{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:48:27Z","timestamp":1791416907450,"version":"4.3.3"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0225191","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T13:49:21Z","timestamp":1581601761000},"page":"e0225191","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Open-label pilot clinical trial of citicoline for fragile X-associated tremor\/ataxia syndrome (FXTAS)"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2772-7851","authenticated-orcid":true,"given":"Deborah A.","family":"Hall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin E.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Leehey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"McAsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bichun","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Berry-Kravis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan A.","family":"O\u2019Keefe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,2,13]]},"reference":[{"key":"pone.0225191.ref001","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1212\/WNL.57.1.127","article-title":"Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X","volume":"57","author":"RJ Hagerman","year":"2001","journal-title":"Neurology"},{"key":"pone.0225191.ref002","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/978-3-642-21649-7_18","article-title":"The fragile X-associated tremor ataxia syndrome","volume":"54","author":"F Tassone","year":"2012","journal-title":"Results Probl Cell Differ"},{"key":"pone.0225191.ref003","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/ajmg.b.32065","article-title":"Prevalence of CGG expansions of the FMR1 gene in a US population-based sample","volume":"159B","author":"MM Seltzer","year":"2012","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"pone.0225191.ref004","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1001\/jama.291.4.460","article-title":"Penetrance of the fragile X-associated tremor\/ataxia syndrome in a premutation carrier population","volume":"291","author":"S Jacquemont","year":"2004","journal-title":"JAMA"},{"key":"pone.0225191.ref005","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/ejhg.2009.51","article-title":"Penetrance of FMR1 premutation associated pathologies in fragile X syndrome families","volume":"17","author":"L Rodriguez-Revenga","year":"2009","journal-title":"Eur J Hum Genet"},{"key":"pone.0225191.ref006","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1358\/mf.1999.21.9.795632","article-title":"Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion","volume":"21","author":"XA Alvarez","year":"1999","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"pone.0225191.ref007","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1093\/hmg\/dds024","article-title":"Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila","volume":"21","author":"A Qurashi","year":"2012","journal-title":"Hum Mol Genet"},{"key":"pone.0225191.ref008","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1212\/01.wnl.0000281692.98200.f5","article-title":"FMR1 CGG repeat length predicts motor dysfunction in premutation carriers","volume":"70","author":"MA Leehey","year":"2008","journal-title":"Neurology"},{"key":"pone.0225191.ref009","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1212\/WNL.53.8.1660","article-title":"Total neuropathy score: validation and reliability study","volume":"53","author":"DR Cornblath","year":"1999","journal-title":"Neurology"},{"key":"pone.0225191.ref010","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1177\/0891988716666379","article-title":"Risk Factors for Cognitive Impairment in Fragile X-Associated Tremor\/Ataxia Syndrome","volume":"29","author":"AL Seritan","year":"2016","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"pone.0225191.ref011","doi-asserted-by":"crossref","first-page":"883","DOI":"10.2466\/pms.1992.74.3.883","article-title":"Reliabilities, norms and factor structure of the Behavioral Dyscontrol Scale","volume":"74","author":"J Grigsby","year":"1992","journal-title":"Percept Mot Skills"},{"key":"pone.0225191.ref012","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1037\/h0054651","article-title":"Studies of interference in serial verbal reactions","volume":"18","author":"JR Stroop","year":"1935","journal-title":"Journal of Experimental Psychology"},{"key":"pone.0225191.ref013","volume-title":"Wechsler Adult Intelligence Scale 3rd Edition (WAIS-3\u00ae)","author":"D Wechsler","year":"1997"},{"key":"pone.0225191.ref014","volume-title":"The assessment of aphasia and related disorders","author":"H Goodglass","year":"1972"},{"key":"pone.0225191.ref015","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0028-3932(67)90015-2","article-title":"Word fluency and brain damage","volume":"5","author":"JG Borkowski","year":"1967","journal-title":"Neuropsychologia"},{"key":"pone.0225191.ref016","volume-title":"Learning disorders: Vol. 3","author":"J Hellmuth","year":"1968"},{"key":"pone.0225191.ref017","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"ZS Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"pone.0225191.ref018","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1109\/TNSRE.2010.2047606","article-title":"iTUG, a sensitive and reliable measure of mobility","volume":"18","author":"A Salarian","year":"2010","journal-title":"IEEE Trans Neural Syst Rehabil Eng"},{"key":"pone.0225191.ref019","first-page":"77","article-title":"Hand strength and dexterity","volume":"25","author":"M Kellor","year":"1971","journal-title":"Am J Occup Ther"},{"key":"pone.0225191.ref020","doi-asserted-by":"crossref","first-page":"M28","DOI":"10.1093\/gerona\/50A.1.M28","article-title":"The Activities-specific Balance Confidence (ABC) Scale","volume":"50A","author":"LE Powell","year":"1995","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"pone.0225191.ref021","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1037\/0022-006X.56.6.893","article-title":"An inventory for measuring clinical anxiety: psychometric properties","volume":"56","author":"AT Beck","year":"1988","journal-title":"J Consult Clin Psychol"},{"key":"pone.0225191.ref022","first-page":"363","volume-title":"Center for Epidemiologic Studies Depression Scale: Review and Revision (CESD and CESD-R). The use of psychological testing for treatment planning and outcomes assessment: Instruments for adults","author":"WW Eaton","year":"2004"},{"key":"pone.0225191.ref023","article-title":"Capturing the fragile X premutation phenotypes: a collaborative effort across multiple cohorts","author":"JE Hunter","year":"2012","journal-title":"Neuropsychology"},{"key":"pone.0225191.ref024","doi-asserted-by":"crossref","first-page":"264","DOI":"10.4088\/JCP.13m08546","article-title":"Memantine for fragile X-associated tremor\/ataxia syndrome: a randomized, double-blind, placebo-controlled trial","volume":"75","author":"AL Seritan","year":"2014","journal-title":"J Clin Psychiatry"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0225191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T17:11:50Z","timestamp":1695748310000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0225191"}},"subtitle":[],"editor":[{"given":"Antony","family":"Bayer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,2,13]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0225191","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,13]]}}}