{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:12:54Z","timestamp":1788246774094,"version":"build-2803163510"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17K10152"],"award-info":[{"award-number":["JP17K10152"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0221686","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T19:00:22Z","timestamp":1567537222000},"page":"e0221686","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Maternal undernutrition aggravates renal tubular necrosis and interstitial fibrosis after unilateral ureteral obstruction in male rat offspring"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9350-5339","authenticated-orcid":true,"given":"Midori","family":"Awazu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tokiya","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Hashiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Hida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"issue":"3","key":"pone.0221686.ref001","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrneph.2014.251","article-title":"Birth weight, malnutrition and kidney-associated outcomes\u2014a global concern","volume":"11","author":"VA Luyckx","year":"2015","journal-title":"Nat Rev Nephrol"},{"issue":"10","key":"pone.0221686.ref002","first-page":"018","article-title":"Tubular dysfunction in extremely low birth weight survivors","volume":"20","author":"K Matsumura","year":"2018","journal-title":"Clin Exp Nephrol"},{"issue":"7","key":"pone.0221686.ref003","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s00467-017-3654-z","article-title":"Polycythemia, capillary rarefaction, and focal glomerulosclerosis in two adolescents born extremely low birth weight and premature","volume":"32","author":"N Asada","year":"2017","journal-title":"Pediatr Nephrol"},{"issue":"1","key":"pone.0221686.ref004","doi-asserted-by":"crossref","first-page":"F202","DOI":"10.1152\/ajprenal.00358.2001","article-title":"Upregulation of renal BSC1 and TSC in prenatally programmed hypertension","volume":"283","author":"J Manning","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"issue":"1","key":"pone.0221686.ref005","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1046\/j.1523-1755.2001.00484.x","article-title":"Prenatal programming of adult hypertension in the rat","volume":"59","author":"VM Vehaskari","year":"2001","journal-title":"Kidney Int"},{"issue":"9","key":"pone.0221686.ref006","doi-asserted-by":"crossref","first-page":"R1153","DOI":"10.1152\/ajpregu.00403.2014","article-title":"Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction","volume":"309","author":"MJ Black","year":"2015","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"pone.0221686.ref007","doi-asserted-by":"crossref","first-page":"F420","DOI":"10.1152\/ajprenal.00045.2011","article-title":"Low birth weight increases susceptibility to renal injury in a rat model of mild ischemia-reperfusion","volume":"301","author":"NB Ojeda","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"issue":"4","key":"pone.0221686.ref008","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1159\/000319045","article-title":"Intrauterine growth restriction following ligation of the uterine arteries leads to more severe glomerulosclerosis after mesangioproliferative glomerulonephritis in the offspring","volume":"32","author":"C Plank","year":"2010","journal-title":"Am J Nephrol"},{"issue":"6","key":"pone.0221686.ref009","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1080\/080352501750258676","article-title":"Association between urinary tract infection, renal damage and birth size","volume":"90","author":"M Hellstrom","year":"2001","journal-title":"Acta Paediatr"},{"issue":"5","key":"pone.0221686.ref010","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1017\/S2040174416000477","article-title":"A review of fundamental principles for animal models of DOHaD research: an Australian perspective","volume":"7","author":"H Dickinson","year":"2016","journal-title":"J Dev Orig Health Dis"},{"issue":"5","key":"pone.0221686.ref011","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/pr.2015.24","article-title":"Maternal nutrient restriction inhibits ureteric bud branching but does not affect the duration of nephrogenesis in rats","volume":"77","author":"M Awazu","year":"2015","journal-title":"Pediatr Res"},{"issue":"4","key":"pone.0221686.ref012","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1111\/j.1523-1755.2004.00511.x","article-title":"Programming of adult blood pressure by maternal protein restriction: role of nephrogenesis","volume":"65","author":"LL Woods","year":"2004","journal-title":"Kidney Int"},{"issue":"6","key":"pone.0221686.ref013","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1172\/JCI109243","article-title":"Deep nephron function after release of acute unilateral ureteral obstruction in the young rat","volume":"62","author":"J Buerkert","year":"1978","journal-title":"J Clin Invest"},{"issue":"3","key":"pone.0221686.ref014","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1046\/j.1523-1755.2000.00274.x","article-title":"TIMP-1 gene expression and PAI-1 antigen after unilateral ureteral obstruction in the adult male rat","volume":"58","author":"C Duymelinck","year":"2000","journal-title":"Kidney Int"},{"issue":"6","key":"pone.0221686.ref015","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/pin.12064","article-title":"Quantification of collagen and elastic fibers using whole-slide images of liver biopsy specimens","volume":"63","author":"T Abe","year":"2013","journal-title":"Pathol Int"},{"issue":"5","key":"pone.0221686.ref016","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0272-6386(99)70421-X","article-title":"Tubular function and tubulointerstitial disease","volume":"33","author":"P Futrakul","year":"1999","journal-title":"Am J Kidney Dis"},{"issue":"12","key":"pone.0221686.ref017","first-page":"3810","article-title":"Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition","volume":"117","author":"DF Higgins","year":"2007","journal-title":"J Clin Invest"},{"issue":"6","key":"pone.0221686.ref018","doi-asserted-by":"crossref","first-page":"F1283","DOI":"10.1152\/ajprenal.00441.2003","article-title":"Renal damage progresses despite improvement of renal function after relief of unilateral ureteral obstruction in adult rats","volume":"287","author":"K Ito","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"issue":"5","key":"pone.0221686.ref019","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1111\/j.1523-1755.2005.00674.x","article-title":"Kidney immune cell infiltration and oxidative stress contribute to prenatally programmed hypertension","volume":"68","author":"T Stewart","year":"2005","journal-title":"Kidney Int"},{"issue":"3","key":"pone.0221686.ref020","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1365-2613.2010.00730.x","article-title":"Oxidative stress in obstructive nephropathy","volume":"92","author":"A Dendooven","year":"2011","journal-title":"Int J Exp Pathol"},{"issue":"6","key":"pone.0221686.ref021","first-page":"F789","article-title":"Antioxidant expression in experimental hydronephrosis: role of mechanical stretch and growth factors","volume":"272","author":"SD Ricardo","year":"1997","journal-title":"Am J Physiol"},{"issue":"6","key":"pone.0221686.ref022","doi-asserted-by":"crossref","first-page":"F1030","DOI":"10.1152\/ajprenal.00266.2003","article-title":"Acatalasemia sensitizes renal tubular epithelial cells to apoptosis and exacerbates renal fibrosis after unilateral ureteral obstruction","volume":"286","author":"R Sunami","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"issue":"3","key":"pone.0221686.ref023","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/j.1523-1755.2005.00157.x","article-title":"Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants","volume":"67","author":"B Pat","year":"2005","journal-title":"Kidney Int"},{"issue":"8","key":"pone.0221686.ref024","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1096\/fj.10-156075","article-title":"Poor maternal nutrition leads to alterations in oxidative stress, antioxidant defense capacity, and markers of fibrosis in rat islets: potential underlying mechanisms for development of the diabetic phenotype in later life","volume":"24","author":"JL Tarry-Adkins","year":"2010","journal-title":"FASEB J"},{"issue":"1","key":"pone.0221686.ref025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.32604\/biocell.2007.31.001","article-title":"Biochemical-molecular markers in unilateral ureteral obstruction","volume":"31","author":"W. Manucha","year":"2007","journal-title":"Biocell"},{"issue":"3","key":"pone.0221686.ref026","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1046\/j.1523-1755.2001.0590031059.x","article-title":"Nitric oxide in unilateral ureteral obstruction: effect on regional renal blood flow","volume":"59","author":"NJ Hegarty","year":"2001","journal-title":"Kidney Int"},{"issue":"6","key":"pone.0221686.ref027","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1111\/j.1523-1755.2004.00643.x","article-title":"Losartan modulation on NOS isoforms and COX-2 expression in early renal fibrogenesis in unilateral obstruction","volume":"65","author":"W Manucha","year":"2004","journal-title":"Kidney Int"},{"issue":"2","key":"pone.0221686.ref028","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1681\/ASN.V92231","article-title":"Tubulointerstitial disease in aging: evidence for underlying peritubular capillary damage, a potential role for renal ischemia","volume":"9","author":"SE Thomas","year":"1998","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"pone.0221686.ref029","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1681\/ASN.V7102202","article-title":"Nitric oxide generation ameliorates the tubulointerstitial fibrosis of obstructive nephropathy","volume":"7","author":"JJ Morrissey","year":"1996","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"pone.0221686.ref030","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/j.juro.2009.12.002","article-title":"Adrenomedullin increases renal nitric oxide production and ameliorates renal injury in mice with unilateral ureteral obstruction","volume":"183","author":"K Ito","year":"2010","journal-title":"J Urol"},{"issue":"4","key":"pone.0221686.ref031","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1046\/j.1523-1755.2001.0590041290.x","article-title":"Role of nitric oxide in renal tubular apoptosis of unilateral ureteral obstruction","volume":"59","author":"A Miyajima","year":"2001","journal-title":"Kidney Int"},{"issue":"2","key":"pone.0221686.ref032","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/jor.20060","article-title":"Nitric oxide enhances collagen synthesis in cultured human tendon cells","volume":"24","author":"W Xia","year":"2006","journal-title":"J Orthop Res"},{"issue":"3","key":"pone.0221686.ref033","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1006\/bbrc.1998.8681","article-title":"Enhanced collagen accumulation following direct transfection of the inducible nitric oxide synthase gene in cutaneous wounds","volume":"246","author":"FJ Thornton","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"pone.0221686.ref034","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2310\/6650.2005.53705","article-title":"Inducible nitric oxide synthase inhibitors reduce urinary markers of systemic oxidant stress in murine proliferative lupus nephritis","volume":"53","author":"CJ Njoku","year":"2005","journal-title":"J Investig Med"},{"issue":"12","key":"pone.0221686.ref035","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1681\/ASN.2014030280","article-title":"Reduced renal methylarginine metabolism protects against progressive kidney damage","volume":"26","author":"JA Tomlinson","year":"2015","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"pone.0221686.ref036","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"P Pacher","year":"2007","journal-title":"Physiol Rev"},{"issue":"3","key":"pone.0221686.ref037","doi-asserted-by":"crossref","first-page":"F648","DOI":"10.1152\/ajprenal.00402.2009","article-title":"Cyclic stretch induces proliferation and TGF-\u00df1-mediated apoptosis via p38 and ERK in ureteric bud cells","volume":"299","author":"H Fujita","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"issue":"1","key":"pone.0221686.ref038","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0008-6363(02)00508-4","article-title":"Intrauterine undernutrition: expression and activity of the endothelial nitric oxide synthase in male and female adult offspring","volume":"56","author":"C Franco Mdo","year":"2002","journal-title":"Cardiovasc Res"},{"issue":"6","key":"pone.0221686.ref039","doi-asserted-by":"crossref","first-page":"L860","DOI":"10.1152\/ajplung.00197.2011","article-title":"Intrauterine growth restriction decreases pulmonary alveolar and vessel growth and causes pulmonary artery endothelial cell dysfunction in vitro in fetal sheep","volume":"301","author":"PJ Rozance","year":"2011","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"7","key":"pone.0221686.ref040","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/pd.4829","article-title":"Nitric oxide synthase and changes in oxidative stress levels in embryonic kidney observed in a rabbit model of intrauterine growth restriction","volume":"36","author":"H Figueroa","year":"2016","journal-title":"Prenat Diagn"},{"issue":"9","key":"pone.0221686.ref041","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/j.1651-2227.2008.00904.x","article-title":"Low birth weight and the developing vascular tree: a systematic review","volume":"97","author":"M. Norman","year":"2008","journal-title":"Acta Paediatr"},{"issue":"2","key":"pone.0221686.ref042","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1113\/jphysiol.2011.220186","article-title":"Protein-energy malnutrition during early gestation in sheep blunts fetal renal vascular and nephron development and compromises adult renal function","volume":"590","author":"LJ Lloyd","year":"2012","journal-title":"J Physiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0221686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T10:09:26Z","timestamp":1664273366000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0221686"}},"subtitle":[],"editor":[{"given":"Michael","family":"Bader","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":42,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0221686","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,3]]}}}