{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:07:29Z","timestamp":1781586449276,"version":"3.54.5"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/00060"],"award-info":[{"award-number":["PI16\/00060"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0224710","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T18:33:27Z","timestamp":1573151607000},"page":"e0224710","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Involvement of extracellular vesicles in the macrophage-tumor cell communication in head and neck squamous cell carcinoma"],"prefix":"10.1371","volume":"14","author":[{"given":"\u00c0ngela Maria","family":"Bellmunt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"L\u00f3pez-Puerto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Lorente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3797-3095","authenticated-orcid":true,"given":"Daniel","family":"Closa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,11,7]]},"reference":[{"key":"pone.0224710.ref001","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.ejca.2012.12.027","article-title":"Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012","volume":"49","author":"J Ferlay","year":"2013","journal-title":"Eur J Cancer"},{"key":"pone.0224710.ref002","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1016\/j.joms.2017.05.008","article-title":"Epidemiological Trends of Head and Neck Cancer in the United States: A SEER Population Study","volume":"75","author":"M Mourad","year":"2017","journal-title":"J Oral Maxillofac Surg"},{"key":"pone.0224710.ref003","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3322\/caac.21386","article-title":"An update on larynx cancer","volume":"67","author":"CE Steuer","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"pone.0224710.ref004","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.canep.2016.06.013","article-title":"The fractions of cancer attributable to modifiable factors: A global review","volume":"44","author":"DC Whiteman","year":"2016","journal-title":"Cancer Epidemiol"},{"key":"pone.0224710.ref005","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/lary.25738","article-title":"Detection of human papillomavirus in laryngeal squamous cell carcinoma: Systematic review and meta-analysis","volume":"126","author":"RR Gama","year":"2016","journal-title":"Laryngoscope"},{"key":"pone.0224710.ref006","article-title":"Pembro Ups Survival in PD-L1-positive HNSCC","year":"2018","journal-title":"Cancer Discov"},{"key":"pone.0224710.ref007","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.canlet.2015.07.039","article-title":"Tumor microenvironment: Sanctuary of the devil","volume":"368","author":"L Hui","year":"2015","journal-title":"Cancer Lett"},{"key":"pone.0224710.ref008","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/path.4824","article-title":"CAFs and TAMs: maestros of the tumour microenvironment","volume":"241","author":"Y Komohara","year":"2017","journal-title":"J Pathol"},{"key":"pone.0224710.ref009","doi-asserted-by":"crossref","first-page":"6749","DOI":"10.7314\/APJCP.2015.16.15.6749","article-title":"Serum Level of Matrix Metalloproteinase-2 and -9 in Patients with Laryngeal Squamous Cell Carcinoma and Clinical Significance","volume":"16","author":"A Lotfi","year":"2015","journal-title":"Asian Pac J Cancer Prev"},{"key":"pone.0224710.ref010","article-title":"Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments","author":"B Solomon","year":"2018","journal-title":"Semin Cancer Biol"},{"key":"pone.0224710.ref011","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fonc.2018.00049","article-title":"Targeting Macrophages in Cancer: From Bench to Bedside","volume":"8","author":"AR Poh","year":"2018","journal-title":"Front Oncol"},{"key":"pone.0224710.ref012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cas.12314","article-title":"Clinical significance of macrophage heterogeneity in human malignant tumors","volume":"105","author":"Y Komohara","year":"2014","journal-title":"Cancer Sci"},{"key":"pone.0224710.ref013","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1084\/jem.192.7.1027","article-title":"Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation","volume":"192","author":"GJ Freeman","year":"2000","journal-title":"J Exp Med"},{"key":"pone.0224710.ref014","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.lungcan.2016.05.013","article-title":"Sarcomatoid lung carcinomas show high levels of programmed death ligand-1 (PD-L1) and strong immune-cell infiltration by TCD3 cells and macrophages","volume":"98","author":"T Vieira","year":"2016","journal-title":"Lung Cancer"},{"key":"pone.0224710.ref015","doi-asserted-by":"crossref","first-page":"11158","DOI":"10.1038\/s41598-018-28944-3","article-title":"Multiplex immunohistochemistry accurately defines the immune context of metastatic melanoma","volume":"8","author":"H Halse","year":"2018","journal-title":"Sci Rep"},{"key":"pone.0224710.ref016","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.smim.2017.12.003","article-title":"Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment","volume":"35","author":"TL Whiteside","year":"2018","journal-title":"Semin Immunol"},{"key":"pone.0224710.ref017","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.semcdb.2015.02.009","article-title":"Exosomes and their roles in immune regulation and cancer","volume":"40","author":"DW Greening","year":"2015","journal-title":"Semin Cell Dev Biol"},{"key":"pone.0224710.ref018","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ceb.2014.05.004","article-title":"Biogenesis and secretion of exosomes","volume":"29C","author":"J Kowal","year":"2014","journal-title":"Curr Opin Cell Biol"},{"key":"pone.0224710.ref019","doi-asserted-by":"crossref","first-page":"87","DOI":"10.18632\/genesandcancer.172","article-title":"Exosomes derived from cancerous and non-cancerous cells regulate the anti-tumor response in the tumor microenvironment","volume":"9","author":"S Bae","year":"2018","journal-title":"Genes Cancer"},{"key":"pone.0224710.ref020","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1189\/jlb.0406249","article-title":"Biochemical and functional characterization of three activated macrophage populations","volume":"80","author":"JP Edwards","year":"2006","journal-title":"J Leukoc Biol"},{"key":"pone.0224710.ref021","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1038\/s41598-017-03244-4","article-title":"REG3\u03b2 modifies cell tumor function by impairing extracellular vesicle uptake","volume":"7","author":"L Bonjoch","year":"2017","journal-title":"Sci Rep"},{"key":"pone.0224710.ref022","article-title":"Long non-coding RNA MYU promotes prostate cancer proliferation by mediating the miR-184\/c-Myc axis","author":"J Wang","year":"2018","journal-title":"Oncol Rep"},{"key":"pone.0224710.ref023","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.gene.2018.07.018","article-title":"Horizontal transfer of exosomal CXCR4 promotes murine hepatocarcinoma cell migration, invasion and lymphangiogenesis","volume":"676","author":"M Li","year":"2018","journal-title":"Gene"},{"key":"pone.0224710.ref024","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.3389\/fimmu.2018.01650","article-title":"TLR-3 Stimulation Skews M2 Macrophages to M1 Through IFN-\u03b1\u03b2 Signaling and Restricts Tumor Progression","volume":"9","author":"A Vidyarthi","year":"2018","journal-title":"Front Immunol"},{"key":"pone.0224710.ref025","doi-asserted-by":"crossref","first-page":"e23562","DOI":"10.4161\/onci.23562","article-title":"Tumor-associated macrophages subvert T-cell function and correlate with reduced survival in clear cell renal cell carcinoma","volume":"2","author":"SR Dannenmann","year":"2013","journal-title":"Oncoimmunology"},{"key":"pone.0224710.ref026","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.molmed.2014.10.009","article-title":"Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway","volume":"21","author":"KC Ohaegbulam","year":"2015","journal-title":"Trends Mol Med"},{"key":"pone.0224710.ref027","doi-asserted-by":"crossref","first-page":"e1442168","DOI":"10.1080\/2162402X.2018.1442168","article-title":"Increase in PD-L1 expression after pre-operative radiotherapy for soft tissue sarcoma","volume":"7","author":"KR Patel","year":"2018","journal-title":"Oncoimmunology"},{"key":"pone.0224710.ref028","article-title":"PD-L1+ tumor-associated macrophages and PD-1+ tumor infiltrating lymphocytes predict survival in primary testicular lymphoma","author":"M Pollari","year":"2018","journal-title":"Haematologica"},{"key":"pone.0224710.ref029","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/j.bbrc.2017.12.032","article-title":"Apatinib inhibits migration and invasion as well as PD-L1 expression in osteosarcoma by targeting STAT3","volume":"495","author":"B Zheng","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"pone.0224710.ref030","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/1878-0261.12135","article-title":"Inhibition of IL-6-JAK\/Stat3 signaling in castration-resistant prostate cancer cells enhances the NK cell-mediated cytotoxicity via alteration of PD-L1\/NKG2D ligand levels","volume":"12","author":"L Xu","year":"2018","journal-title":"Mol Oncol"},{"key":"pone.0224710.ref031","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3389\/fimmu.2018.00871","article-title":"Breast Cancer-Derived Exosomes Alter Macrophage Polarization via gp130\/STAT3 Signaling","volume":"9","author":"S Ham","year":"2018","journal-title":"Front Immunol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0224710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T02:29:10Z","timestamp":1611800950000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0224710"}},"subtitle":[],"editor":[{"given":"Chien-Chung","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,11,7]]},"references-count":31,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0224710","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,7]]}}}