{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:41:15Z","timestamp":1792802475245,"version":"4.5.0"},"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Basic Research Program of China","award":["2014CB964901"],"award-info":[{"award-number":["2014CB964901"]}]},{"name":"the National Key Research and Development Program of China","award":["2016YFC0901700"],"award-info":[{"award-number":["2016YFC0901700"]}]},{"name":"the National High-tech R&D Program of China","award":["2015AA020100"],"award-info":[{"award-number":["2015AA020100"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81571136"],"award-info":[{"award-number":["81571136"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Municipal Science & Technology Commission","award":["Z171100001017144"],"award-info":[{"award-number":["Z171100001017144"]}],"id":[{"id":"https:\/\/ror.org\/034k14f91","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0221811","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T13:28:12Z","timestamp":1568813292000},"page":"e0221811","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Gene dysregulation in peripheral blood of moyamoya disease and comparison with other vascular disorders"],"prefix":"10.1371","volume":"14","author":[{"given":"Xing","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengshan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongqing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiqi","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengxing","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0496-0386","authenticated-orcid":true,"given":"Hongxing","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,9,18]]},"reference":[{"issue":"3","key":"pone.0221811.ref001","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/archneur.1969.00480090076012","article-title":"Cerebrovascular \"moyamoya\" disease. Disease showing abnormal net-like vessels in base of brain","volume":"20","author":"J Suzuki","year":"1969","journal-title":"Archives of neurology"},{"issue":"2","key":"pone.0221811.ref002","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000369524","article-title":"Clinical features, surgical treatment, and long-term outcome in pediatric patients with moyamoya disease in China","volume":"39","author":"XY Bao","year":"2015","journal-title":"Cerebrovascular diseases (Basel, Switzerland)"},{"issue":"4","key":"pone.0221811.ref003","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000343225","article-title":"Clinical features, surgical treatment and long-term outcome in adult patients with Moyamoya disease in China","volume":"34","author":"XY Bao","year":"2012","journal-title":"Cerebrovascular diseases (Basel, Switzerland)"},{"issue":"1","key":"pone.0221811.ref004","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1161\/STROKEAHA.111.621300","article-title":"Moyamoya disease in China: its clinical features and outcomes","volume":"43","author":"L Duan","year":"2012","journal-title":"Stroke"},{"issue":"3","key":"pone.0221811.ref005","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.clineuro.2009.11.009","article-title":"Epidemiological and clinical features of Moyamoya disease in Nanjing, China","volume":"112","author":"W Miao","year":"2010","journal-title":"Clinical neurology and neurosurgery"},{"issue":"1","key":"pone.0221811.ref006","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/jhg.2010.132","article-title":"A genome-wide association study identifies RNF213 as the first Moyamoya disease gene","volume":"56","author":"F Kamada","year":"2011","journal-title":"Journal of human genetics"},{"issue":"7","key":"pone.0221811.ref007","doi-asserted-by":"crossref","first-page":"e22542","DOI":"10.1371\/journal.pone.0022542","article-title":"Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development","volume":"6","author":"W Liu","year":"2011","journal-title":"PloS one"},{"issue":"4","key":"pone.0221811.ref008","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.3171\/2016.2.JNS152173","article-title":"RNF213 as the major susceptibility gene for Chinese patients with moyamoya disease and its clinical relevance","volume":"126","author":"Q Zhang","year":"2017","journal-title":"Journal of neurosurgery"},{"issue":"10","key":"pone.0221811.ref009","doi-asserted-by":"crossref","first-page":"e48179","DOI":"10.1371\/journal.pone.0048179","article-title":"Molecular analysis of RNF213 gene for moyamoya disease in the Chinese Han population","volume":"7","author":"Z Wu","year":"2012","journal-title":"PloS one"},{"issue":"11","key":"pone.0221811.ref010","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1212\/WNL.0b013e318249f71f","article-title":"Homozygous c.14576G>A variant of RNF213 predicts early-onset and severe form of moyamoya disease","volume":"78","author":"S Miyatake","year":"2012","journal-title":"Neurology"},{"issue":"5","key":"pone.0221811.ref011","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.001862","article-title":"Systematic Validation of RNF213 Coding Variants in Japanese Patients With Moyamoya Disease","volume":"4","author":"Y Moteki","year":"2015","journal-title":"Journal of the American Heart Association"},{"key":"pone.0221811.ref012","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.brainres.2014.01.011","article-title":"Temporal profile of the vascular anatomy evaluated by 9.4-T magnetic resonance angiography and histopathological analysis in mice lacking RNF213: a susceptibility gene for moyamoya disease","volume":"1552","author":"S Sonobe","year":"2014","journal-title":"Brain research"},{"issue":"1","key":"pone.0221811.ref013","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/STROKEAHA.109.562264","article-title":"Association of thyroid autoantibodies with moyamoya-type cerebrovascular disease: a prospective study","volume":"41","author":"SJ Kim","year":"2010","journal-title":"Stroke"},{"issue":"1\u20132","key":"pone.0221811.ref014","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jns.2015.02.037","article-title":"Prevalence of autoimmune disease in moyamoya disease patients in Western Chinese population","volume":"351","author":"JB Chen","year":"2015","journal-title":"Journal of the neurological sciences"},{"issue":"7","key":"pone.0221811.ref015","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1161\/STROKEAHA.111.000307","article-title":"Moyamoya disease in a primarily white, midwestern US population: increased prevalence of autoimmune disease","volume":"44","author":"RS Bower","year":"2013","journal-title":"Stroke"},{"key":"pone.0221811.ref016","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.wneu.2017.01.012","article-title":"Moyamoya and Inflammation","volume":"100","author":"JC Mejia-Munne","year":"2017","journal-title":"World neurosurgery"},{"issue":"3\u20134","key":"pone.0221811.ref017","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000442298","article-title":"Research Progresses in Understanding the Pathophysiology of Moyamoya Disease","volume":"41","author":"A Bersano","year":"2016","journal-title":"Cerebrovascular diseases (Basel, Switzerland)"},{"issue":"6","key":"pone.0221811.ref018","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1136\/jnnp.2009.191817","article-title":"Plasma matrix metalloproteinases, cytokines and angiogenic factors in moyamoya disease","volume":"81","author":"HS Kang","year":"2010","journal-title":"Journal of neurology, neurosurgery, and psychiatry"},{"issue":"4","key":"pone.0221811.ref019","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3171\/jns.1998.89.4.0623","article-title":"Role of transforming growth factor-beta1 in the pathogenesis of moyamoya disease","volume":"89","author":"M Hojo","year":"1998","journal-title":"Journal of neurosurgery"},{"issue":"4","key":"pone.0221811.ref020","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000121249","article-title":"Elevation of cerebrospinal fluid levels of basic fibroblast growth factor in moyamoya and central nervous system disorders","volume":"27","author":"AM Malek","year":"1997","journal-title":"Pediatric neurosurgery"},{"issue":"12","key":"pone.0221811.ref021","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1161\/01.STR.27.12.2160","article-title":"Angiogenic factors in moyamoya disease","volume":"27","author":"T Yoshimoto","year":"1996","journal-title":"Stroke"},{"issue":"5","key":"pone.0221811.ref022","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.3171\/2013.1.JNS12565","article-title":"Intracranial atherosclerotic disease associated with moyamoya collateral formation: histopathological findings","volume":"118","author":"T Jiang","year":"2013","journal-title":"Journal of neurosurgery"},{"issue":"2","key":"pone.0221811.ref023","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00381-010-1241-8","article-title":"Common genetic polymorphisms in moyamoya and atherosclerotic disease in Europeans","volume":"27","author":"C Roder","year":"2011","journal-title":"Child's nervous system: ChNS: official journal of the International Society for Pediatric Neurosurgery"},{"issue":"20","key":"pone.0221811.ref024","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1161\/CIRCULATIONAHA.112.136473","article-title":"Coronary artery stenosis in moyamoya disease: tissue characterization by 256-slice multi-detector CT and virtual histology","volume":"127","author":"JH Lee","year":"2013","journal-title":"Circulation"},{"key":"pone.0221811.ref025","doi-asserted-by":"crossref","first-page":"7124072","DOI":"10.1155\/2019\/7124072","article-title":"ST-Elevation Myocardial Infarction (STEMI) in a Patient with Moyamoya Disease","volume":"2019","author":"J Livesay","year":"2019","journal-title":"Case reports in cardiology"},{"issue":"12","key":"pone.0221811.ref026","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1161\/CIRCULATIONAHA.108.827782","article-title":"Image in cardiovascular medicine. Multiple coronary stenosis in infantile Moyamoya disease","volume":"119","author":"T Murakami","year":"2009","journal-title":"Circulation"},{"issue":"4","key":"pone.0221811.ref027","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3346\/jkms.2015.30.4.470","article-title":"Coronary heart disease in moyamoya disease: are they concomitant or coincidence?","volume":"30","author":"TM Nam","year":"2015","journal-title":"Journal of Korean medical science"},{"issue":"8","key":"pone.0221811.ref028","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/S0002-9149(99)00081-8","article-title":"Bilateral aortoostial coronary artery disease: moyamoya of the heart?","volume":"83","author":"FG St Goar","year":"1999","journal-title":"The American journal of cardiology"},{"issue":"1","key":"pone.0221811.ref029","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2176\/nmc.41.37","article-title":"Moyamoya disease and coronary artery disease\u2014case report","volume":"41","author":"M Komiyama","year":"2001","journal-title":"Neurologia medico-chirurgica"},{"issue":"11","key":"pone.0221811.ref030","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1161\/01.STR.22.11.1358","article-title":"Systemic vascular changes in spontaneous occlusion of the circle of Willis","volume":"22","author":"E Ikeda","year":"1991","journal-title":"Stroke"},{"issue":"3\u20134","key":"pone.0221811.ref031","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11568-008-9017-x","article-title":"Peripheral blood gene expression profiling for cardiovascular disease assessment","volume":"1","author":"H Aziz","year":"2007","journal-title":"Genomic medicine"},{"issue":"11","key":"pone.0221811.ref032","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1212\/WNL.0b013e3181f2b37f","article-title":"Genomic biomarkers and cellular pathways of ischemic stroke by RNA gene expression profiling","volume":"75","author":"TL Barr","year":"2010","journal-title":"Neurology"},{"issue":"13","key":"pone.0221811.ref033","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1152\/physiolgenomics.00243.2010","article-title":"Gene expression variation between African Americans and whites is associated with coronary artery calcification: the multiethnic study of atherosclerosis","volume":"43","author":"CC Huang","year":"2011","journal-title":"Physiological genomics"},{"issue":"6","key":"pone.0221811.ref034","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.thromres.2011.06.003","article-title":"Whole blood gene expression analyses in patients with single versus recurrent venous thromboembolism","volume":"128","author":"DA Lewis","year":"2011","journal-title":"Thrombosis research"},{"issue":"15","key":"pone.0221811.ref035","doi-asserted-by":"crossref","first-page":"12970","DOI":"10.18632\/oncotarget.4001","article-title":"Assessment and diagnostic relevance of novel serum biomarkers for early decision of ST-elevation myocardial infarction","volume":"6","author":"HJ Park","year":"2015","journal-title":"Oncotarget"},{"issue":"9","key":"pone.0221811.ref036","doi-asserted-by":"crossref","first-page":"e7037","DOI":"10.1371\/journal.pone.0007037","article-title":"Gene expression patterns in peripheral blood correlate with the extent of coronary artery disease","volume":"4","author":"PR Sinnaeve","year":"2009","journal-title":"PloS one"},{"issue":"5","key":"pone.0221811.ref037","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2176\/nmc.52.245","article-title":"Guidelines for diagnosis and treatment of moyamoya disease (spontaneous occlusion of the circle of Willis)","volume":"52","author":"Research Committee on the Pathology and Treatment of Spontaneous Occlusion of the Circle of Willis, Health Labour Sciences Research Grant for Research on Measures for Intractable Diseases","year":"2012","journal-title":"Neurologia medico-chirurgica"},{"issue":"1","key":"pone.0221811.ref038","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.gpb.2017.01.001","article-title":"GSA: Genome Sequence Archive","volume":"15","author":"Y Wang","year":"2017","journal-title":"Genomics, proteomics & bioinformatics"},{"issue":"1","key":"pone.0221811.ref039","first-page":"10","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"M Martin","year":"2011","journal-title":"EMBnetjournal"},{"issue":"1","key":"pone.0221811.ref040","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"A Dobin","year":"2013","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"2","key":"pone.0221811.ref041","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a Python framework to work with high-throughput sequencing data","volume":"31","author":"S Anders","year":"2015","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"12","key":"pone.0221811.ref042","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"MI Love","year":"2014","journal-title":"Genome biology"},{"key":"pone.0221811.ref043","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2164-15-33","article-title":"Sex differences in the human peripheral blood transcriptome","volume":"15","author":"R Jansen","year":"2014","journal-title":"BMC genomics"},{"issue":"2","key":"pone.0221811.ref044","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"RA Irizarry","year":"2003","journal-title":"Biostatistics (Oxford, England)"},{"issue":"22","key":"pone.0221811.ref045","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1093\/bioinformatics\/btl476","article-title":"RankProd: a bioconductor package for detecting differentially expressed genes in meta-analysis","volume":"22","author":"F Hong","year":"2006","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"10","key":"pone.0221811.ref046","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/ng.2756","article-title":"Systematic identification of trans eQTLs as putative drivers of known disease associations","volume":"45","author":"HJ Westra","year":"2013","journal-title":"Nature genetics"},{"key":"pone.0221811.ref047","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"AM Newman","year":"2015","journal-title":"Nature methods"},{"issue":"8","key":"pone.0221811.ref048","first-page":"e0182294","article-title":"The frontline of immune response in peripheral blood","volume":"12","author":"F Song","year":"2017"},{"issue":"3","key":"pone.0221811.ref049","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","article-title":"Structure and function of matrix metalloproteinases and TIMPs","volume":"69","author":"H Nagase","year":"2006","journal-title":"Cardiovascular research"},{"issue":"5","key":"pone.0221811.ref050","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.surneu.2008.10.009","article-title":"Increased expression of serum Matrix Metalloproteinase-9 in patients with moyamoya disease","volume":"72","author":"M Fujimura","year":"2009","journal-title":"Surgical neurology"},{"issue":"12","key":"pone.0221811.ref051","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1161\/01.STR.24.12.1960","article-title":"Smooth muscle cell proliferation and localization of macrophages and T cells in the occlusive intracranial major arteries in moyamoya disease","volume":"24","author":"J Masuda","year":"1993","journal-title":"Stroke"},{"issue":"6","key":"pone.0221811.ref052","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.3171\/jns.2005.102.6.1013","article-title":"Moyamoya disease associated with Graves disease: special considerations regarding clinical significance and management","volume":"102","author":"SH Im","year":"2005","journal-title":"Journal of neurosurgery"},{"issue":"5","key":"pone.0221811.ref053","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2176\/nmc.52.267","article-title":"Review of past research and current concepts on the etiology of moyamoya disease","volume":"52","author":"K Houkin","year":"2012","journal-title":"Neurologia medico-chirurgica"},{"key":"pone.0221811.ref054","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.brainres.2017.11.013","article-title":"Increased serum production of soluble CD163 and CXCL5 in patients with moyamoya disease: Involvement of intrinsic immune reaction in its pathogenesis","volume":"1679","author":"M Fujimura","year":"2018","journal-title":"Brain research"},{"issue":"2","key":"pone.0221811.ref055","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3171\/2013.9.JNS131000","article-title":"Smooth-muscle progenitor cells isolated from patients with moyamoya disease: novel experimental cell model","volume":"120","author":"HS Kang","year":"2014","journal-title":"Journal of neurosurgery"},{"issue":"5957","key":"pone.0221811.ref056","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1126\/science.1176009","article-title":"The extracellular matrix: not just pretty fibrils","volume":"326","author":"RO Hynes","year":"2009","journal-title":"Science (New York, NY)"},{"issue":"4","key":"pone.0221811.ref057","first-page":"1041","article-title":"Vascular smooth muscle cells from injured rat aortas display elevated matrix production associated with transforming growth factor-beta activity","volume":"147","author":"LM Rasmussen","year":"1995","journal-title":"The American journal of pathology"},{"issue":"22","key":"pone.0221811.ref058","doi-asserted-by":"crossref","first-page":"10759","DOI":"10.1073\/pnas.90.22.10759","article-title":"Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia","volume":"90","author":"EG Nabel","year":"1993","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"pone.0221811.ref059","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/jcp.1041550119","article-title":"Modulation of transforming growth factor-beta 1 stimulated elastin and collagen production and proliferation in porcine vascular smooth muscle cells and skin fibroblasts by basic fibroblast growth factor, transforming growth factor-alpha, and insulin-like growth factor-I","volume":"155","author":"JM Davidson","year":"1993","journal-title":"Journal of cellular physiology"},{"issue":"4787","key":"pone.0221811.ref060","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1126\/science.2432664","article-title":"Angiogenic factors","volume":"235","author":"J Folkman","year":"1987","journal-title":"Science (New York, NY)"},{"issue":"13","key":"pone.0221811.ref061","doi-asserted-by":"crossref","first-page":"9603","DOI":"10.1016\/S0021-9258(17)36924-7","article-title":"Transforming growth factor beta 1 stimulates type V collagen expression in bovine vascular smooth muscle cells","volume":"269","author":"R Lawrence","year":"1994","journal-title":"The Journal of biological chemistry"},{"key":"pone.0221811.ref062","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1046\/j.1440-1789.2000.00300.x","article-title":"Moyamoya disease","volume":"20","author":"M Fukui","year":"2000","journal-title":"Neuropathology: official journal of the Japanese Society of Neuropathology"},{"issue":"11","key":"pone.0221811.ref063","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1038\/jcbfm.2008.67","article-title":"Circulating endothelial progenitor cells as a pathogenetic marker of moyamoya disease","volume":"28","author":"KH Jung","year":"2008","journal-title":"Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"3","key":"pone.0221811.ref064","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/jnr.22228","article-title":"Decreased level and defective function of circulating endothelial progenitor cells in children with moyamoya disease","volume":"88","author":"JH Kim","year":"2010","journal-title":"Journal of neuroscience research"},{"issue":"2","key":"pone.0221811.ref065","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1161\/STROKEAHA.108.529420","article-title":"Increased levels of circulating endothelial progenitor cells in patients with Moyamoya disease","volume":"40","author":"N Rafat","year":"2009","journal-title":"Stroke"},{"issue":"6","key":"pone.0221811.ref066","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/jcbfm.2008.1","article-title":"Increase in circulating CD34-positive cells in patients with angiographic evidence of moyamoya-like vessels","volume":"28","author":"T Yoshihara","year":"2008","journal-title":"Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"1","key":"pone.0221811.ref067","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1038\/s41598-017-03278-8","article-title":"Association of increased Treg and Th17 with pathogenesis of moyamoya disease","volume":"7","author":"L Weng","year":"2017","journal-title":"Scientific reports"},{"issue":"6","key":"pone.0221811.ref068","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/CRD.0000000000000006","article-title":"Inflammation in coronary artery disease","volume":"22","author":"G Christodoulidis","year":"2014","journal-title":"Cardiology in review"},{"key":"pone.0221811.ref069","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.3389\/fimmu.2018.02031","article-title":"Stress and Inflammation in Coronary Artery Disease: A Review Psychoneuroendocrineimmunology-Based","volume":"9","author":"M Fioranelli","year":"2018","journal-title":"Frontiers in immunology"},{"issue":"21","key":"pone.0221811.ref070","first-page":"3568","article-title":"Inflammation in coronary artery diseases","volume":"124","author":"JJ Li","year":"2011","journal-title":"Chinese medical journal"},{"issue":"2","key":"pone.0221811.ref071","doi-asserted-by":"crossref","first-page":"456s","DOI":"10.1093\/ajcn\/83.2.456S","article-title":"Inflammation and cardiovascular disease mechanisms","volume":"83","author":"P Libby","year":"2006","journal-title":"The American journal of clinical nutrition"},{"issue":"5","key":"pone.0221811.ref072","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/biof.1024","article-title":"Inflammatory markers in coronary artery disease","volume":"38","author":"I Ikonomidis","year":"2012","journal-title":"BioFactors (Oxford, England)"},{"key":"pone.0221811.ref073","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2741\/s508","article-title":"Inflammatory biomarkers of coronary heart disease","volume":"10","author":"H Li","year":"2018","journal-title":"Frontiers in bioscience (Scholar edition)"},{"key":"pone.0221811.ref074","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/bmb\/ldr043","article-title":"Inflammatory markers in coronary heart disease","volume":"100","author":"M Madjid","year":"2011","journal-title":"British medical bulletin"},{"issue":"22","key":"pone.0221811.ref075","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.2174\/0929867322666150420124427","article-title":"Novel Inflammatory Biomarkers in Coronary Artery Disease: Potential Therapeutic Approaches","volume":"22","author":"KV Voudris","year":"2015","journal-title":"Current medicinal chemistry"},{"issue":"1","key":"pone.0221811.ref076","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1038\/s41598-018-21482-y","article-title":"Prediction of coronary disease incidence by biomarkers of inflammation, oxidation, and metabolism","volume":"8","author":"I Subirana","year":"2018","journal-title":"Scientific reports"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0221811","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T14:41:24Z","timestamp":1721745684000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0221811"}},"subtitle":[],"editor":[{"given":"Zhejun","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,9,18]]},"references-count":76,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0221811","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,18]]}}}