{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:01:53Z","timestamp":1770487313374,"version":"3.49.0"},"reference-count":12,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["T32DA013911"],"award-info":[{"award-number":["T32DA013911"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Translational Science Institute","award":["1UL1TR001430"],"award-info":[{"award-number":["1UL1TR001430"]}]},{"name":"Flemish Fund for Scientific Research","award":["FWO G0F8316N"],"award-info":[{"award-number":["FWO G0F8316N"]}]},{"name":"Brown University School of Public Health Nora Kahn Piore Award","award":["fellowship"],"award-info":[{"award-number":["fellowship"]}]},{"DOI":"10.13039\/100001949","name":"American Society of Tropical Medicine and Hygiene","doi-asserted-by":"publisher","award":["fellowship"],"award-info":[{"award-number":["fellowship"]}],"id":[{"id":"10.13039\/100001949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0223308","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T13:42:28Z","timestamp":1571319748000},"page":"e0223308","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A\u00a0retrospective cohort analysis"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1521-148X","authenticated-orcid":true,"given":"Tara C.","family":"Bouton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaretha","family":"de Vos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth J.","family":"Ragan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura F.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonie","family":"Van Zyl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danie","family":"Theron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Robert","family":"Horsburgh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin M.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen R.","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,10,17]]},"reference":[{"key":"pone.0223308.ref001","first-page":"418","article-title":"Multidrug-resistant tuberculosis treatment outcomes in relation to treatment and initial versus acquired second-line drug resistance","volume":"62","author":"JP Cegielski","year":"2016","journal-title":"Clin Infect Dis"},{"key":"pone.0223308.ref002","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1093\/jac\/dkx107","article-title":"Adverse drug reactions during drug-resistant TB treatment in high HIV prevalence settings: a systematic review and meta-analysis","volume":"72","author":"K Schnippel","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"pone.0223308.ref003","doi-asserted-by":"crossref","first-page":"167","DOI":"10.5588\/ijtld.16.0493","article-title":"Examples of bedaquiline introduction for the management of multidrug-resistant tuberculosis in five countries","volume":"21","author":"L Guglielmetti","year":"2017","journal-title":"Int J Tuberc Lung Dis"},{"key":"pone.0223308.ref004","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1093\/cid\/cix992","article-title":"Bedaquiline resistance: its emergence, mechanism, and prevention","volume":"66","author":"TVA Nguyen","year":"2018","journal-title":"Clin Infect Dis"},{"key":"pone.0223308.ref005","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/resp.13143","article-title":"Recent controversies about MDR and XDR-TB: Global implementation of the WHO shorter MDR-TB regimen and bedaquiline for all with MDR-TB?","volume":"23","author":"K Dheda","year":"2018","journal-title":"Respirology"},{"key":"pone.0223308.ref006","first-page":"684","article-title":"Unexpected high prevalence of resistance-associated Rv0678 variants in MDR-TB patients without documented prior use of clofazimine or bedaquiline","volume":"72","author":"C Villellas","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"pone.0223308.ref007","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0140-6736(18)31644-1","article-title":"Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis","volume":"392","author":"Collaborative Group for the Meta-Analysis of Individual Patient Data in MDR-TB treatment\u20132017","year":"2018","journal-title":"Lancet"},{"key":"pone.0223308.ref008","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(14)60844-8","article-title":"Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"CJL Murray","year":"2018","journal-title":"Lancet"},{"key":"pone.0223308.ref009","author":"WHO","year":"2018","journal-title":"Rapid Communication: Key changes to treatment of multidrug- and rifampicin-resistant tuberculosis"},{"key":"pone.0223308.ref010","author":"Department of Health Republic of South Africa","year":"2015","journal-title":"Introduction of new drugs and drug regimens for the management of drug-resistant tuberculosis in South Africa: policy framework version 1.1"},{"key":"pone.0223308.ref011","first-page":"ciy727","article-title":"Improved treatment outcomes with bedaquiline when substituted for second-line injectable agents in multidrug resistant tuberculosis: a retrospective cohort study","author":"Y Zhao","year":"2018","journal-title":"Clin Infect Dis"},{"key":"pone.0223308.ref012","doi-asserted-by":"crossref","first-page":"e0133869","DOI":"10.1371\/journal.pone.0133869","article-title":"A global perspective on pyrazinamide resistance: systematic review and meta-analysis","volume":"10","author":"M Whitfield","year":"2015","journal-title":"PLoS One"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0223308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:43:14Z","timestamp":1588966994000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0223308"}},"subtitle":[],"editor":[{"given":"HASNAIN SEYED","family":"EHTESHAM","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,10,17]]},"references-count":12,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0223308","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,17]]}}}