{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T15:26:12Z","timestamp":1759073172241,"version":"3.37.3"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Research Council","award":["ERC-SG 281719"],"award-info":[{"award-number":["ERC-SG 281719"]}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/SAU-MIC\/122082\/2010"],"award-info":[{"award-number":["PTDC\/SAU-MIC\/122082\/2010"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/BIA-BCM\/105610\/2008"],"award-info":[{"award-number":["PTDC\/BIA-BCM\/105610\/2008"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Italian National Research Programme","award":["PRIN-2015"],"award-info":[{"award-number":["PRIN-2015"]}]},{"DOI":"10.13039\/501100003448","name":"General Secretariat for Research and Technology","doi-asserted-by":"publisher","award":["MIS-448301"],"award-info":[{"award-number":["MIS-448301"]}],"id":[{"id":"10.13039\/501100003448","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["PCOFUND-GA-2010-267332"],"award-info":[{"award-number":["PCOFUND-GA-2010-267332"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0222226","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T17:36:03Z","timestamp":1569432963000},"page":"e0222226","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Malaria transmission through the mosquito requires the function of the OMD protein"],"prefix":"10.1371","volume":"14","author":[{"given":"Chiara","family":"Curr\u00e0","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5084-3485","authenticated-orcid":true,"given":"Jessica","family":"Kehrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2832-6806","authenticated-orcid":true,"given":"Leandro","family":"Lemgruber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A. G. C.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4278-2376","authenticated-orcid":true,"given":"Lucia","family":"Bertuccini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Superti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasino","family":"Pace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Ponzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich","family":"Frischknecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1572-5840","authenticated-orcid":true,"given":"Inga","family":"Siden-Kiamos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar R.","family":"Mair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"key":"pone.0222226.ref001","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nrmicro.2017.86","article-title":"Gliding motility powers invasion and egress in Apicomplexa","volume":"15","author":"K Frenal","year":"2017","journal-title":"Nat Rev Microbiol"},{"key":"pone.0222226.ref002","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.chom.2016.10.020","article-title":"An Apicomplexan Actin-Binding Protein Serves as a Connector and Lipid Sensor to Coordinate Motility and Invasion","volume":"20","author":"D Jacot","year":"2016","journal-title":"Cell Host Microbe"},{"key":"pone.0222226.ref003","doi-asserted-by":"crossref","first-page":"6221","DOI":"10.1093\/emboj\/18.22.6221","article-title":"CTRP is essential for mosquito infection by malaria ookinetes","volume":"18","author":"JT Dessens","year":"1999","journal-title":"Embo J"},{"key":"pone.0222226.ref004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2958.2000.01821.x","article-title":"Developmental arrest of the human malaria parasite Plasmodium falciparum within the mosquito midgut via CTRP gene disruption","volume":"36","author":"TJ Templeton","year":"2000","journal-title":"Mol Microbiol"},{"key":"pone.0222226.ref005","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1084\/jem.190.11.1711","article-title":"Targeted disruption of the plasmodium berghei CTRP gene reveals its essential role in malaria infection of the vector mosquito","volume":"190","author":"M Yuda","year":"1999","journal-title":"J Exp Med"},{"key":"pone.0222226.ref006","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1046\/j.1365-2958.2003.03566.x","article-title":"SOAP, a novel malaria ookinete protein involved in mosquito midgut invasion and oocyst development","volume":"49","author":"JT Dessens","year":"2003","journal-title":"Mol Microbiol"},{"key":"pone.0222226.ref007","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0166-6851(01)00304-8","article-title":"von Willebrand Factor A domain-related protein, a novel microneme protein of the malaria ookinete highly conserved throughout Plasmodium parasites","volume":"116","author":"M Yuda","year":"2001","journal-title":"Mol Biochem Parasitol"},{"key":"pone.0222226.ref008","doi-asserted-by":"crossref","first-page":"e1000599","DOI":"10.1371\/journal.ppat.1000599","article-title":"A cyclic GMP signalling module that regulates gliding motility in a malaria parasite","volume":"5","author":"RW Moon","year":"2009","journal-title":"PLoS Pathog"},{"key":"pone.0222226.ref009","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1111\/j.1365-2958.2006.05189.x","article-title":"Plasmodium berghei calcium-dependent protein kinase 3 is required for ookinete gliding motility and mosquito midgut invasion","volume":"60","author":"I Siden-Kiamos","year":"2006","journal-title":"Mol Microbiol"},{"key":"pone.0222226.ref010","doi-asserted-by":"crossref","first-page":"e1001806","DOI":"10.1371\/journal.pbio.1001806","article-title":"Phosphoinositide metabolism links cGMP-dependent protein kinase G to essential Ca(2)(+) signals at key decision points in the life cycle of malaria parasites","volume":"12","author":"M Brochet","year":"2014","journal-title":"PLoS Biol"},{"key":"pone.0222226.ref011","doi-asserted-by":"crossref","first-page":"e1002948","DOI":"10.1371\/journal.ppat.1002948","article-title":"A unique protein phosphatase with kelch-like domains (PPKL) in Plasmodium modulates ookinete differentiation, motility and invasion","volume":"8","author":"DS Guttery","year":"2012","journal-title":"PLoS Pathog"},{"key":"pone.0222226.ref012","doi-asserted-by":"crossref","first-page":"W465","DOI":"10.1093\/nar\/gkn180","article-title":"Phylogeny.fr: robust phylogenetic analysis for the non-specialist","volume":"36","author":"A Dereeper","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"pone.0222226.ref013","doi-asserted-by":"crossref","first-page":"e1000767","DOI":"10.1371\/journal.ppat.1000767","article-title":"Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development","volume":"6","author":"GR Mair","year":"2010","journal-title":"PLoS Pathog"},{"key":"pone.0222226.ref014","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.molbiopara.2005.09.007","article-title":"High efficiency transfection of Plasmodium berghei facilitates novel selection procedures","volume":"145","author":"CJ Janse","year":"2006","journal-title":"Mol Biochem Parasitol"},{"key":"pone.0222226.ref015","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1111\/cmi.12131","article-title":"A perforin-like protein mediates disruption of the erythrocyte membrane during egress of Plasmodium berghei male gametocytes","volume":"15","author":"E Deligianni","year":"2013","journal-title":"Cell Microbiol"},{"key":"pone.0222226.ref016","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.molbiopara.2011.11.002","article-title":"Evidence for filamentous actin in ookinetes of a malarial parasite","volume":"181","author":"I Siden-Kiamos","year":"2012","journal-title":"Mol Biochem Parasitol"},{"key":"pone.0222226.ref017","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.celrep.2013.01.032","article-title":"An ancient protein phosphatase, SHLP1, is critical to microneme development in Plasmodium ookinetes and parasite transmission","volume":"3","author":"EM Patzewitz","year":"2013","journal-title":"Cell Rep"},{"key":"pone.0222226.ref018","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.exppara.2017.08.001","article-title":"Structured illumination microscopy reveals actin I localization in discreet foci in Plasmodium berghei gametocytes","volume":"181","author":"C Curra","year":"2017","journal-title":"Exp Parasitol"},{"key":"pone.0222226.ref019","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1365-3024.1988.tb00214.x","article-title":"Ookinete antigens of Plasmodium berghei. Appearance on the zygote surface of an Mr 21 kD determinant identified by transmission-blocking monoclonal antibodies","volume":"10","author":"LA Winger","year":"1988","journal-title":"Parasite Immunol"},{"key":"pone.0222226.ref020","doi-asserted-by":"crossref","first-page":"e1002046","DOI":"10.1371\/journal.ppat.1002046","article-title":"Transition of Plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein Pumilio","volume":"7","author":"CS Gomes-Santos","year":"2011","journal-title":"PLoS Pathog"},{"key":"pone.0222226.ref021","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"A Waterhouse","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"pone.0222226.ref022","doi-asserted-by":"crossref","first-page":"D539","DOI":"10.1093\/nar\/gkn814","article-title":"PlasmoDB: a functional genomic database for malaria parasites","volume":"37","author":"C Aurrecoechea","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"pone.0222226.ref023","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.cell.2017.06.030","article-title":"Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes","volume":"170","author":"E Bushell","year":"2017","journal-title":"Cell"},{"key":"pone.0222226.ref024","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1111\/j.1462-5822.2011.01686.x","article-title":"Stage-specific depletion of myosin A supports an essential role in motility of malarial ookinetes","volume":"13","author":"I Siden-Kiamos","year":"2011","journal-title":"Cell Microbiol"},{"key":"pone.0222226.ref025","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.molbiopara.2006.09.003","article-title":"Involvement of actin and myosins in Plasmodium berghei ookinete motility","volume":"150","author":"I Siden-Kiamos","year":"2006","journal-title":"Mol Biochem Parasitol"},{"key":"pone.0222226.ref026","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/0092-8674(87)90086-9","article-title":"A C-terminal signal prevents secretion of luminal ER proteins","volume":"48","author":"S Munro","year":"1987","journal-title":"Cell"},{"key":"pone.0222226.ref027","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1016\/j.febslet.2009.10.053","article-title":"The KDEL receptor: new functions for an old protein","volume":"583","author":"M Capitani","year":"2009","journal-title":"FEBS Lett"},{"key":"pone.0222226.ref028","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.str.2010.11.017","article-title":"Structural characterization of the Boca\/Mesd maturation factors for LDL-receptor-type beta propeller domains","volume":"19","author":"MN Collins","year":"2011","journal-title":"Structure"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0222226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T01:05:13Z","timestamp":1590109513000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0222226"}},"subtitle":[],"editor":[{"given":"Georges","family":"Snounou","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,9,25]]},"references-count":28,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0222226","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2019,9,25]]}}}