{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:24:28Z","timestamp":1778084668283,"version":"3.51.4"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T00:00:00Z","timestamp":1569456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0222668","type":"journal-article","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T00:18:46Z","timestamp":1569543526000},"page":"e0222668","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Geospatial modeling of microcephaly and zika virus spread patterns in Brazil"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2505-035X","authenticated-orcid":true,"given":"Pedro","family":"Amaral","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3618-3967","authenticated-orcid":true,"given":"Lucas","family":"Resende de Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Augusto","family":"Hernandes Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00fabia Cristina","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Ricardo Nickenig","family":"Vissoci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,9,26]]},"reference":[{"key":"pone.0222668.ref001","unstructured":"World Health Organization. Zika virus and complications: Public Health Emergency of International Concern. World Heal. Organ.\u2014Program. 2016. http:\/\/www.who.int\/emergencies\/zika-virus\/en\/"},{"key":"pone.0222668.ref002","unstructured":"European Centre for Disease Prevention and Control. Current Zika transmission worldwide [Internet]. 2017. https:\/\/ecdc.europa.eu\/en\/publications-data\/current-zika-transmission-worldwide"},{"key":"pone.0222668.ref003","unstructured":"Brasil-SINAN\/SUS. Ministry of Health. Sistema de informa\u00e7\u00e3o de agravos de notifica\u00e7\u00e3o (SINAN\/SUS). 2019. Accessed 15 nov. 2018."},{"issue":"10026","key":"pone.0222668.ref004","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/S0140-6736(16)30058-7","article-title":"Guillain-Barr\u00e9 syndrome associated with Zika virus infection","author":"P Brasil","year":"2016","journal-title":"Lancet"},{"issue":"10047","key":"pone.0222668.ref005","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0140-6736(16)30902-3","article-title":"Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation","volume":"388","author":"GVA Fran\u00e7a","year":"2016","journal-title":"Lancet (London, England)"},{"issue":"6287","key":"pone.0222668.ref006","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1126\/science.aaf6116","article-title":"Zika virus impairs growth in human neurospheres and brain organoids","volume":"352","author":"PP Garcez","year":"2016","journal-title":"Science"},{"issue":"6","key":"pone.0222668.ref007","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1473-3099(16)00095-5","article-title":"Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study","volume":"16","author":"G Calvet","year":"2017","journal-title":"Lancet Infect. Dis"},{"issue":"24","key":"pone.0222668.ref008","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1073\/pnas.1718476115","article-title":"Implications of Zika virus and congenital Zika syndrome for the number of live births in Brazil","volume":"115","author":"M. C. Castro","year":"2018","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"3","key":"pone.0222668.ref009","doi-asserted-by":"crossref","first-page":"e1002755","DOI":"10.1371\/journal.pmed.1002755","article-title":"\u201cThe association between Zika virus infection and microcephaly in Brazil 2015\u20132017: An observational analysis of over 4 million births.\u201d","volume":"16","author":"Oliver J. Brady","year":"2019","journal-title":"PLoS medicine"},{"issue":"4","key":"pone.0222668.ref010","doi-asserted-by":"crossref","first-page":"e0006392","DOI":"10.1371\/journal.pntd.0006392","article-title":"Zika virus infection and microcephaly: Evidence regarding geospatial associations","volume":"12","author":"JRN Vissoci","year":"2018","journal-title":"PLoS Negl. Trop. Dis"},{"issue":"1","key":"pone.0222668.ref011","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0277-9536(01)00214-3","article-title":"Place effects on health: How can we conceptualise, operationalise and measure them?","volume":"55","author":"S Macintyre","year":"2002","journal-title":"Soc. Sci. Med"},{"issue":"2","key":"pone.0222668.ref012","doi-asserted-by":"crossref","DOI":"10.1590\/0102-311x00186615","article-title":"Difus\u00e3o espa\u00e7o-tempo do dengue no Munic\u00edpio do Rio de Janeiro, Brasil, no per\u00edodo de 2000\u20132013","volume":"33","author":"DR Xavier","year":"2017","journal-title":"Cad. Saude Publica"},{"issue":"8","key":"pone.0222668.ref013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0003977","article-title":"Spatial and temporal clustering of chikungunya virus transmission in dominica","volume":"9","author":"EO Nsoesie","year":"2015","journal-title":"PLoS Negl. Trop. Dis"},{"issue":"3","key":"pone.0222668.ref014","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2471\/BLT.16.178608","article-title":"Risk of microcephaly after Zika virus infection in Brazil, 2015 to 2016","volume":"95","author":"T Jaenisch","year":"2017","journal-title":"Bull. World Health Organ"},{"issue":"10","key":"pone.0222668.ref015","doi-asserted-by":"crossref","first-page":"e1001885","DOI":"10.1371\/journal.pmed.1001885","article-title":"The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement","volume":"12","author":"RECORD Working Committee","year":"2015","journal-title":"PLoS medicine"},{"issue":"9779","key":"pone.0222668.ref016","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/S0140-6736(11)60054-8","article-title":"The Brazilian health system: History, advances, and challenges","volume":"377","author":"J Paim","year":"2011","journal-title":"Lancet"},{"issue":"3","key":"pone.0222668.ref017","first-page":"135","article-title":"Sistema de Informa\u00e7\u00e3o de Agravos de Notifica\u00e7\u00e3o (Sinan): desafios no desenvolvimento de um sistema de informa\u00e7\u00e3o em sa\u00fade","volume":"13","author":"J Laguardia","year":"2004","journal-title":"Epidemiol. e Servi\u00e7os Sa\u00fade"},{"key":"pone.0222668.ref018","unstructured":"Brasil-IBGE. Estimativas de Popula\u00e7\u00e3o. Instituto Brasileiro de Geografia e Estat\u00edstica. 2016. http:\/\/www.ibge.gov.br\/home\/estatistica\/populacao\/estimativa2016\/default.shtm. Accessed 15 nov. 2018."},{"key":"pone.0222668.ref019","unstructured":"Ribeiro LC de Q, Ribeiro MG. IBEU Municipal\u2014\u00cdndice de bem-estar urbano dos munic\u00edpios brasileiros. Rio de Janeiro; 2013."},{"key":"pone.0222668.ref020","unstructured":"Brasil. IBGE. Produto interno bruto dos munic\u00edpios. Instituto Brasileiro de Geografia e Estat\u00edstica. 2013. https:\/\/ww2.ibge.gov.br\/home\/estatistica\/economia\/pibmunicipios\/2014\/default_base.shtm. Accessed 23 abr. 2018."},{"issue":"4","key":"pone.0222668.ref021","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1538-4632.1995.tb00912.x","article-title":"Local Spatial Autocorrelation Statistics: distributional Issues and an Application","volume":"27","author":"J.K. Ord","year":"1995","journal-title":"Geographical Analysis"},{"key":"pone.0222668.ref022","unstructured":"ESRI. ArcGIS Desktop: Release 10.3. Redlands CA. 2014. p. Environmental Systems Research Institute."},{"issue":"1","key":"pone.0222668.ref023","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2307\/1907382","article-title":"Estimation of relationships for limited dependent variables","volume":"26","author":"James Tobin","year":"1958","journal-title":"Econometrica: journal of the Econometric Society"},{"key":"pone.0222668.ref024","volume-title":"Advanced econometrics","author":"T. Amemiya","year":"1985"},{"issue":"4","key":"pone.0222668.ref025","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/pirs.12034","article-title":"Finite sample properties of Moran\u2019s I test for spatial autocorrelation in tobit models","volume":"93","author":"P V. Amaral","year":"2014","journal-title":"Pap. Reg. Sci"},{"key":"pone.0222668.ref026","doi-asserted-by":"crossref","DOI":"10.1201\/9781420064254","volume-title":"Introduction to spatial econometrics","author":"J. LeSage","year":"2009"},{"issue":"1","key":"pone.0222668.ref027","doi-asserted-by":"crossref","first-page":"130","DOI":"10.32614\/RJ-2013-013","article-title":"Estimating Spatial Probit Models in R","volume":"5","author":"S Wilhelm","year":"2013","journal-title":"R Journal"},{"key":"pone.0222668.ref028","doi-asserted-by":"crossref","DOI":"10.1201\/9780429258411","volume-title":"Bayesian Data Analysis","author":"A. Gelman","year":"1995"},{"issue":"2","key":"pone.0222668.ref029","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0378-3782(01)00123-2","article-title":"Pathologic and laboratory correlation in microcephaly associated with prenatal cocaine exposure","volume":"63","author":"A Kesrouani","year":"2001","journal-title":"Early Hum Dev"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0222668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T01:01:16Z","timestamp":1588986076000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0222668"}},"subtitle":[],"editor":[{"given":"James","family":"Weger-Lucarelli","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,9,26]]},"references-count":29,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0222668","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,26]]}}}