{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:05:42Z","timestamp":1790172342512,"version":"4.1.0"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["Nos 81502360"],"award-info":[{"award-number":["Nos 81502360"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0221964","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T17:27:22Z","timestamp":1568136442000},"page":"e0221964","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Association of antibiotic exposure with the mortality in metastatic colorectal cancer patients treated with bevacizumab-containing chemotherapy: A hospital-based retrospective cohort study"],"prefix":"10.1371","volume":"14","author":[{"given":"Linbin","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erqian","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5316-6512","authenticated-orcid":true,"given":"Xiong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,9,10]]},"reference":[{"issue":"2","key":"pone.0221964.ref001","first-page":"87","article-title":"Global cancer statistics, 2012","volume":"65","author":"LA Torre","year":"2015","journal-title":"CA: a cancer journal for clinicians"},{"issue":"23","key":"pone.0221964.ref002","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1056\/NEJMoa032691","article-title":"Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer","volume":"350","author":"H Hurwitz","year":"2004","journal-title":"The New England journal of medicine"},{"issue":"12","key":"pone.0221964.ref003","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1200\/JCO.2006.09.6305","article-title":"Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200","volume":"25","author":"BJ Giantonio","year":"2007","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"issue":"3","key":"pone.0221964.ref004","doi-asserted-by":"crossref","first-page":"370","DOI":"10.6004\/jnccn.2017.0036","article-title":"Colon Cancer, Version 1.2017, NCCN Clinical Practice Guidelines in Oncology","volume":"15","author":"AB Benson","year":"2017","journal-title":"Journal of the National Comprehensive Cancer Network: JNCCN"},{"issue":"6","key":"pone.0221964.ref005","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1053\/j.gastro.2017.08.022","article-title":"Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice","volume":"153","author":"SH Wong","year":"2017","journal-title":"Gastroenterology"},{"issue":"6103","key":"pone.0221964.ref006","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1126\/science.1224820","article-title":"Intestinal inflammation targets cancer-inducing activity of the microbiota","volume":"338","author":"JC Arthur","year":"2012","journal-title":"Science (New York, NY)"},{"issue":"3","key":"pone.0221964.ref007","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.cell.2017.07.008","article-title":"Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy","volume":"170","author":"T Yu","year":"2017","journal-title":"Cell"},{"issue":"6","key":"pone.0221964.ref008","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nrgastro.2017.20","article-title":"Gut microbiota modulation of chemotherapy efficacy and toxicity","volume":"14","author":"JL Alexander","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"6161","key":"pone.0221964.ref009","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1126\/science.1240537","article-title":"The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide","volume":"342","author":"S Viaud","year":"2013","journal-title":"Science (New York, NY)"},{"issue":"6264","key":"pone.0221964.ref010","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.aad1329","article-title":"Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota","volume":"350","author":"M Vetizou","year":"2015","journal-title":"Science (New York, NY)"},{"issue":"6161","key":"pone.0221964.ref011","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1126\/science.1240527","article-title":"Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment","volume":"342","author":"N Iida","year":"2013","journal-title":"Science (New York, NY)"},{"issue":"6005","key":"pone.0221964.ref012","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1126\/science.1191175","article-title":"Alleviating cancer drug toxicity by inhibiting a bacterial enzyme","volume":"330","author":"BD Wallace","year":"2010","journal-title":"Science (New York, NY)"},{"key":"pone.0221964.ref013","article-title":"Commensal Bifidobacterium promotes antitumor immunity and facilitates anti\u2013PD-L1 efficacy","author":"ASL Corrales","year":"2015","journal-title":"Science (New York, NY)"},{"key":"pone.0221964.ref014","unstructured":"Gut microbiome influences efficacy of PD-1\u2013based immunotherapy against epithelial tumors."},{"issue":"6","key":"pone.0221964.ref015","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/annonc\/mdy103","article-title":"Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer","volume":"29","author":"L Derosa","year":"2018","journal-title":"Ann Oncol"},{"issue":"3","key":"pone.0221964.ref016","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3164\/jcbn.16-107","article-title":"Chemopreventive effects of a low-side-effect antibiotic drug, erythromycin, on mouse intestinal tumors","volume":"60","author":"T Hamoya","year":"2017","journal-title":"Journal of clinical biochemistry and nutrition"},{"issue":"6369","key":"pone.0221964.ref017","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1126\/science.aal5240","article-title":"Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer","volume":"358","author":"S Bullman","year":"2017","journal-title":"Science (New York, NY)"},{"issue":"12","key":"pone.0221964.ref018","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.15252\/emmm.201606531","article-title":"Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization","volume":"8","author":"EM Andriessen","year":"2016","journal-title":"EMBO molecular medicine"},{"issue":"4","key":"pone.0221964.ref019","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1158\/2159-8290.CD-17-1134","article-title":"The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression","volume":"8","author":"S Pushalkar","year":"2018","journal-title":"Cancer discovery"},{"key":"pone.0221964.ref020","article-title":"Commensal Microbiota Promote Lung Cancer Development via gamma-delta T Cells","author":"C Jin","year":"2019","journal-title":"Cell"},{"issue":"5","key":"pone.0221964.ref021","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/gut.34.5.611","article-title":"Sex differences in the incidence of colorectal cancer: an exploration of oestrogen and progesterone receptors","volume":"34","author":"S Singh","year":"1993","journal-title":"Gut"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0221964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:40:50Z","timestamp":1588966850000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0221964"}},"subtitle":[],"editor":[{"given":"Jason Chia-Hsun","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,9,10]]},"references-count":21,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0221964","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,10]]}}}