{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:15:39Z","timestamp":1792462539124,"version":"4.5.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["NRF-2017M3A9E8033207"],"award-info":[{"award-number":["NRF-2017M3A9E8033207"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0220880","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T17:46:16Z","timestamp":1565286376000},"page":"e0220880","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Comparison of systemic conditions at diagnosis between central retinal vein occlusion and branch retinal vein occlusion"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0244-388X","authenticated-orcid":true,"given":"Bum-Joo","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Hyun","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6521-303X","authenticated-orcid":true,"given":"Sang Min","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Chul","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Won","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Kyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1543-981X","authenticated-orcid":true,"given":"Soonil","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,8,8]]},"reference":[{"key":"ref1","first-page":"133","article-title":"The epidemiology of retinal vein occlusion: the Beaver Dam Eye Study","volume":"98","author":"R Klein","year":"2000","journal-title":"Trans Am Ophthalmol Soc"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/IAE.0000000000000843","article-title":"Retinal Vein Occlusions, from Basics to the Latest Treatment","volume":"36","author":"M Ho","year":"2016","journal-title":"Retina"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2014.04.001","article-title":"Ocular vascular occlusive disorders: natural history of visual outcome","volume":"41","author":"SS Hayreh","year":"2014","journal-title":"Prog Retin Eye Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"724780","DOI":"10.1155\/2014\/724780","article-title":"Risk factors for central and branch retinal vein occlusion: a meta-analysis of published clinical data","volume":"2014","author":"P. Kolar","year":"2014","journal-title":"J Ophthalmol"},{"key":"ref5","first-page":"1","article-title":"Retinal Vein Occlusion in a Multi-Ethnic Asian Population: The Singapore Epidemiology of Eye Disease Study","author":"V Koh","year":"2016","journal-title":"Ophthalmic Epidemiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3233\/CH-162056","article-title":"Influence of hemorheological factors on the development of retinal vein occlusion","volume":"63","author":"K Michalska-Malecka","year":"2016","journal-title":"Clin Hemorheol Microcirc"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/j.1445-5994.2008.01720.x","article-title":"Retinal vein occlusion: an approach to diagnosis, systemic risk factors and management","volume":"38","author":"JW Yau","year":"2008","journal-title":"Intern Med J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0002-9394(00)00709-1","article-title":"Systemic diseases associated with various types of retinal vein occlusion","volume":"131","author":"SS Hayreh","year":"2001","journal-title":"Am J Ophthalmol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/jth.12982","article-title":"Prevalence and risk factors of retinal vein occlusion: the Gutenberg Health Study","volume":"13","author":"KA Ponto","year":"2015","journal-title":"J Thromb Haemost"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2147\/OPTH.S128341","article-title":"Systemic abnormalities associated with retinal vein occlusion in young patients","volume":"11","author":"S Sinawat","year":"2017","journal-title":"Clin Ophthalmol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s004170100266","article-title":"The heterozygous 20210 G\/A genotype prevalence in patients affected by central and branch retinal vein occlusion: a pilot study","volume":"239","author":"C Incorvaia","year":"2001","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s00417-001-0421-3","article-title":"Hematologic abnormalities associated with various types of retinal vein occlusion","volume":"240","author":"SS Hayreh","year":"2002","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref13","first-page":"381","article-title":"Designing a Clinical Data Warehouse Architecture to Support Quality Improvement Initiatives","volume":"2016","author":"JD Chelico","year":"2016","journal-title":"AMIA Annu Symp Proc"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3389\/fneur.2017.00526","article-title":"Clinical Implications of Associations between Headache and Gastrointestinal Disorders: A Study Using the Hallym Smart Clinical Data Warehouse","volume":"8","author":"SH Lee","year":"2017","journal-title":"Front Neurol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1097\/IAE.0b013e3182870c15","article-title":"Branch retinal vein occlusion: epidemiology, pathogenesis, risk factors, clinical features, diagnosis, and complications. An update of the literature","volume":"33","author":"A Jaulim","year":"2013","journal-title":"Retina"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1442-9071.2011.02713.x","article-title":"Central retinal vein occlusion: a review","volume":"40","author":"IL McAllister","year":"2012","journal-title":"Clin Experiment Ophthalmol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.ophtha.2013.12.024","article-title":"Nationwide incidence of clinically diagnosed retinal vein occlusion in Korea, 2008 through 2011: preponderance of women and the impact of aging","volume":"121","author":"SJ Park","year":"2014","journal-title":"Ophthalmology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1001\/archopht.1996.01100130537006","article-title":"Risk factors for central retinal vein occlusion","volume":"114","year":"1996","journal-title":"Arch Ophthalmol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0002-9394(14)71345-5","article-title":"Risk factors for branch retinal vein occlusion","volume":"116","year":"1993","journal-title":"Am J Ophthalmol"},{"key":"ref20","first-page":"17","article-title":"Retinal vascular abnormalities in the hyperlipidaemias","volume":"101","author":"PM Dodson","year":"1981","journal-title":"Trans Ophthalmol Soc U K"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.ophtha.2015.01.020","article-title":"Retinal vein occlusion and the risk of stroke development: a 9-year nationwide population-based study","volume":"122","author":"TH Rim","year":"2015","journal-title":"Ophthalmology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"34708","DOI":"10.1038\/srep34708","article-title":"Evaluation of the Association Between Retinal Vein Occlusion and the Risk of Atrial Fibrillation Development: A 12-Year, Retrospective Nationwide Cohort Study","volume":"6","author":"TH Rim","year":"2016","journal-title":"Sci Rep"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e0184016","DOI":"10.1371\/journal.pone.0184016","article-title":"Association between retinal vein occlusion and an increased risk of acute myocardial infarction: A nationwide population-based follow-up study","volume":"12","author":"YY Chen","year":"2017","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1001\/archopht.126.5.692","article-title":"Retinal vein occlusion and traditional risk factors for atherosclerosis","volume":"126","author":"PR O'Mahoney","year":"2008","journal-title":"Arch Ophthalmol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/IAE.0000000000001163","article-title":"INCREASED SERUM LEVELS OF UREA AND CREATININE ARE SURROGATE MARKERS FOR DISRUPTION OF RETINAL PHOTORECEPTOR EXTERNAL LIMITING MEMBRANE AND INNER SEGMENT ELLIPSOID ZONE IN TYPE 2 DIABETES MELLITUS","volume":"37","author":"S Saxena","year":"2017","journal-title":"Retina"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3109\/1354750X.2015.1094142","article-title":"Increased serum urea and creatinine levels correlate with decreased retinal nerve fibre layer thickness in diabetic retinopathy","volume":"20","author":"K Srivastav","year":"2015","journal-title":"Biomarkers"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1111\/j.1538-7836.2005.01364.x","article-title":"Mechanisms of homocysteine-induced atherothrombosis","volume":"3","author":"SR Lentz","year":"2005","journal-title":"J Thromb Haemost"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1741s","DOI":"10.1093\/jn\/136.6.1741S","article-title":"Pathophysiological consequences of homocysteine excess","volume":"136","author":"H. Jakubowski","year":"2006","journal-title":"J Nutr"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2174\/1389200052997357","article-title":"Mechanisms of increased vascular oxidant stress in hyperhomocys-teinemia and its impact on endothelial function","volume":"6","author":"N. Weiss","year":"2005","journal-title":"Curr Drug Metab"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ajo.2004.06.084","article-title":"Homocysteine and retinal vein occlusion: a population-based study","volume":"139","author":"B Chua","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0002-9394(99)00476-6","article-title":"Hyperhomocysteinemia: a risk factor for central retinal vein occlusion","volume":"129","author":"AK Vine","year":"2000","journal-title":"Am J Ophthalmol"},{"key":"ref32","first-page":"287","article-title":"Homocysteine: a risk factor for retinal venous occlusive disease","volume":"109","author":"BA Brown","year":"2002","journal-title":"Ophthalmology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1167\/iovs.06-0290","article-title":"Plasma homocysteine and cysteine levels in retinal vein occlusion","volume":"47","author":"A Pinna","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.ophtha.2009.02.033","article-title":"Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism, and risk of retinal vein occlusion: a meta-analysis","volume":"116","author":"SJ McGimpsey","year":"2009","journal-title":"Ophthalmology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1160\/TH05-05-0313","article-title":"Homocysteine and thrombosis: from basic science to clinical evidence","volume":"94","author":"A Undas","year":"2005","journal-title":"Thromb Haemost"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0002-9149(02)03416-1","article-title":"Relation of admission white blood cell count to long-term outcomes after primary coronary angioplasty for acute myocardial infarction (The Stent PAMI Trial)","volume":"91","author":"GG Pellizzon","year":"2003","journal-title":"Am J Cardiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.amjcard.2010.09.039","article-title":"Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure","volume":"107","author":"S Uthamalingam","year":"2011","journal-title":"Am J Cardiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.amjcard.2005.10.034","article-title":"Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention","volume":"97","author":"BK Duffy","year":"2006","journal-title":"Am J Cardiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"343","DOI":"10.5301\/ejo.5000570","article-title":"Association of neutrophil\/lymphocyte ratio and retinal vein occlusion","volume":"25","author":"A Dursun","year":"2015","journal-title":"Eur J Ophthalmol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0220880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T09:20:05Z","timestamp":1610788805000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0220880"}},"subtitle":[],"editor":[{"given":"Bang V","family":"Bui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,8,8]]},"references-count":39,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0220880","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,8]]}}}