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Isolation, characterization, cloning and insights into its mechanism of action","volume":"268","author":"RH Valente","year":"2001","journal-title":"Eur J Biochem"},{"key":"pone.0222206.ref063","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jprot.2016.05.027","article-title":"Proteomic comparisons of venoms of long-term captive and recently wild-caught Eastern brown snakes (Pseudonaja textilis) indicate venom does not change due to captivity","volume":"144","author":"RJR McCleary","year":"2016","journal-title":"J Proteomics"},{"issue":"4\u20135","key":"pone.0222206.ref064","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1159\/000092431","article-title":"The Potential of Bothrops moojeni Venom in the Field of Hemostasis","volume":"34","author":"AM Perchuc","year":"2005","journal-title":"Pathophysiol Haemost Thromb"},{"key":"pone.0222206.ref065","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jprot.2016.02.030","article-title":"Proteomic identification of gender molecular markers in Bothrops jararaca venom","volume":"139","author":"A Zelanis","year":"2016","journal-title":"J Proteomics"},{"key":"pone.0222206.ref066","article-title":"An in-depth snake venom proteopeptidome characterization: Benchmarking Bothrops jararaca","author":"CA Nicolau","year":"2016","journal-title":"J Proteomics"},{"key":"pone.0222206.ref067","first-page":"2533","article-title":"Secreted Phospholipases A2 of Snake Venoms: Effects on the Peripheral Neuromuscular System with Comments on the Role of Phospholipases A2 in Disorders of the CNS and Their Uses in Industry","author":"JB Harris","year":"2013"},{"issue":"1","key":"pone.0222206.ref068","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.toxicon.2011.10.015","article-title":"Toxicon Venom lethality and diet: Differential responses of natural prey and model organisms to the venom of the saw-scaled vipers (Echis)","volume":"59","author":"DP Richards","year":"2012","journal-title":"Toxicon"},{"issue":"5","key":"pone.0222206.ref069","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1046\/j.1523-1739.1997.96098.x","article-title":"Population genetic structure in the black rat snake: implications for management","volume":"11","author":"KA Prior","year":"1997","journal-title":"Conserv Biol"},{"key":"pone.0222206.ref070","first-page":"33","article-title":"Serpentes pe\u00e7onhentas do Brasil","author":"AR Melgarejo","year":"2003","journal-title":"Cardoso, LC al Animais Pe\u00e7onhentos no Bras Biol cl\u00ednica e Ter dos Acid S\u00e3o Paulo Savier"},{"key":"pone.0222206.ref071","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2307\/1565528","article-title":"Is the venom related to diet and tail color during Bothrops moojeni ontogeny?","author":"V Andrade D","year":"1996","journal-title":"J Herpetol"},{"issue":"8","key":"pone.0222206.ref072","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.toxicon.2008.10.002","article-title":"Interspecific variation in venom composition and toxicity of Brazilian snakes from Bothrops genus","volume":"52","author":"GP Queiroz","year":"2008","journal-title":"Toxicon"},{"issue":"9","key":"pone.0222206.ref073","doi-asserted-by":"crossref","first-page":"e2442","DOI":"10.1371\/journal.pntd.0002442","article-title":"Comparison of phylogeny, venom composition and neutralization by antivenom in diverse species of bothrops complex","volume":"7","author":"LF Sousa","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"issue":"6","key":"pone.0222206.ref074","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3390\/toxins9060179","article-title":"Venom On-a-Chip: A Fast and Efficient Method for Comparative Venomics","volume":"9","author":"G Zancolli","year":"2017","journal-title":"Toxins (Basel)"},{"key":"pone.0222206.ref075","article-title":"An\u00e1lise da variabilidade ontogen\u00e9tica do veneno de Bothrops insularis (Amaral, 1921): implica\u00e7\u00f5es adaptativas aos itens alimentares","volume":"104","author":"AZP Pereira","year":"2006","journal-title":"Inst Bioci\u00eancias, Dep Fisiol"},{"issue":"4","key":"pone.0222206.ref076","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jprot.2011.01.003","article-title":"Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management","volume":"74","author":"JJ Calvete","year":"2011","journal-title":"J Proteomics"},{"issue":"3","key":"pone.0222206.ref077","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0041-0101(97)00133-5","article-title":"A rapid procedure for the isolation of the Lys-49 myotoxin II from Bothrops moojeni (caissaca) venom: biochemical characterization, crystallization, myotoxic and edematogenic activity","volume":"36","author":"AM Soares","year":"1998","journal-title":"Toxicon"},{"issue":"8","key":"pone.0222206.ref078","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0041-0101(02)00392-6","article-title":"Hemorrhagic activity of Bothrops venoms determined by two different methods and relationship with proteolytic activity on gelatin and lethality","volume":"41","author":"AR de Roodt","year":"2003","journal-title":"Toxicon"},{"issue":"4","key":"pone.0222206.ref079","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0041-0101(85)90374-5","article-title":"Isolation of the major proteolytic enzyme from the venom of the snake Bothrops moojeni (caissaca)","volume":"23","author":"MT Assakura","year":"1985","journal-title":"Toxicon"},{"key":"pone.0222206.ref080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxicon.2013.08.063","article-title":"In vitro comparison of enzymatic effects among Brazilian Bothrops spp. venoms","volume":"76","author":"LB Campos","year":"2013","journal-title":"Toxicon"},{"issue":"7","key":"pone.0222206.ref081","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.toxicon.2012.08.008","article-title":"Isolation and biochemical, functional and structural characterization of a novel L-amino acid oxidase from Lachesis muta snake venom","volume":"60","author":"C Bregge-Silva","year":"2012","journal-title":"Toxicon"},{"key":"pone.0222206.ref082","first-page":"2014","article-title":"Snake venom l-amino acid oxidases: trends in pharmacology and biochemistry","author":"LFM Izidoro","year":"2014","journal-title":"Biomed Res Int"},{"issue":"7","key":"pone.0222206.ref083","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.bbagen.2011.04.003","article-title":"Cytotoxicity and inhibition of platelet aggregation caused by an l-amino acid oxidase from Bothrops leucurus venom","volume":"1810","author":"GB Naumann","year":"2011","journal-title":"Biochim Biophys Acta (BBA)-General Subj"},{"issue":"2","key":"pone.0222206.ref084","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/abbi.1999.1287","article-title":"Isolation and structural characterization of a cytotoxic L-amino acid oxidase from Agkistrodon contortrix laticinctus snake venom: preliminary crystallographic data","volume":"368","author":"DHF Souza","year":"1999","journal-title":"Arch Biochem Biophys"},{"issue":"11","key":"pone.0222206.ref085","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/0041-0101(95)00085-Z","article-title":"Phospholipase A 2 myotoxins from Bothrops snake venoms","volume":"33","author":"J Guti\u00e9rrez","year":"1995","journal-title":"Toxicon"},{"issue":"9","key":"pone.0222206.ref086","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0300-9084(00)01163-9","article-title":"Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage","volume":"82","author":"JM Guti\u00e9rrez","year":"2000","journal-title":"Biochimie"},{"issue":"2","key":"pone.0222206.ref087","first-page":"213","article-title":"Structure, function and biophysical aspects of the myotoxins from snake venoms","volume":"17","author":"CL Ownby","year":"1998","journal-title":"Toxin Rev"},{"issue":"10","key":"pone.0222206.ref088","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3390\/toxins10100411","article-title":"Coagulotoxicity of Bothrops (lancehead pit-vipers) venoms from Brazil: differential biochemistry and antivenom efficacy resulting from prey-driven venom variation","volume":"10","author":"L Sousa","year":"2018","journal-title":"Toxins (Basel)"},{"issue":"4","key":"pone.0222206.ref089","first-page":"183","article-title":"Why do we study animal toxins?","volume":"36","author":"Y Zhang","year":"2015","journal-title":"Zool Res"},{"key":"pone.0222206.ref090","first-page":"134","volume-title":"WHO guidelines for the production, control and regulation of snake antivenom immunoglobulins","author":"WHO World Health Organization","year":"2010"},{"key":"pone.0222206.ref091","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.toxicon.2017.11.011","article-title":"Examination of biochemical and biological activities of Bothrops jararaca (Serpentes: Viperidae; Wied-Neuwied 1824) snake venom after up to 54 years of storage","volume":"141","author":"DM Hatakeyama","year":"2018","journal-title":"Toxicon"},{"issue":"1","key":"pone.0222206.ref092","doi-asserted-by":"crossref","first-page":"e0007017","DOI":"10.1371\/journal.pntd.0007017","article-title":"Naja annulifera Snake: New insights into the venom components and pathogenesis of envenomation","volume":"13","author":"F Silva-de-Fran\u00e7a","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"pone.0222206.ref093","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0041-0101(92)90505-Y","article-title":"Biological activities of venoms from South American snakes","volume":"30","author":"EF Sanchez","year":"1992","journal-title":"Toxicon"},{"issue":"3","key":"pone.0222206.ref094","doi-asserted-by":"crossref","first-page":"e622","DOI":"10.1371\/journal.pntd.0000622","article-title":"Diversity of Micrurus snake species related to their venom toxic effects and the prospective of antivenom neutralization","volume":"4","author":"GD Tanaka","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"pone.0222206.ref095","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0041-0101(03)00171-5","article-title":"D\u00edaz A, Guti\u00e9rrez JM. Ontogenetic variability of Bothrops atrox and Bothrops asper snake venoms from Colombia","volume":"42","author":"MM Saldarriaga","year":"2003","journal-title":"Toxicon"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0222206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:18:55Z","timestamp":1588961935000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0222206"}},"subtitle":[],"editor":[{"given":"Luis Eduardo M.","family":"Quintas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,9,12]]},"references-count":95,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0222206","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,12]]}}}