{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T06:41:51Z","timestamp":1768718511860,"version":"3.49.0"},"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T00:00:00Z","timestamp":1565827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","award":["114Z875"],"award-info":[{"award-number":["114Z875"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o de Apio \u00e0 Pesquisa do Estado de S\u00e3o Paulo (BR)","award":["2010\/51906-1 and 2017\/04372-0"],"award-info":[{"award-number":["2010\/51906-1 and 2017\/04372-0"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0221362","type":"journal-article","created":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T17:47:40Z","timestamp":1565891260000},"page":"e0221362","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Investigation of base excision repair gene variants in late-onset Alzheimer\u2019s disease"],"prefix":"10.1371","volume":"14","author":[{"given":"Tugce","family":"Ertuzun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asli","family":"Semerci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Emin","family":"Cakir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysegul","family":"Ekmekcioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Oguz","family":"Gok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela T.","family":"Soltys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadja C.","family":"de Souza-Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugur","family":"Sezerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5372-4780","authenticated-orcid":true,"given":"Meltem","family":"Muftuoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,8,15]]},"reference":[{"issue":"R1","key":"pone.0221362.ref001","doi-asserted-by":"crossref","first-page":"R12","DOI":"10.1093\/hmg\/ddq160","article-title":"Molecular mechanisms of neurodegeneration in Alzheimer's disease","volume":"19","author":"L Crews","year":"2010","journal-title":"Hum Mol Genet"},{"issue":"2","key":"pone.0221362.ref002","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy","volume":"9","author":"CC Liu","year":"2013","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"pone.0221362.ref003","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s11682-013-9272-x","article-title":"Apolipoprotein E, gender, and Alzheimer's disease: an overlooked, but potent and promising interaction","volume":"8","author":"L Ungar","year":"2014","journal-title":"Brain Imaging Behav"},{"issue":"5","key":"pone.0221362.ref004","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/gim.2015.117","article-title":"The genetic landscape of Alzheimer disease: clinical implications and perspectives","volume":"18","author":"C Van Cauwenberghe","year":"2016","journal-title":"Genet Med"},{"issue":"16","key":"pone.0221362.ref005","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1093\/nar\/gkm605","article-title":"Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment","volume":"35","author":"L Weissman","year":"2007","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"pone.0221362.ref006","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/j.1471-4159.2005.03053.x","article-title":"Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease","volume":"93","author":"J Wang","year":"2005","journal-title":"J Neurochem"},{"issue":"5","key":"pone.0221362.ref007","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1046\/j.1471-4159.1998.71052034.x","article-title":"Increased nuclear DNA oxidation in the brain in Alzheimer's disease","volume":"71","author":"SP Gabbita","year":"1998","journal-title":"J Neurochem"},{"issue":"5","key":"pone.0221362.ref008","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/ana.410360510","article-title":"Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease","volume":"36","author":"P Mecocci","year":"1994","journal-title":"Ann Neurol"},{"issue":"22","key":"pone.0221362.ref009","doi-asserted-by":"crossref","first-page":"7497","DOI":"10.1093\/nar\/gkm821","article-title":"Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease","volume":"35","author":"MA Lovell","year":"2007","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"pone.0221362.ref010","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3109\/10715762.2011.648188","article-title":"Nuclear and mitochondrial DNA oxidation in Alzheimer's disease","volume":"46","author":"RX Santos","year":"2012","journal-title":"Free Radic Res"},{"issue":"5","key":"pone.0221362.ref011","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1046\/j.1471-4159.1997.68052061.x","article-title":"An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease","volume":"68","author":"L Lyras","year":"1997","journal-title":"J Neurochem"},{"issue":"1","key":"pone.0221362.ref012","first-page":"47","article-title":"Elevated levels of oxidative DNA damage in lymphocytes from patients with Alzheimer's disease","volume":"23","author":"M Morocz","year":"2002","journal-title":"Neurobiol Aging"},{"issue":"2","key":"pone.0221362.ref013","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1046\/j.1471-4159.1999.0720771.x","article-title":"Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF","volume":"72","author":"MA Lovell","year":"1999","journal-title":"J Neurochem"},{"issue":"6","key":"pone.0221362.ref014","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.freeradbiomed.2012.07.018","article-title":"Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype","volume":"53","author":"M Ramamoorthy","year":"2012","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"pone.0221362.ref015","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1212\/WNL.51.4.1014","article-title":"Oxidative damage to DNA in lymphocytes from AD patients","volume":"51","author":"P Mecocci","year":"1998","journal-title":"Neurology"},{"key":"pone.0221362.ref016","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jns.2016.07.008","article-title":"The levels of 7,8-dihydrodeoxyguanosine (8-oxoG) and 8-oxoguanine DNA glycosylase 1 (OGG1)\u2014A potential diagnostic biomarkers of Alzheimer's disease","volume":"368","author":"A Sliwinska","year":"2016","journal-title":"J Neurol Sci"},{"issue":"5","key":"pone.0221362.ref017","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.neurobiolaging.2004.07.016","article-title":"Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients","volume":"26","author":"L Migliore","year":"2005","journal-title":"Neurobiol Aging"},{"issue":"1","key":"pone.0221362.ref018","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0006-8993(99)02335-5","article-title":"Decreased base excision repair and increased helicase activity in Alzheimer's disease brain","volume":"855","author":"MA Lovell","year":"2000","journal-title":"Brain Res"},{"issue":"8","key":"pone.0221362.ref019","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.dnarep.2013.04.010","article-title":"The role of DNA repair in brain related disease pathology","volume":"12","author":"C Canugovi","year":"2013","journal-title":"DNA Repair (Amst)."},{"key":"pone.0221362.ref020","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mito.2013.10.007","article-title":"A short review on the implications of base excision repair pathway for neurons: relevance to neurodegenerative diseases","volume":"16","author":"AK Mantha","year":"2014","journal-title":"Mitochondrion"},{"issue":"42","key":"pone.0221362.ref021","doi-asserted-by":"crossref","first-page":"43952","DOI":"10.1074\/jbc.M408025200","article-title":"Suppression of uracil-DNA glycosylase induces neuronal apoptosis","volume":"279","author":"II Kruman","year":"2004","journal-title":"J Biol Chem"},{"issue":"5","key":"pone.0221362.ref022","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1523\/JNEUROSCI.22-05-01752.2002","article-title":"Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease","volume":"22","author":"II Kruman","year":"2002","journal-title":"J Neurosci"},{"issue":"3","key":"pone.0221362.ref023","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1093\/ajcn\/82.3.636","article-title":"Homocysteine and folate as risk factors for dementia and Alzheimer disease","volume":"82","author":"G Ravaglia","year":"2005","journal-title":"Am J Clin Nutr"},{"issue":"43","key":"pone.0221362.ref024","doi-asserted-by":"crossref","first-page":"10949","DOI":"10.1523\/JNEUROSCI.2793-06.2006","article-title":"DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid","volume":"26","author":"A Copani","year":"2006","journal-title":"J Neurosci"},{"issue":"37","key":"pone.0221362.ref025","doi-asserted-by":"crossref","first-page":"14948","DOI":"10.1073\/pnas.1204156109","article-title":"Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice","volume":"109","author":"C Canugovi","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"pone.0221362.ref026","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.neurobiolaging.2014.01.004","article-title":"Base excision DNA repair levels in mitochondrial lysates of Alzheimer's disease","volume":"35","author":"C Canugovi","year":"2014","journal-title":"Neurobiol Aging"},{"issue":"2","key":"pone.0221362.ref027","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/nar\/gku1356","article-title":"DNA polymerase beta deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes","volume":"43","author":"P Sykora","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"pone.0221362.ref028","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/acel.12541","article-title":"DNA polymerase beta decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease","volume":"16","author":"M Misiak","year":"2017","journal-title":"Aging Cell"},{"key":"pone.0221362.ref029","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neurobiolaging.2018.09.015","article-title":"Lower mitochondrial DNA content but not increased mutagenesis associates with decreased base excision repair activity in brains of AD subjects","volume":"73","author":"DT Soltys","year":"2019","journal-title":"Neurobiol Aging"},{"issue":"10","key":"pone.0221362.ref030","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.mad.2013.09.002","article-title":"Transient OGG1, APE1, PARP1 and Polbeta expression in an Alzheimer's disease mouse model","volume":"134","author":"MS Lillenes","year":"2013","journal-title":"Mech Ageing Dev"},{"issue":"3","key":"pone.0221362.ref031","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1006\/geno.1996.0485","article-title":"Human uracil-DNA glycosylase gene: sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1","volume":"36","author":"T Haug","year":"1996","journal-title":"Genomics"},{"issue":"20","key":"pone.0221362.ref032","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1093\/nar\/26.20.4611","article-title":"Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localisation signal and a strong classical mitochondrial localisation signal, respectively","volume":"26","author":"M Otterlei","year":"1998","journal-title":"Nucleic Acids Res"},{"issue":"Pt B","key":"pone.0221362.ref033","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.pnpbp.2017.07.010","article-title":"Decreased expression level of BER genes in Alzheimer's disease patients is not derivative of their DNA methylation status","volume":"79","author":"A Sliwinska","year":"2017","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"1","key":"pone.0221362.ref034","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13041-016-0237-z","article-title":"Altered DNA base excision repair profile in brain tissue and blood in Alzheimer's disease","volume":"9","author":"MS Lillenes","year":"2016","journal-title":"Mol Brain"},{"issue":"3","key":"pone.0221362.ref035","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000381985","article-title":"Variants of Base Excision Repair Genes MUTYH, PARP1 and XRCC1 in Alzheimer's Disease Risk","volume":"71","author":"D Kwiatkowski","year":"2015","journal-title":"Neuropsychobiology"},{"issue":"2","key":"pone.0221362.ref036","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000444643","article-title":"Association between Single-Nucleotide Polymorphisms of the hOGG1,NEIL1,APEX1, FEN1,LIG1, and LIG3 Genes and Alzheimer's Disease Risk","volume":"73","author":"D Kwiatkowski","year":"2016","journal-title":"Neuropsychobiology"},{"issue":"11","key":"pone.0221362.ref037","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1089\/dna.2009.0926","article-title":"Expression and polymorphisms of gene 8-oxoguanine glycosylase 1 and the level of oxidative DNA damage in peripheral blood lymphocytes of patients with Alzheimer's disease","volume":"28","author":"J Dorszewska","year":"2009","journal-title":"DNA Cell Biol"},{"issue":"4","key":"pone.0221362.ref038","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3233\/JAD-2010-1415","article-title":"Evidence linking genetics, environment, and epigenetics to impaired DNA repair in Alzheimer's disease","volume":"20","author":"F Coppede","year":"2010","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"pone.0221362.ref039","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neulet.2006.12.035","article-title":"A Ser326Cys polymorphism in the DNA repair gene hOGG1 is not associated with sporadic Alzheimer's disease","volume":"414","author":"F Coppede","year":"2007","journal-title":"Neurosci Lett"},{"issue":"1","key":"pone.0221362.ref040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10072-007-0744-x","article-title":"The Arg194Trp polymorphism in DNA repair gene XRCC1 and the risk for sporadic late-onset Alzheimer's disease","volume":"28","author":"S Dogru-Abbasoglu","year":"2007","journal-title":"Neurol Sci"},{"key":"pone.0221362.ref041","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.freeradbiomed.2013.05.010","article-title":"Alzheimer's disease-associated polymorphisms in human OGG1 alter catalytic activity and sensitize cells to DNA damage","volume":"63","author":"KD Jacob","year":"2013","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"pone.0221362.ref042","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1093\/nar\/gkm189","article-title":"Identification and characterization of OGG1 mutations in patients with Alzheimer's disease","volume":"35","author":"G Mao","year":"2007","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"pone.0221362.ref043","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neulet.2008.07.047","article-title":"Single nucleotide polymorphisms in base-excision repair genes hOGG1, APE1 and XRCC1 do not alter risk of Alzheimer's disease","volume":"442","author":"H Parildar-Karpuzoglu","year":"2008","journal-title":"Neurosci Lett"},{"issue":"1\u20132","key":"pone.0221362.ref044","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jns.2010.05.002","article-title":"Association of polymorphism of DNA repair gene XRCC1 with sporadic late-onset Alzheimer's disease and age of onset in elderly Han Chinese","volume":"295","author":"Y Qian","year":"2010","journal-title":"J Neurol Sci"},{"key":"pone.0221362.ref045","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neulet.2017.02.062","article-title":"Mitochondrial transcription factor A (TFAM) rs1937 and AP endonuclease 1 (APE1) rs1130409 alleles are associated with reduced cognitive performance.","volume":"645","author":"MS Lillenes","year":"2017","journal-title":"Neurosci Lett"},{"issue":"3","key":"pone.0221362.ref046","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/jcla.20379","article-title":"Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease","volume":"24","author":"HP Liu","year":"2010","journal-title":"J Clin Lab Anal"},{"issue":"2","key":"pone.0221362.ref047","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nprot.2010.182","article-title":"Basic statistical analysis in genetic case-control studies","volume":"6","author":"GM Clarke","year":"2011","journal-title":"Nat Protoc"},{"issue":"7571","key":"pone.0221362.ref048","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"C Genomes Project","year":"2015","journal-title":"Nature"},{"issue":"4","key":"pone.0221362.ref049","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1093\/nar\/25.4.750","article-title":"Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene","volume":"25","author":"H Nilsen","year":"1997","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"pone.0221362.ref050","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0921-8777(00)00063-X","article-title":"Sequence variation in the human uracil-DNA glycosylase (UNG) gene","volume":"461","author":"K Kvaloy","year":"2001","journal-title":"Mutat Res"},{"issue":"12","key":"pone.0221362.ref051","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1007\/s00296-011-2185-3","article-title":"Genetic polymorphisms of the DNA repair gene UNG are associated with the susceptibility of rheumatoid arthritis","volume":"32","author":"SF Lo","year":"2012","journal-title":"Rheumatol Int"},{"issue":"1","key":"pone.0221362.ref052","first-page":"11","article-title":"DNA repair genotype and lung cancer risk in the beta-carotene and retinol efficacy trial","volume":"4","author":"JA Doherty","year":"2013","journal-title":"Int J Mol Epidemiol Genet"},{"issue":"11","key":"pone.0221362.ref053","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s12032-014-0272-5","article-title":"Uracil-DNA glycosylase (UNG) rs246079 G\/A polymorphism is associated with decreased risk of esophageal cancer in a Chinese population","volume":"31","author":"J Yin","year":"2014","journal-title":"Med Oncol"},{"issue":"4","key":"pone.0221362.ref054","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/0891988716640373","article-title":"The Association Between Clusterin and APOE Polymorphisms and Late-Onset Alzheimer Disease in a Turkish Cohort","volume":"29","author":"M Alaylioglu","year":"2016","journal-title":"J Geriatr Psychiatry Neurol"},{"issue":"2","key":"pone.0221362.ref055","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/153331750101600207","article-title":"Apolipoprotein-E gene polymorphism and lipid profiles in Alzheimer's disease","volume":"16","author":"T Isbir","year":"2001","journal-title":"Am J Alzheimers Dis Other Demen"},{"issue":"16","key":"pone.0221362.ref056","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"LA Farrer","year":"1997","journal-title":"JAMA"},{"issue":"8","key":"pone.0221362.ref057","doi-asserted-by":"crossref","first-page":"e1003685","DOI":"10.1371\/journal.pgen.1003685","article-title":"The PSEN1, p.E318G variant increases the risk of Alzheimer's disease in APOE-epsilon4 carriers.","volume":"9","author":"BA Benitez","year":"2013","journal-title":"PLoS Genet"},{"issue":"5","key":"pone.0221362.ref058","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.neuron.2007.05.022","article-title":"GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers","volume":"54","author":"EM Reiman","year":"2007","journal-title":"Neuron"},{"issue":"1","key":"pone.0221362.ref059","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13195-016-0187-9","article-title":"The algorithm for Alzheimer risk assessment based on APOE promoter polymorphisms","volume":"8","author":"A Limon-Sztencel","year":"2016","journal-title":"Alzheimers Res Ther"},{"issue":"1","key":"pone.0221362.ref060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000334607","article-title":"Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4\/4) among patients diagnosed with Alzheimer's disease: a systematic review and meta-analysis","volume":"38","author":"A Ward","year":"2012","journal-title":"Neuroepidemiology"},{"issue":"1","key":"pone.0221362.ref061","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/WAD.0b013e31815a9da7","article-title":"Polymorphisms of APOE and LRP genes in Brazilian individuals with Alzheimer disease","volume":"22","author":"VS Bahia","year":"2008","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"5","key":"pone.0221362.ref062","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1590\/S0100-879X2000000500007","article-title":"Association of apolipoprotein E polymorphism with plasma lipids and Alzheimer's disease in a Southern Brazilian population","volume":"33","author":"FM de-Andrade","year":"2000","journal-title":"Braz J Med Biol Res"},{"key":"pone.0221362.ref063","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuroscience.2012.06.035","article-title":"Analysis of SNAP25 mRNA expression and promoter DNA methylation in brain areas of Alzheimer's Disease patients","volume":"220","author":"TK Furuya","year":"2012","journal-title":"Neuroscience"},{"issue":"12","key":"pone.0221362.ref064","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1212\/WNL.54.12.2319","article-title":"Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimer's disease","volume":"54","author":"A Tamaoka","year":"2000","journal-title":"Neurology"},{"issue":"4","key":"pone.0221362.ref065","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0896-6273(93)90070-8","article-title":"Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions","volume":"11","author":"GW Rebeck","year":"1993","journal-title":"Neuron"},{"issue":"8","key":"pone.0221362.ref066","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/sj.mp.4001097","article-title":"Variation at the APOE -491 promoter locus is associated with altered brain levels of apolipoprotein E","volume":"7","author":"SM Laws","year":"2002","journal-title":"Mol Psychiatry"},{"key":"pone.0221362.ref067","doi-asserted-by":"crossref","first-page":"974361","DOI":"10.4061\/2011\/974361","article-title":"Function and comorbidities of apolipoprotein e in Alzheimer's disease","volume":"2011","author":"V Leduc","year":"2011","journal-title":"Int J Alzheimers Dis"},{"issue":"3","key":"pone.0221362.ref068","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/0306-4522(95)00331-C","article-title":"Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease","volume":"69","author":"Z Nagy","year":"1995","journal-title":"Neuroscience"},{"key":"pone.0221362.ref069","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.exger.2017.10.020","article-title":"Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses","volume":"107","author":"AI Yashin","year":"2018","journal-title":"Exp Gerontol"},{"issue":"Suppl 1","key":"pone.0221362.ref070","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12868-018-0413-4","article-title":"Haplotype analysis of APOE intragenic SNPs","volume":"19","author":"VN Babenko","year":"2018","journal-title":"BMC Neurosci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0221362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T02:02:57Z","timestamp":1721613777000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0221362"}},"subtitle":[],"editor":[{"given":"Stephen D.","family":"Ginsberg","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,8,15]]},"references-count":70,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0221362","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,15]]}}}