{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:45:28Z","timestamp":1791434728700,"version":"4.3.3"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"crossref","award":["2017G006010"],"award-info":[{"award-number":["2017G006010"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Clinical Science and Technology Innovation Plan of Jinan","award":["201805052"],"award-info":[{"award-number":["201805052"]}]},{"name":"the project of orthognathic and orthodontic combination therapy","award":["LCJZ[2013]171"],"award-info":[{"award-number":["LCJZ[2013]171"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0225247","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T18:39:12Z","timestamp":1576089552000},"page":"e0225247","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["The association between chronic periodontitis and oral Helicobacter pylori: A meta-analysis"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7557-0919","authenticated-orcid":true,"given":"Xiang","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Qiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao-Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"issue":"6","key":"pone.0225247.ref001","first-page":"568","article-title":"A cross-sectional study on periodontal conditions in elderly people in Wuxi city","volume":"19","author":"LQ Tang","year":"2010","journal-title":"Shanghai Kou Qiang Yi Xue"},{"issue":"6","key":"pone.0225247.ref002","first-page":"561","article-title":"The sampling survey of teeth defect and denture restoration among 1579 middle aged and elder people in Shanghai","volume":"18","author":"H Cheng","year":"2009","journal-title":"Shanghai Kou Qiang Yi Xue"},{"issue":"1","key":"pone.0225247.ref003","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1600-0757.2011.00425.x","article-title":"The global burden of periodontal disease: towards integration with chronic disease prevention and control","volume":"60","author":"PE Petersen","year":"2012","journal-title":"Periodontol 2000"},{"key":"pone.0225247.ref004","first-page":"27","article-title":"Systemic effects of periodontitis","volume":"18","author":"BG Loos","year":"2006","journal-title":"Ann R Australas Coll Dent Surg"},{"issue":"10","key":"pone.0225247.ref005","doi-asserted-by":"crossref","first-page":"e46508","DOI":"10.1371\/journal.pone.0046508","article-title":"Periodontal disease and risk of chronic obstructive pulmonary disease: a meta-analysis of observational studies","volume":"7","author":"XT Zeng","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"pone.0225247.ref006","doi-asserted-by":"crossref","first-page":"371","DOI":"10.14219\/jada.archive.2013.0130","article-title":"The association between periodontitis and coronary heart disease: a quality assessment of systematic reviews","volume":"144","author":"JT Kelly","year":"2013","journal-title":"J Am Dent Assoc"},{"issue":"10","key":"pone.0225247.ref007","doi-asserted-by":"crossref","first-page":"e79017","DOI":"10.1371\/journal.pone.0079017","article-title":"Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies","volume":"8","author":"XT Zeng","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"pone.0225247.ref008","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.11607\/jomi.3544","article-title":"History of periodontitis as a risk factor for long-term survival of dental implants: a meta-analysis","volume":"29","author":"X Wen","year":"2014","journal-title":"Int J Oral Maxillofac Implants"},{"issue":"1","key":"pone.0225247.ref009","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1902\/annals.2001.6.1.99","article-title":"Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective","volume":"6","author":"GW Taylor","year":"2001","journal-title":"Ann Periodontol"},{"issue":"2","key":"pone.0225247.ref010","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/154405910308200202","article-title":"Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases","volume":"82","author":"TE Van Dyke","year":"2003","journal-title":"Journal of dental research"},{"issue":"Suppl 1","key":"pone.0225247.ref011","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/adj.12280","article-title":"Periodontal considerations in older individuals","volume":"60","author":"I. Darby","year":"2015","journal-title":"Aust Dent J"},{"issue":"11\u201312","key":"pone.0225247.ref012","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0003-9969(85)90133-5","article-title":"The relationships between streptococcal species and periodontopathic bacteria in human dental plaque","volume":"30","author":"JD Hillman","year":"1985","journal-title":"Arch Oral Biol"},{"issue":"1","key":"pone.0225247.ref013","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0003-9969(82)90180-7","article-title":"Bacterial interference in the oral ecology of Actinobacillus actinomycetemcomitans and its relationship to human periodontosis","volume":"27","author":"JD Hillman","year":"1982","journal-title":"Arch Oral Biol"},{"issue":"1","key":"pone.0225247.ref014","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1038\/s41598-017-03804-8","article-title":"Dysbiosis in chronic periodontitis: Key microbial players and interactions with the human host","volume":"7","author":"ZL Deng","year":"2017","journal-title":"Sci Rep"},{"issue":"2","key":"pone.0225247.ref015","doi-asserted-by":"crossref","first-page":"47","DOI":"10.4248\/ijos.09029","article-title":"Oral microbiology: past, present and future","volume":"1","author":"XS He","year":"2009","journal-title":"Int J Oral Sci"},{"issue":"4","key":"pone.0225247.ref016","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1172\/JCI119588","article-title":"Ecology of Helicobacter pylori in the human stomach","volume":"100","author":"MJ Blaser","year":"1997","journal-title":"J Clin Invest"},{"issue":"9","key":"pone.0225247.ref017","first-page":"16741","article-title":"Relation between periodontitis and helicobacter pylori infection","volume":"8","author":"P Zheng","year":"2015","journal-title":"Int J Clin Exp Med"},{"issue":"38","key":"pone.0225247.ref018","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.2174\/138161210794519075","article-title":"Helicobacter pylori and inflammation","volume":"16","author":"P. Ruggiero","year":"2010","journal-title":"Curr Pharm Des"},{"issue":"6","key":"pone.0225247.ref019","doi-asserted-by":"crossref","first-page":"310","DOI":"10.5694\/j.1326-5377.1997.tb125076.x","article-title":"Helicobacter pylori infection in an Australian regional city: prevalence and risk factors","volume":"167","author":"HG Peach","year":"1997","journal-title":"Med J Australia"},{"issue":"2","key":"pone.0225247.ref020","first-page":"131","article-title":"Detection of Helicobacter pylori colonization in dental plaques and tongue scrapings of patients with chronic gastritis","volume":"32","author":"A Ozdemir","year":"2001","journal-title":"Quintessence Int"},{"issue":"2","key":"pone.0225247.ref021","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1067\/moe.2001.113589","article-title":"The relationship between gastric-oral Helicobacter pylori and oral hygiene in patients with vitamin B-12-deficiency anemia","volume":"92","author":"N Avcu","year":"2001","journal-title":"Oral Surg Oral Med O"},{"issue":"1","key":"pone.0225247.ref022","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1046\/j.1523-5378.2000.00004.x","article-title":"Influence of oral Helicobacter pylori on the success of eradication therapy against gastric Helicobacter pylori","volume":"5","author":"H Miyabayashi","year":"2000","journal-title":"Helicobacter"},{"issue":"10","key":"pone.0225247.ref023","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1177\/0022034509344559","article-title":"Periodontal Therapy Improves Gastric Helicobacter pylori Eradication","volume":"88","author":"S Zaric","year":"2009","journal-title":"Journal of dental research"},{"issue":"7","key":"pone.0225247.ref024","doi-asserted-by":"crossref","first-page":"e1000100","DOI":"10.1371\/journal.pmed.1000100","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"6","author":"A Liberati","year":"2009","journal-title":"PLoS Med"},{"issue":"3","key":"pone.0225247.ref025","doi-asserted-by":"crossref","first-page":"398","DOI":"10.4103\/0972-124X.100919","article-title":"Presence of Helicobacter pylori in subgingival plaque of periodontitis patients with and without dyspepsia, detected by polymerase chain reaction and culture","volume":"16","author":"S Agarwal","year":"2012","journal-title":"J Indian Soc Periodontol"},{"issue":"10","key":"pone.0225247.ref026","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/aje\/kwg074","article-title":"Estimating the relative risk in cohort studies and clinical trials of common outcomes","volume":"157","author":"LA McNutt","year":"2003","journal-title":"Am J Epidemiol"},{"issue":"7414","key":"pone.0225247.ref027","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"JP Higgins","year":"2003","journal-title":"BMJ"},{"issue":"7109","key":"pone.0225247.ref028","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"M Egger","year":"1997","journal-title":"BMJ"},{"issue":"9","key":"pone.0225247.ref029","first-page":"16741","article-title":"Relation between periodontitis and helicobacter pylori infection","volume":"8","author":"P Zheng","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"pone.0225247.ref030","doi-asserted-by":"crossref","first-page":"121","DOI":"10.12659\/MSM.894583","article-title":"Association Between Helicobacter pylori Infection and Risk of Periodontal Diseases in Han Chinese: A Case-Control Study","volume":"22","author":"J Yang","year":"2016","journal-title":"Med Sci Monit"},{"issue":"1","key":"pone.0225247.ref031","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1902\/jop.2008.070241","article-title":"Detection of Helicobacter pylori by polymerase chain reaction in the subgingival biofilm and saliva of non-dyspeptic periodontal patients","volume":"79","author":"R Souto","year":"2008","journal-title":"J Periodontol"},{"issue":"2","key":"pone.0225247.ref032","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/2230-8229.97934","article-title":"Incidence of helicobacter pylori in dental plaque of saudi gastritis patients","volume":"9","author":"AN Al-Refai","year":"2002","journal-title":"J Family Community Med"},{"issue":"3","key":"pone.0225247.ref033","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1155\/2009\/950527","article-title":"Is the presence of Helicobacter pylori in dental plaque of patients with chronic periodontitis a risk factor for gastric infection?","volume":"23","author":"M Al Asqah","year":"2009","journal-title":"Can J Gastroenterol"},{"issue":"20","key":"pone.0225247.ref034","first-page":"5886","article-title":"The clinical study on the effects of chronic periodontitis and periodontal initial therapy for the infection and eradication of Helicobacter pylori","volume":"35","author":"WJ, Z Miao","year":"2015","journal-title":"Chinese Journal of Gerontology"},{"issue":"4","key":"pone.0225247.ref035","first-page":"625","article-title":"The research of relationship between periodontitis and helicobacter pylori","volume":"14","author":"L-X Gong","year":"2011","journal-title":"J coal industry"},{"issue":"12","key":"pone.0225247.ref036","first-page":"1251","article-title":"Association Between Helicobacter pylori Infection and Risk of Periodontal Diseases in Han non-smoking Chinese","volume":"31","author":"LJ, S. Jing","year":"2015","journal-title":"J dent research"},{"issue":"3","key":"pone.0225247.ref037","first-page":"0248","article-title":"The significance of detection Helicobacter pylori in the tissue of chronic periodontitis utilizing PCR technique","volume":"13","author":"W. Li","year":"2001","journal-title":"J Henan Medical College for Staff and Workers"},{"issue":"1","key":"pone.0225247.ref038","first-page":"5","article-title":"Correlativity of the chronic periodontitis with helicobacter pylori infection","volume":"27","author":"GS, Z Jing","year":"2011","journal-title":"J Clin Stomatol"},{"issue":"5","key":"pone.0225247.ref039","first-page":"274","article-title":"Effect of oral environmental changes on Helicobacter pylori in patients with periodontitis","volume":"24","author":"JH, X Ying","year":"2002","journal-title":"Med Zhejiang"},{"issue":"29","key":"pone.0225247.ref040","doi-asserted-by":"crossref","first-page":"9922","DOI":"10.3748\/wjg.v20.i29.9922","article-title":"Helicobacter pylori and oral pathology: relationship with the gastric infection","volume":"20","author":"I Adler","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"36","key":"pone.0225247.ref041","doi-asserted-by":"crossref","first-page":"12847","DOI":"10.3748\/wjg.v20.i36.12847","article-title":"Diagnosis of Helicobacter pylori: what should be the gold standard?","volume":"20","author":"SK Patel","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"2","key":"pone.0225247.ref042","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1046\/j.1365-2168.2001.01684.x","article-title":"Randomized clinical trial of Helicobacter pylori from dental plaque","volume":"88","author":"AK Butt","year":"2001","journal-title":"The British journal of surgery"},{"issue":"3","key":"pone.0225247.ref043","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/01.SMJ.0000051069.50950.2B","article-title":"Oral colonization of Helicobacter pylori: risk factors and response to eradication therapy","volume":"96","author":"AK Gurbuz","year":"2003","journal-title":"Southern medical journal"},{"issue":"5","key":"pone.0225247.ref044","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1600-051X.2006.00915.x","article-title":"Persistence of Helicobacter pylori in the oral cavity after systemic eradication therapy","volume":"33","author":"EC Gebara","year":"2006","journal-title":"Journal of clinical periodontology"},{"issue":"19","key":"pone.0225247.ref045","doi-asserted-by":"crossref","first-page":"5639","DOI":"10.3748\/wjg.v20.i19.5639","article-title":"Role of dental plaque, saliva and periodontal disease in Helicobacter pylori infection","volume":"20","author":"PS Anand","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"11","key":"pone.0225247.ref046","doi-asserted-by":"crossref","first-page":"e354","DOI":"10.1902\/jop.2014.140317","article-title":"Association between interleukin-4 gene -590 c\/t, -33 c\/t, and 70-base-pair polymorphisms and periodontitis susceptibility: a meta-analysis","volume":"85","author":"Y Yan","year":"2014","journal-title":"J Periodontol"},{"issue":"7","key":"pone.0225247.ref047","doi-asserted-by":"crossref","first-page":"4795","DOI":"10.1007\/s11033-014-3350-z","article-title":"Association between cyclooxygenase-2 gene polymorphisms and risk of periodontitis: a meta-analysis involving 5653 individuals","volume":"41","author":"L Jiang","year":"2014","journal-title":"Mol Biol Rep"},{"issue":"3","key":"pone.0225247.ref048","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cden.2005.03.003","article-title":"Epidemiology and risk factors of periodontal diseases","volume":"49","author":"JM Albandar","year":"2005","journal-title":"Dent Clin North Am"},{"issue":"11","key":"pone.0225247.ref049","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.2105\/AJPH.92.11.1809","article-title":"The relationship between periodontal disease attributes and Helicobacter pylori infection among adults in the United States","volume":"92","author":"BA Dye","year":"2002","journal-title":"Am J Public Health"},{"issue":"Suppl 1","key":"pone.0225247.ref050","doi-asserted-by":"crossref","first-page":"e12515","DOI":"10.1111\/hel.12515","article-title":"Diagnosis of Helicobacter pylori infection","volume":"23","author":"S Skrebinska","year":"2018","journal-title":"Helicobacter"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0225247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:51:16Z","timestamp":1695505876000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0225247"}},"subtitle":[],"editor":[{"given":"David M.","family":"Ojcius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,12,11]]},"references-count":50,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,12,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0225247","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,11]]}}}