{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:43:02Z","timestamp":1791924182869,"version":"4.3.4"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0221957","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T17:25:13Z","timestamp":1568827513000},"page":"e0221957","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4588-8280","authenticated-orcid":true,"given":"Patrick N.","family":"Cunningham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan L.","family":"Grove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda M.","family":"Cooper-DeHoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber L.","family":"Beitelshees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Gums","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen T.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Boerwinkle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene B.","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,9,18]]},"reference":[{"issue":"1","key":"pone.0221957.ref001","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1001\/2013.jamainternmed.857","article-title":"Racial differences in the impact of elevated systolic blood pressure on stroke risk","volume":"173","author":"G Howard","year":"2013","journal-title":"JAMA Intern Med"},{"issue":"9","key":"pone.0221957.ref002","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1681\/ASN.2010070730","article-title":"The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans","volume":"21","author":"BI Freedman","year":"2010","journal-title":"J Am Soc Nephrol"},{"issue":"5993","key":"pone.0221957.ref003","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1193032","article-title":"Association of trypanolytic ApoL1 variants with kidney disease in African Americans","volume":"329","author":"G Genovese","year":"2010","journal-title":"Science"},{"issue":"10","key":"pone.0221957.ref004","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/ng.226","article-title":"MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis","volume":"40","author":"JB Kopp","year":"2008","journal-title":"Nat Genet"},{"issue":"5","key":"pone.0221957.ref005","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1161\/CIRCRESAHA.114.302347","article-title":"Increased burden of cardiovascular disease in carriers of APOL1 genetic variants","volume":"114","author":"K Ito","year":"2014","journal-title":"Circ Res"},{"issue":"2","key":"pone.0221957.ref006","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1161\/ATVBAHA.115.305970","article-title":"APOL1 Genotype, Kidney and Cardiovascular Disease, and Death in Older Adults","volume":"36","author":"KJ Mukamal","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"pone.0221957.ref007","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.kint.2016.04.027","article-title":"APOL1 renal-risk variants associate with reduced cerebral white matter lesion volume and increased gray matter volume","volume":"90","author":"BI Freedman","year":"2016","journal-title":"Kidney Int"},{"issue":"1","key":"pone.0221957.ref008","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/ki.2014.255","article-title":"APOL1 associations with nephropathy, atherosclerosis, and all-cause mortality in African Americans with type 2 diabetes","volume":"87","author":"BI Freedman","year":"2015","journal-title":"Kidney Int"},{"issue":"1","key":"pone.0221957.ref009","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/ki.2014.254","article-title":"Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial","volume":"87","author":"CD Langefeld","year":"2015","journal-title":"Kidney Int"},{"issue":"2","key":"pone.0221957.ref010","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.kint.2016.02.032","article-title":"APOL1 renal-risk genotypes associate with longer hemodialysis survival in prevalent nondiabetic African American patients with end-stage renal disease","volume":"90","author":"L Ma","year":"2016","journal-title":"Kidney Int"},{"issue":"4","key":"pone.0221957.ref011","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.kint.2017.03.028","article-title":"APOL1 genetic variants are not associated with longitudinal blood pressure in young black adults","volume":"92","author":"TK Chen","year":"2017","journal-title":"Kidney Int"},{"issue":"4","key":"pone.0221957.ref012","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.kint.2017.05.030","article-title":"APOL1 and blood pressure changes in young adults","volume":"92","author":"GN Nadkarni","year":"2017","journal-title":"Kidney Int"},{"issue":"12","key":"pone.0221957.ref013","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.jacc.2017.01.040","article-title":"Apolipoprotein L1 Variants and Blood Pressure Traits in African Americans","volume":"69","author":"GN Nadkarni","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"pone.0221957.ref014","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1161\/CIRCGENETICS.112.964080","article-title":"Hypertension susceptibility loci and blood pressure response to antihypertensives: results from the pharmacogenomic evaluation of antihypertensive responses study","volume":"5","author":"Y Gong","year":"2012","journal-title":"Circ Cardiovasc Genet"},{"issue":"2","key":"pone.0221957.ref015","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1161\/HYPERTENSIONAHA.111.00436","article-title":"Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide","volume":"62","author":"ST Turner","year":"2013","journal-title":"Hypertension"},{"issue":"3","key":"pone.0221957.ref016","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1046\/j.1523-1755.2002.00200.x","article-title":"Predictors of antihypertensive response to a standard dose of hydrochlorothiazide for essential hypertension","volume":"61","author":"AB Chapman","year":"2002","journal-title":"Kidney Int"},{"issue":"9","key":"pone.0221957.ref017","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ajh.2010.98","article-title":"Plasma renin activity predicts blood pressure responses to beta-blocker and thiazide diuretic as monotherapy and add-on therapy for hypertension","volume":"23","author":"ST Turner","year":"2010","journal-title":"Am J Hypertens"},{"issue":"3","key":"pone.0221957.ref018","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1161\/HYPERTENSIONAHA.115.06345","article-title":"Pharmacogenomic Genome-Wide Meta-Analysis of Blood Pressure Response to beta-Blockers in Hypertensive African Americans","volume":"67","author":"Y Gong","year":"2016","journal-title":"Hypertension"},{"issue":"1","key":"pone.0221957.ref019","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/ajh.2007.24","article-title":"Predictors of blood pressure response to the angiotensin receptor blocker candesartan in essential hypertension","volume":"21","author":"VJ Canzanello","year":"2008","journal-title":"Am J Hypertens"},{"issue":"2","key":"pone.0221957.ref020","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/clpt.2014.62","article-title":"Impact of CYP2D6 polymorphisms on clinical efficacy and tolerability of metoprolol tartrate","volume":"96","author":"IS Hamadeh","year":"2014","journal-title":"Clin Pharmacol Ther"},{"issue":"3","key":"pone.0221957.ref021","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ahj.2008.11.018","article-title":"Pharmacogenomics of antihypertensive drugs: rationale and design of the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) study","volume":"157","author":"JA Johnson","year":"2009","journal-title":"Am Heart J"},{"issue":"7","key":"pone.0221957.ref022","doi-asserted-by":"crossref","first-page":"e68095","DOI":"10.1371\/journal.pone.0068095","article-title":"Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium","volume":"8","author":"ML Grove","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"pone.0221957.ref023","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.clpt.2004.08.020","article-title":"Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension","volume":"76","author":"I Zineh","year":"2004","journal-title":"Clin Pharmacol Ther"},{"issue":"8","key":"pone.0221957.ref024","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1002\/gepi.20533","article-title":"MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes","volume":"34","author":"Y Li","year":"2010","journal-title":"Genet Epidemiol"},{"key":"pone.0221957.ref025","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.genom.9.081307.164242","article-title":"Genotype imputation","volume":"10","author":"Y Li","year":"2009","journal-title":"Annu Rev Genomics Hum Genet"},{"issue":"3","key":"pone.0221957.ref026","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/clpt.2008.218","article-title":"Impact of the CYP2D6 genotype on the clinical effects of metoprolol: a prospective longitudinal study","volume":"85","author":"T Rau","year":"2009","journal-title":"Clin Pharmacol Ther"},{"issue":"11","key":"pone.0221957.ref027","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1681\/ASN.2014050469","article-title":"APOL1 Risk Variants Are Strongly Associated with HIV-Associated Nephropathy in Black South Africans","volume":"26","author":"AN Kasembeli","year":"2015","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"pone.0221957.ref028","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.semnephrol.2015.04.008","article-title":"APOL1 Kidney Disease Risk Variants: An Evolving Landscape","volume":"35","author":"PD Dummer","year":"2015","journal-title":"Semin Nephrol"},{"issue":"2","key":"pone.0221957.ref029","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1681\/ASN.2013091017","article-title":"Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines","volume":"26","author":"L Ma","year":"2015","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"pone.0221957.ref030","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1161\/ATVBAHA.117.309384","article-title":"APOL1 Risk Variants and Cardiovascular Disease: Results From the AASK (African American Study of Kidney Disease and Hypertension)","volume":"37","author":"TK Chen","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"pone.0221957.ref031","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ekir.2017.08.007","article-title":"APOL1 Risk Variants Independently Associated With Early Cardiovascular Disease Death","volume":"3","author":"MD Hughson","year":"2018","journal-title":"Kidney Int Rep"},{"issue":"8","key":"pone.0221957.ref032","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1001\/jamacardio.2018.1827","article-title":"Association of APOL1 With Heart Failure With Preserved Ejection Fraction in Postmenopausal African American Women","volume":"3","author":"N Franceschini","year":"2018","journal-title":"JAMA Cardiol"},{"issue":"1","key":"pone.0221957.ref033","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/modpathol.2014.92","article-title":"Histopathologic findings associated with APOL1 risk variants in chronic kidney disease","volume":"28","author":"CP Larsen","year":"2015","journal-title":"Mod Pathol"},{"issue":"9","key":"pone.0221957.ref034","doi-asserted-by":"crossref","first-page":"878","DOI":"10.4330\/wjc.v6.i9.878","article-title":"African Americans, hypertension and the renin angiotensin system","volume":"6","author":"SF Williams","year":"2014","journal-title":"World J Cardiol"},{"issue":"1","key":"pone.0221957.ref035","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1161\/01.HYP.26.1.124","article-title":"Differing mechanisms of action of angiotensin-converting enzyme inhibition in black and white hypertensive patients. The Trandolapril Multicenter Study Group","volume":"26","author":"MR Weir","year":"1995","journal-title":"Hypertension"},{"issue":"2","key":"pone.0221957.ref036","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1046\/j.1523-1755.1999.00579.x","article-title":"Renal response to captopril reflects state of local renin system in healthy humans","volume":"56","author":"ND Fisher","year":"1999","journal-title":"Kidney Int"},{"issue":"11","key":"pone.0221957.ref037","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1681\/ASN.V10112382","article-title":"The paradox of the low-renin state in diabetic nephropathy","volume":"10","author":"DA Price","year":"1999","journal-title":"J Am Soc Nephrol"},{"issue":"7","key":"pone.0221957.ref038","doi-asserted-by":"crossref","first-page":"4419","DOI":"10.4049\/jimmunol.176.7.4419","article-title":"CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues","volume":"176","author":"DM Kraus","year":"2006","journal-title":"J Immunol"},{"issue":"6","key":"pone.0221957.ref039","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1097\/HJH.0000000000000541","article-title":"TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives","volume":"33","author":"M Chittani","year":"2015","journal-title":"J Hypertens"},{"issue":"6","key":"pone.0221957.ref040","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/CIRCGENETICS.113.000307","article-title":"Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese","volume":"6","author":"J He","year":"2013","journal-title":"Circ Cardiovasc Genet"},{"issue":"4","key":"pone.0221957.ref041","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1248\/bpb.29.772","article-title":"Multiple regression analysis of pharmacogenetic variability of carvedilol disposition in 54 healthy Japanese volunteers","volume":"29","author":"M Honda","year":"2006","journal-title":"Biol Pharm Bull"},{"issue":"10","key":"pone.0221957.ref042","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.5551\/jat.4291","article-title":"Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population","volume":"17","author":"H Koriyama","year":"2010","journal-title":"J Atheroscler Thromb"},{"issue":"6","key":"pone.0221957.ref043","doi-asserted-by":"crossref","first-page":"448","DOI":"10.4161\/chan.3.6.10216","article-title":"A novel N-terminal motif of dipeptidyl peptidase-like proteins produces rapid inactivation of KV4.2 channels by a pore-blocking mechanism","volume":"3","author":"HH Jerng","year":"2009","journal-title":"Channels (Austin)"},{"issue":"4","key":"pone.0221957.ref044","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.jmb.2004.09.003","article-title":"Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family","volume":"343","author":"P Strop","year":"2004","journal-title":"J Mol Biol"},{"issue":"24","key":"pone.0221957.ref045","first-page":"2989","article-title":"Association between DPP6 polymorphism and the risk of sporadic amyotrophic lateral sclerosis in Chinese patients","volume":"122","author":"XG Li","year":"2009","journal-title":"Chin Med J (Engl)"},{"issue":"9","key":"pone.0221957.ref046","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.ejmg.2013.06.008","article-title":"Loss-of-function variation in the DPP6 gene is associated with autosomal dominant microcephaly and mental retardation","volume":"56","author":"C Liao","year":"2013","journal-title":"Eur J Med Genet"},{"issue":"4","key":"pone.0221957.ref047","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10048-014-0418-9","article-title":"DPP6 gene disruption in a family with Gilles de la Tourette syndrome","volume":"15","author":"P Prontera","year":"2014","journal-title":"Neurogenetics"},{"issue":"4","key":"pone.0221957.ref048","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.hrthm.2015.12.006","article-title":"Detailed characterization of familial idiopathic ventricular fibrillation linked to the DPP6 locus","volume":"13","author":"JN Ten Sande","year":"2016","journal-title":"Heart Rhythm"},{"issue":"19","key":"pone.0221957.ref049","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1001\/jama.288.19.2421","article-title":"Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial","volume":"288","author":"JT Wright","year":"2002","journal-title":"Jama"},{"issue":"3","key":"pone.0221957.ref050","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/bcpt.12682","article-title":"Gene-Gene Interactions Among PRKCA, NOS3 and BDKRB2 Polymorphisms Affect the Antihypertensive Effects of Enalapril","volume":"120","author":"GH Oliveira-Paula","year":"2017","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"6","key":"pone.0221957.ref051","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/HYP.0b013e31825b30f8","article-title":"Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker","volume":"59","author":"ST Turner","year":"2012","journal-title":"Hypertension"},{"issue":"8","key":"pone.0221957.ref052","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1093\/ajh\/hpt047","article-title":"The role of plasma renin activity, age, and race in selecting effective initial drug therapy for hypertension","volume":"26","author":"GL Schwartz","year":"2013","journal-title":"Am J Hypertens"},{"issue":"2","key":"pone.0221957.ref053","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.kint.2016.09.033","article-title":"Strict blood pressure control associates with decreased mortality risk by APOL1 genotype","volume":"91","author":"E Ku","year":"2017","journal-title":"Kidney Int"},{"key":"pone.0221957.ref054","article-title":"APOL1-G1 in Nephrocytes Induces Hypertrophy and Accelerates Cell Death","author":"Y Fu","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"pone.0221957.ref055","article-title":"APOL1-Mediated Cell Injury Involves Disruption of Conserved Trafficking Processes","author":"E Kruzel-Davila","year":"2016","journal-title":"J Am Soc Nephrol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0221957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:21:38Z","timestamp":1664410898000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0221957"}},"subtitle":[],"editor":[{"given":"Tatsuo","family":"Shimosawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,9,18]]},"references-count":55,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0221957","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,18]]}}}