{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:03:47Z","timestamp":1790240627192,"version":"4.1.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health, Labour and Welfare of Japan","award":["H29-Nanchitou(Zatsu)-Ippan028"],"award-info":[{"award-number":["H29-Nanchitou(Zatsu)-Ippan028"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0221130","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T13:35:31Z","timestamp":1565703331000},"page":"e0221130","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Development of an electronic medical record-based algorithm to identify patients with Stevens-Johnson syndrome and toxic epidermal necrolysis in Japan"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7147-0737","authenticated-orcid":true,"given":"Toshiki","family":"Fukasawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norin","family":"Kameyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihori","family":"Furuhata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanae","family":"Tanemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Amagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Urushihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1097\/CCM.0b013e31821201ed","article-title":"Toxic epidermal necrolysis and Stevens-Johnson syndrome: a review","volume":"39","author":"R Gerull","year":"2011","journal-title":"Crit Care Med"},{"issue":"9","key":"ref2","first-page":"1637","article-title":"Japanese Clinical Guidelines for Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"126","year":"2016","journal-title":"Jpn J Dermatol"},{"issue":"12","key":"ref3","first-page":"2467","article-title":"Epidemiological Study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis throughout Japan","volume":"121","author":"A Kitami","year":"2011","journal-title":"Jpn J Dermatol"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1093\/hmg\/ddq537","article-title":"Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population","volume":"20","author":"T Ozeki","year":"2011","journal-title":"Hum Mol Genet"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2217\/17410541.2.3.225","article-title":"HLA-B genotyping to detect carbamazepine-induced Stevens-Johnson syndrome: implications for personalizing medicine","volume":"2","author":"S-I Hung","year":"2005","journal-title":"Per Med"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1056\/NEJMoa1013297","article-title":"HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans","volume":"364","author":"M McCormack","year":"2011","journal-title":"N Engl J Med"},{"key":"ref7","unstructured":"Pharmaceuticals and Medical Devices Agency. Revision of the Ministerial Ordinance on Good Post-marketing Study Practice (GPSP Ordinance) [cited 2019 May 4]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.pmda.go.jp\/files\/000220721.pdf\" xlink:type=\"simple\">https:\/\/www.pmda.go.jp\/files\/000220721.pdf<\/ext-link>. (in Japanese)."},{"issue":"Suppl 1","key":"ref8","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/pds.2331","article-title":"A systematic review of validated methods for identifying erythema multiforme major\/minor\/not otherwise specified, Stevens-Johnson Syndrome, or toxic epidermal necrolysis using administrative and claims data","volume":"21","author":"G Schneider","year":"2012","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/pds.3276","article-title":"Validation of a claims-based diagnostic code for Stevens-Johnson syndrome in a commercially insured population","volume":"21","author":"DF Eisenberg","year":"2012","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/pds.3778","article-title":"Identification of Stevens-Johnson syndrome and toxic epidermal necrolysis in electronic health record databases","volume":"24","author":"RL Davis","year":"2015","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/pds.4124","article-title":"Validation of Stevens-Johnson syndrome or toxic epidermal necrolysis diagnoses in the Clinical Practice Research Datalink","volume":"26","author":"N Frey","year":"2017","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000330835","article-title":"The National Trauma Registry as a Canadian spine trauma database: A validation study using an institutional clinical database","volume":"37","author":"JC Furlan","year":"2011","journal-title":"Neuroepidemiology"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00415-012-6686-0","article-title":"How accurate is the reporting of stroke in hospital discharge data? A pilot validation study using a population-based stroke registry as control","volume":"260","author":"C Aboa-Eboul\u00e9","year":"2013","journal-title":"J Neurol"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","DOI":"10.1186\/ar4425","article-title":"Veterans Affairs databases are accurate for gout-related health care utilization: A validation study","volume":"15","author":"JA Singh","year":"2013","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/bjd.13041","article-title":"The validity of the diagnostic code for hidradenitis suppurativa in an electronic database","volume":"171","author":"GE Kim","year":"2014","journal-title":"Br J Dermatol"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1248\/bpb.b14-00543","article-title":"The Accuracy of Japanese Claims Data in Identifying Breast Cancer Cases","volume":"38","author":"I Sato","year":"2015","journal-title":"Biol Pharm Bull"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jfma.2013.09.009","article-title":"Validating the diagnosis of acute ischemic stroke in a National Health Insurance claims database","volume":"114","author":"CY Hsieh","year":"2015","journal-title":"J Formos Med Assoc"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ijcard.2015.07.075","article-title":"Validity of in-hospital mortality data among patients with acute myocardial infarction or stroke in National Health Insurance Research Database in Taiwan","volume":"201","author":"CL Cheng","year":"2015","journal-title":"Int J Cardiol"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/pds.4044","article-title":"Validation of claims-based algorithms for gout flares","volume":"25","author":"LA MacFarlane","year":"2016","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/cpt.526","article-title":"Development and validation of algorithms for the detection of statin myopathy signals from electronic medical records","volume":"101","author":"SL Chan","year":"2017","journal-title":"Clin Pharmacol Ther"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","DOI":"10.1186\/s12913-018-3727-0","article-title":"Positive predictive value of ICD-10 codes for acute myocardial infarction in Japan: A validation study at a single center","volume":"18","author":"T Ando","year":"2018","journal-title":"BMC Health Serv Res"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2015.06.033","article-title":"Skin biopsy: Biopsy issues in specific diseases","volume":"74","author":"DM Elston","year":"2016","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2332\/allergolint.O-07-483","article-title":"Analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis in Japan from 2000 to 2006","volume":"56","author":"Y Yamane","year":"2007","journal-title":"Allergol Int"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/1346-8138.12925","article-title":"Efficacy of additional i.v. immunoglobulin to steroid therapy in Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"42","author":"M Aihara","year":"2015","journal-title":"J Dermatol"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1744-9987.1998.tb00094.x","article-title":"A study of the efficacy of plasmapheresis for the treatment of drug induced toxic epidermal necrolysis","volume":"2","author":"H Yamada","year":"1998","journal-title":"Ther Apher"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ophtha.2008.12.048","article-title":"Diagnosis and treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis with ocular complications","volume":"116","author":"C Sotozono","year":"2009","journal-title":"Ophthalmology"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.ajo.2008.12.040","article-title":"Successful treatment of Stevens-Johnson syndrome with steroid pulse therapy at disease onset","volume":"147","author":"Y Araki","year":"2009","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1172\/JCI3647","article-title":"Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice","volume":"102","author":"M Amagai","year":"1998","journal-title":"J Clin Invest"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0895-4356(03)00177-X","article-title":"The diagnostic odds ratio: a single indicator of test performance","volume":"56","author":"AS Glas","year":"2003","journal-title":"J Clin Epidemiol"},{"issue":"8","key":"ref30","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/(SICI)1097-0258(19980430)17:8<857::AID-SIM777>3.0.CO;2-E","article-title":"Two-sided confidence intervals for the single proportion: comparison of seven methods","volume":"17","author":"RG Newcombe","year":"1998","journal-title":"Stat Med"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1469-1809.1955.tb01285.x","article-title":"The estimation and significance of the logarithm of a ratio of frequencies","volume":"20","author":"J. B. Haldane","year":"1956","journal-title":"Ann Hum Genet"},{"issue":"6947","key":"ref32","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/bmj.309.6947.102","article-title":"Diagnostic tests 2: Predictive values","volume":"309","author":"DG Altman","year":"1994","journal-title":"BMJ"},{"issue":"16","key":"ref33","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1158\/1078-0432.CCR-15-2872","article-title":"Cytotoxic Cutaneous Adverse Drug Reactions during Anti-PD-1 Therapy","volume":"22","author":"SM Goldinger","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"9863","key":"ref34","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0140-6736(12)61140-4","article-title":"Pemphigoid diseases","volume":"381","author":"E Schmidt","year":"2013","journal-title":"Lancet (London, England)"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0923-1811(02)00109-3","article-title":"BP180 ELISA using bacterial recombinant NC16a protein as a diagnostic and monitoring tool for bullous pemphigoid","volume":"30","author":"M Kobayashi","year":"2002","journal-title":"J Dermatol Sci"},{"key":"ref36","first-page":"108","article-title":"Clinical epidemiology: The essentials","author":"RH Fletcher","year":"2012"},{"key":"ref37","first-page":"345","article-title":"Modern Epidemiology","author":"S Greenland","year":"2008"},{"key":"ref38","unstructured":"Health Insurance Bureau, Ministry of Health, Labour and Welfare. Various Information of Medical Fee [cited 2019 May 4]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.iryohoken.go.jp\/shinryohoshu\/\" xlink:type=\"simple\">http:\/\/www.iryohoken.go.jp\/shinryohoshu\/<\/ext-link>. (in Japanese)."},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/ije\/dys223","article-title":"Why representativeness should be avoided","volume":"42","author":"KJ Rothman","year":"2013","journal-title":"Int J Epidemiol"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/ije\/dyt101","article-title":"Commentary: On representativeness","volume":"42","author":"JM Elwood","year":"2013","journal-title":"Int J Epidemiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0221130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:41:24Z","timestamp":1588970484000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0221130"}},"subtitle":[],"editor":[{"given":"Beatrice","family":"Nardone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,8,13]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0221130","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,13]]}}}