{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:59:40Z","timestamp":1792645180153,"version":"4.5.0"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0225122","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T13:29:42Z","timestamp":1573565382000},"page":"e0225122","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of 6-mercaptopurine in pressure overload induced right heart failure"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1221-0115","authenticated-orcid":true,"given":"Julie Birkmose","family":"Axelsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stine","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Ringgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janus Adler","family":"Hyldebrandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kondababu","family":"Kurakula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Jos\u00e9","family":"Goumans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances S.","family":"de Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Erik","family":"Nielsen-Kudsk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harm-Jan","family":"Bogaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asger","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"issue":"2","key":"pone.0225122.ref001","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/CIRCULATIONAHA.109.911818","article-title":"Survival in Patients With Idiopathic, Familial, and Anorexigen-Associated Pulmonary Arterial Hypertension in the Modern Management Era","volume":"122","author":"M Humbert","year":"2010","journal-title":"Circulation"},{"issue":"1","key":"pone.0225122.ref002","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1183\/09031936.00092306","article-title":"An epidemiological study of pulmonary arterial hypertension","volume":"30","author":"AJ Peacock","year":"2007","journal-title":"The European respiratory journal"},{"issue":"9","key":"pone.0225122.ref003","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1164\/rccm.200510-1668OC","article-title":"Pulmonary arterial hypertension in France: results from a national registry","volume":"173","author":"M Humbert","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"pone.0225122.ref004","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1378\/chest.14-0701","article-title":"Signs of Right Ventricular Deterioration in Clinically Stable Patients With Pulmonary Arterial Hypertension","volume":"147","author":"MC van de Veerdonk","year":"2015","journal-title":"Chest"},{"issue":"24","key":"pone.0225122.ref005","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1016\/j.jacc.2011.06.068","article-title":"Progressive Right Ventricular Dysfunction in Patients With Pulmonary Arterial Hypertension Responding to Therapy","volume":"58","author":"MC van de Veerdonk","year":"2011","journal-title":"Journal of the American College of Cardiology"},{"issue":"6","key":"pone.0225122.ref006","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1378\/chest.10-1293","article-title":"Integration of clinical and hemodynamic parameters in the prediction of long-term survival in patients with pulmonary arterial hypertension","volume":"139","author":"GC Kane","year":"2011","journal-title":"Chest"},{"issue":"5","key":"pone.0225122.ref007","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1183\/09031936.00072709","article-title":"Survival in pulmonary arterial hypertension: a reappraisal of the NIH risk stratification equation","volume":"35","author":"T Thenappan","year":"2010","journal-title":"The European respiratory journal"},{"issue":"2","key":"pone.0225122.ref008","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1378\/chest.11-1460","article-title":"An Evaluation of Long-term Survival From Time of Diagnosis in Pulmonary Arterial Hypertension From the REVEAL Registry","volume":"142","author":"RL Benza","year":"2012","journal-title":"Chest"},{"issue":"1","key":"pone.0225122.ref009","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0165-6147(96)01007-3","article-title":"Thiopurine biology and pharmacology","volume":"18","author":"J Aarbakke","year":"1997","journal-title":"Trends in Pharmacological Sciences"},{"issue":"2","key":"pone.0225122.ref010","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s002800050873","article-title":"Metabolism of 6-mercaptopurine in the erythrocytes, liver, and kidney of rats during multiple-dose regimens","volume":"43","author":"F Innocenti","year":"1999","journal-title":"Cancer chemotherapy and pharmacology"},{"issue":"9","key":"pone.0225122.ref011","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.4049\/jimmunol.1302527","article-title":"Inhibition of GTPase Rac1 in endothelium by 6-mercaptopurine results in immunosuppression in nonimmune cells: new target for an old drug","volume":"192","author":"G Marinkovic","year":"2014","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"issue":"27","key":"pone.0225122.ref012","doi-asserted-by":"crossref","first-page":"24776","DOI":"10.1074\/jbc.M300088200","article-title":"The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine","volume":"278","author":"KD Wansa","year":"2003","journal-title":"The Journal of biological chemistry"},{"issue":"4","key":"pone.0225122.ref013","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1161\/CIRCULATIONAHA.106.626838","article-title":"Activation of nuclear receptor Nur77 by 6-mercaptopurine protects against neointima formation","volume":"115","author":"NM Pires","year":"2007","journal-title":"Circulation"},{"key":"pone.0225122.ref014","doi-asserted-by":"crossref","first-page":"1802400","DOI":"10.1183\/13993003.02400-2018","article-title":"6-mercaptopurine, an agonist of Nur77, reduces progression of pulmonary hypertension by enhancing BMP signalling","author":"K Kurakula","year":"2019","journal-title":"European Respiratory Journal"},{"key":"pone.0225122.ref015","doi-asserted-by":"crossref","first-page":"15404","DOI":"10.1038\/srep15404","article-title":"Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling","volume":"5","author":"L Medzikovic","year":"2015","journal-title":"Scientific reports"},{"issue":"19","key":"pone.0225122.ref016","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1128\/MCB.00229-15","article-title":"Orphan Nuclear Receptor Nur77 Inhibits Cardiac Hypertrophic Response to Beta-Adrenergic Stimulation","volume":"35","author":"G Yan","year":"2015","journal-title":"Mol Cell Biol"},{"issue":"1","key":"pone.0225122.ref017","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/emmm.201201369","article-title":"The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signalling","volume":"5","author":"RH Wang","year":"2013","journal-title":"EMBO molecular medicine"},{"issue":"36","key":"pone.0225122.ref018","doi-asserted-by":"crossref","first-page":"14001","DOI":"10.1074\/jbc.RA118.003099","article-title":"Transcriptional up-regulation of relaxin-3 by Nur77 attenuates beta-adrenergic agonist-induced apoptosis in cardiomyocytes","volume":"293","author":"X You","year":"2018","journal-title":"The Journal of biological chemistry"},{"issue":"8","key":"pone.0225122.ref019","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2459\/JCM.0000000000000134","article-title":"Immunosuppressive treatment for myocarditis: a meta-analysis of randomized controlled trials","volume":"17","author":"C Lu","year":"2016","journal-title":"Journal of Cardiovascular Medicine"},{"issue":"1","key":"pone.0225122.ref020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1161\/01.CIR.104.1.39","article-title":"Randomized, placebo-controlled study for immunosuppressive treatment of inflammatory dilated cardiomyopathy: two-year follow-up results","volume":"104","author":"R Wojnicz","year":"2001","journal-title":"Circulation"},{"issue":"16","key":"pone.0225122.ref021","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1093\/eurheartj\/ehp249","article-title":"Randomized study on the efficacy of immunosuppressive therapy in patients with virus-negative inflammatory cardiomyopathy: the TIMIC study","volume":"30","author":"A Frustaci","year":"2009","journal-title":"European heart journal"},{"issue":"2","key":"pone.0225122.ref022","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00796819","article-title":"Favorable effects of immunosuppressive therapy in children with dilated cardiomyopathy and active myocarditis","volume":"16","author":"PR Camargo","year":"1995","journal-title":"Pediatric Cardiology"},{"key":"pone.0225122.ref023","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/modpathol.3800594","article-title":"Cell death, proliferation and repair in human myocarditis responding to immunosuppressive therapy","volume":"19","author":"A Frustaci","year":"2006","journal-title":"Modern Pathology"},{"issue":"1","key":"pone.0225122.ref024","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1124\/jpet.117.239921","article-title":"Docetaxel Reverses Pulmonary Vascular Remodeling by Decreasing Autophagy and Resolves Right Ventricular Fibrosis","volume":"363","author":"YF Ibrahim","year":"2017","journal-title":"The Journal of pharmacology and experimental therapeutics"},{"issue":"2","key":"pone.0225122.ref025","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/cvr\/cvw047","article-title":"Carfilzomib reverses pulmonary arterial hypertension","volume":"110","author":"X Wang","year":"2016","journal-title":"Cardiovasc Res"},{"issue":"1","key":"pone.0225122.ref026","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/jnci\/djp440","article-title":"Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention","volume":"102","author":"A Albini","year":"2010","journal-title":"Journal of the National Cancer Institute"},{"issue":"suppl 61","key":"pone.0225122.ref027","first-page":"OA4660","article-title":"The effect of 6-mercaptopurine treatment on experimentally induced pulmonary arterial hypertension","volume":"50","author":"X-Q Sun","year":"2017","journal-title":"European Respiratory Journal"},{"key":"pone.0225122.ref028","unstructured":"Mercaptopurine (Rx) [updated February 2019; cited 2019 9\/11]. In Medscape\u2014Drugs & Diseases. Available from: https:\/\/reference.medscape.com\/drug\/purinethol-purixan-mercaptopurine-342094."},{"issue":"141","key":"pone.0225122.ref029","doi-asserted-by":"crossref","DOI":"10.3791\/58050","article-title":"A Pulmonary Trunk Banding Model of Pressure Overload Induced Right Ventricular Hypertrophy and Failure","author":"S Andersen","year":"2018","journal-title":"Journal of visualized experiments: JoVE"},{"issue":"4","key":"pone.0225122.ref030","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s10741-015-9479-6","article-title":"Right ventricular failure due to chronic pressure load: What have we learned in animal models since the NIH working group statement?","volume":"20","author":"MAJ Borgdorff","year":"2015","journal-title":"Heart Failure Reviews"},{"issue":"3","key":"pone.0225122.ref031","doi-asserted-by":"crossref","first-page":"549","DOI":"10.17219\/acem\/61855","article-title":"Prognostic factors in pulmonary arterial hypertension: Literature review","volume":"26","author":"E Stepnowska","year":"2017","journal-title":"Advances in clinical and experimental medicine: official organ Wroclaw Medical University"},{"issue":"25 Suppl","key":"pone.0225122.ref032","doi-asserted-by":"crossref","first-page":"D22","DOI":"10.1016\/j.jacc.2013.10.027","article-title":"Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology","volume":"62","author":"A Vonk-Noordegraaf","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"pone.0225122.ref033","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1172\/JCI119770","article-title":"Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium","volume":"100","author":"BD Lowes","year":"1997","journal-title":"The Journal of clinical investigation"},{"issue":"3","key":"pone.0225122.ref034","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1378\/chest.08-0492","article-title":"The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension","volume":"135","author":"HJ Bogaard","year":"2009","journal-title":"Chest"},{"issue":"1","key":"pone.0225122.ref035","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/cvr\/cvw014","article-title":"Modulators of right ventricular apoptosis and contractility in a rat model of pulmonary hypertension","volume":"110","author":"M Zungu-Edmondson","year":"2016","journal-title":"Cardiovascular Research"},{"issue":"2","key":"pone.0225122.ref036","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1254\/jphs.09112FP","article-title":"Effects of telmisartan on right ventricular remodeling induced by monocrotaline in rats","volume":"111","author":"M Okada","year":"2009","journal-title":"Journal of pharmacological sciences"},{"issue":"8","key":"pone.0225122.ref037","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1161\/01.CIR.102.8.865","article-title":"Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension","volume":"102","author":"N Nagaya","year":"2000","journal-title":"Circulation"},{"issue":"3","key":"pone.0225122.ref038","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1017\/S1047951115000402","article-title":"Evaluation of cardiac electrophysiological properties in an experimental model of right ventricular hypertrophy and failure","volume":"26","author":"JG Schultz","year":"2016","journal-title":"Cardiology in the young"},{"issue":"1","key":"pone.0225122.ref039","doi-asserted-by":"crossref","first-page":"H1","DOI":"10.1152\/ajpheart.00335.2010","article-title":"Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects","volume":"299","author":"B Lopez","year":"2010","journal-title":"American journal of physiology Heart and circulatory physiology"},{"issue":"7","key":"pone.0225122.ref040","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0945-053X(98)90012-9","article-title":"Lysyl oxidase: properties, regulation and multiple functions in biology","volume":"16","author":"LI Smith-Mungo","year":"1998","journal-title":"Matrix biology: journal of the International Society for Matrix Biology"},{"issue":"1","key":"pone.0225122.ref041","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/cvr\/cvt100","article-title":"Osteopontin-mediated myocardial fibrosis in heart failure: a role for lysyl oxidase?","volume":"99","author":"B L\u00f3pez","year":"2013","journal-title":"Cardiovascular Research"},{"issue":"3","key":"pone.0225122.ref042","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1748-1716.2008.01936.x","article-title":"Connective tissue growth factor and cardiac fibrosis","volume":"195","author":"A Daniels","year":"2009","journal-title":"Acta physiologica (Oxford, England)"},{"issue":"7","key":"pone.0225122.ref043","article-title":"Right Ventricular Myocardial Stiffness in Experimental Pulmonary Arterial Hypertension","volume":"9","author":"S Rain","year":"2016","journal-title":"Relative Contribution of Fibrosis and Myofibril Stiffness"},{"issue":"1","key":"pone.0225122.ref044","doi-asserted-by":"crossref","first-page":"H85","DOI":"10.1152\/ajpheart.00089.2016","article-title":"Distinct right ventricle remodeling in response to pressure overload in the rat","volume":"311","author":"P Mendes-Ferreira","year":"2016","journal-title":"American journal of physiology Heart and circulatory physiology"},{"key":"pone.0225122.ref045","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.matbio.2018.01.010","article-title":"Right ventricular fibrosis and dysfunction: Actual concepts and common misconceptions","volume":"68\u201369","author":"B Egemnazarov","year":"2018","journal-title":"Matrix biology: journal of the International Society for Matrix Biology"},{"issue":"7","key":"pone.0225122.ref046","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1093\/cvr\/cvz049","article-title":"Protection against pressure overload-induced right heart failure by uncoupling protein 2 silencing","volume":"115","author":"A Esfandiary","year":"2019","journal-title":"Cardiovascular Research"},{"issue":"3","key":"pone.0225122.ref047","doi-asserted-by":"crossref","first-page":"H699","DOI":"10.1152\/ajpheart.00047.2018","article-title":"Multiscale structure-function relationships in right ventricular failure due to pressure overload","volume":"315","author":"TC Cheng","year":"2018","journal-title":"American journal of physiology Heart and circulatory physiology"},{"issue":"3","key":"pone.0225122.ref048","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/cvr\/cvu264","article-title":"Functional crosstalk between cardiac fibroblasts and adult cardiomyocytes by soluble mediators","volume":"105","author":"JE Cartledge","year":"2015","journal-title":"Cardiovasc Res"},{"key":"pone.0225122.ref049","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.yjmcc.2014.01.013","article-title":"Fibroblast-mediated pathways in cardiac hypertrophy","volume":"70","author":"K Fujiu","year":"2014","journal-title":"J Mol Cell Cardiol"},{"issue":"4","key":"pone.0225122.ref050","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00395-018-0682-1","article-title":"NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2alpha","volume":"113","author":"H Zhou","year":"2018","journal-title":"Basic research in cardiology"},{"issue":"4","key":"pone.0225122.ref051","doi-asserted-by":"crossref","first-page":"e94732","DOI":"10.1371\/journal.pone.0094732","article-title":"Chymase Mediates Injury and Mitochondrial Damage in Cardiomyocytes during Acute Ischemia\/Reperfusion in the Dog","volume":"9","author":"J Zheng","year":"2014","journal-title":"PLOS ONE"},{"issue":"17","key":"pone.0225122.ref052","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1093\/eurheartj\/ehq496","article-title":"Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis","volume":"32","author":"Z Cheng","year":"2011","journal-title":"European heart journal"},{"issue":"12","key":"pone.0225122.ref053","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/cvr\/cvx159","article-title":"Role of cardiac inflammation in right ventricular failure","volume":"113","author":"XQ Sun","year":"2017","journal-title":"Cardiovasc Res"},{"issue":"3","key":"pone.0225122.ref054","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0008-6363(03)00470-X","article-title":"Right ventricular hypertrophy and apoptosis after pulmonary artery banding: regulation of PKC isozymes","volume":"59","author":"MU Braun","year":"2003","journal-title":"Cardiovasc Res"},{"issue":"9","key":"pone.0225122.ref055","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1161\/CIRCULATIONAHA.109.933762","article-title":"Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension","volume":"122","author":"E Soon","year":"2010","journal-title":"Circulation"},{"issue":"9","key":"pone.0225122.ref056","doi-asserted-by":"crossref","first-page":"S198","DOI":"10.1016\/j.cardfail.2016.07.244","article-title":"Inhibition of Nuclear Factor-kappaB-Mediated Inflammation Reverses Fibrosis and Improves RV Function in Rats with Pulmonary Artery Banding","volume":"22","author":"K Yoshida","journal-title":"Journal of Cardiac Failure"},{"issue":"1","key":"pone.0225122.ref057","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1161\/CIRCULATIONAHA.108.829713","article-title":"Opposite Effects of Training in Rats With Stable and Progressive Pulmonary Hypertension","volume":"120","author":"ML Handoko","year":"2009","journal-title":"Circulation"},{"issue":"115","key":"pone.0225122.ref058","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1183\/09059180.00007109","article-title":"Perspectives on novel therapeutic strategies for right heart failure in pulmonary arterial hypertension: lessons from the left heart","volume":"19","author":"ML Handoko","year":"2010","journal-title":"European respiratory review: an official journal of the European Respiratory Society"},{"issue":"27","key":"pone.0225122.ref059","doi-asserted-by":"crossref","first-page":"24791","DOI":"10.1074\/jbc.M302167200","article-title":"Identification of the Antineoplastic Agent 6-Mercaptopurine as an Activator of the Orphan Nuclear Hormone Receptor Nurr1","volume":"278","author":"P Ordentlich","year":"2003","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"pone.0225122.ref060","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12974-016-0543-5","article-title":"6-Mercaptopurine attenuates tumor necrosis factor-\u03b1 production in microglia through Nur77-mediated transrepression and PI3K\/Akt\/mTOR signaling-mediated translational regulation","volume":"13","author":"H-Y Huang","year":"2016","journal-title":"Journal of neuroinflammation"},{"issue":"26","key":"pone.0225122.ref061","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1038\/sj.onc.1210149","article-title":"6-Mercaptopurine, an activator of Nur77, enhances transcriptional activity of HIF-1alpha resulting in new vessel formation","volume":"26","author":"YG Yoo","year":"2007","journal-title":"Oncogene"},{"issue":"4","key":"pone.0225122.ref062","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/BF02220605","article-title":"The clinical pharmacology of 6-mercaptopurine","volume":"43","author":"L Lennard","year":"1992","journal-title":"European Journal of Clinical Pharmacology"},{"issue":"3","key":"pone.0225122.ref063","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1136\/gut.39.3.401","article-title":"6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity","volume":"39","author":"C Cuffari","year":"1996","journal-title":"Gut"},{"key":"pone.0225122.ref064","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2147\/PPA.S133288","article-title":"Targeted drugs for pulmonary arterial hypertension: a network meta-analysis of 32 randomized clinical trials","volume":"11","author":"X-F Gao","year":"2017","journal-title":"Patient preference and adherence"},{"issue":"12","key":"pone.0225122.ref065","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.7863\/jum.2010.29.12.1771","article-title":"Effects of heart rate and anesthetic timing on high-resolution echocardiographic assessment under isoflurane anesthesia in mice. Journal of ultrasound in medicine: official journal of the","volume":"29","author":"J Wu","year":"2010","journal-title":"American Institute of Ultrasound in Medicine"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0225122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T13:30:04Z","timestamp":1573565404000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0225122"}},"subtitle":[],"editor":[{"given":"Vincenzo","family":"Lionetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,11,12]]},"references-count":65,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0225122","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,12]]}}}