{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:14:04Z","timestamp":1789834444683,"version":"4.0.1"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T00:00:00Z","timestamp":1569542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25111001"],"award-info":[{"award-number":["25111001"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["15H04843"],"award-info":[{"award-number":["15H04843"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H02744"],"award-info":[{"award-number":["18H02744"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18KT0027"],"award-info":[{"award-number":["18KT0027"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18KK0242"],"award-info":[{"award-number":["18KK0242"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["AMED-CREST"],"award-info":[{"award-number":["AMED-CREST"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["Brain\/MINDs"],"award-info":[{"award-number":["Brain\/MINDs"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["18dk0207026s0402"],"award-info":[{"award-number":["18dk0207026s0402"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0223113","type":"journal-article","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T13:31:38Z","timestamp":1569591098000},"page":"e0223113","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy"],"prefix":"10.1371","volume":"14","author":[{"given":"Akio","family":"Mori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei-Ichi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9732-8488","authenticated-orcid":true,"given":"Shinji","family":"Saiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6808-0444","authenticated-orcid":true,"given":"Taku","family":"Hatano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Oji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayami","family":"Okuzumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Fujimaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Koinuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Ichi","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Imamichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutaka","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,9,27]]},"reference":[{"issue":"4","key":"pone.0223113.ref001","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nrneurol.2017.26","article-title":"Multiple system atrophy: insights into a rare and debilitating movement disorder","volume":"13","author":"F Krismer","year":"2017","journal-title":"Nature reviews Neurology"},{"issue":"6","key":"pone.0223113.ref002","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1212\/WNL.42.6.1142","article-title":"What features improve the accuracy of clinical diagnosis in Parkinson's disease: a clinicopathologic study","volume":"42","author":"AJ Hughes","year":"1992","journal-title":"Neurology"},{"issue":"7","key":"pone.0223113.ref003","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S1474-4422(17)30157-6","article-title":"Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches","volume":"16","author":"AL Boxer","year":"2017","journal-title":"The Lancet Neurology"},{"issue":"2","key":"pone.0223113.ref004","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1136\/jnnp-2017-315813","article-title":"Recent advances in neuropathology, biomarkers and therapeutic approach of multiple system atrophy","volume":"89","author":"S Koga","year":"2018","journal-title":"Journal of neurology, neurosurgery, and psychiatry"},{"issue":"5","key":"pone.0223113.ref005","doi-asserted-by":"crossref","first-page":"e404","DOI":"10.1212\/WNL.0000000000004888","article-title":"Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease","volume":"90","author":"M Fujimaki","year":"2018","journal-title":"Neurology"},{"key":"pone.0223113.ref006","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.parkreldis.2017.10.010","article-title":"Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy","volume":"46","author":"Y Compta","year":"2018","journal-title":"Parkinsonism & related disorders"},{"issue":"8","key":"pone.0223113.ref007","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1001\/jamaneurol.2016.1325","article-title":"Plasma Coenzyme Q10 Levels in Patients With Multiple System Atrophy","volume":"73","author":"J Mitsui","year":"2016","journal-title":"JAMA neurology"},{"issue":"2","key":"pone.0223113.ref008","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.parkreldis.2009.07.007","article-title":"Consecutive analyses of cerebrospinal fluid axonal and glial markers in Parkinson's disease and atypical Parkinsonian disorders","volume":"16","author":"R Constantinescu","year":"2010","journal-title":"Parkinsonism & related disorders"},{"key":"pone.0223113.ref009","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.nbd.2015.05.004","article-title":"Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative","volume":"80","author":"B Laurens","year":"2015","journal-title":"Neurobiology of disease"},{"issue":"3","key":"pone.0223113.ref010","doi-asserted-by":"crossref","DOI":"10.3390\/metabo7030042","article-title":"Biomarker Research in Parkinson's Disease Using Metabolite Profiling","volume":"7","author":"JF Havelund","year":"2017","journal-title":"Metabolites"},{"issue":"9","key":"pone.0223113.ref011","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1212\/01.wnl.0000324625.00404.15","article-title":"Second consensus statement on the diagnosis of multiple system atrophy","volume":"71","author":"S Gilman","year":"2008","journal-title":"Neurology"},{"issue":"2","key":"pone.0223113.ref012","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/mds.10680","article-title":"Accuracy of clinical diagnosis of progressive supranuclear palsy","volume":"19","author":"Y Osaki","year":"2004","journal-title":"Movement disorders: official journal of the Movement Disorder Society"},{"issue":"1","key":"pone.0223113.ref013","doi-asserted-by":"crossref","first-page":"7328","DOI":"10.1038\/s41598-017-06767-y","article-title":"Decreased long-chain acylcarnitines from insufficient beta-oxidation as potential early diagnostic markers for Parkinson's disease","volume":"7","author":"S Saiki","year":"2017","journal-title":"Scientific reports"},{"issue":"2","key":"pone.0223113.ref014","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1039\/B714176A","article-title":"Depiction of metabolome changes in histidine-starved Escherichia coli by CE-TOFMS","volume":"4","author":"Y Ohashi","year":"2008","journal-title":"Molecular bioSystems"},{"issue":"1","key":"pone.0223113.ref015","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.plipres.2009.08.004","article-title":"Acylcarnitines: role in brain","volume":"49","author":"LL Jones","year":"2010","journal-title":"Progress in lipid research"},{"issue":"6","key":"pone.0223113.ref016","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/mds.26992","article-title":"metabolic profiling of Parkinson's disease and mild cognitive impairment","volume":"32","author":"F Burte","year":"2017","journal-title":"Movement disorders: official journal of the Movement Disorder Society"},{"issue":"8","key":"pone.0223113.ref017","doi-asserted-by":"crossref","first-page":"18865","DOI":"10.3390\/ijms160818865","article-title":"Major Alterations of Phosphatidylcholine and Lysophosphotidylcholine Lipids in the Substantia Nigra Using an Early Stage Model of Parkinson's Disease","volume":"16","author":"K Farmer","year":"2015","journal-title":"International journal of molecular sciences"},{"key":"pone.0223113.ref018","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.steroids.2016.01.017","article-title":"Nongenomic actions of neurosteroid pregnenolone and its metabolites","volume":"111","author":"JH Weng","year":"2016","journal-title":"Steroids"},{"issue":"3","key":"pone.0223113.ref019","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1046\/j.1471-4159.2001.00295.x","article-title":"Dehydroepiandrosterone inhibits lipopolysaccharide-induced nitric oxide production in BV-2 microglia","volume":"77","author":"MJ Wang","year":"2001","journal-title":"Journal of neurochemistry"},{"issue":"24","key":"pone.0223113.ref020","doi-asserted-by":"crossref","first-page":"14033","DOI":"10.1073\/pnas.241503698","article-title":"The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: distinct mechanisms","volume":"98","author":"Y Akwa","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"12","key":"pone.0223113.ref021","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrn3820","article-title":"Polyunsaturated fatty acids and their metabolites in brain function and disease","volume":"15","author":"RP Bazinet","year":"2014","journal-title":"Nature reviews Neuroscience"},{"issue":"5","key":"pone.0223113.ref022","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1365-2265.2011.04244.x","article-title":"The association of specific metabolites of lipid metabolism with markers of oxidative stress, inflammation and arterial stiffness in men with newly diagnosed type 2 diabetes","volume":"76","author":"CY Ha","year":"2012","journal-title":"Clinical endocrinology"},{"issue":"3","key":"pone.0223113.ref023","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3233\/JAD-2012-110629","article-title":"Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer's disease","volume":"29","author":"SC Cunnane","year":"2012","journal-title":"Journal of Alzheimer's disease: JAD"},{"key":"pone.0223113.ref024","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jprot.2014.01.014","article-title":"Combination of metabolomic and phospholipid-profiling approaches for the study of Alzheimer's disease","volume":"104","author":"R Gonzalez-Dominguez","year":"2014","journal-title":"Journal of proteomics"},{"issue":"14","key":"pone.0223113.ref025","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1002\/mds.26052","article-title":"Neuropathology of multiple system atrophy: new thoughts about pathogenesis","volume":"29","author":"KA Jellinger","year":"2014","journal-title":"Movement disorders: official journal of the Movement Disorder Society"},{"key":"pone.0223113.ref026","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.redox.2017.10.016","article-title":"Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation","volume":"14","author":"PR Angelova","year":"2018","journal-title":"Redox biology"},{"issue":"3","key":"pone.0223113.ref027","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/mds.26466","article-title":"Low serum uric acid levels in progressive supranuclear palsy","volume":"31","author":"JM Oropesa-Ruiz","year":"2016","journal-title":"Movement disorders: official journal of the Movement Disorder Society"},{"issue":"18","key":"pone.0223113.ref028","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.clinbiochem.2008.08.074","article-title":"Biomarkers of oxidative stress and endothelial dysfunction in glucose intolerance and diabetes mellitus","volume":"41","author":"EC Pereira","year":"2008","journal-title":"Clinical biochemistry"},{"key":"pone.0223113.ref029","doi-asserted-by":"crossref","first-page":"4156293","DOI":"10.1155\/2016\/4156293","article-title":"Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology.","volume":"2016","author":"M Jesus","year":"2016","journal-title":"Journal of analytical methods in chemistry"},{"issue":"9","key":"pone.0223113.ref030","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1212\/WNL.0000000000003663","article-title":"Metabolomic biomarkers as strong correlates of Parkinson disease progression","volume":"88","author":"PA LeWitt","year":"2017","journal-title":"Neurology"},{"issue":"12","key":"pone.0223113.ref031","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1002\/mds.27173","article-title":"Profiling novel metabolic biomarkers for Parkinson's disease using in-depth metabolomic analysis","volume":"32","author":"W Han","year":"2017","journal-title":"Mov Disord"},{"issue":"4","key":"pone.0223113.ref032","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1039\/C5MB00711A","article-title":"Multi-platform mass spectrometry analysis of the CSF and plasma metabolomes of rigorously matched amyotrophic lateral sclerosis, Parkinson's disease and control subjects","volume":"12","author":"A Wuolikainen","year":"2016","journal-title":"Mol Biosyst"},{"issue":"3","key":"pone.0223113.ref033","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1136\/jnnp-2014-309676","article-title":"Identification of novel biomarkers for Parkinson's disease by metabolomic technologies","volume":"87","author":"T Hatano","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"pone.0223113.ref034","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3233\/JPD-140389","article-title":"Metabolite and peptide levels in plasma and CSF differentiating healthy controls from patients with newly diagnosed Parkinson's disease","volume":"4","author":"M Trupp","year":"2014","journal-title":"J Parkinsons Dis"},{"key":"pone.0223113.ref035","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1423-0127-16-63","article-title":"Metabolic profiling of Parkinson's disease: evidence of biomarker from gene expression analysis and rapid neural network detection","volume":"16","author":"SS Ahmed","year":"2009","journal-title":"J Biomed Sci"},{"issue":"10","key":"pone.0223113.ref036","doi-asserted-by":"crossref","first-page":"e7551","DOI":"10.1371\/journal.pone.0007551","article-title":"Metabolomic profiling in LRRK2-related Parkinson's disease","volume":"4","author":"KK Johansen","year":"2009","journal-title":"PLoS One"},{"issue":"Pt 2","key":"pone.0223113.ref037","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/brain\/awm304","article-title":"Metabolomic profiling to develop blood biomarkers for Parkinson's disease","volume":"131","author":"M Bogdanov","year":"2008","journal-title":"Brain"},{"issue":"9","key":"pone.0223113.ref038","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1093\/ndt\/gfl292","article-title":"Symmetric dimethylarginine (SDMA) as endogenous marker of renal function\u2014a meta-analysis.","volume":"21","author":"JT Kielstein","year":"2006","journal-title":"Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association\u2014European Renal Association"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0223113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:48:48Z","timestamp":1588963728000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0223113"}},"subtitle":[],"editor":[{"given":"Per","family":"Svenningsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,9,27]]},"references-count":38,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0223113","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,27]]}}}