key":"ref1","unstructured":"World Health Organization. World Malaria Report 2018 [Internet]. 2018 Nov. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/275867\/9789241565653-eng.pdf?ua=1\" xlink:type=\"simple\">https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/275867\/9789241565653-eng.pdf?ua=1<\/ext-link>"},{"year":"2001","key":"ref2"},{"key":"ref3","unstructured":"WHO. Guidelines for the treatment of malaria. Third edition [Internet]. 2015. <comment>doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1080\/07293682.1982.9658069\" xlink:type=\"simple\">10.1080\/07293682.1982.9658069<\/ext-link><\/comment>"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2052-3211-7-15","article-title":"Adherence to treatment guidelines for uncomplicated malaria at two public health facilities in Nigeria; implications for the \u2018test and treat\u2019 policy of malaria case management","volume":"7","author":"CC Ezenduka","year":"2014","journal-title":"J Pharm Policy Pract"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2875-10-155","article-title":"Treatment of uncomplicated malaria at public health facilities and medicine retailers in south-eastern Nigeria","volume":"10","author":"LJ Mangham","year":"2011","journal-title":"Malar J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0169-4758(96)10055-7","article-title":"Strategies for the prevention of antimalarial drug resistance: Rationale for combination chemotherapy for malaria","volume":"12","author":"NJ White","year":"1996","journal-title":"Parasitol Today"},{"key":"ref7","unstructured":"Ministerio de Sanidad y Bienestar Social y Ministerio de Econom\u00eda Planificaci\u00f3n e Inversiones P\u00fablicas Guinea Ecuatorial. Encuesta Demogr\u00e1fica y de Salud (EDSGE-I) 2011 Guinea Ecuatorial [Internet]. 2012. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/dhsprogram.com\/pubs\/pdf\/FR271\/FR271.pdf\" xlink:type=\"simple\">https:\/\/dhsprogram.com\/pubs\/pdf\/FR271\/FR271.pdf<\/ext-link>"},{"key":"ref8","unstructured":"World Health Organization. World Health Statistics 2012 [Internet]. 2012. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/gho\/publications\/world_health_statistics\/EN_WHS2012_Full.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/gho\/publications\/world_health_statistics\/EN_WHS2012_Full.pdf<\/ext-link>"},{"key":"ref9","unstructured":"Minsiterio de Sanidad y Bienestar Social. Guia terap\u00e9utica nacional del paludismo en Guinea Ecuatorial. 2014."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e0135887","DOI":"10.1371\/journal.pone.0135887","article-title":"Rural-Urban Differences in Household Treatment-Seeking Behaviour for Suspected Malaria in Children at Bata District, Equatorial Guinea","volume":"10","author":"M Romay-Barja","year":"2015","journal-title":"PLoS One"},{"key":"ref11","first-page":"107","article-title":"The use and preference of artemether as a first-choice treatment for malaria: results from a cross-sectional survey in the Bata district, Equatorial Guinea","volume":"17","author":"M Romay-Barja","year":"2018","journal-title":"Malar J. BioMed Central"},{"key":"ref12","unstructured":"Nauli TS, Sanskrit MW, Samhita G. Emergence and spread of artemisinin resistance calls for intensified efforts to withdraw oral artemisinin-based monotherapy from the market. 2014; 1\u201315. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/malaria\/publications\/atoz\/policy-brief-withdrawal-of-oral-artemisinin-based-monotherapies\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/malaria\/publications\/atoz\/policy-brief-withdrawal-of-oral-artemisinin-based-monotherapies\/en\/<\/ext-link>"},{"key":"ref13","first-page":"243","article-title":"Reviewing the literature on access to prompt and effective malaria treatment in Kenya: implications for meeting the Abuja targets","volume":"8","author":"J Chuma","year":"2009","journal-title":"Malar J. BioMed Central"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1136\/bmj.331.7519.734","article-title":"Treatment of paediatric malaria during a period of drug transition to artemether-lumefantrine in Zambia: cross sectional study","volume":"331","author":"D Zurovac","year":"2005","journal-title":"BMJ"},{"key":"ref15","first-page":"34","article-title":"Poor adherence to the malaria management protocol among health workers attending under-five year old febrile children at Omdurman Hospital, Sudan","volume":"14","author":"JA Bilal","year":"2015","journal-title":"Malar J. BioMed Central"},{"key":"ref16","first-page":"483","article-title":"Prescription practices for malaria in Mozambique: poor adherence to the national protocols for malaria treatment in 22 public health facilities","volume":"14","author":"CA Salom\u00e3o","year":"2015","journal-title":"Malar J. BioMed Central"},{"key":"ref17","first-page":"1","article-title":"Changes in health workers\u2019 malaria diagnosis and treatment practices in Kenya","volume":"10","author":"E Juma","year":"2011","journal-title":"Malar J. BioMed Central"},{"key":"ref18","first-page":"218","article-title":"Taking stock: Provider prescribing practices in the presence and absence of ACT stock","volume":"10","author":"B Hensen","year":"2011","journal-title":"Malar J. BioMed Central Ltd"},{"key":"ref19","unstructured":"Instituto Nacional de Estad\u00edstica de Guinea Ecuatorial INEGE. Guinea Ecuatorial en cifras 2018 [Internet]. 2018. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.inege.gq\/wp-content\/uploads\/2019\/01\/GE_Cifras_2018.pdf\" xlink:type=\"simple\">http:\/\/www.inege.gq\/wp-content\/uploads\/2019\/01\/GE_Cifras_2018.pdf<\/ext-link>"},{"key":"ref20","doi-asserted-by":"crossref","DOI":"10.1186\/s12936-015-0986-7","article-title":"Malaria prevalence in Bata district, Equatorial Guinea: A cross-sectional study","volume":"14","author":"P Ncogo","year":"2015","journal-title":"Malar J"},{"key":"ref21","first-page":"154","article-title":"Five years of malaria control in the continental region, Equatorial Guinea","volume":"12","author":"AM Rehman","year":"2013","journal-title":"Malar J. BioMed Central"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.21586\/ross0000004","article-title":"Handling the Hawthorne effect: The challenges surrounding a participant observer","volume":"1","author":"D Oswald","year":"2016","journal-title":"Rev Soc Stud"},{"key":"ref23","first-page":"1","article-title":"Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity","year":"2013","journal-title":"Miner Nutr Inf Syst World Heal Organ"},{"key":"ref24","first-page":"1","article-title":"Health worker adherence to malaria treatment guidelines at outpatient health facilities in southern Malawi following implementation of universal access to diagnostic testing","volume":"16","author":"M Kobayashi","year":"2017","journal-title":"Malar J. BioMed Central"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1093\/ije\/dyh253","article-title":"Predictors of the quality of health worker treatment practices for uncomplicated malaria at government health facilities in Kenya","volume":"33","author":"D Zurovac","year":"2004","journal-title":"Int J Epidemiol"},{"key":"ref26","first-page":"327","article-title":"Monitoring fever treatment behaviour and equitable access to effective medicines in the context of initiatives to improve ACT access: baseline results and implications for programming in six African countries","volume":"10","author":"M Littrell","year":"2011","journal-title":"Malar J. BioMed Central"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2458-12-11","article-title":"Progress towards implementation of ACT malaria case-management in public health facilities in the Republic of Sudan: A cluster-sample survey","volume":"12","author":"TM Abdelgader","year":"2012","journal-title":"BMC Public Health. BioMed Central Ltd"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1046\/j.1365-3156.1999.00471.x","article-title":"A community perspective on the efficacy of malaria treatment options for children in Lundazi District, Zambia","volume":"4","author":"HA Williams","year":"1999","journal-title":"Trop Med Int Heal"},{"key":"ref29","first-page":"135","article-title":"Anthropological perspectives on injections: A review","volume":"78","author":"A V. Reeler","year":"2000","journal-title":"Bull World Health Organ"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.socscimed.2003.11.010","article-title":"A critical review of behavioral issues related to malaria control in sub-Saharan Africa: what contributions have social scientists made?","volume":"59","author":"HA Williams","year":"2004","journal-title":"Soc Sci Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1126\/science.1155165","article-title":"Qinghaosu (artemisinin): The price of success","volume":"320","author":"NJ White","year":"2008","journal-title":"Science"},{"key":"ref32","first-page":"222","article-title":"Adherence to treatment with artemether\u2013lumefantrine or amodiaquine\u2013artesunate for uncomplicated malaria in children in Sierra Leone: a randomized trial","volume":"17","author":"K Banek","year":"2018","journal-title":"Malar J. BioMed Central"},{"key":"ref33","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2458-10-409","article-title":"Community perceptions of malaria and malaria treatment behaviour in a rural district of Ghana: Implications for artemisinin combination therapy","volume":"10","author":"KP Asante","year":"2010","journal-title":"BMC Public Health"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/S0140-6736(05)67787-2","article-title":"Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6","volume":"366","author":"R Jambou","year":"2005","journal-title":"Lancet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1314981","article-title":"Spread of Artemisinin Resistance in <italic>Plasmodium falciparum<\/italic> Malaria","volume":"371","author":"EA Ashley","year":"2014","journal-title":"N Engl J Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/S0140-6736(81)92239-X","article-title":"Resistance of Plasmodium falciparum malaria to sulfadoxine-pyrimethamine (&apos;Fansidar\u2019) in a refugee camp in Thailand","volume":"317","author":"ES Hurwitz","year":"1981","journal-title":"Lancet"},{"key":"ref37","first-page":"1","article-title":"Profile of molecular mutations in pfdhfr, pfdhps, pfmdr1, and pfcrt genes of Plasmodium falciparum related to resistance to different anti-malarial drugs in the Bata District (Equatorial Guinea)","volume":"16","author":"P Berzosa","year":"2017","journal-title":"Malar J. BioMed Central"},{"key":"ref38","first-page":"305","article-title":"Private sector drug shops frequently dispense parenteral anti-malarials in a rural region of Western Uganda","volume":"17","author":"LT Wang","year":"2018","journal-title":"Malar J. BioMed Central"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1056\/NEJMra043207","article-title":"Effectiveness of Antimalarial Drugs","volume":"352","author":"JK Baird","year":"2005","journal-title":"N Engl J Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1136\/bmj.39073.496829.AE","article-title":"Rapid diagnostic tests compared with malaria microscopy for guiding outpatient treatment of febrile illness in Tanzania: randomised trial","volume":"334","author":"H Reyburn","year":"2007","journal-title":"BMJ"},{"key":"ref41","first-page":"136","article-title":"Test and treat or presumptive treatment for malaria in high transmission situations? A reflection on the latest WHO guidelines","volume":"10","author":"B Graz","year":"2011","journal-title":"Malar J. BioMed Central"},{"key":"ref42","unstructured":"World Health Organization. Guidelines for follow-up after training in the WHO\/UNICEF course on Integrated Management of Childhood Illness for first-level health workers [Internet]. 1999. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/66095\/WHO_FCH_CAH_99.1A.pdf;sequence=1\" xlink:type=\"simple\">https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/66095\/WHO_FCH_CAH_99.1A.pdf;sequence=1<\/ext-link>"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0220789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:58:23Z","timestamp":1588967903000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0220789"}},"subtitle":[],"editor":[{"given":"Thomas A.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,8,2]]},"references-count":42,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0220789","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2019,8,2]]}}}