{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:04:24Z","timestamp":1788671064477,"version":"build-2803163510"},"reference-count":92,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0221973","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T17:35:37Z","timestamp":1572456937000},"page":"e0221973","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Multi-breed genome-wide association studies across countries for electronically recorded behavior traits in local dual-purpose cows"],"prefix":"10.1371","volume":"14","author":[{"given":"Tong","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Jaeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1189-2297","authenticated-orcid":true,"given":"Carsten","family":"Scheper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorz","family":"Grodkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2264-4638","authenticated-orcid":true,"given":"Tomasz","family":"Sakowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0790-980X","authenticated-orcid":true,"given":"Marija","family":"Klop\u010di\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Bapst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"pone.0221973.ref001","first-page":"623","article-title":"Inheritance of behavioural characteristics in livestock: A review","volume":"54","author":"WD Hohenboken","year":"1986","journal-title":"Anim Breed Abstr"},{"key":"pone.0221973.ref002","volume-title":"Foraging behaviour: experience or inheritance: Grazing behaviour of livestock and wildlife","author":"K. L. Launchbaugh","year":"1999"},{"key":"pone.0221973.ref003","doi-asserted-by":"crossref","first-page":"486","DOI":"10.2527\/2001.792486x","article-title":"Genetic and phenotypic parameters for dietary selection of mountain big sagebrush (Artemisia tridentata Nutt. ssp. vaseyana [Rydb] Beetle) in Rambouillet sheep","volume":"79","author":"GD Snowder","year":"2001","journal-title":"J Anim Sci"},{"key":"pone.0221973.ref004","doi-asserted-by":"crossref","first-page":"E31","DOI":"10.3168\/jds.S0022-0302(01)70194-4","article-title":"Genetic Control of Dairy Cattle Behavior","volume":"84","author":"MM Schutz","year":"2001","journal-title":"Journal of Dairy Science"},{"key":"pone.0221973.ref005","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3168\/jds.2015-9838","article-title":"An investigation into genetic and phenotypic variation in time budgets and yield of dairy cows","volume":"99","author":"P L\u00f8vendahl","year":"2016","journal-title":"Journal of Dairy Science"},{"key":"pone.0221973.ref006","doi-asserted-by":"crossref","first-page":"9635","DOI":"10.3168\/jds.2016-12511","article-title":"Genetic parameters of rumination time and feed efficiency traits in primiparous Holstein cows under research and commercial conditions","volume":"100","author":"MV Byskov","year":"2017","journal-title":"Journal of Dairy Science"},{"key":"pone.0221973.ref007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.livsci.2013.01.016","article-title":"Genetic analysis and evaluation of behavioural traits in cattle","volume":"154","author":"K Adamczyk","year":"2013","journal-title":"Livestock Science"},{"key":"pone.0221973.ref008","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1007\/s11033-011-1229-9","article-title":"Analysis of multiple polymorphisms in the bovine neuropeptide Y5 receptor gene and structural modelling of the encoded protein","volume":"39","author":"T Alam","year":"2012","journal-title":"Mol Biol Rep"},{"key":"pone.0221973.ref009","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1007\/s11033-011-1133-3","article-title":"Identification and analysis of MC4R polymorphisms and their association with economic traits of Korean cattle (Hanwoo)","volume":"39","author":"J Seong","year":"2012","journal-title":"Mol Biol Rep"},{"key":"pone.0221973.ref010","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1471-2164-15-62","article-title":"Multibreed genome wide association can improve precision of mapping causative variants underlying milk production in dairy cattle","volume":"15","author":"L-A Raven","year":"2014","journal-title":"BMC Genomics"},{"key":"pone.0221973.ref011","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1534\/genetics.107.084301","article-title":"Linkage disequilibrium and persistence of phase in Holstein-Friesian, Jersey and Angus cattle","volume":"179","author":"AP de Roos","year":"2008","journal-title":"Genetics"},{"key":"pone.0221973.ref012","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1126\/science.1167936","article-title":"Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds","volume":"324","author":"Bovine HapMap Consortium","year":"2009","journal-title":"Science"},{"key":"pone.0221973.ref013","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1297-9686-42-5","article-title":"The impact of genetic relationship information on genomic breeding values in German Holstein cattle","volume":"42","author":"D Habier","year":"2010","journal-title":"Genet Sel Evol"},{"key":"pone.0221973.ref014","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1101\/gr.3147604","article-title":"Extensive and breed-specific linkage disequilibrium in Canis familiaris","volume":"14","author":"NB Sutter","year":"2004","journal-title":"Genome Res"},{"key":"pone.0221973.ref015","first-page":"167","article-title":"An interpretive review of selective sweep studies in Bos taurus cattle populations: identification of unique and shared selection signals across breeds","volume":"6","author":"B Guti\u00e9rrez-Gil","year":"2015","journal-title":"Front Genet"},{"key":"pone.0221973.ref016","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1186\/s12864-015-2181-1","article-title":"WIDDE: a Web-Interfaced next generation database for genetic diversity exploration, with a first application in cattle","volume":"16","author":"G Semp\u00e9r\u00e9","year":"2015","journal-title":"BMC Genomics"},{"key":"pone.0221973.ref017","first-page":"5","article-title":"Insights into the genetic history of French cattle from dense SNP data on 47 worldwide breeds","author":"M Gautier","year":"2010","journal-title":"PLoS ONE"},{"key":"pone.0221973.ref018","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.livsci.2014.05.008","article-title":"Genomic evaluation of cattle in a multi-breed context","volume":"166","author":"MS Lund","journal-title":"Livestock Science. 2014"},{"key":"pone.0221973.ref019","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12711-016-0254-5","article-title":"Identification of selective sweeps reveals divergent selection between Chinese Holstein and Simmental cattle populations","volume":"48","author":"M Chen","year":"2016","journal-title":"Genetics Selection Evolution"},{"key":"pone.0221973.ref020","unstructured":"M\u00fcgge, B., Lutz, W.E., S\u00fcdbeck, H., Zelfel, S. Deutsche Holsteins. Die Geschichte einer Zucht.: Verlag Eugen Ulmer.; 1999."},{"key":"pone.0221973.ref021","first-page":"262","article-title":"Studien zur Inzucht und Verwandtschaft beim 'Deutschen Schwarzbunten Niederungsrind' (DSN) auf Basis eigens berechneter Rasseanteile","volume":"90","author":"M. Jaeger","year":"2018","journal-title":"Z\u00fcchtungskunde"},{"key":"pone.0221973.ref022","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1365-2052.2009.02016.x","article-title":"A genome-wide scan for signatures of recent selection in Holstein cattle","volume":"41","author":"S Qanbari","year":"2010","journal-title":"Anim Genet"},{"key":"pone.0221973.ref023","volume-title":"Tropical cattle: origins, breeds and breeding policies","author":"WJA Payne","year":"1997"},{"key":"pone.0221973.ref024","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1017\/S1751731116001063","article-title":"Pancorbo MM de. Genetic characterization and founder effect analysis of recently introduced Salers cattle breed population","volume":"11","author":"D Gamarra","year":"2017","journal-title":"Animal"},{"key":"pone.0221973.ref025","volume-title":"History of Hereford Cattle","author":"E Heath-Agnew","year":"1983"},{"key":"pone.0221973.ref026","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.3168\/jds.2013-7543","article-title":"Genomic selection for producer-recorded health event data in US dairy cattle","volume":"97","author":"KL Parker Gaddis","year":"2014","journal-title":"Journal of Dairy Science"},{"key":"pone.0221973.ref027","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.3168\/jds.2018-15333","article-title":"Genomic selection of milk fatty acid composition in Sarda dairy sheep: Effect of different phenotypes and relationship matrices on heritability and breeding value accuracy","volume":"102","author":"A Cesarani","year":"2019","journal-title":"Journal of Dairy Science"},{"key":"pone.0221973.ref028","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3920\/978-90-8686-712-7_12","volume-title":"Modelling nutrient digestion and utilisation in farm animals","author":"P N\u00f8rgaard","year":"2011"},{"key":"pone.0221973.ref029","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.3168\/jds.S0022-0302(97)76075-2","article-title":"Creating a System for Meeting the Fiber Requirements of Dairy Cows","volume":"80","author":"DR Mertens","year":"1997","journal-title":"Journal of Dairy Science"},{"key":"pone.0221973.ref030","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.3168\/jds.S0022-0302(02)74271-9","article-title":"Effects of Forage Particle Size and Grain Fermentability in Midlactation Cows. II. Ruminal pH and Chewing Activity","volume":"85","author":"KM Krause","year":"2002","journal-title":"Journal of Dairy Science"},{"key":"pone.0221973.ref031","doi-asserted-by":"crossref","first-page":"6486","DOI":"10.3168\/jds.2015-9614","article-title":"Short communication: grazing pattern of dairy cows that were selected for divergent residual feed intake as calves","volume":"98","author":"P Gregorini","year":"2015","journal-title":"Journal of Dairy Science"},{"key":"pone.0221973.ref032","unstructured":"European Commission. An overview of estimates of costs of production and gross margins of milk production in the EU: EU Agricultural and Farm Economics Briefs. Available: https:\/\/ec.europa.eu\/agriculture\/sites\/agriculture\/files\/rural-area-economics\/briefs\/pdf\/016_en.pdf. Accessed 23 August 2018."},{"key":"pone.0221973.ref033","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.3168\/jds.S0022-0302(98)75673-5","article-title":"Selection for Economic Efficiency of Dairy Cattle Using Information on Live Weight and Feed Intake: A Review","volume":"81","author":"RF Veerkamp","year":"1998","journal-title":"Journal of Dairy Science"},{"key":"pone.0221973.ref034","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.livprodsci.2004.06.011","article-title":"Genetic parameters for feed efficiency, fatness, muscle area and feeding behaviour of feedlot finished beef cattle","volume":"90","author":"DL Robinson","year":"2004","journal-title":"Livestock Production Science"},{"key":"pone.0221973.ref035","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0301-6226(00)00234-7","article-title":"Behaviour, performance and health indicators of welfare for dairy cows housed in strawyard or cubicle systems","volume":"68","author":"JA Fregonesi","year":"2001","journal-title":"Livestock Production Science"},{"key":"pone.0221973.ref036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0022029909990227","article-title":"Influence of milk yield, stage of lactation, and body condition on dairy cattle lying behaviour measured using an automated activity monitoring sensor","volume":"77","author":"JM Bewley","year":"2010","journal-title":"J Dairy Res"},{"key":"pone.0221973.ref037","first-page":"68","article-title":"Use of Accelerometer Data for Genetic Evaluation in Dairy Cattle","volume":"48","author":"K Sch\u00f6pke","year":"2014","journal-title":"Interbull Bulletin"},{"key":"pone.0221973.ref038","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.3168\/jds.2014-8940","article-title":"Estrus traits derived from activity measurements are heritable and closely related to the time from calving to first insemination","volume":"98","author":"A Ismael","year":"2015","journal-title":"Journal of Dairy Science"},{"key":"pone.0221973.ref039","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.5665\/sleep.6170","article-title":"Heritability and Genome-Wide Association Analyses of Sleep Duration in Children: The EAGLE Consortium","volume":"39","author":"M Marinelli","year":"2016","journal-title":"Sleep"},{"key":"pone.0221973.ref040","doi-asserted-by":"crossref","first-page":"12340","DOI":"10.1038\/s41598-017-12460-x","article-title":"Heritability of siesta and night-time sleep as continuously assessed by a circadian-related integrated measure","volume":"7","author":"J Lopez-Minguez","journal-title":"Sci Rep"},{"key":"pone.0221973.ref041","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.3168\/jds.2011-4306","article-title":"Heritability of rectal temperature and genetic correlations with production and reproduction traits in dairy cattle","volume":"95","author":"S Dikmen","year":"2012","journal-title":"Journal of Dairy Science"},{"key":"pone.0221973.ref042","unstructured":"Adnan Jabbar Jadoa Al-Kanaan. Heat stress response for physiological traits in dairy and dual-purpose cattle populations on phenotypic and genetic scales. PhD Thesis, Department of Animal Breeding, Faculty of Organic Agriculture, Kassel University. 2016."},{"key":"pone.0221973.ref043","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1017\/S1751731116000616","article-title":"Heritability of body surface temperature in hens estimated by infrared thermography at normal or hot temperatures and genetic correlations with egg and feather quality","volume":"10","author":"T Loyau","year":"2016","journal-title":"Animal"},{"key":"pone.0221973.ref044","first-page":"137","author":"DM Seath","year":"1947","journal-title":"Heritability of Heat Tolerance in Dairy Cattle"},{"key":"pone.0221973.ref045","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/j.1365-2052.2012.02323.x","article-title":"Genome-wide association analysis for quantitative trait loci influencing Warner-Bratzler shear force in five taurine cattle breeds","volume":"43","author":"MC McClure","year":"2012","journal-title":"Anim Genet"},{"key":"pone.0221973.ref046","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12711-017-0344-z","article-title":"Within-breed and multi-breed GWAS on imputed whole-genome sequence variants reveal candidate mutations affecting milk protein composition in dairy cattle","volume":"49","author":"M-P Sanchez","year":"2017","journal-title":"Genet Sel Evol"},{"key":"pone.0221973.ref047","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.ajhg.2012.10.010","article-title":"Improved heritability estimation from genome-wide SNPs","volume":"91","author":"D Speed","year":"2012","journal-title":"Am J Hum Genet"},{"key":"pone.0221973.ref048","doi-asserted-by":"crossref","first-page":"32894","DOI":"10.1038\/srep32894","article-title":"Fast set-based association analysis using summary data from GWAS identifies novel gene loci for human complex traits","volume":"6","author":"A Bakshi","year":"2016","journal-title":"Sci Rep"},{"key":"pone.0221973.ref049","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1365-2052.2011.02182.x","article-title":"Global gene expression profiling reveals genes expressed differentially in cattle with high and low residual feed intake","volume":"42","author":"Y Chen","year":"2011","journal-title":"Anim Genet"},{"key":"pone.0221973.ref050","doi-asserted-by":"crossref","first-page":"D754","DOI":"10.1093\/nar\/gkx1098","article-title":"Ensembl 2018","volume":"46","author":"DR Zerbino","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"pone.0221973.ref051","doi-asserted-by":"crossref","first-page":"e71509","DOI":"10.1371\/journal.pone.0071509","article-title":"Genome-wide association study reveals genetic architecture of eating behavior in pigs and its implications for humans obesity by comparative mapping","volume":"8","author":"DN Do","year":"2013","journal-title":"PLoS ONE"},{"key":"pone.0221973.ref052","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/nn1320","article-title":"Essential role of Ca2+ -binding protein 4, a Cav 1.4 channel regulator, in photoreceptor synaptic function","author":"F Haeseleer","year":"2004","journal-title":"Nature Neuroscience"},{"key":"pone.0221973.ref053","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/brain\/awq329","article-title":"A mutation in the RNF170 gene causes autosomal dominant sensory ataxia","volume":"134","author":"PN Valdmanis","year":"2011","journal-title":"Brain"},{"key":"pone.0221973.ref054","first-page":"2913","article-title":"Differential expression profile of innate immune response genes between indigenous and crossbred cattle","volume":"9","author":"A Chauhan","year":"2015","journal-title":"Journal of Pure and Applied Microbiology"},{"key":"pone.0221973.ref055","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1186\/1471-2164-8-400","article-title":"Innate gene repression associated with Mycobacterium bovis infection in cattle: toward a gene signature of disease","volume":"8","author":"KG Meade","year":"2007","journal-title":"BMC Genomics"},{"key":"pone.0221973.ref056","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1017\/S0022029912000210","article-title":"Genes of the transforming growth factor-beta signalling pathway are associated with pre-implantation embryonic development in cattle","volume":"79","author":"G Li","year":"2012","journal-title":"J Dairy Res"},{"key":"pone.0221973.ref057","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1074\/jbc.275.2.1247","article-title":"Five Members of a Novel Ca2+-binding Protein (CABP) Subfamily with Similarity to Calmodulin*","volume":"275","author":"F Haeseleer","year":"2000","journal-title":"J Biol Chem"},{"key":"pone.0221973.ref058","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1086\/508067","article-title":"Mutations in CABP4, the gene encoding the Ca2+-binding protein 4, cause autosomal recessive night blindness","volume":"79","author":"C Zeitz","year":"2006","journal-title":"Am J Hum Genet"},{"key":"pone.0221973.ref059","doi-asserted-by":"crossref","first-page":"16826","DOI":"10.1038\/s41598-017-17195-3","article-title":"Monocyte gene expression in childhood obesity is associated with obesity and complexity of atherosclerosis in adults","volume":"7","author":"GC Keustermans","year":"2017","journal-title":"Sci Rep"},{"key":"pone.0221973.ref060","first-page":"680","article-title":"Innate immune programing by endotoxin and its pathological consequences","volume":"5","author":"MC Morris","year":"2014","journal-title":"Front Immunol"},{"key":"pone.0221973.ref061","doi-asserted-by":"crossref","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses","volume":"54","author":"G Stelzer","year":"2016","journal-title":"Curr Protoc Bioinformatics"},{"key":"pone.0221973.ref062","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12263-018-0602-x","article-title":"Investigation of the influence of high glucose on molecular and genetic responses: an in vitro study using a human intestine model","volume":"13","author":"T Boztepe","year":"2018","journal-title":"Genes Nutr"},{"key":"pone.0221973.ref063","doi-asserted-by":"crossref","first-page":"528","DOI":"10.7150\/ijbs.5.528","article-title":"Discovery of novel genetic networks associated with 19 economically important traits in beef cattle","volume":"5","author":"Z Jiang","year":"2009","journal-title":"Int. J. Biol. Sci"},{"key":"pone.0221973.ref064","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2156-8-43","article-title":"A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition","volume":"8","author":"SE Harris","year":"2007","journal-title":"BMC Genet"},{"key":"pone.0221973.ref065","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.mad.2008.09.020","article-title":"Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey","volume":"129","author":"JM Starr","year":"2008","journal-title":"Mech Ageing Dev"},{"key":"pone.0221973.ref066","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1096\/fj.99-0834com","article-title":"Characterization of novel UCP5\/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation","volume":"14","author":"XX Yu","year":"2000","journal-title":"FASEB J"},{"key":"pone.0221973.ref067","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0014-5793(98)01713-X","article-title":"UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells","volume":"443","author":"W Mao","year":"1999","journal-title":"FEBS Letters"},{"key":"pone.0221973.ref068","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.applanim.2019.01.008","article-title":"Associations between precision sensor data with productivity, health and welfare indicator traits in native black and white dual-purpose cattle under grazing conditions","volume":"212","author":"M Jaeger","year":"2019","journal-title":"Applied Animal Behaviour Science"},{"key":"pone.0221973.ref069","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.3168\/jds.2013-6620","article-title":"Rumination time during the summer season and its relationships with metabolic conditions and milk production","volume":"96","author":"N Soriani","year":"2013","journal-title":"Journal of Dairy Science"},{"key":"pone.0221973.ref070","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.3168\/jds.2008-1048","article-title":"Lameness, activity time-budgets, and estrus expression in dairy cattle","volume":"91","author":"SL Walker","year":"2008","journal-title":"Journal of Dairy Science"},{"key":"pone.0221973.ref071","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.3168\/jds.S0022-0302(03)73803-X","article-title":"Effects of Heat-Stress on Production in Dairy Cattle","volume":"86","author":"JW West","year":"2003","journal-title":"Journal of Dairy Science"},{"key":"pone.0221973.ref072","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1472-6793-3-7","article-title":"Daily and estrous rhythmicity of body temperature in domestic cattle","volume":"3","author":"G Piccione","year":"2003","journal-title":"BMC Physiol"},{"key":"pone.0221973.ref073","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.livsci.2012.04.017","article-title":"Genetic parameters for gaussian and categorical traits in organic and low input dairy cattle herds based on random regression methodology","volume":"147","author":"T Yin","year":"2012","journal-title":"Livestock Science"},{"key":"pone.0221973.ref074","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.3168\/jds.2009-2431","article-title":"Invited review: Body condition score and its association with dairy cow productivity, health, and welfare","volume":"92","author":"JR Roche","year":"2009","journal-title":"Journal of Dairy Science"},{"key":"pone.0221973.ref075","doi-asserted-by":"crossref","first-page":"5453","DOI":"10.3168\/jds.2006-821","article-title":"On the use of milk composition measures to predict the energy balance of dairy cows","volume":"90","author":"NC Friggens","year":"2007","journal-title":"Journal of Dairy Science"},{"key":"pone.0221973.ref076","unstructured":"Welfare assessment protocol. Welfare Quality\u00ae Assessment protocol for cattle. ASG Veehouderij BV, Lelystad, The Netherlands.; 2009. Available: www.welfarequality.net\/media\/1017\/cattle_protocol_without_veal.PDF. Accessed 23 May 2018."},{"key":"pone.0221973.ref077","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"pone.0221973.ref078","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1086\/521987","article-title":"Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering","volume":"81","author":"SR Browning","year":"2007","journal-title":"Am J Hum Genet"},{"key":"pone.0221973.ref079","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","article-title":"GCTA: a tool for genome-wide complex trait analysis","volume":"88","author":"J Yang","year":"2011","journal-title":"Am J Hum Genet"},{"key":"pone.0221973.ref080","unstructured":"Madsen P, Jensen J. A user's guide to DMU: A package for analysing multivariate mixed models.; 2013. Accessed 26 June 2018."},{"key":"pone.0221973.ref081","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.3168\/jds.2009-2061","article-title":"A relationship matrix including full pedigree and genomic information","volume":"92","author":"A Legarra","year":"2009","journal-title":"Journal of Dairy Science"},{"key":"pone.0221973.ref082","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1297-9686-41-55","article-title":"Deregressing estimated breeding values and weighting information for genomic regression analyses","volume":"41","author":"DJ Garrick","year":"2009","journal-title":"Genet Sel Evol"},{"key":"pone.0221973.ref083","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12711-018-0444-4","article-title":"Genome-wide associations and detection of potential candidate genes for direct genetic and maternal genetic effects influencing dairy cattle body weight at different ages","volume":"51","author":"T Yin","year":"2019","journal-title":"Genet Sel Evol"},{"key":"pone.0221973.ref084","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society. Series B (Methodological)"},{"key":"pone.0221973.ref085","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology. Tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"M Ashburner","year":"2000","journal-title":"Nat Genet"},{"key":"pone.0221973.ref086","doi-asserted-by":"crossref","first-page":"D331","DOI":"10.1093\/nar\/gkw1108","article-title":"Expansion of the Gene Ontology knowledgebase and resources","volume":"45","author":"The Gene Ontology Consortium","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"pone.0221973.ref087","doi-asserted-by":"crossref","first-page":"D492","DOI":"10.1093\/nar\/gkp858","article-title":"The NCBI BioSystems database","volume":"38","author":"LY Geer","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"pone.0221973.ref088","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4939-6783-4_1","article-title":"Protein Bioinformatics Databases and Resources","volume":"1558","author":"C Chen","year":"2017","journal-title":"Methods Mol Biol"},{"key":"pone.0221973.ref089","volume-title":"Biosocial Surveys","author":"GD Smith","year":"2008"},{"key":"pone.0221973.ref090","volume-title":"A modern approach","author":"JM Wooldridge","year":"2013"},{"key":"pone.0221973.ref091","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ng.3538","article-title":"Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets","volume":"48","author":"Z Zhu","year":"2016","journal-title":"Nat Genet"},{"key":"pone.0221973.ref092","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41467-017-02317-2","article-title":"Causal associations between risk factors and common diseases inferred from GWAS summary data","volume":"9","author":"Z Zhu","journal-title":"Nature Communications"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0221973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T23:38:23Z","timestamp":1721950703000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0221973"}},"subtitle":[],"editor":[{"given":"Gregory P.","family":"Copenhaver","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,10,30]]},"references-count":92,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0221973","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,30]]}}}