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neurotrophins","volume":"228","author":"H Al-Amin","year":"2011","journal-title":"Exp Neurol"},{"issue":"17","key":"pone.0223435.ref076","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1523\/JNEUROSCI.3667-13.2014","article-title":"Nerve injury-induced neuropathic pain causes disinhibition of the anterior cingulate cortex","volume":"34","author":"SM Blom","year":"2014","journal-title":"J Neurosci"},{"key":"pone.0223435.ref077","article-title":"Peripheral nerve injury induces adult brain neurogenesis and remodelling","author":"G Rusanescu","year":"2016","journal-title":"J Cell Mol Med"},{"issue":"8","key":"pone.0223435.ref078","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1523\/JNEUROSCI.05-08-02051.1985","article-title":"An immunohistochemical and quantitative examination of dorsal root ganglion neuronal subpopulations","volume":"5","author":"J. 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