{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T07:09:17Z","timestamp":1775200157258,"version":"3.50.1"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0224169","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T17:57:02Z","timestamp":1571853422000},"page":"e0224169","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Iron is increased in the brains of ageing mice lacking the neurofilament light gene"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5671-4879","authenticated-orcid":true,"given":"James C.","family":"Vickers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna E.","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme H.","family":"McCormack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0943-2702","authenticated-orcid":true,"given":"Aidan D.","family":"Bindoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Adlard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"key":"pone.0224169.ref001","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/jnc.13425","article-title":"Iron neurochemistry in Alzheimer\u2019s disease and Parkinson\u2019s disease: targets for therapeutics","volume":"139","author":"AA Belaidi","year":"2016","journal-title":"J Neurochem"},{"key":"pone.0224169.ref002","doi-asserted-by":"crossref","first-page":"E2506","DOI":"10.3390\/ijms18122506","article-title":"Zinc signal in brain diseases","volume":"18","author":"AD Portbury","year":"2017","journal-title":"Int J Mol Sci"},{"key":"pone.0224169.ref003","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1021\/acs.molpharmaceut.7b00841","article-title":"The pivotal role of copper in neurodegeneration: A new strategy for the therapy of neurodegenerative disorders","volume":"15","author":"R Giampietro","year":"2018","journal-title":"Mol Pharm"},{"key":"pone.0224169.ref004","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3233\/JAD-2006-102-303","article-title":"Metals and Alzheimer\u2019s disease","volume":"10","author":"PA Adlard","year":"2006","journal-title":"J Alzheimers Dis"},{"key":"pone.0224169.ref005","doi-asserted-by":"crossref","first-page":"9812178","DOI":"10.1155\/2016\/9812178","article-title":"Metals and neuronal metal binding proteins implicated in Alzheimer\u2019s disease","volume":"2016","author":"JS Crist\u00f3v\u00e3o","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"pone.0224169.ref006","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.cell.2010.08.014","article-title":"Iron-export ferroxidase activity of \u03b2-amyloid precursor protein is inhibited by zinc in Alzheimer\u2019s disease","volume":"142","author":"JA Duce","year":"2010","journal-title":"Cell"},{"key":"pone.0224169.ref007","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/mp.2016.96","article-title":"Lithium suppression of tau induces brain iron accumulation and neurodegeneration","volume":"22","author":"P Lei","year":"2017","journal-title":"Mol Psychiatry"},{"key":"pone.0224169.ref008","doi-asserted-by":"crossref","first-page":"15.10","DOI":"10.3389\/fnins.2019.00015","article-title":"The contribution of iron to protein aggregation disorders in the central nervous system","volume":"13","author":"K Joppe","year":"2019","journal-title":"Frontiers Neurosci"},{"key":"pone.0224169.ref009","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1007\/s12035-015-9146-x","article-title":"Alpha-Synuclein over-expression induces increased iron accumulation and redistribution in iron-exposed neurons","volume":"53","author":"R Ortega","year":"2016","journal-title":"Mol Neurobiol"},{"key":"pone.0224169.ref010","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.mcn.2017.05.010","article-title":"The third wave: Intermediate filaments in the maturing nervous system","volume":"84","author":"MTK Kirkcaldie","year":"2017","journal-title":"Mol Cell Neurosci"},{"key":"pone.0224169.ref011","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1136\/jnnp.57.9.1039","article-title":"Loss of non-phosphorylated neurofilament immunoreactivity with preservation of tyrosine hydroxylase in surviving substantia nigra neurons in Parkinson\u2019s disease","volume":"57","author":"WP Gai","year":"1994","journal-title":"J Neurol Neurosurg Psychiat"},{"key":"pone.0224169.ref012","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.brainresbull.2009.08.004","article-title":"Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system","volume":"80","author":"JC Vickers","year":"2009","journal-title":"Brain Res Bull"},{"key":"pone.0224169.ref013","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.brainresbull.2016.07.012","article-title":"Alterations in neurofilaments and the transformation of the cytoskeleton in axons may provide insight into the aberrant neuronal changes of Alzheimer\u2019s disease","volume":"126","author":"JC Vickers","year":"2016","journal-title":"Brain Res Bull"},{"key":"pone.0224169.ref014","doi-asserted-by":"crossref","first-page":"8503","DOI":"10.1021\/bi00422a031","article-title":"Characterization of the cation-binding properties of porcine neurofilaments","volume":"27","author":"S Lefebvre","year":"1988","journal-title":"Biochemistry"},{"key":"pone.0224169.ref015","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1016\/j.neurobiolaging.2015.07.003","article-title":"Neurofilament light gene deletion exacerbates amyloid, dystrophic neurite, and synaptic pathology in the APP\/PS1 transgenic model of Alzheimer\u2019s disease","volume":"36","author":"CM Fernandez-Martos","year":"2015","journal-title":"Neurobiol Aging"},{"key":"pone.0224169.ref016","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/exnr.1997.6654","article-title":"Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments","volume":"148","author":"Q Zhu","year":"1997","journal-title":"Exp Neurol"},{"key":"pone.0224169.ref017","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1002\/cne.23261","article-title":"Cytoskeletal changes during development and aging in the cortex of neurofilament light protein knockout mice","volume":"521","author":"Y Liu","year":"2013","journal-title":"J Comp Neurol"},{"key":"pone.0224169.ref018","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.2041-210x.2012.00261.x","article-title":"A general and simple method for obtaining R2 from generalized linear mixed\u2010effects models","volume":"4","author":"S Nakagawa","year":"2013","journal-title":"Methods Ecol Evolution"},{"key":"pone.0224169.ref019","doi-asserted-by":"crossref","first-page":"6421","DOI":"10.1074\/jbc.274.10.6421","article-title":"Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5\u2019-untranslated region sequences","volume":"274","author":"JT Rogers","year":"1999","journal-title":"J Biol Chem"},{"key":"pone.0224169.ref020","doi-asserted-by":"crossref","first-page":"45518","DOI":"10.1074\/jbc.M207435200","article-title":"An iron-responsive element type II in the 5\u2019-untranslated region of the Alzheimer\u2019s amyloid precursor protein transcript","volume":"277","author":"JT Rogers","year":"2002","journal-title":"J Biol Chem"},{"key":"pone.0224169.ref021","doi-asserted-by":"crossref","first-page":"37111","DOI":"10.1074\/jbc.274.52.37111","article-title":"Cu(II) potentiation of alzheimer Abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction","volume":"274","author":"X Huang","year":"1999","journal-title":"J Biol Chem"},{"key":"pone.0224169.ref022","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1007\/s00775-004-0602-8","article-title":"Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer\u2019s Abeta peptides","volume":"9","author":"X Huang","year":"2004","journal-title":"J Biol Inorg Chem"},{"key":"pone.0224169.ref023","doi-asserted-by":"crossref","first-page":"4248","DOI":"10.1074\/jbc.M110.158980","article-title":"Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation","volume":"286","author":"B Liu","year":"2011","journal-title":"J Biol Chem"},{"key":"pone.0224169.ref024","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/j.1471-4159.1993.tb03639.x","article-title":"Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide","volume":"61","author":"PW Mantyh","year":"1993","journal-title":"J Neurochem"},{"key":"pone.0224169.ref025","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1006\/bbrc.1995.2678","article-title":"The role of iron in beta amyloid toxicity","volume":"216","author":"D Schubert","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"pone.0224169.ref026","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11010-010-0563-x","article-title":"Metals, oxidative stress and neurodegenerative disorders","volume":"345","author":"K Jomova","year":"2010","journal-title":"Mol Cell Biochem"},{"key":"pone.0224169.ref027","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1046\/j.1471-4159.2002.t01-1-01061.x","article-title":"Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer\u2019s disease","volume":"82","author":"A Yamamoto","year":"2002","journal-title":"J Neurochem"},{"key":"pone.0224169.ref028","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/ana.410310310","article-title":"Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer\u2019s disease: a laser microprobe (LAMMA) study","volume":"31","author":"PF Good","year":"1992","journal-title":"Ann Neurol"},{"key":"pone.0224169.ref029","doi-asserted-by":"crossref","first-page":"5010","DOI":"10.1523\/JNEUROSCI.0526-12.2012","article-title":"Iron deficiency disrupts axon maturation of the developing auditory nerve","volume":"32","author":"DL Lee","year":"2012","journal-title":"J Neurosci"},{"key":"pone.0224169.ref030","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00005072-199505000-00004","article-title":"Covalent crosslinking of neurofilament proteins by oxidized catechols as a potential mechanism of Lewy body formation","volume":"54","author":"TJ Montine","year":"1995","journal-title":"J Neuropathol Exp Neurol"},{"key":"pone.0224169.ref031","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/S0006-291X(88)80080-9","article-title":"200 Kd neurofilament protein binds Al, Cu and Zn","volume":"152","author":"KB Pierson","year":"1988","journal-title":"Biochem Biophys Res Commun"},{"key":"pone.0224169.ref032","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.bpj.2010.01.062","article-title":"Elasticity in ionically cross-linked neurofilament networks","volume":"98","author":"NY Yao","year":"2010","journal-title":"Biophys J"},{"key":"pone.0224169.ref033","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1021\/acs.nanolett.5b00073","article-title":"Probing the interactions of intrinsically disordered proteins using nanoparticle tags","volume":"15","author":"S Pregent","year":"2015","journal-title":"Nano Lett"},{"key":"pone.0224169.ref034","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1021\/acs.biochem.8b00007","article-title":"Structural regulation of a neurofilament-inspired intrinsically disordered protein brush by multisite phosphorylation","volume":"57","author":"R Lei","year":"2018","journal-title":"Biochemistry"},{"key":"pone.0224169.ref035","article-title":"Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis","author":"and the NFL Group","year":"2019","journal-title":"JAMA Neurol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0224169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T00:59:28Z","timestamp":1588985968000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0224169"}},"subtitle":[],"editor":[{"given":"Stephen D","family":"Ginsberg","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,10,23]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0224169","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,23]]}}}