{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:23:05Z","timestamp":1788506585983,"version":"build-2803163510"},"reference-count":12,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","award":["CRDPJ 505236-16"],"award-info":[{"award-number":["CRDPJ 505236-16"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Connaught Fund, University of Toronto"},{"name":"Fluidigm Canada, Inc"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0221714","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T14:00:14Z","timestamp":1567519214000},"page":"e0221714","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Methods for analyzing tellurium imaging mass cytometry data"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3682-4629","authenticated-orcid":true,"given":"Jay","family":"Bassan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Nitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"pone.0221714.ref001","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.2869","article-title":"Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry","volume":"11","author":"C Giesen","year":"2014","journal-title":"Nat Methods"},{"issue":"November","key":"pone.0221714.ref002","first-page":"1","article-title":"Biodistribution of cisplatin revealed by imaging mass cytometry identifies extensive collagen binding in tumor and normal tissues","volume":"6","author":"Q Chang","year":"2016","journal-title":"Sci Rep"},{"issue":"5","key":"pone.0221714.ref003","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/00000421-200110000-00011","article-title":"Hypoxic Heterogeneity in Human Tumors","volume":"24","author":"SM Evans","year":"2001","journal-title":"Am J Clin Oncol"},{"issue":"25","key":"pone.0221714.ref004","doi-asserted-by":"crossref","first-page":"7027","DOI":"10.1039\/C5OB00593K","article-title":"Organotellurium scaffolds for mass cytometry reagent development","volume":"13","author":"H Park","year":"2015","journal-title":"Org Biomol Chem"},{"issue":"17","key":"pone.0221714.ref005","doi-asserted-by":"crossref","first-page":"8155","DOI":"10.1073\/pnas.1821151116","article-title":"TePhe, a tellurium-containing phenylalanine mimic, allows monitoring of protein synthesis in vivo with mass cytometry","volume":"116","author":"J Bassan","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"42","key":"pone.0221714.ref006","doi-asserted-by":"crossref","first-page":"13159","DOI":"10.1002\/anie.201607483","article-title":"Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution","volume":"55","author":"LJ Edgar","year":"2016","journal-title":"Angew Chemie\u2014Int Ed"},{"issue":"9","key":"pone.0221714.ref007","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nmeth.4391","article-title":"HistoCAT: Analysis of cell phenotypes and interactions in multiplex image cytometry data","volume":"14","author":"D Schapiro","year":"2017","journal-title":"Nat Methods"},{"issue":"4","key":"pone.0221714.ref008","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/path.5049","article-title":"Ruthenium counterstaining for imaging mass cytometry","volume":"244","author":"R Catena","year":"2018","journal-title":"J Pathol"},{"key":"pone.0221714.ref009","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.cels.2018.02.010","article-title":"Compensation of Signal Spillover in Suspension and Imaging Mass Cytometry","volume":"6","author":"S Chevrier","year":"2018","journal-title":"Cell Systems"},{"key":"pone.0221714.ref010","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/cyto.a.22648","article-title":"Evaluating the efficiency of isotope transmission for improved panel design and a comparison of the detection sensitivities of mass cytometer instruments","volume":"87","author":"S Tricot","year":"2015","journal-title":"Cytom A"},{"key":"pone.0221714.ref011","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/0584-8547(96)01506-6","article-title":"Fundamental aspects of ion extraction in inductively coupled plasma mass spectrometry","volume":"51","author":"H Niu","year":"1996","journal-title":"Spectrochim Acta B"},{"key":"pone.0221714.ref012","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/cyto.a.22271","article-title":"Normalization of mass cytometry data with bead standards","volume":"83","author":"R Finck","year":"2013","journal-title":"Cytom A"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0221714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T11:04:56Z","timestamp":1589022296000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0221714"}},"subtitle":[],"editor":[{"given":"Giovanni","family":"Signore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":12,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0221714","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/567685","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,3]]}}}