{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:44:12Z","timestamp":1790214252141,"version":"4.1.0"},"reference-count":135,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100013130","name":"Center for Neuroscience and Regenerative Medicine","doi-asserted-by":"publisher","award":["310185-6.01-65310"],"award-info":[{"award-number":["310185-6.01-65310"]}],"id":[{"id":"10.13039\/100013130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0222153","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T17:24:37Z","timestamp":1567704277000},"page":"e0222153","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Sex differences in cued fear responses and parvalbumin cell density in the hippocampus following repetitive concussive brain injuries in C57BL\/6J mice"],"prefix":"10.1371","volume":"14","author":[{"given":"Laura B.","family":"Tucker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2997-7689","authenticated-orcid":true,"given":"Brian S.","family":"Winston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"Velosky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda H.","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antigone A.","family":"Grillakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1159-7442","authenticated-orcid":true,"given":"Joseph T.","family":"McCabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,9,5]]},"reference":[{"key":"pone.0222153.ref001","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.neubiorev.2017.08.023","article-title":"Psychiatric phenotypes in chronic traumatic encephalopathy","volume":"83","author":"I Mahar","year":"2017","journal-title":"Neurosci Biobehav Rev"},{"issue":"3","key":"pone.0222153.ref002","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/mp.2010.80","article-title":"The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research?","volume":"16","author":"G MacQueen","year":"2011","journal-title":"Mol Psychiatry"},{"issue":"2","key":"pone.0222153.ref003","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.biopsych.2009.07.023","article-title":"Automatic mood-congruent amygdala responses to masked facial expressions in major depression","volume":"67","author":"T Suslow","year":"2010","journal-title":"Biol Psychiatry"},{"issue":"5","key":"pone.0222153.ref004","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.biopsych.2015.04.010","article-title":"Fear generalization and anxiety: Behavioral and neural mechanisms","volume":"78","author":"JE Dunsmoor","year":"2015","journal-title":"Biol Psychiatry"},{"issue":"Pt 1","key":"pone.0222153.ref005","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/brain\/aws307","article-title":"The spectrum of disease in chronic traumatic encephalopathy","volume":"136","author":"AC McKee","year":"2013","journal-title":"Brain"},{"key":"pone.0222153.ref006","article-title":"Repeated mild closed head injuries induce long-term white matter pathology and neuronal loss that are correlated with behavioral deficits","volume":"10","author":"EM Gold","year":"2018","journal-title":"ASN Neuro"},{"key":"pone.0222153.ref007","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.bbr.2017.02.017","article-title":"Cognitive performance of male and female C57BL\/6J mice after repetitive concussive brain injuries","volume":"324","author":"AG Velosky","year":"2017","journal-title":"Behav Brain Res"},{"issue":"13","key":"pone.0222153.ref008","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1089\/neu.2013.3255","article-title":"The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: A novel mouse model of chronic traumatic encephalopathy","volume":"31","author":"AL Petraglia","year":"2014","journal-title":"J Neurotrauma"},{"issue":"18","key":"pone.0222153.ref009","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1089\/neu.2012.2498","article-title":"Repetitive mild traumatic brain injury in a mouse model produces learning and memory deficits accompanied by histological changes","volume":"29","author":"B Mouzon","year":"2012","journal-title":"J Neurotrauma"},{"key":"pone.0222153.ref010","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3389\/fneur.2019.00509","article-title":"Chronic neurobehavioral sex differences in a murine model of repetitive concussive brain injury","volume":"10","author":"LB Tucker","year":"2019","journal-title":"Front Neurol"},{"key":"pone.0222153.ref011","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.expneurol.2015.12.019","article-title":"Alterations of functional properties of hippocampal networks following repetitive closed-head injury","volume":"277","author":"OC Logue","year":"2016","journal-title":"Exp Neurol"},{"issue":"7","key":"pone.0222153.ref012","doi-asserted-by":"crossref","first-page":"e102627","DOI":"10.1371\/journal.pone.0102627","article-title":"Reduced GABAergic inhibition in the basolateral amygdala and the development of anxiety-like behaviors after mild traumatic brain injury","volume":"9","author":"CP Almeida-Suhett","year":"2014","journal-title":"PLoS ONE"},{"key":"pone.0222153.ref013","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.expneurol.2015.07.028","article-title":"GABAergic interneuronal loss and reduced inhibitory synaptic transmission in the hippocampal CA1 region after mild traumatic brain injury","volume":"273","author":"CP Almeida-Suhett","year":"2015","journal-title":"Exp Neurol"},{"issue":"1","key":"pone.0222153.ref014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2005.01.052","article-title":"Regional hippocampal alteration associated with cognitive deficit following experimental brain injury: a systems, network and cellular evaluation","volume":"133","author":"BM Witgen","year":"2005","journal-title":"Neuroscience"},{"key":"pone.0222153.ref015","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.expneurol.2016.01.004","article-title":"Diminished amygdala activation and behavioral threat response following traumatic brain injury","volume":"277","author":"CP Palmer","year":"2016","journal-title":"Exp Neurol"},{"issue":"69","key":"pone.0222153.ref016","first-page":"e4411","article-title":"Investigations on alterations of hippocampal circuit function following mild traumatic brain injury","author":"CJ Smith","year":"2012","journal-title":"J Vis Exp"},{"key":"pone.0222153.ref017","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.neuro.23.1.155","article-title":"Emotion circuits in the brain","volume":"23","author":"JE LeDoux","year":"2000","journal-title":"Annu Rev Neurosci"},{"issue":"6","key":"pone.0222153.ref018","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2174\/1570159X14666160309123554","article-title":"Neuroprotection by estrogen and progesterone in traumatic brain injury and spinal cord injury","volume":"14","author":"E Brotfain","year":"2016","journal-title":"Curr Neuropharmacol"},{"issue":"2","key":"pone.0222153.ref019","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.brainresrev.2007.06.012","article-title":"Progesterone exerts neuroprotective effects after brain injury","volume":"57","author":"DG Stein","year":"2008","journal-title":"Brain Res Rev"},{"issue":"5","key":"pone.0222153.ref020","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1089\/neu.2000.17.367","article-title":"Gender differences in acute CNS trauma and stroke: neuroprotective effects of estrogen and progesterone","volume":"17","author":"RL Roof","year":"2000","journal-title":"J Neurotrauma"},{"issue":"4 Suppl","key":"pone.0222153.ref021","doi-asserted-by":"crossref","first-page":"S210","DOI":"10.1016\/j.whi.2011.04.019","article-title":"Psychiatric diagnoses and neurobehavioral symptom severity among OEF\/OIF VA patients with deployment-related traumatic brain injury: a gender comparison","volume":"21","author":"KM Iverson","year":"2011","journal-title":"Womens Health Issues"},{"issue":"22","key":"pone.0222153.ref022","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1089\/neu.2015.4252","article-title":"Prevalence of and Risk Factors for Anxiety and Depressive Disorders after Traumatic Brain Injury: A Systematic Review","volume":"33","author":"AC Scholten","year":"2016","journal-title":"J Neurotrauma"},{"issue":"9","key":"pone.0222153.ref023","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1080\/02699050010025777","article-title":"Depression amongst outpatients with traumatic brain injury","volume":"15","author":"MB Glenn","year":"2001","journal-title":"Brain Inj"},{"issue":"4","key":"pone.0222153.ref024","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1089\/neu.2016.4508","article-title":"Neuropsychiatric symptom modeling in male and female C57BL\/6J mice after experimental traumatic brain injury","volume":"34","author":"LB Tucker","year":"2017","journal-title":"J Neurotrauma"},{"issue":"9","key":"pone.0222153.ref025","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1089\/neu.2015.3977","article-title":"Performance of male and female C57BL\/6J mice on motor and cognitive tasks commonly used in pre-clinical traumatic brain injury research","volume":"33","author":"LB Tucker","year":"2016","journal-title":"J Neurotrauma"},{"issue":"16","key":"pone.0222153.ref026","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1089\/neu.2018.5744","article-title":"A bump on the head or late to bed: Behavioral and pathophysiological effects of sleep deprivation after repetitive mild traumatic brain injury in adolescent rats","volume":"35","author":"S Salberg","year":"2018","journal-title":"J Neurotrauma"},{"issue":"5","key":"pone.0222153.ref027","doi-asserted-by":"crossref","first-page":"e0197187","DOI":"10.1371\/journal.pone.0197187","article-title":"Repeated mild traumatic brain injury can cause acute neurologic impairment without overt structural damage in juvenile rats","volume":"13","author":"A Meconi","year":"2018","journal-title":"PLoS One"},{"issue":"12","key":"pone.0222153.ref028","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.jpain.2018.06.004","article-title":"Nociceptive and cognitive changes in a murine model of polytrauma","volume":"19","author":"P Sahbaie","year":"2018","journal-title":"J Pain"},{"key":"pone.0222153.ref029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2018.09.014","article-title":"Sex-dependent effects of mild blast-induced traumatic brain injury on corticotropin-releasing factor receptor gene expression: Potential link to anxiety-like behaviors","volume":"392","author":"AL Russell","year":"2018","journal-title":"Neuroscience"},{"issue":"6","key":"pone.0222153.ref030","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nmeth.2935","article-title":"Olfactory exposure to males, including men, causes stress and related analgesia in rodents","volume":"11","author":"RE Sorge","year":"2014","journal-title":"Nat Methods"},{"key":"pone.0222153.ref031","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bbr.2017.08.029","article-title":"Evidence-based severity assessment: Impact of repeated versus single open-field testing on welfare in C57BL\/6J mice","volume":"336","author":"C Bodden","year":"2018","journal-title":"Behav Brain Res"},{"issue":"5","key":"pone.0222153.ref032","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0031-9384(01)00528-5","article-title":"The use of behavioral test batteries: effects of training history","volume":"73","author":"KL McIlwain","year":"2001","journal-title":"Physiol Behav"},{"issue":"13","key":"pone.0222153.ref033","article-title":"Behavior of male and female C57BL\/6J mice is more consistent with repeated trials in the elevated zero maze than in the elevated plus maze","volume":"11","author":"L Tucker","year":"2017","journal-title":"Front Behav Neurosci"},{"issue":"59","key":"pone.0222153.ref034","first-page":"e3769","article-title":"The tail suspension test","author":"A Can","year":"2012","journal-title":"J Vis Exp"},{"key":"pone.0222153.ref035","volume-title":"Paxinos and Franklin\u2019s the mouse brain in stereotaxic coordinates","author":"G Paxinos","year":"2013","edition":"4th ed"},{"key":"pone.0222153.ref036","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.brainres.2018.08.034","article-title":"Transient disruption of mouse home cage activities and assessment of orexin immunoreactivity following concussive- or blast-induced brain injury","volume":"1700","author":"PA Vu","year":"2018","journal-title":"Brain Res"},{"key":"pone.0222153.ref037","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neuroscience.2012.07.025","article-title":"Modulation of parvalbumin interneuron number by developmentally transient neocortical vasopressin receptor 1a (V1aR)","volume":"222","author":"EA Hammock","year":"2012","journal-title":"Neuroscience"},{"issue":"12","key":"pone.0222153.ref038","doi-asserted-by":"crossref","first-page":"e53569","DOI":"10.1371\/journal.pone.0053569","article-title":"Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice","volume":"7","author":"L Leung","year":"2012","journal-title":"PLoS One"},{"key":"pone.0222153.ref039","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.neulet.2018.10.028","article-title":"Hippocampal distribution of parvalbumin neurons in female and male rats submitted to the same volume and intensity of aerobic exercise","volume":"690","author":"EVD Placencia","year":"2019","journal-title":"Neurosci Lett"},{"issue":"2","key":"pone.0222153.ref040","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1037\/0735-7044.106.2.274","article-title":"Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning","volume":"106","author":"RG Phillips","year":"1992","journal-title":"Behav Neurosci"},{"issue":"2","key":"pone.0222153.ref041","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.bbr.2006.11.014","article-title":"Acute cognitive impairment after lateral fluid percussion brain injury recovers by 1 month: evaluation by conditioned fear response","volume":"177","author":"J Lifshitz","year":"2007","journal-title":"Behav Brain Res"},{"issue":"1","key":"pone.0222153.ref042","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1073\/pnas.0910280107","article-title":"Dietary branched chain amino acids ameliorate injury-induced cognitive impairment","volume":"107","author":"JT Cole","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"pone.0222153.ref043","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1089\/neu.1992.9.11","article-title":"Cognitive deficits following traumatic brain injury produced by controlled cortical impact","volume":"9","author":"RJ Hamm","year":"1992","journal-title":"J Neurotrauma"},{"key":"pone.0222153.ref044","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.brainresbull.2017.11.016","article-title":"GABAergic interneurons: The orchestra or the conductor in fear learning and memory?","volume":"141","author":"EK Lucas","year":"2018","journal-title":"Brain Res Bull"},{"issue":"7501","key":"pone.0222153.ref045","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nature13258","article-title":"Amygdala interneuron subtypes control fear learning through disinhibition","volume":"509","author":"SB Wolff","year":"2014","journal-title":"Nature"},{"key":"pone.0222153.ref046","doi-asserted-by":"crossref","first-page":"15039","DOI":"10.1038\/ncomms15039","article-title":"Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation","volume":"8","author":"N Ognjanovski","year":"2017","journal-title":"Nature communications"},{"key":"pone.0222153.ref047","doi-asserted-by":"crossref","first-page":"e27868","DOI":"10.7554\/eLife.27868","article-title":"Parvalbumin-positive interneurons mediate neocortical-hippocampal interactions that are necessary for memory consolidation","volume":"6","author":"F Xia","year":"2017","journal-title":"eLife"},{"issue":"10","key":"pone.0222153.ref048","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.4103\/1673-5374.238618","article-title":"Cognitive impairment after traumatic brain injury is associated with reduced long-term depression of excitatory postsynaptic potential in the rat hippocampal dentate gyrus","volume":"13","author":"BL Zhang","year":"2018","journal-title":"Neural regeneration research"},{"key":"pone.0222153.ref049","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuroscience.2011.07.074","article-title":"Progressive loss of phasic, but not tonic, GABAA receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats","volume":"194","author":"I Pavlov","year":"2011","journal-title":"Neuroscience"},{"key":"pone.0222153.ref050","article-title":"Pre-treatment with microRNA-181a antagomir prevents loss of parvalbumin expression and preserves novel object recognition following mild traumatic brain injury","author":"BB Griffiths","year":"2019","journal-title":"Neuromolecular Med"},{"issue":"4","key":"pone.0222153.ref051","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/neu.1993.10.405","article-title":"Mild experimental brain injury in the rat induces cognitive deficits associated with regional neuronal loss in the hippocampus","volume":"10","author":"RR Hicks","year":"1993","journal-title":"J Neurotrauma"},{"issue":"12","key":"pone.0222153.ref052","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.1523\/JNEUROSCI.12-12-04846.1992","article-title":"Selective vulnerability of dentate hilar neurons following traumatic brain injury: a potential mechanistic link between head trauma and disorders of the hippocampus","volume":"12","author":"DH Lowenstein","year":"1992","journal-title":"J Neurosci"},{"issue":"6","key":"pone.0222153.ref053","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1089\/neu.1997.14.385","article-title":"Neuronal cell loss in the CA3 subfield of the hippocampus following cortical contusion utilizing the optical disector method for cell counting","volume":"14","author":"SA Baldwin","year":"1997","journal-title":"J Neurotrauma"},{"issue":"10","key":"pone.0222153.ref054","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1089\/089771503770195786","article-title":"Neuronal and glial cell number in the hippocampus after experimental traumatic brain injury: analysis by stereological estimation","volume":"20","author":"MS Grady","year":"2003","journal-title":"J Neurotrauma"},{"issue":"2","key":"pone.0222153.ref055","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/BF00241120","article-title":"Long-term potentiation deficits and excitability changes following traumatic brain injury","volume":"106","author":"TM Reeves","year":"1995","journal-title":"Exp Brain Res"},{"issue":"6","key":"pone.0222153.ref056","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/hipo.20183","article-title":"Mechanisms underlying the inability to induce area CA1 LTP in the mouse after traumatic brain injury","volume":"16","author":"E Schwarzbach","year":"2006","journal-title":"Hippocampus"},{"issue":"2","key":"pone.0222153.ref057","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/brain\/awx350","article-title":"Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model","volume":"141","author":"CA Tagge","year":"2018","journal-title":"Brain"},{"issue":"31","key":"pone.0222153.ref058","doi-asserted-by":"crossref","first-page":"E6420","DOI":"10.1073\/pnas.1707661114","article-title":"Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury","volume":"114","author":"A Chou","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"pone.0222153.ref059","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1089\/089771503767168465","article-title":"Interaction between anesthesia, gender, and functional outcome task following diffuse traumatic brain injury in rats","volume":"20","author":"CA O\u2019Connor","year":"2003","journal-title":"J Neurotrauma"},{"issue":"2","key":"pone.0222153.ref060","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.neubiorev.2005.06.005","article-title":"Neural circuits and mechanisms involved in Pavlovian fear conditioning: a critical review","volume":"30","author":"JJ Kim","year":"2006","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"pone.0222153.ref061","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0166-4328(97)00088-0","article-title":"Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats","volume":"88","author":"S Maren","year":"1997","journal-title":"Behav Brain Res"},{"issue":"4","key":"pone.0222153.ref062","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1037\/0735-7044.112.4.863","article-title":"The dorsal hippocampus is essential for context discrimination but not for contextual conditioning","volume":"112","author":"PW Frankland","year":"1998","journal-title":"Behav Neurosci"},{"issue":"1\u20132","key":"pone.0222153.ref063","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0166-4328(99)00186-2","article-title":"Contextual fear, gestalt memories, and the hippocampus","volume":"110","author":"MS Fanselow","year":"2000","journal-title":"Behav Brain Res"},{"issue":"20","key":"pone.0222153.ref064","doi-asserted-by":"crossref","first-page":"5484","DOI":"10.1523\/JNEUROSCI.2685-05.2006","article-title":"Context fear learning in the absence of the hippocampus","volume":"26","author":"BJ Wiltgen","year":"2006","journal-title":"J Neurosci"},{"issue":"7","key":"pone.0222153.ref065","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1089\/neu.1998.15.545","article-title":"Neuroprotective effect of eliprodil: attenuation of a conditioned freezing deficit induced by traumatic injury of the right parietal cortex in the rat","volume":"15","author":"S Hogg","year":"1998","journal-title":"J Neurotrauma"},{"issue":"4","key":"pone.0222153.ref066","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1037\/0735-7044.102.4.471","article-title":"Spatial cognitive maps: differential role of parietal cortex and hippocampal formation","volume":"102","author":"BD DiMattia","year":"1988","journal-title":"Behav Neurosci"},{"issue":"4","key":"pone.0222153.ref067","first-page":"569","article-title":"Contralateral somatosensory neglect in unrestrained rats after lesion of the parietal cortex of the left hemisphere","volume":"53","author":"S Holm","year":"1993","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"pone.0222153.ref068","article-title":"The mouse posterior parietal cortex: Anatomy and functions","author":"D Lyamzin","year":"2018","journal-title":"Neurosci Res"},{"issue":"27","key":"pone.0222153.ref069","doi-asserted-by":"crossref","first-page":"7095","DOI":"10.1523\/JNEUROSCI.3212-15.2016","article-title":"Chronic cognitive dysfunction after traumatic brain injury is improved with a phosphodiesterase 4B inhibitor","volume":"36","author":"DJ Titus","year":"2016","journal-title":"J Neurosci"},{"key":"pone.0222153.ref070","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.nlm.2017.12.008","article-title":"A negative allosteric modulator of PDE4D enhances learning after traumatic brain injury","volume":"148","author":"DJ Titus","year":"2018","journal-title":"Neurobiol Learn Mem"},{"issue":"8","key":"pone.0222153.ref071","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1096\/fj.201601288RRR","article-title":"Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma","volume":"31","author":"J Egawa","year":"2017","journal-title":"FASEB J"},{"issue":"12","key":"pone.0222153.ref072","doi-asserted-by":"crossref","first-page":"e115765","DOI":"10.1371\/journal.pone.0115765","article-title":"Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice","volume":"9","author":"JS Cheng","year":"2014","journal-title":"PLoS One"},{"issue":"9","key":"pone.0222153.ref073","doi-asserted-by":"crossref","first-page":"e74510","DOI":"10.1371\/journal.pone.0074510","article-title":"Repetitive concussive traumatic brain injury interacts with post-injury foot shock stress to worsen social and depression-like behavior in mice","volume":"8","author":"KC Klemenhagen","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"pone.0222153.ref074","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1089\/neu.2006.0011","article-title":"Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury","volume":"24","author":"DL Brody","year":"2007","journal-title":"J Neurotrauma"},{"issue":"5","key":"pone.0222153.ref075","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.neuron.2014.04.042","article-title":"Amygdala microcircuits controlling learned fear","volume":"82","author":"S Duvarci","year":"2014","journal-title":"Neuron"},{"issue":"20","key":"pone.0222153.ref076","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1089\/neu.2013.3252","article-title":"CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury","volume":"31","author":"CL Hsieh","year":"2014","journal-title":"J Neurotrauma"},{"issue":"12","key":"pone.0222153.ref077","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1002\/jnr.23114","article-title":"A cannabinoid type 2 receptor agonist attenuates blood-brain barrier damage and neurodegeneration in a murine model of traumatic brain injury","volume":"90","author":"PS Amenta","year":"2012","journal-title":"J Neurosci Res"},{"issue":"5","key":"pone.0222153.ref078","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1089\/neu.2009.1223","article-title":"Blockade of acute microglial activation by minocycline promotes neuroprotection and reduces locomotor hyperactivity after closed head injury in mice: a twelve-week follow-up study","volume":"27","author":"S Homsi","year":"2010","journal-title":"J Neurotrauma"},{"key":"pone.0222153.ref079","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neuropharm.2012.11.009","article-title":"Etazolate, an \u03b1-secretase activator, reduces neuroinflammation and offers persistent neuroprotection following traumatic brain injury in mice","volume":"67","author":"E Siopi","year":"2013","journal-title":"Neuropharmacology"},{"issue":"6","key":"pone.0222153.ref080","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.3171\/2014.7.JNS14272","article-title":"Chronic gliosis and behavioral deficits in mice following repetitive mild traumatic brain injury","volume":"121","author":"R Mannix","year":"2014","journal-title":"J Neurosurg"},{"issue":"1","key":"pone.0222153.ref081","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jneumeth.2011.09.003","article-title":"A mouse model of human repetitive mild traumatic brain injury","volume":"203","author":"MJ Kane","year":"2012","journal-title":"J Neurosci Methods"},{"issue":"2","key":"pone.0222153.ref082","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.nlm.2008.05.008","article-title":"Excitotoxic lesions restricted to the dorsal CA1 field of the hippocampus impair spatial memory and extinction learning in C57BL\/6 mice","volume":"90","author":"GM Dillon","year":"2008","journal-title":"Neurobiol Learn Mem"},{"key":"pone.0222153.ref083","article-title":"Automated dissection of permanent effects of hippocampal or prefrontal lesions on performance at spatial, working memory and circadian timing tasks of C57BL\/6 mice in IntelliCage","author":"V Voikar","year":"2017","journal-title":"Behav Brain Res"},{"issue":"2","key":"pone.0222153.ref084","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0166-4328(01)00401-6","article-title":"Hippocampal cytotoxic lesion effects on species-typical behaviours in mice","volume":"132","author":"RM Deacon","year":"2002","journal-title":"Behav Brain Res"},{"issue":"1","key":"pone.0222153.ref085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2008.06.033","article-title":"The hyperactive syndrome: metanalysis of genetic alterations, pharmacological treatments and brain lesions which increase locomotor activity","volume":"194","author":"D Viggiano","year":"2008","journal-title":"Behav Brain Res"},{"issue":"2","key":"pone.0222153.ref086","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/ana.24064","article-title":"Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model","volume":"75","author":"BC Mouzon","year":"2014","journal-title":"Ann Neurol"},{"issue":"1","key":"pone.0222153.ref087","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/acn3.510","article-title":"Lifelong behavioral and neuropathological consequences of repetitive mild traumatic brain injury","volume":"5","author":"BC Mouzon","year":"2018","journal-title":"Annals of clinical and translational neurology"},{"issue":"20","key":"pone.0222153.ref088","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1089\/neu.2018.5731","article-title":"Repeated mild head injury leads to wide-ranging deficits in higher-order cognitive functions associated with the prefrontal cortex","volume":"35","author":"A Nolan","year":"2018","journal-title":"J Neurotrauma"},{"issue":"1","key":"pone.0222153.ref089","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/02699052.2017.1380228","article-title":"Repeated mild traumatic brain injury produces neuroinflammation, anxiety-like behaviour and impaired spatial memory in mice","volume":"32","author":"JI Broussard","year":"2018","journal-title":"Brain Inj"},{"issue":"10","key":"pone.0222153.ref090","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1089\/neu.2010.1318","article-title":"Effects of traumatic brain injury of different severities on emotional, cognitive, and oxidative stress-related parameters in mice","volume":"27","author":"ML Schwarzbold","year":"2010","journal-title":"J Neurotrauma"},{"issue":"5","key":"pone.0222153.ref091","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1007\/s11357-012-9464-0","article-title":"Exendin-4 induced glucagon-like peptide-1 receptor activation reverses behavioral impairments of mild traumatic brain injury in mice","volume":"35","author":"L Rachmany","year":"2013","journal-title":"Age (Dordr)"},{"issue":"3","key":"pone.0222153.ref092","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1089\/neu.2009.0891","article-title":"The influence of alcohol on behavioral recovery after mTBI in mice","volume":"27","author":"R Baratz","year":"2010","journal-title":"J Neurotrauma"},{"key":"pone.0222153.ref093","doi-asserted-by":"crossref","first-page":"11178","DOI":"10.1038\/srep11178","article-title":"Temporal MRI characterization, neurobiochemical and neurobehavioral changes in a mouse repetitive concussive head injury model","volume":"5","author":"Z Yang","year":"2015","journal-title":"Sci Rep"},{"issue":"Pt B","key":"pone.0222153.ref094","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbr.2015.10.052","article-title":"Greater neurobehavioral deficits occur in adult mice after repeated, as compared to single, mild traumatic brain injury (mTBI)","volume":"298","author":"JN Nichols","year":"2016","journal-title":"Behav Brain Res"},{"key":"pone.0222153.ref095","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.brainres.2012.05.041","article-title":"NMDA preconditioning prevents object recognition memory impairment and increases brain viability in mice exposed to traumatic brain injury","volume":"1466","author":"VK Moojen","year":"2012","journal-title":"Brain Res"},{"key":"pone.0222153.ref096","first-page":"213","article-title":"Neurobehavioral, neuropathological and biochemical profiles in a novel mouse model of co-morbid post-traumatic stress disorder and mild traumatic brain injury","volume":"8","author":"JO Ojo","year":"2014","journal-title":"Front Behav Neurosci"},{"issue":"1","key":"pone.0222153.ref097","doi-asserted-by":"crossref","first-page":"36","DOI":"10.55782\/ane-2011-1821","article-title":"Behavioral consequences of minimal traumatic brain injury in mice","volume":"71","author":"O Zohar","year":"2011","journal-title":"Acta Neurobiol Exp (Wars)"},{"issue":"2","key":"pone.0222153.ref098","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.bbr.2004.05.028","article-title":"Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer\u2019s disease","volume":"156","author":"E Ognibene","year":"2005","journal-title":"Behav Brain Res"},{"key":"pone.0222153.ref099","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2013.03.042","article-title":"Effect of the bone marrow cell transplantation on elevated plus-maze performance in hippocampal-injured mice","volume":"248","author":"LB da Cruz e Alves-de-Moraes","year":"2013","journal-title":"Behav Brain Res"},{"issue":"5","key":"pone.0222153.ref100","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1037\/0735-7044.116.5.884","article-title":"Double dissociation of function within the hippocampus: spatial memory and hyponeophagia","volume":"116","author":"DM Bannerman","year":"2002","journal-title":"Behav Neurosci"},{"issue":"9","key":"pone.0222153.ref101","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1007\/s00429-017-1452-9","article-title":"Traumatic brain injury causes long-term behavioral changes related to region-specific increases of cerebral blood flow","volume":"222","author":"B P\u00f6ttker","year":"2017","journal-title":"Brain Struct Funct"},{"issue":"13","key":"pone.0222153.ref102","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1089\/neu.2012.2456","article-title":"The effect of injury severity on behavior: a phenotypic study of cognitive and emotional deficits after mild, moderate, and severe controlled cortical impact injury in mice","volume":"29","author":"PM Washington","year":"2012","journal-title":"J Neurotrauma"},{"key":"pone.0222153.ref103","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fnbeh.2019.00006","article-title":"Long-term effects of traumatic brain injury on anxiety-like behaviors in mice: Behavioral and neural correlates","volume":"13","author":"J Popovitz","year":"2019","journal-title":"Front Behav Neurosci"},{"issue":"16","key":"pone.0222153.ref104","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1089\/neu.2016.4823","article-title":"Environmental enrichment mitigates deficits after repetitive mild traumatic brain injury","volume":"34","author":"X Liu","year":"2017","journal-title":"J Neurotrauma"},{"issue":"1","key":"pone.0222153.ref105","doi-asserted-by":"crossref","first-page":"e0146886","DOI":"10.1371\/journal.pone.0146886","article-title":"Mild concussion, but not moderate traumatic brain injury, is associated with long-term depression-like phenotype in mice","volume":"11","author":"NM Bajwa","year":"2016","journal-title":"PLoS One"},{"issue":"9","key":"pone.0222153.ref106","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1089\/neu.2005.22.1003","article-title":"Mild traumatic brain injury induces persistent cognitive deficits and behavioral disturbances in mice","volume":"22","author":"A Milman","year":"2005","journal-title":"J Neurotrauma"},{"issue":"Pt B","key":"pone.0222153.ref107","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.mcn.2015.02.005","article-title":"The pathophysiology of repetitive concussive traumatic brain injury in experimental models; new developments and open questions","volume":"66","author":"DL Brody","year":"2015","journal-title":"Mol Cell Neurosci"},{"key":"pone.0222153.ref108","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3389\/fneur.2013.00157","article-title":"Traumatic brain injury\u2014modeling neuropsychiatric symptoms in rodents","volume":"4","author":"O Malkesman","year":"2013","journal-title":"Front Neurol"},{"issue":"2","key":"pone.0222153.ref109","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/msj.20097","article-title":"Neurobehavioral sequelae of traumatic brain injury","volume":"76","author":"S Riggio","year":"2009","journal-title":"Mt Sinai J Med"},{"issue":"6","key":"pone.0222153.ref110","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1176\/appi.ajp.2009.08111676","article-title":"Depression and cognitive complaints following mild traumatic brain injury","volume":"166","author":"JM Silver","year":"2009","journal-title":"Am J Psychiatry"},{"issue":"13","key":"pone.0222153.ref111","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1212\/WNL.0b013e3182a55f7f","article-title":"Clinical presentation of chronic traumatic encephalopathy","volume":"81","author":"RA Stern","year":"2013","journal-title":"Neurology"},{"issue":"5","key":"pone.0222153.ref112","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13195-014-0068-z","article-title":"Clinical subtypes of chronic traumatic encephalopathy: literature review and proposed research diagnostic criteria for traumatic encephalopathy syndrome","volume":"6","author":"PH Montenigro","year":"2014","journal-title":"Alzheimers Res Ther"},{"issue":"4","key":"pone.0222153.ref113","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/jama.2017.8334","article-title":"Clinicopathological evaluation of chronic traumatic encephalopathy in players of American football","volume":"318","author":"J Mez","year":"2017","journal-title":"JAMA"},{"issue":"4","key":"pone.0222153.ref114","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0091-6773(75)90636-7","article-title":"Rodent sex differences in emotional and related behavior","volume":"14","author":"J Archer","year":"1975","journal-title":"Behav Biol"},{"issue":"20","key":"pone.0222153.ref115","doi-asserted-by":"crossref","first-page":"4595","DOI":"10.1111\/bph.12710","article-title":"Sex differences in animal models of psychiatric disorders","volume":"171","author":"N Kokras","year":"2014","journal-title":"Br J Pharmacol"},{"issue":"2","key":"pone.0222153.ref116","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.bbr.2008.09.001","article-title":"Effects of rat sex differences and lighting on locomotor exploration of a circular open field with free-standing central corners and without peripheral walls","volume":"196","author":"J Alstott","year":"2009","journal-title":"Behav Brain Res"},{"issue":"5420","key":"pone.0222153.ref117","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1126\/science.284.5420.1670","article-title":"Genetics of mouse behavior: interactions with laboratory environment","volume":"284","author":"JC Crabbe","year":"1999","journal-title":"Science"},{"issue":"1","key":"pone.0222153.ref118","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1001\/archpsyc.1994.03950010008002","article-title":"Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States","volume":"51","author":"RC Kessler","year":"1994","journal-title":"Results from the National Comorbidity Survey. Arch Gen Psychiatry"},{"issue":"5","key":"pone.0222153.ref119","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00424-013-1271-7","article-title":"Sex differences in anxiety and emotional behavior","volume":"465","author":"NC Donner","year":"2013","journal-title":"Pflugers Arch"},{"issue":"3","key":"pone.0222153.ref120","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0149-7634(01)00010-0","article-title":"Animal models of anxiety and depression: how are females different?","volume":"25","author":"P Palanza","year":"2001","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"pone.0222153.ref121","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0149-7634(98)00027-X","article-title":"Utility of ethological analysis to overcome locomotor confounds in elevated maze models of anxiety","volume":"23","author":"SM Weiss","year":"1998","journal-title":"Neurosci Biobehav Rev"},{"issue":"5\u20136","key":"pone.0222153.ref122","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/FBP.0b013e32830c3658","article-title":"Pitfalls in the interpretation of genetic and pharmacological effects on anxiety-like behaviour in rodents","volume":"19","author":"JA Bouwknecht","year":"2008","journal-title":"Behav Pharmacol"},{"issue":"3","key":"pone.0222153.ref123","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/BF02245961","article-title":"Evidence that the anxiolytic-like effects of chlordiazepoxide on the elevated plus maze are confounded by increases in locomotor activity","volume":"118","author":"GR Dawson","year":"1995","journal-title":"Psychopharmacology (Berl)"},{"issue":"2","key":"pone.0222153.ref124","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1538\/expanim.60.111","article-title":"Strain and sex differences in anxiety-like and social behaviors in C57BL\/6J and BALB\/cJ mice","volume":"60","author":"XL An","year":"2011","journal-title":"Exp Anim"},{"key":"pone.0222153.ref125","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.expneurol.2014.07.002","article-title":"Scaling in neurotrauma: how do we apply animal experiments to people?","volume":"261","author":"MB Panzer","year":"2014","journal-title":"Exp Neurol"},{"key":"pone.0222153.ref126","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1471-2148-8-73","article-title":"Cranial bone morphometric study among mouse strains","volume":"8","author":"M Kawakami","year":"2008","journal-title":"BMC Evol Biol"},{"issue":"1","key":"pone.0222153.ref127","first-page":"102","article-title":"Skull morphometry and sexual size dimorphism in Mus musculus from Slovakia","volume":"14","author":"A \u010csan\u00e1dy","year":"2018","journal-title":"North-Western Journal of Zoology"},{"issue":"1","key":"pone.0222153.ref128","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0014-4886(02)00048-1","article-title":"Cytoskeletal protein degradation and neurodegeneration evolves differently in males and females following experimental head injury","volume":"180","author":"NC Kupina","year":"2003","journal-title":"Exp Neurol"},{"key":"pone.0222153.ref129","first-page":"92","article-title":"Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico","volume":"6","author":"AM Maga","year":"2015","journal-title":"Front Physiol"},{"key":"pone.0222153.ref130","first-page":"417","article-title":"Postnatal ontogeny of the cranial base and craniofacial skeleton in male C57BL\/6J mice: A reference standard for quantitative analysis","volume":"6","author":"SR Vora","year":"2015","journal-title":"Front Physiol"},{"issue":"4","key":"pone.0222153.ref131","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.neuroimage.2007.02.023","article-title":"Sexual dimorphism revealed in the structure of the mouse brain using three-dimensional magnetic resonance imaging","volume":"35","author":"S Spring","year":"2007","journal-title":"Neuroimage"},{"issue":"1","key":"pone.0222153.ref132","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1038\/s41467-018-04921-2","article-title":"Mouse MRI shows brain areas relatively larger in males emerge before those larger in females","volume":"9","author":"LR Qiu","year":"2018","journal-title":"Nature communications"},{"key":"pone.0222153.ref133","article-title":"Chronic neurobehavioral sex differences in a murine model of repetitive concussive brain injury","author":"LB Tucker","journal-title":"Front Neurol"},{"issue":"20","key":"pone.0222153.ref134","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.1111\/bph.12732","article-title":"Reconceptualizing sex, brain and psychopathology: interaction, interaction, interaction","volume":"171","author":"D Joel","year":"2014","journal-title":"Br J Pharmacol"},{"issue":"1\u20132","key":"pone.0222153.ref135","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/jnr.23861","article-title":"Preclinical sex differences in depression and antidepressant response: Implications for clinical research","volume":"95","author":"N Kokras","year":"2017","journal-title":"J Neurosci Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0222153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:50:11Z","timestamp":1721695811000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0222153"}},"subtitle":[],"editor":[{"given":"Judith","family":"Homberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,9,5]]},"references-count":135,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0222153","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,5]]}}}